Platelet Activating GPCR Signaling

Overview of Platelet Signaling Through Activating GPCRs

G protein-coupled receptors (GPCR) enahance platelet activation in response to 5-HT (serotonin), the purines ADP and ATP, prostaglandin E2, thromboxane A2, adenosine, norepinephrine, and thrombin. GPCR signaling leads to the activation of G proteins, Src familiy kinases, PKC, and PI-3 Kinase. GPCR signaling induces platelet granule release, integrin activation, and production of thromboxane A2. Pharmacologic blockade of the P2Y12 receptor is a key component of anti-thrombotic treatment.