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Cyclin-dependent Kinase Inhibitors Small Molecules and Peptides

What are Cyclins?

Cyclins are a heterogeneous family of proteins that have a common 100 amino acid sequence called the cyclin box. Their only cellular role is to activate CDKs, and their expression fluctuates throughout the cell cycle, dependent on the cell cycle phase they are involved in. There are several subfamilies of cyclins, and several 'orphan' cyclins for which no CDK binding partner has been identified.

CDK Structure & Localization

CDKs are constitutively expressed and range in size ...

PD 0332991 isethionate

Catalog #: 4786

Alternate Names:	Palbociclib
Chemical Name:	6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt
Purity:	≥98%

Chemical Name:	5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
Purity:	≥98%

Chemical Name:	(2R)-2-[[9-(Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol trihydrochloride
Purity:	≥98%

Chemical Name:	2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Purity:	≥98%

Chemical Name:	4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride
Purity:	≥98%

Alternate Names:	CYC 202,Seliciclib
Chemical Name:	(2R)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
Purity:	≥98%

Chemical Name:	N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
Purity:	≥95%

Chemical Name:	9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one
Purity:	≥98%

Alternate Names:	NG 60
Chemical Name:	(2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Purity:	≥98%

Alternate Names:	NG 95
Chemical Name:	(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Purity:	≥98%

Chemical Name:	(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl) (2,6-difluoro-4-methylphenyl)methanone
Purity:	≥97%

Alternate Names:	L 86-8275
Chemical Name:	2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
Purity:	≥98%

Chemical Name:	1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride
Purity:	≥98%

Chemical Name:	4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide
Purity:	≥98%

Chemical Name:	2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride
Purity:	≥98%

Chemical Name:	4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
Purity:	≥98%

Alternate Names:	BMS-387032
Chemical Name:	N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
Purity:	≥98%

Chemical Name:	3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
Purity:	≥98%

Chemical Name:	rel-N²-[(1R,2S)-2-Aminocyclohexyl]-N⁶-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine dihydrochloride
Purity:	≥98%

Chemical Name:	N⁵-(6-Aminohexyl)-3-(1-methylethyl)-N⁷-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride
Purity:	≥98%

Chemical Name:	[4-Amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)methanone
Purity:	≥98%

Cyclin-dependent Kinase Inhibitors Small Molecules and Peptides

What are Cyclins?

CDK Structure & Localization

PD 0332991 isethionate

Ro 3306

(R)-CR8

Ryuvidine

Senexin A

Roscovitine

YKL 5-124

Kenpaullone

Purvalanol A

Purvalanol B

Flavopiridol hydrochloride

PHA 767491 hydrochloride

NU 6140

(R)-DRF053 dihydrochloride

AZD 5438

SNS 032

CGP 60474

CGP 74514 dihydrochloride

BS 181 dihydrochloride

R 547

BMS 265246

CVT 313

THAL SNS 032

NVP 2

K 03861

Chemical Name:	2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol]
Purity:	≥98%

Chemical Name:	N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide
Purity:	≥98%

Chemical Name:	4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile
Purity:	≥97%

Alternate Names:	AUZ 454
Chemical Name:	N-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea
Purity:	≥98%