Platelet Activated Integrin alpha 2b beta 3 Signaling

Activation
Activation
Inactive Integrin
alpha 2b beta 3
Inactive Integrin
alpha 2b beta 3
RIAM
RIAM
Rap1
Rap1
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FERMT3
FERMT3
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Talin1
Talin1
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LAT
LAT
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PLC-gamma
PLC-gamma
BTK
BTK
Vav-1
Vav-1
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SLP-76
SLP-76
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IP3
IP3
DAG
DAG
Calcium Release
Calcium Release
PKC alpha
PKC beta
PKC alpha
PKC beta
CalDAG-GEFI
CalDAG-GEFI
Granule
Release
Granule
Release
RIAM
RIAM
Rap1
Rap1
Integrin
Activation
Integrin
Activation
Lyn
Lyn
Fyn
Fyn
PI 3-Kinase
PI 3-Kinase
Rap1B
Rap1B
Integrin
Activation
Integrin
Activation
MAPK
MAPK
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PLA2G4A
PLA2G4A
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Thromboxane Synthase
Thromboxane Synthase
Thromboxane A2
Production
Thromboxane A2
Production
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CD151
CD151
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Active Integrin
alpha 2b beta 3
Active Integrin
alpha 2b beta 3
Src
Src
Csk
Csk
Lyn
Lyn
Fyn
Fyn
G alpha 13
G alpha 13
Complex
Formation
Complex
Formation
DEP-1/CD148
DEP-1/CD148
Fc gamma RIIA/CD32a
Fc gamma RIIA/CD32a
Syk
Syk
Inflammatory
Signaling
Inflammatory
Signaling
Also Recruited to Activated Integrins:
Also Recruited to Activated Integrins:
FAK
FAK
PYK2/FAK2
PYK2/FAK2
Myosin Light Chain 1
Myosin Light Chain 1
Paxillin
Paxillin
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Vinculin
Vinculin
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alpha-Actinin 1
alpha-Actinin 1

Overview of Platelet Signaling Through Activated Integrin α2bβ3

Integrin heterodimers are expressed on resting platelets in inactive conformations. They become activated by the recruitment of a RIAM-Rap1 containing protein complex in response to signaling from GP glycoproteins, GPCRs, and integrins themselves. Of the various integrin heterodimers expressed on platelets, Integrin α2bβ3 plays a primary role in platelet activation. Integrin α2bβ3 signaling leads to the activation of Src family kinases, PLC gamma, PKC, and PI-3 Kinase as well as the activation of proinflammatory signaling pathways. Integrin α2bβ3 signaling induces platelet granule release, integrin activation, and production of thromboxane A2.

Platelet Activated Integrin alpha 2b beta 3 Signaling background image 1