Platelet Activation Inhibitory Signaling

Integrin alpha 2b beta 3
GPVI
CLEC-2
Integrin alpha 2b beta 3
GPVI
CLEC-2
Src
Src
Csk
Csk
Lyn
Lyn
Fyn
Fyn
SHIP
SHIP
CD31/
PECAM-1
CD31/
PECAM-1
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G6b
G6b
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Shp1,2
Shp1,2
PI 3-Kinase
PI 3-Kinase
PLC-gamma
PLC-gamma
alpha-2 Adrenergic R
P2Y12
PTGER3
alpha-2 Adrenergic R
P2Y12
PTGER3
G alpha i
G alpha i
PTGER2,4
PTGIR
Adenosine A2a,A2b R
VIP R1/VPAC1
PTGER2,4
PTGIR
Adenosine A2a,A2b R
VIP R1/VPAC1
G alpha s
G alpha s
PTGER3
PTGER3
G alpha z
G alpha z
Adenylyl Cyclase
Adenylyl Cyclase
cAMP
cAMP
AMP
AMP
PKA
PKA
Phosphodiesterase 2,3
Phosphodiesterase 2,3
Caldesmon
Caldesmon
Filamin A
Filamin A
G alpha 13
G alpha 13
GPIb
GPIb
HSP27
HSP27
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IP3 Receptor
IP3 Receptor
LASP
LASP
MAPK
MAPK
Phosphodiesterase 3A
Phosphodiesterase 3A
Rap1
Rap1
Rap1GAP2
Rap1GAP2
TRPC6
TRPC6
VASP
VASP
Nitric Oxide
Nitric Oxide
L-Arginine
L-Arginine
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eNOS
eNOS
Citrulline
Citrulline
Nitric Oxide
Nitric Oxide
Soluble
Guanylyl
Cyclase
Soluble
Guanylyl
Cyclase
cGMP
cGMP
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GMP
GMP
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Phosphodiesterase 5A
Phosphodiesterase 5A
PKG
PKG
HSP27
HSP27
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IP3 Receptor
IP3 Receptor
LASP
LASP
Myosin Light
Chain Kinase
Myosin Light
Chain Kinase
MAPK
MAPK
PI 3-Kinase
PI 3-Kinase
Phosphodiesterase 5A
Phosphodiesterase 5A
Rap1
Rap1
Rap1GAP2
Rap1GAP2
Thromboxane A2 R
Thromboxane A2 R
TRPC6
TRPC6
VASP
VASP
Inhibition of
Inhibition of
Granule Release
Granule Release
Calcium Release
Calcium Release
Integrin Activation
Integrin Activation

Overview of Inhibitory Signaling in Platelets

Unrestricted platelet activation can lead to life threatening thrombosis. In order to maintain control of this process, multiple steps in the platelet activation are regulated by cell surface receptors that block activation signals and by receptors that induce both activating and inhibitory signaling. Healthy vascular endothelial cells release nitric oxide and prostaglandin I2 (prostacyclin) into the blood where they maintain platelet quiescence by blocking granule release and integrin activation.

Platelet Activation Inhibitory Signaling background image 1