30 results for "Compounds for Stem Cell Proliferation and Renewal Small Molecules and Peptides" in Products
Compounds for Stem Cell Proliferation and Renewal Small Molecules and Peptides
Pluripotent Stem Cell Maintenance
Proliferation and self-renewal of stem cells occurs via the division of a cell into two identical daughter cells, resulting in the production of cells identical to the parent. Unlike other cell types, such as muscle or blood cells, stem cells are able to replicate many times. Under the right conditions stem cells can continue to proliferate in culture over many months without differentiation and specialization, yielding millions of cells; this is known as ...
Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component
| Alternate Names: | y27632,Y-27632 2HCl,ROCK inhibitor,ROCK1 inhibitor |
| Chemical Name: | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
| Purity: | ≥98% |
Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
| Chemical Name: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
| Purity: | ≥99% |
Y-27632 synthesized to cGMP guidelines
| Chemical Name: | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
| Purity: | ≥99% |
SB 431542 synthesized to cGMP guidelines
| Chemical Name: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
| Purity: | ≥99% |
Selective inhibitor of TGF-βRI, ALK4 and ALK7
| Chemical Name: | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| Purity: | ≥98% |
Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin
| Alternate Names: | PGE2 |
| Chemical Name: | (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid |
| Purity: | ≥98% |
PORCN inhibitor; inhibits Wnt processing and secretion
| Chemical Name: | N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide |
| Purity: | ≥98% |
Selective inhibitor of p38 MAPK
| Alternate Names: | Adezmapimod |
| Chemical Name: | 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine |
| Purity: | ≥98% |
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
| Chemical Name: | 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride |
| Purity: | ≥99% |
MEK inhibitor
| Chemical Name: | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% |
Potent AMPK activator
| Chemical Name: | 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile |
| Purity: | ≥98% |
FGFR1 and -3 inhibitor
| Chemical Name: | N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea |
| Purity: | ≥98% |
Potent, selective GSK-3 inhibitor
| Chemical Name: | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% |
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis
| Chemical Name: | (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride |
| Purity: | ≥98% |
Potent GSK-3 inhibitor; also inhibits cdks
| Alternate Names: | 6BIO |
| Chemical Name: | (2'Z,3'E)-6-Bromoindirubin-3'-oxime |
| Purity: | ≥98% |
Potent pan-caspase inhibitor
| Chemical Name: | N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide |
| Purity: | ≥98% |
Minimal recognition sequence for integrin binding; potent integrin inhibitor
| Purity: | ≥95% |
Potent and selective Lck and Src inhibitor; also inhibits SIK
| Alternate Names: | KIN112 |
| Chemical Name: | 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate |
| Purity: | ≥98% |
Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo
| Chemical Name: | 5-(3-Methoxyphenoxy)-N2-[4-(1-methylethyl)phenyl]-2,4-quinazolinediamine hydrochloride |
| Purity: | ≥98% |
A 83-01 synthesized to Ancillary Material Grade
| Chemical Name: | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| Purity: | ≥98% |
Selective PPARγ agonist; antidiabetic agent
| Alternate Names: | Rezulin |
| Chemical Name: | 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione |
| Purity: | ≥98% |
Enhances survival of human ESCs following enzymatic dissociation
| Chemical Name: | N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide |
| Purity: | ≥98% |
DYRK1A/B inhibitor
| Chemical Name: | (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone |
| Purity: | ≥98% |
Heparin sulfate antagonist
| Chemical Name: | N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea dihydrochloride |
| Purity: | ≥98% |
R-Spondin-1 substitute used to initiate small intestinal organoids
| Chemical Name: | 3,7-Dihydro-3,7-dimethyl-8-(2-quinolinylthio)-1H-purine-2,6-dione |
| Purity: | ≥98% |
