Detection of Human PI 3-Kinase p110 beta by Western Blot. Western blot shows lysates of A431 human epithelial carcinoma cell line and Jurkat human acute T cell leukemia cell line. PVDF membrane was probed with 1 µg/mL of Human PI 3‑Kinase p110 beta Monoclonal Antibody (Catalog # MAB2686) followed by HRP‑conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PI 3‑Kinase p110 beta at approximately 110 kDa (as indicated). This experiment was conducted using Immunoblot Buffer Group 1.
Preparation and Storage
Reconstitute at 0.5 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: PI 3-Kinase p110 beta
Class IA phosphoinositide 3-kinases (PI 3-kinases) are a family of p85/p110 heterodimeric lipid kinases that function as signal transducers downstream of growth factor receptors, mainly receptor tyrosine kinases. Mammals express three class IA catalytic subunits: p110 alpha, p110 beta, and p110δ. Reports suggest that the p110 beta subunit may have special importance in promoting cell proliferation.
Protein Tyrosine Phosphatase 1B
Entrez Gene IDs:
P110BETA; PI 3Kinase p110 beta; PI 3-Kinase p110 beta; PI3K; PI3KBETA; PIK3C1; PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; PIK3CB
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