Human IL-17RA/IL-17R Antibody (133621)

Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleotropic cytokine. IL-17 binds to IL-17 receptor A (IL-17 RA), also known as IL-17 receptor (IL-17 R). IL-17 RA shares no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, the IL-17 RA mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. Human IL-17 RA is a 120 kDa, 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy-proximal transmembrane domain, and a 525 aa cytoplasmic tail. Within the ECD, human IL-17 RA shares 72% aa sequence identity with mouse and rat IL-17 RA. The signaling events of IL-17 includes activation of NF-kappa B and JNK, and require TNF receptor-associated factors 6 (TRAF6) in the signaling pathway.