Human PI 3-Kinase p110 beta Antibody

Catalog # Availability Size / Price Qty
MAB2686
MAB2686-SP
Human PI 3-Kinase p110 beta  Antibody in Western Blot
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Product Details
Citations (2)
FAQs
Supplemental Products
Reviews (2)

Human PI 3-Kinase p110 beta Antibody Summary

Species Reactivity
Human
Specificity
Detects endogenous human PI 3-kinase p110 beta in Western blots.
Source
Monoclonal Mouse IgG2B Clone # 269020
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human PI 3-Kinase p110 beta
Met152-Val349
Accession # P42338
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Western Blot Detection of Human PI 3-Kinase p110 beta  by Western Blot. View Larger

Detection of Human PI 3-Kinase p110 beta by Western Blot. Western blot shows lysates of A431 human epithelial carcinoma cell line and Jurkat human acute T cell leukemia cell line. PVDF membrane was probed with 1 µg/mL of Human PI 3-Kinase p110 beta Monoclonal Antibody (Catalog # MAB2686) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PI 3-Kinase p110 beta at approximately 110 kDa (as indicated). This experiment was conducted using Immunoblot Buffer Group 1.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PI 3-Kinase p110 beta

Class IA phosphoinositide 3-kinases (PI 3-kinases) are a family of p85/p110 heterodimeric lipid kinases that function as signal transducers downstream of growth factor receptors, mainly receptor tyrosine kinases. Mammals express three class IA catalytic subunits: p110 alpha, p110 beta, and p110δ. Reports suggest that the p110 beta subunit may have special importance in promoting cell proliferation.

Long Name
Protein Tyrosine Phosphatase 1B
Entrez Gene IDs
5291 (Human)
Alternate Names
P110BETA; PI 3Kinase p110 beta; PI 3-Kinase p110 beta; PI3K; PI3KBETA; PIK3C1; PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; PIK3CB

Product Datasheets

Citations for Human PI 3-Kinase p110 beta Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. The PI3K subunits, P110&alpha and P110&beta are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer
    Authors: L Zhang, Y Li, Q Wang, Z Chen, X Li, Z Wu, C Hu, D Liao, W Zhang, ZS Chen
    Mol. Cancer, 2020;19(1):10.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  2. Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis.
    Authors: Matsuda N, Yamamoto S, Yokoo H, Tobe K, Hattori Y
    Crit. Care Med., 2009;37(10):2791-9.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot

FAQs

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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Reviews for Human PI 3-Kinase p110 beta Antibody

Average Rating: 4 (Based on 2 Reviews)

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Human PI 3-Kinase p110 beta Antibody
By Anonymous on 02/07/2020
Application: MiAr Sample Tested: EDTA Plasma Species: Human

Antibody was printed on custom arrays and incubated with fluorescently labeled human EDTA plasma


Human PI 3-Kinase p110 beta Antibody
By Anonymous on 11/14/2018
Application: Microarrays Sample Tested: EDTA Plasma Species: Human