29 results for "Bromodomain Inhibitors" in Products
Bromodomain Inhibitors
Bromodomain Structure and Function
There are approximately 61 unique human Bromodomains. These protein modules have been identified in 42 proteins with diverse functions from the histone acetyltransferase (HAT) PCAF, which adds acetyl groups to lysine residues on histone tails, to the ATP-dependent helicase SNF2L2. This diversity has made it difficult to characterize the function of a given BRD-containing protein, particularly as some proteins may contain one or more additional epigenetic ...
Potent and selective BET bromodomain inhibitor; cell permeable
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester |
| Purity: | ≥98% |
BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes
| Chemical Name: | 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride |
| Purity: | ≥98% |
ERK5/BMK1 inhibitor; also BRD4 inhibitor
| Chemical Name: | 2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
| Purity: | ≥98% |
Potent and selective BRD9 inhibitor
| Chemical Name: | 5-Ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide |
| Purity: | ≥98% |
BET bromodomain inhibitor
| Chemical Name: | 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide |
| Purity: | ≥98% |
Broad spectrum bromodomain inhibitor
| Chemical Name: | N-[(6-3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate |
| Purity: | ≥98% |
Potent CBP/p300 BRD inhibitor
| Chemical Name: | 2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole |
| Purity: | ≥98% |
Potent and selective SMARCA2/4 and polybromo 1 inhibitor
| Chemical Name: | (2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one |
| Purity: | ≥98% |
Selective BAZ2 inhibitor
| Chemical Name: | 4-[4-(1-Methyl-1H-pyrazole-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]benzonitrile |
| Purity: | ≥98% |
BET bromodomain inhibitor; arrests cell cycle at G1 phase
| Alternate Names: | TEN 010 |
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% |
Potent and selective BRPF bromodomain inhibitor
| Chemical Name: | 4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-methoxybenzene-1-sulfonamide |
| Purity: | ≥98% |
Potent and selective BRD9 and BRD7 inhibitor; orally active
| Chemical Name: | 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one |
| Purity: | ≥98% |
Selective BRD7 and BRD9 inhibitor
| Chemical Name: | N-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide |
| Purity: | ≥98% |
Potent and selective CECR2 inhibitor
| Chemical Name: | N-Cyclopropyl-2-(propylsulfonyl)-6-(1-(2,2,6,6-tetramethylpiperidin-4-yl)-1H-indol-5-yl)pyrimidin-4-amine |
| Purity: | ≥98% |
Potent and selective BRD1 and TAF1 inhibitor
| Chemical Name: | 6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione |
| Purity: | ≥98% |
Potent BRD9/7 inhibitor
| Chemical Name: | 3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide |
| Purity: | ≥98% |
BET bromodomain inhibitor; orally bioavailable
| Alternate Names: | Birabresib |
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% |
Potent and selective BRPF1 inhibitor
| Chemical Name: | N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxybenzamide |
| Purity: | ≥98% |
High affinity and selective PCAF bromodomain inhibitor
| Chemical Name: | (1S, 2S)-N1,N1-Dimethyl-N2-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride |
| Purity: | ≥98% |
Potent and high affinity BET bromodomain inhibitor; anti-inflammatory; orally bioavailable.
| Alternate Names: | GSK525762A,Molibresib |
| Chemical Name: | (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide |
| Purity: | ≥98% |
CECR2 and BPTF/FALZ inhibitor
| Chemical Name: | N-[(3-(1H)-Pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine hydrochloride |
| Purity: | ≥98% |
TAF1 inhibitor
| Chemical Name: | N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide |
| Purity: | ≥98% |
Potent and selective pan-BD2 inhibitor; orally bioavailable
| Alternate Names: | GSK046 |
| Chemical Name: | 4-(Acetylamino)-3-fluoro-N-(trans-4-hydroxycyclohexyl)-5-[(1S)-1-phenylethoxy]benzamide |
| Purity: | ≥98% |
Potent and selective SMARCA2/4 and PB1(bromo 5)-selective SWI/SNF bromodomain inhibitor
| Chemical Name: | 1,1-Dimethylethyl 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylate bromodomains |
| Purity: | ≥98% |
Selective MLLT1/3 inhibitor
| Chemical Name: | N-[2-[[(2S)-2-Methyl-1-pyrrolidinyl]methyl]-1H-benzimidazol-6-yl]-6-isoquinolinecarboxamide |
| Purity: | ≥98% |
