Resting Platelet Adhesion Receptors and GPCRs

Overview of Adhesion Receptors and GPCRs on Resting Platelets

Platelets express multiple surface proteins for adhesion to damaged vascular endothelium or to leukocytes such as monocytes and neutrophils. These include the GP family of glycoproteins, integrin heterodimers, and many others. Integrins are expressed in an inactive conformation that does not support robust adhesion until they become activated during the platelet activation process. Platelets also express G protein-coupled receptors (GPCR) that contribute to activation in response to small molecules such as thromboxanes, prostaglandins, purines, nicotinic and adrenergic ligands, adenosine, and 5-HT (serotonin).