Resting Platelet Adhesion Receptors and GPCRs

Adhesion Proteins
Adhesion Proteins
GPIb
GPIb
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GPIX/CD42a
GPIX/CD42a
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Glycoprotein V/CD42d
Glycoprotein V/CD42d
GPIIa
GPIIa
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GPIIIb
GPIIIb
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Fc epsilon R gamma/FCER1G
Fc epsilon R gamma/FCER1G
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GPVI
GPVI
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G6b
G6b
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Integrin alpha 2 beta 1
Integrin alpha 2 beta 1
Integrin alpha 5 beta 1
Integrin alpha 5 beta 1
Integrin alpha 6 beta 1
Integrin alpha 6 beta 1
Integrin alpha 2b beta 3
Integrin alpha 2b beta 3
Integrin alpha V beta 3
Integrin alpha V beta 3
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CD9
CD9
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CD31/PECAM-1
CD31/PECAM-1
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CD36/SR-B3
CD36/SR-B3
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CD151
CD151
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CEACAM-1/CD66a
CEACAM-1/CD66a
CLEC-2
CLEC-2
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ESAM
ESAM
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ICAM-1,2
ICAM-1,2
PSGL-1/CD162
PSGL-1/CD162
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TSPAN9
TSPAN9
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GPCRs
GPCRs
GPR92
GPR92
SUCNR1/GPR91
SUCNR1/GPR91
5-HT2A,4
5-HT2A,4
alpha-2 Adrenergic R
alpha-2 Adrenergic R
Adenosine A2a, A2b, R
Adenosine A2a, A2b, R
Nicotinic Acetylcholine R
alpha 7
Nicotinic Acetylcholine R
alpha 7
Nicotinic Acetylcholine R
beta 2
Nicotinic Acetylcholine R
beta 2
P2Y1,12
P2Y1,12
P2X1/P2RX1
P2X1/P2RX1
DP1/PTGDR
DP1/PTGDR
PTGER2,3,4
PTGER2,3,4
PTGIR
PTGIR
Thromboxane A2 R
Thromboxane A2 R
Alternative Names for Adhesion Proteins
Alternative Names for Adhesion Proteins
GPIa
GPIa
GPIIa
GPIIa
GPIIIb
GPIIIb
CD49b
CD49b
CD29
CD29
CD36
CD36
Integrin alpha 2
Integrin alpha 2
Integrin beta 1
Integrin beta 1
SR-B3
SR-B3

Overview of Adhesion Receptors and GPCRs on Resting Platelets

Platelets express multiple surface proteins for adhesion to damaged vascular endothelium or to leukocytes such as monocytes and neutrophils. These include the GP family of glycoproteins, integrin heterodimers, and many others. Integrins are expressed in an inactive conformation that does not support robust adhesion until they become activated during the platelet activation process. Platelets also express G protein-coupled receptors (GPCR) that contribute to activation in response to small molecules such as thromboxanes, prostaglandins, purines, nicotinic and adrenergic ligands, adenosine, and 5-HT (serotonin).

Resting Platelet Adhesion Receptors and GPCRs background image 1