Mouse NKp46/NCR1 Antibody

Catalog # Availability Size / Price Qty
AF2225
AF2225-SP

Save Up to 40% on RUO Reagents with BIOSPRING24 (See Details)

Mouse NKp46/NCR1 Antibody Induces IFN-gamma  Secretion in Activated Mouse NK Cells.
5 Images
Product Details
Citations (32)
FAQs
Supplemental Products
Reviews (1)

Mouse NKp46/NCR1 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse NKp46/NCR1 in direct ELISAs and Western blots. In direct ELISAs, less than 15% cross-reactivity with recombinant human (rh) NKp46 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse NKp46/NCR1
Glu22-Asn255
Accession # Q8C567
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse NKp46/NCR1 Fc Chimera (Catalog # 2225-NK)
Flow Cytometry
2.5 µg/106 cells
See below
Immunohistochemistry
3-15 µg/mL
See below
Agonist Activity
0.4-2.4 µg/mL
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Agonist Activity Mouse NKp46/NCR1 Antibody Induces IFN-? Secretion antibody in Activated Mouse NK Cells. View Larger

Mouse NKp46/NCR1 Antibody Induces IFN-gamma Secretion in Activated Mouse NK Cells. Mouse NKp46/NCR1 Antigen Affinity-purified Polyclonal Antibody induces IFN-? secretion in mouse natural killer (NK) cells activated with 25 ng/mL Recombinant Mouse IL-2 (Catalog # 402-ML) and 25 ng/mL Recombinant Mouse IL-12 (Catalog # 419-ML), in a dose-dependent manner, as measured using the Quantikine Mouse IFN-? ELISA Kit (Catalog # MIF00). The ED50 for this effect is typically 0.4-2.4 µg/mL.

Flow Cytometry Detection of NKp46/NCR1 antibody in Mouse DX5/CD49b<SUP>+</SUP>Splenocytes antibody by Flow Cytometry. View Larger

Detection of NKp46/NCR1 in Mouse DX5/CD49b+Splenocytes by Flow Cytometry. Mouse DX5/CD49b+splenocytes were stained with Goat Anti-Mouse NKp46/NCR1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2225, filled histogram) or control antibody (Catalog # AB-108-C, open histogram), followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0108).

Immunohistochemistry NKp46/NCR1 antibody in Mouse Spleen by Immunohistochemistry (IHC-Fr). View Larger

