Hydrolases

Hydrolases can be considered as a special class of transferases in which the donor group is transferred to water. The generalized reaction involves the hydrolytic cleavage of C-O, C-N, O-P and C-S bonds. This large group of enzymes is within the E.C. 3 class and also includes esterases, phosphatases, proteases, glycosylases and GTPases.

Hydrolase Target Files

Ceramidases (View All) Ceramidase Inhibitors	Lysosomal Acid Lipase (LIPA) Lysosomal Acid Lipase Inhibitors
Fatty Acid Amide Hydrolase (FAAH) Fatty Acid Amide Hydrolase Inhibitors Fatty Acid Amide Hydrolase Substrates	Monoacylglycerol Lipase Monoacylglycerol Lipase Inhibitors
Glutaminase (Glutaminase, GLS2) Glutaminase Inhibitors	MTH1 (MTH1) MTH1 Inhibitors
Leukotriene A₄ Hydrolase (LTA4H) Leukotriene A₄ Hydrolase Inhibitors	Poly(ADP-ribose) Glycohydrolase (PARG) PARG Inhibitors

Related Targets

Esterases Esterase Products	PFKFB3 (PFKFB3) PFKFB3 Inhibitors
Glycosylases Glycosylase Activators Glycosylase Inhibitors	Phosphatases Phosphatases and Regulators
GTPases GTPase Products	Proteases Proteases & Other Enzymes
Other Hydrolases Hydrolase Inhibitors Other Hydrolase Degraders