Platelet Adhesion Proteins and Ligands

Activated Integrin
alpha 2 beta 1
Activated Integrin
alpha 2 beta 1
Activated Integrin
alpha 2b beta 3
Activated Integrin
alpha 2b beta 3
Activated Integrin
alpha 5 beta 1
Activated Integrin
alpha 5 beta 1
Activated Integrin
alpha 6 beta 1
Activated Integrin
alpha 6 beta 1
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GPVI
GPVI
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FCER1G
FCER1G
GPIb
GPIb
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GPIX
GPIX
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Glycoprotein V
Glycoprotein V
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G6b
G6b
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CLEC-2
CLEC-2
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CD36/SR-B3/
GPIIIb
CD36/SR-B3/
GPIIIb
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P-Selectin/
CD62P
P-Selectin/
CD62P
CD40 Ligand/
TNFSF5
CD40 Ligand/
TNFSF5
Ligands of Activated
Adhesion Proteins
Ligands of Activated
Adhesion Proteins
Collagen
Collagen
C1q
C1q
Decorin
Decorin
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E-Cadherin
E-Cadherin
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Laminin
Laminin
Fibrinogen
Fibrinogen
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Fibronectin
Fibronectin
Plasminogen
Plasminogen
Prothrombin
Prothrombin
Thrombospondin
Thrombospondin
Vitronectin
Vitronectin
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Fibronectin
Fibronectin
Laminin
Laminin
Collagen
Collagen
Collagen
Collagen
Factor XI, XII
Factor XI, XII
Kininogen
Kininogen
P-Selectin
P-Selectin
Thrombin
Thrombin
vWF-A2
vWF-A2
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Heparin
Heparin
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Podoplanin
Rhodocytin
Podoplanin
Rhodocytin
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Thrombospondin
Thrombospondin
PSGL-1/CD162
PSGL-1/CD162
CD40/TNFRSF5
CD40/TNFRSF5
Extracellular matrix molecules are exposed in damaged vascular endothelium.
Extracellular matrix molecules are exposed in damaged vascular endothelium.
Platelet adhesion to endothelium is stabilized by activated integrin binding.
Platelet adhesion to endothelium is stabilized by activated integrin binding.
Ligands are expressed on leukocytes.
Ligands are expressed on leukocytes.
Adhesion does not require interaction with vasculature.
Adhesion does not require interaction with vasculature.
Interaction promotes leukocyte activation.
Interaction promotes leukocyte activation.

Overview of Platelet Adhesion Proteins and Ligands

Platelets adhere to the vascular endothelium at sites of endothelial injury where extracellular matrix (ECM) components in the sub-endothelial space are exposed to the circulation. GP family glycoproteins mediate rapid tethering to ECM molecules at these sites. Integrin heterodimers become activated and then provide robust platelet adhesion. Adhesion is an early phase of platelet activation and limits bleeding by promoting platelet aggregation and clot formation (thrombosis). Circulating molecules, such as vWF-A2 and Thrombospondin also contribute to platelet aggregate formation. In addition, platelets can form circulating aggregates with monocytes and leukocytes to enhance systemic inflammatory responses.

Platelet Adhesion Proteins and Ligands background image 1