NKp46/NCR1 in Mouse Spleen. NKp46/NCR1 was detected in perfusion fixed frozen sections of mouse spleen using Goat Anti-Mouse NKp46/NCR1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2225) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in lymphocytes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Immunocytochemistry/ Immunofluorescence Detection of Mouse NKp46/NCR1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse NKp46/NCR1 by Immunocytochemistry/Immunofluorescence IL-2/Anti-IL-2 Antibody Complex Treatment Triggers NK Cell-Dependent Acute Sensory Loss after Partial Sciatic Nerve Crush(A) Peripheral blood sampled 16 days post-injury in IL-2 complex or IgG control mice. NKp46+DX5+ NK cells (U = 15.00, p = 0.0019); CD3+CD8+ T cells (t = 15.78, p < 0.0001); CD3+CD4+ T cells (t = 9.719, p < 0.0001). Mann-Whitney or Student’s unpaired t test was used.(B) Daily pinprick response. Male wild-type C57BL/6 mice received partial crush of the sciatic nerve on day 0 followed by daily injection of IL-2 complex or IgG control (i.p.) for 4 consecutive days (arrows). Two-way ANOVA was used. Effect of treatment: F(1,315) = 20.69, p < 0.0001. Bonferroni post-test ∗∗p < 0.01 (t = 3.784), ∗∗∗p < 0.001 (t = 4.741).(C) Heatmap showing mean sensitivity to pinprick along the lateral hind paw. Note the broad loss of sensitivity at day 6 in IL-2-complex-treated mice.(D) Area under the curve measurements in IL-2-complex-treated and IgG control mice. Days 1–4: p = 0.9513, t = 0.06181; days 5–10: ∗∗∗p = 0.0083, t = 2.916; days 11–15: p = 0.4354, t = 0.7951. Student’s unpaired t test was used.(E) Effect of IL-2 complex treatment on NKp46-YFP+ cell infiltration to sciatic nerve 6 days after partial crush injury. Sciatic nerve sections (14 μm) were immunolabeled with anti-GFP and beta -tubulin III antibodies. Scale bars, 100 μm. Arrows indicate individual YFP+ cells.(F) Quantification of NKp46-YFP+ cells per square millimeter in images of different regions of the nerve. Two-way ANOVA: effect of IL-2 complex, F(1,16) = 56.31, p < 0.0001; effect of region, F(3,16) = 23.73, p < 0.0001. Bonferroni post-tests: crush, t = 8.062; distal, t = 6.414 ∗∗∗p < 0.001. ns, not significant. n = 3 sections per region, per mouse, per treatment.(G) Photograph of spleens isolated from mice 1 day after final injection of IgG or IL-2 complex.(H) Peripheral blood sampled 16 days post-injury in IL-2-complex-treated wild-type mice, which received either anti-NK1.1 antibody or isotype control. NKp46+DX5+ NK cells (t = 15.37, ∗∗∗p < 0.0001), CD3+CD8+ T cells (U = 22.00, p = 0.1473), and CD3+CD4+ T cells (t = 3.035, p = 0.0079). Student’s unpaired t test was used.(I) Loss of NKp46-YFP+ cells from peripheral blood in anti-NK1.1-antibody-treated mice. Student’s unpaired t test, t = 15.51, ∗∗∗p = 0.0001.(J) Wild-type mice received either anti-NK1.1 to deplete NK cells or isotype control antibody followed by partial crush of the sciatic nerve on day 0. All mice were treated with IL-2 antibody complex (arrows). Two-way ANOVA. Effect of antibody depletion: F(1,240) = 21.21, p < 0.0001. Bonferroni post-test, ∗∗∗p < 0.001 (t = 4.542).(K) Heatmap showing mean sensitivity to pinprick along the lateral hind paw. Note the broad loss of sensitivity at day 6 in isotype control mice.(L) Area under the curve measurements in isotype control and anti-NK1.1-treated mice following IL-2 complex treatment. days 1–4: t = 0.1508, p = 0.8815; days 5–10: t = 2.390, p = 0.0295; days 11–15: t = 1.040, p = 0.3130). Student’s unpaired t test was used.See also Figure S5. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/30712871), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse NKp46/NCR1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse NKp46/NCR1 by Immunocytochemistry/Immunofluorescence Acutely Cultured Embryonic but Not Adult DRG Neurons Reveal Susceptibility to NK-Mediated Cytotoxicity by RAE1(A) Immunolabeling of co-culture (4 h) between embryonic (top) or adult (bottom) DRG neurons ( beta -tubulin, magenta) and either freshly isolated (control) or IL-2-stimulated natural killer (NK) cells (NKp46, green). The inset shows a high-magnification image of NK cell in contact with embryonic DRG neurite.(B) LDH-release cytotoxicity assay of acutely cultured (1 day in vitro) embryonic (top) and adult (bottom) DRG at various Effector (NK):Target (DRG) (E:T) ratios. Matched two-way ANOVA: embryonic DRG, F(1,10) = 100.01, p < 0.0001); adult DRG, F(1,10) = 1.25, p = 0.2982). Three replicate co-cultures for each DRG group.(C) Still images of in vitro time-lapse confocal Ca2+ imaging of rhodamine 3 AM-loaded embryonic (top) and adult (bottom) DRG (magenta) co-cultured with IL-2-stimulated NK cells (green) isolated from adult male NKp46-YFP mice.(D) Frequency histogram (30 s time bins) of neurite Ca2+ events in embryonic (top) and adult (bottom) DRG during NK co-culture. Cumulative area under the curve (right). Student’s paired t test; t = 2.290, p = 0.045. n = 6 fields of view from two repeat co-cultures per group.(E) RT-PCR of mRNA transcripts in freshly isolated splenic NK cells and embryonic and adult DRG.(F) qRT-PCR shows higher Raet1 mRNA expression in embryonic compared to adult DRG tissue. Student’s paired t test; t = 16.16, p < 0.0001. n = 5 mice, or replicates per group.(G) Western blot of embryonic and adult mouse DRG tissue (40 μg loading) with pan-RAE1 antibody and beta -actin control. Images are representative of three independent experiments.(H) Selective siRNA knockdown reduces RAE1 protein (top) and Raet1 mRNA (bottom) expression in embryonic DRG (2 d culture). Student’s unpaired t test; t = 9.060, p = 0.0008. n = 3 mice, or replicates per group.(I) LDH-release cytotoxicity assay of negative control or Raet1-selective siRNA knockdown embryonic DRG. Three replicate co-cultures for each siRNA group. Matched two-way ANOVA F(1,10) = 133.85, p < 0.0001).See also Figure S1. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/30712871), licensed under a CC-BY license. Not internally tested by R&D Systems.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Loading...
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: NKp46/NCR1

NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR) (1). These receptors are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. In human systems, the CD56dimCD16+ subpopulation that makes up the majority of NK cells in the peripheral blood and spleen expresses NKp46 in both resting and activated states (2). The main NK cell population of the lymph node (CD56brightCD16-) expresses low levels of NKp46 in resting cells, but expression is upregulated by IL-2. Mouse NKp46, also known as MAR-1 (3), is a type I transmembrane protein with two extracellular Ig-like domains. It has a positive charge in its transmembrane domain that permits association with the ITAM-bearing signal adapter proteins, CD3 zeta and Fc epsilon RI gamma (4). Studies with neutralizing antibodies indicate that the three NCR are primarily responsible for triggering the NK-mediated lysis of many human tumor cell lines. Blocking any of the NCRs individually resulted in partial inhibition of tumor cell lysis, but nearly complete inhibition of lysis was observed if all three receptors were blocked simultaneously (5). NKp46 has also been implicated in recognition of virus-infected cells through its capacity to bind to viral hemagglutinins (6-8).

References
  1. Moretta, L. and A. Moretta (2004) EMBO J. 23:255.
  2. Ferlazzo, G. et al. (2004) J. Immunol. 172:1455.
  3. Biassoni, R. et al. (1999) Eur. J. Immunol. 29:1014.
  4. Westgaard, I. et al. (2004) J. Leukoc. Biol. PMID 15356098.
  5. Pende, D. et al. (1999) J. Exp. Med. 190:1505.
  6. Arnon, T. et al. (2004) Blood 103:664.
  7. Arnon, T. et al. (2001) Eur. J. Immunol. 31:2680.
  8. Mandelboim, O. et al. (2001) Nature 409:1055.
Entrez Gene IDs
9437 (Human); 17086 (Mouse); 100141419 (Porcine); 102115479 (Cynomolgus Monkey)
Alternate Names
CD335 antigen; CD335; hNKp46; Ly94; LY94lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); Lymphocyte antigen 94 homolog; MAR-1; natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; NCR1; NK cell-activating receptor; NKp46; NKP46FLJ99094; NK-p46lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46)

Product Datasheets

You must select a language.

x

Citations for Mouse NKp46/NCR1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

32 Citations: Showing 1 - 10
Filter your results:

Filter by:

