Platelet GP Adhesion Protein Signaling

Overview of Platelet Signaling Through GP Adhesion Proteins

The GP family of glycoproteins mediate the initial adhesion of platelets to the endothelium. They interact with several ECM molecules at sites of endothelial damage and also with circulating soluble factors. GP adhesion proteins associate in cis with other platelet surface molecules and initiate intracellular signaling that leads to the activation of Src family kinases, PLC gamma, PKC, PI-3 Kinase, and eNOS. GP signaling induces platelet granule release, integrin activation, and production of thromboxane A2.