Human/Mouse CXCL12/SDF-1 Antibody

Catalog # Availability Size / Price Qty
MAB350-SP
MAB350-100
MAB350-500
Human/Mouse CXCL12/SDF-1 Antibody in Data
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Product Details
Citations (71)
FAQs
Supplemental Products
Reviews (9)

Human/Mouse CXCL12/SDF-1 Antibody Summary

Species Reactivity
Human, Mouse
Specificity
Detects human and mouse CXCL12/SDF-1 alpha and CXCL12/SDF-1 beta in ELISAs.
Source
Monoclonal Mouse IgG1 Clone # 79018
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human CXCL12/SDF‑1 alpha
Lys22-Lys89
Accession # Q6ICW0
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunohistochemistry
8-25 µg/mL
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Dual RNAscope ISH-IHC
5-25 µg/mL
See below
Immunocytochemistry
8-15 µg/mL
See below
Intracellular Staining by Flow Cytometry
0.25 µg/106 cells
See below

Human/Mouse CXCL12/SDF-1 Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Human/Mouse CXCL12/SDF‑1 Biotinylated Antibody (Catalog # BAF310)

Standard: Recombinant Mouse CXCL12/SDF-1 alpha Protein (Catalog # 460-SD)

Standard: Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha (Catalog # 350-NS)

Human CXCL12/SDF-1 beta Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Human CXCL12/SDF‑1 beta Biotinylated Antibody (Catalog # BAF351)

Standard: Recombinant Human/Feline CXCL12/SDF-1 beta (aa 22-93) (Catalog # 351-FS)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Examples

Immunocytochemistry CXCL12/SDF‑1 in Human PBMCs and K562 Human Cell Line. View Larger

CXCL12/SDF‑1 in Human PBMCs and K562 Human Cell Line. CXCL12/SDF-1 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs; positive staining) and K562 human chronic myelogenous leukemia cell line (negative staining) using Mouse Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350) at 8 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cell membranes. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Immunohistochemistry CXCL12/SDF‑1 in Human Tonsil. View Larger

CXCL12/SDF‑1 in Human Tonsil. CXCL12/SDF‑1 was detected in immersion fixed paraffin-embedded sections of human tonsil using 15 µg/mL Human/Mouse CXCL12/SDF‑1 Monoclonal Antibody (Catalog # MAB350) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific labeling was localized to epithelial cells in cripts. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Immunohistochemistry CXCL12/SDF‑1 in Human Tonsil. View Larger

CXCL12/SDF‑1 in Human Tonsil. CXCL12/SDF‑1 was detected in immersion fixed paraffin-embedded sections of human tonsil using Human/Mouse CXCL12/SDF‑1 Monoclonal Antibody (Catalog # MAB350) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Intracellular Staining by Flow Cytometry Detection of CXCL12/SDF‑1 in HT1080 Human Cell Line by Flow Cytometry. View Larger

Detection of CXCL12/SDF‑1 in HT1080 Human Cell Line by Flow Cytometry. HT1080 human fibrosarcoma cell line was stained with Mouse Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). To facilitate intracellular staining, cells were fixed and permeabilized with FlowX FoxP3 Fixation & Permeabilization Buffer Kit (Catalog # FC012). View our protocol for Staining Intracellular Molecules.

Dual RNAscope ISH-IHC Compatible CXCL12/SDF‑1 alpha  in Human Tonsil Using Dual RNAscope<sup>®</sup>ISH and IHC. View Larger

CXCL12/SDF‑1 alpha in Human Tonsil Using Dual RNAscope®ISH and IHC. CXCL12/SDF-1a mRNA was detected in formalin-fixed paraffin-embedded tissue sections of human tonsil probed with ACD RNAScope®Probe (Catalog # 422991) and stained using ACD RNAscope®2.5 HD Detection Reagents-Red (top image, Catalog # 32260). Adjacent tissue section was processed for immunohistochemistry using R&D Systems Mouse Anti-Human CXCL12/SDF-1a Monoclonal Antibody (Catalog # MAB350) at 5 ug/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte HRP Polymer Antibody (R&D Systems, Catalog # VC001) and DAB chromogen (lower image, yellow-brown). Tissues were counterstained with hematoxylin (blue).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CXCL12/SDF-1

CXCL12, also known as SDF-1, is a CXC chemokine that interacts with CXCR4. SDF-1 alpha and SDF-1 beta are alternatively spliced isoforms of CXCL12. SDF-1 beta has an additional 4 amino acids at the carboxy-terminus.

