Platelet Activated Integrin alpha 2b beta 3 Signaling

Overview of Platelet Signaling Through Activated Integrin α2bβ3

Integrin heterodimers are expressed on resting platelets in inactive conformations. They become activated by the recruitment of a RIAM-Rap1 containing protein complex in response to signaling from GP glycoproteins, GPCRs, and integrins themselves. Of the various integrin heterodimers expressed on platelets, Integrin α2bβ3 plays a primary role in platelet activation. Integrin α2bβ3 signaling leads to the activation of Src family kinases, PLC gamma, PKC, and PI-3 Kinase as well as the activation of proinflammatory signaling pathways. Integrin α2bβ3 signaling induces platelet granule release, integrin activation, and production of thromboxane A2.