  1. An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
    Authors: B Xu, L Tian, J Chen, J Wang, R Ma, W Dong, A Li, J Zhang, E Antonio Ch, B Kaur, M Feng, MA Caligiuri, J Yu
    Nature Communications, 2021-10-08;12(1):5908.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  2. Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition
    Authors: WN Jin, K Shi, W He, JH Sun, L Van Kaer, FD Shi, Q Liu
    Nature Neuroscience, 2020-11-30;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  3. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation
    Authors: FM Kobia, K Preusse, Q Dai, N Weaver, MR Hass, P Chaturvedi, SJ Stein, WS Pear, Z Yuan, RA Kovall, Y Kuang, N Eafergen, D Sprinzak, B Gebelein, EW Brunskill, R Kopan
    PLoS Biol, 2020-10-05;18(10):e3000850.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  4. Corneal dysfunction precedes the onset of hyperglycemia in a mouse model of diet-induced obesity
    Authors: A Hargrave, JA Courson, V Pham, P Landry, S Magadi, P Shankar, S Hanlon, A Das, RE Rumbaut, CW Smith, AR Burns
    PLoS ONE, 2020-09-04;15(9):e0238750.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  5. Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR-cMet Bispecific Antibody, in Diverse Models of EGFR Exon 20 Insertion-Driven NSCLC
    Authors: J Yun, SH Lee, SY Kim, SY Jeong, JH Kim, KH Pyo, CW Park, SG Heo, MR Yun, S Lim, SM Lim, MH Hong, HR Kim, M Thayu, JC Curtin, RE Knoblauch, MV Lorenzi, A Roshak, BC Cho
    Cancer Discov, 2020-05-15;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  6. Forced expression of CXCL10 prevents liver metastasis of colon carcinoma cells by the recruitment of natural killer cells
    Authors: N Kikuchi, J Ye, J Hirakawa, H Kawashima
    Biol. Pharm. Bull., 2018-11-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice
    Authors: S Nishina, A Yamauchi, T Kawaguchi, K Kaku, M Goto, K Sasaki, Y Hara, Y Tomiyama, F Kuribayash, T Torimura, K Hino
    Cell Mol Gastroenterol Hepatol, 2018-09-11;7(1):115-134.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  8. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization
    Authors: EE Er, M Valiente, K Ganesh, Y Zou, S Agrawal, J Hu, B Griscom, M Rosenblum, A Boire, E Brogi, FG Giancotti, M Schachner, S Malladi, J Massagué
    Nat. Cell Biol., 2018-07-23;20(8):966-978.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer
    Authors: KB Singh, X Ji, SV Singh
    Mol. Cancer Ther., 2018-07-20;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Preclinical, non-genetic models of lung adenocarcinoma: a comparative survey
    Authors: F Janker, W Weder, JH Jang, W Jungraithm
    Oncotarget, 2018-07-17;9(55):30527-30538.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  11. Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment.
    Authors: A Martin, C Seignez, C Racoeur, N Isambert, Isambert N, N Mabrouk, Mabrouk N, A Scagliarin, Scagliarini A, S Reveneau, Reveneau S, L Arnould, Arnould L, A Bettaieb, JF Jeannin, Jeannin J, C Paul
    Oncotarget, 2018-06-19;9(47):28364-28378.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. NKp46 Calibrates Tumoricidal Potential of Type 1 Innate Lymphocytes by Regulating TRAIL Expression
    Authors: G Turchinovi, S Ganter, A Bärenwaldt, D Finke
    J. Immunol., 2018-04-16;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. NK cell heparanase controls tumor invasion and immune surveillance
    Authors: EM Putz, AJ Mayfosh, K Kos, DS Barkauskas, K Nakamura, L Town, KJ Goodall, DY Yee, IK Poon, N Baschuk, F Souza-Fons, MD Hulett, MJ Smyth
    J. Clin. Invest., 2017-06-05;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  14. Dependence of Glomerulonephritis Induction on Novel Intraglomerular Alternatively Activated Bone Marrow-Derived Macrophages and Mac-1 and PD-L1 in Lupus-Prone NZM2328 Mice
    Authors: SJ Sung, Y Ge, C Dai, H Wang, SM Fu, R Sharma, YS Hahn, J Yu, TH Le, MD Okusa, WK Bolton, JR Lawler
    J. Immunol, 2017-02-20;0(0):.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC
  15. Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells
    Sci Rep, 2016-12-01;6(0):37996.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Functional Assay
  16. Murine liver-resident group 1 innate lymphoid cells regulate optimal priming of anti-viral CD8+ T cells
    J Leukoc Biol, 2016-08-04;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  17. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo
    Sci Rep, 2016-08-01;6(0):30636.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Functional Assay
  18. Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival
    Authors: W Rabacal, SK Pabbisetty, KL Hoek, D Cendron, Y Guo, D Maseda, E Sebzda
    Proc Natl Acad Sci USA, 2016-04-25;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  19. IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-gamma.
    Authors: Guo Y, Luan L, Rabacal W, Bohannon J, Fensterheim B, Hernandez A, Sherwood E
