Platelet Activation Overview

Extracellular Matrix
Extracellular Matrix
Collagen
Collagen
Fibronectin
Fibronectin
Laminin
Laminin
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Vitronectin
Vitronectin
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Vascular Endothelium
Vascular Endothelium
Endothelial
Injury
Endothelial
Injury
Healthy Endothelium
Healthy Endothelium
Integrins
Integrins
Integrin alpha 2b
beta 3
Integrin alpha 2b
beta 3
activation
activation
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Integrin alpha 2b
beta 3
Integrin alpha 2b
beta 3
Rap1
Rap1
RIAM
RIAM
LAT
LAT
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PI 3-K
PI 3-K
PKC
PKC
Src
Src
GP Adhesion
Proteins
GP Adhesion
Proteins
GPIb,IX,V
GPIb,IX,V
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GPVI
GPVI
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eNOS
eNOS
LAT
LAT
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PI 3-K
PI 3-K
PKC
PKC
Rap1
Rap1
RIAM
RIAM
Src
Src
G Protein
Coupled Receptors
G Protein
Coupled Receptors
P2Y1,12
P2Y1,12
PAR1,3,4
PAR1,3,4
5-HT2A,4
5-HT2A,4
Thromboxane A2 R
Thromboxane A2 R
PI 3K
PI 3K
PKC
PKC
PLC
PLC
Rap1
Rap1
RIAM
RIAM
Src
Src
Inhibitory
Receptors
Inhibitory
Receptors
CD31/PECAM-1
CD31/PECAM-1
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G6b
G6b
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PTGIR
PTGIR
PKA
PKA
PKG
PKG
Immune
Receptors
Immune
Receptors
CCR1,2,3,4
CCR1,2,3,4
CX3CR1
CX3CR1
CXCR4,6
CXCR4,6
CD40 Ligand
CD40 Ligand
Fc gamma RIIA
Fc gamma RIIA
IGF-I R
IGF-I R
PDGF R alpha
PDGF R alpha
PDGF R beta
PDGF R beta
P-Selectin
P-Selectin
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RAGE
RAGE
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TLR1,2,4,6
TLR1,2,4,6
Alpha Granule
Alpha Granule
Dense Granule
Dense Granule
Lysosome
Lysosome
Coagulation regulators
Coagulation regulators
Inflammatory mediators
Inflammatory mediators
Wound healing factors
Wound healing factors
Bioactive amines
Bioactive amines
Polyphosphates
Polyphosphates
Purines
Purines
Glycosidases
Glycosidases
Proteases
Proteases
Calcium release
Calcium release
Integrin activation
Integrin activation
Granule release
Granule release
Thromboxane A2 production
Thromboxane A2 production

Overview of Platelet Activation

Platelet activation encompasses a complex and very rapid series of processes that are critical for hemostasis and inflammation. Resting platelets express many cell surface receptors which respond to ligands generated or exposed during inflammation and damage to the vascular endothelium. Activated platelets promote clot formation (thrombosis), broaden inflammatory responses, and contribute to wound healing. Impaired platelet activation can lead to uncontrolled bleeding. Pathological activation of platelets is characteristic of several diseases (e.g. atherosclerosis, stroke, hypertension, and deep vein thrombosis) and is a common target of anti-thrombotic treatment for these patients.

Platelet Activation Overview background image 1