Platelet GP Adhesion Protein Signaling

Granule
Release
Granule
Release
DEP-1/CD148
DEP-1/CD148
CLEC-2
CLEC-2
Src
Src
GPIb-IX-V
GPIb-IX-V
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Src
Src
Lyn
Lyn
FCER1G
FCER1G
Syk
Syk
Complex
Formation
Complex
Formation
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LAT
LAT
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BTK
BTK
PLC-gamma
PLC-gamma
Vav-1
Vav-1
ProductsClose
SLP-76
SLP-76
ProductsClose
IP3
IP3
DAG
DAG
Calcium Release
Calcium Release
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PKC alpha
PKC beta
PKC alpha
PKC beta
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CalDAG-GEFI
CalDAG-GEFI
RIAM
RIAM
Rap1
Rap1
Integrin
Activation
Integrin
Activation
Lyn
Lyn
Fyn
Fyn
PI 3-Kinase
PI 3-Kinase
FCER1G
FCER1G
Syk
Syk
ProductsClose
GPVI
GPVI
ProductsClose
Lyn
Lyn
Fyn
Fyn
DEP-1/CD148
DEP-1/CD148
Complex
Formation
Complex
Formation
Rap1B
Rap1B
Integrin
Activation
Integrin
Activation
MAPK
MAPK
ProductsClose
PLA2G4A
PLA2G4A
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Thromboxane Synthase
Thromboxane Synthase
Thromboxane A2
Production
Thromboxane A2
Production
Akt
Akt
eNOS
eNOS
Soluble
Guanylyl
Cyclase
Soluble
Guanylyl
Cyclase
cGMP
cGMP
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PKG
PKG
MAPK
MAPK
ERK1/2
ERK1/2
Granule
Release
Granule
Release

Overview of Platelet Signaling Through GP Adhesion Proteins

The GP family of glycoproteins mediate the initial adhesion of platelets to the endothelium. They interact with several ECM molecules at sites of endothelial damage and also with circulating soluble factors. GP adhesion proteins associate in cis with other platelet surface molecules and initiate intracellular signaling that leads to the activation of Src family kinases, PLC gamma, PKC, PI-3 Kinase, and eNOS. GP signaling induces platelet granule release, integrin activation, and production of thromboxane A2.

Platelet GP Adhesion Protein Signaling background image 1