    J Immunol, 2015-07-27;195(5):2353-64.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  20. NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery.
    Authors: Spada R, Rojas J, Perez-Yague S, Mulens V, Cannata-Ortiz P, Bragado R, Barber D
    J Leukoc Biol, 2015-01-12;97(3):583-98.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC, IHC-P
  21. Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke.
    Authors: Mracsko E, Liesz A, Stojanovic A, Lou W, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R
    J Neurosci, 2014-12-10;34(50):16784-95.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. BCMab1, a monoclonal antibody against aberrantly glycosylated integrin alpha3beta1, has potent antitumor activity of bladder cancer in vivo.
    Authors: Li C, Yang Z, Du Y, Tang H, Chen J, Hu D, Fan Z
    Clin Cancer Res, 2014-07-07;20(15):4001-13.
    Species: Mouse
    Sample Types:
  23. Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure.
    Authors: Stolberg V, Martin B, Mancuso P, Olszewski M, Freeman C, Curtis J, Chensue S
    Am J Pathol, 2013-12-09;184(2):454-63.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  24. TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.
    Authors: Biroccio A, Cherfils-Vicini J, Augereau A, Pinte S, Bauwens S, Ye J, Simonet T, Horard B, Jamet K, Cervera L, Mendez-Bermudez A, Poncet D, Grataroli R, de Rodenbeeke C, Salvati E, Rizzo A, Zizza P, Ricoul M, Cognet C, Kuilman T, Duret H, Lepinasse F, Marvel J, Verhoeyen E, Cosset F, Peeper D, Smyth M, Londono-Vallejo A, Sabatier L, Picco V, Pages G, Scoazec J, Stoppacciaro A, Leonetti C, Vivier E, Gilson E
    Nat Cell Biol, 2013-06-23;15(7):818-28.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  25. Mechanisms of NK cell-macrophage Bacillus anthracis crosstalk: a balance between stimulation by spores and differential disruption by toxins.
    Authors: Klezovich-Benard M, Corre JP, Jusforgues-Saklani H, Fiole D, Burjek N, Tournier JN, Goossens PL
    PLoS Pathog., 2012-01-12;8(1):e1002481.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  26. Recognition and killing of human and murine pancreatic beta cells by the NK receptor NKp46.
    Authors: Gur C, Enk J, Kassem SA, Suissa Y, Magenheim J, Stolovich-Rain M, Nir T, Achdout H, Glaser B, Shapiro J, Naparstek Y, Porgador A, Dor Y, Mandelboim O
    J. Immunol., 2011-08-17;187(6):3096-103.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  27. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells.
    Authors: Eidenschenk C, Crozat K, Krebs P, Arens R, Popkin D, Arnold CN, Blasius AL, Benedict CA, Moresco EM, Xia Y, Beutler B
    Proc. Natl. Acad. Sci. U.S.A., 2010-05-10;107(21):9759-64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Functional Assay
  28. Distinct phenotype and function of NK cells in the pancreas of nonobese diabetic mice.
    Authors: Brauner H, Elemans M, Lemos S, Broberger C, Holmberg D, Flodstrom-Tullberg M, Karre K, Hoglund P
    J. Immunol., 2010-02-03;184(5):2272-80.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Functional Assay, IHC
  29. T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice.
    Authors: Strissel KJ, DeFuria J, Shaul ME, Bennett G, Greenberg AS, Obin MS
    Obesity (Silver Spring), 2010-01-28;18(10):1918-25.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  30. Mouse ChemR23 is expressed in dendritic cell subsets and macrophages, and mediates an anti-inflammatory activity of chemerin in a lung disease model.
    Authors: Luangsay S, Wittamer V, Bondue B, De Henau O, Rouger L, Brait M, Franssen JD, de Nadai P, Huaux F, Parmentier M
    J. Immunol., 2009-10-19;183(10):6489-99.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  31. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.
    Authors: Kang SJ, Liang HE, Reizis B, Locksley RM
    Immunity, 2008-11-14;29(5):819-33.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  32. CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells.
    Authors: Vosshenrich CA, Lesjean-Pottier S, Hasan M, Richard-Le Goff O, Corcuff E, Mandelboim O, Di Santo JP
    J. Exp. Med., 2007-10-08;204(11):2569-78.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry

FAQs

No product specific FAQs exist for this product, however you may

View all Antibody FAQs
Loading...

Reviews for Mouse NKp46/NCR1 Antibody

Average Rating: 5 (Based on 1 Review)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Mouse NKp46/NCR1 Antibody?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Mouse NKp46/NCR1 Antibody
By Efstathios Stamatiades on 07/10/2019
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Salivary gland tissue Species: Mouse

PLP-fixed salivary gland cryosections were stained with anti NKp46/NCR1 for 4h at room temperature. After washing, the samples were stained with Donkey anti-goat alexa546 2ndary antibody for 1h at room temperature. NKp46 in red, CD3 in green & Hoechst in blue.