Entrez Gene IDs
6387 (Human); 20315 (Mouse); 493806 (Feline); 574334 (Rhesus Macaque)
Alternate Names
chemokine (C-X-C motif) ligand 12; C-X-C motif chemokine 12; CXCL12; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF; PBSFSDF-1a; Pre-B cell growth-stimulating factor; SCYB12; SDF1; SDF-1; SDF1A; SDF1B; SDF1SDF-1b; stromal cell-derived factor 1; TLSF; TLSF-a; TLSF-b; TPAR1

Product Datasheets

Citations for Human/Mouse CXCL12/SDF-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

71 Citations: Showing 1 - 10
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  1. A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.
    Authors: Klink B, Miletic H, Stieber D, Huszthy P, Campos Valenzuela J, Balss J, Wang J, Schubert M, Sakariassen P, Sundstrom T, Torsvik A, Aarhus M, Mahesparan R, von Deimling A, Kaderali L, Niclou S, Schrock E, Bjerkvig R, Nigro J
    PLoS ONE, 3013;8(3):e59773.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  2. SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo
    Authors: CN Tsai, SC Yu, CW Lee, JS Pang, CH Wu, SE Lin, YH Chung, CL Tsai, SY Hsieh, MC Yu
    Oncogene, 2020;0(0):.
    Species: Human
    Sample Types:
    Applications: Functional Assay
  3. Age-related differences in the bone marrow stem cell niche generate specialized microenvironments for the distinct regulation of normal hematopoietic and leukemia stem cells
    Authors: GY Lee, SY Jeong, HR Lee, IH Oh
    Sci Rep, 2019;9(1):1007.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-alpha and stromal-derived cell factor 1
    Authors: X Liu, R Tonello, Y Ling, YJ Gao, T Berta
    J Neuroinflammation, 2019;16(1):209.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  5. Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling
    Authors: G Kalpana, C Figy, M Yeung, KC Yeung
    Sci Rep, 2019;9(1):16351.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  6. Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies
    Authors: D Baci, A Bruno, C Cascini, M Gallazzi, L Mortara, F Sessa, G Pelosi, A Albini, DM Noonan
    J. Exp. Clin. Cancer Res., 2019;38(1):464.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. The CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In Vitro
    Authors: K Pansy, J Feichtinge, B Ehall, B Uhl, M Sedej, D Roula, B Pursche, A Wolf, M Zoidl, E Steinbauer, V Gruber, HT Greinix, KT Prochazka, GG Thallinger, A Heinemann, C Beham-Schm, P Neumeister, TM Wrodnigg, K Fechter, AJ Deutsch
    Int J Mol Sci, 2019;20(19):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  8. Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema
    Authors: W Tang, Y Chen, X Wang, Y Chen, J Zhang, Z Lin
    Oncol Lett, 2018;15(2):2501-2507.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  9. The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer
    Authors: M Wang, X Yang, M Wei, Z Wang
    J Cancer, 2018;9(21):3898-3903.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  10. Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice
    Authors: MJ Chau, TC Deveau, X Gu, YS Kim, Y Xu, SP Yu, L Wei
    BMC Neurosci, 2018;19(1):20.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  11. Senescent fibroblasts drive ageing pigmentation: ?A potential therapeutic target for senile lentigo
    Authors: JE Yoon, Y Kim, S Kwon, M Kim, YH Kim, JH Kim, TJ Park, HY Kang
    Theranostics, 2018;8(17):4620-4632.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  12. CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors
    Authors: CS Marques, AR Santos, A Gameiro, J Correia, F Ferreira
    BMC Cancer, 2018;18(1):741.
    Species: Feline
    Sample Types: Whole Tissue
    Applications: IHC
  13. Tumor Microenvironment in Functional Adrenocortical Adenomas: Immune Cell Infiltration in Cortisol-producing Adrenocortical Adenoma
    Authors: Y Kitawaki, Y Nakamura, F Kubota-Nak, Y Yamazaki, Y Miki, S Hata, K Ise, K Kikuchi, R Morimoto, F Satoh, H Sasano
    Hum. Pathol., 2018;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  14. Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer
    Authors: J Zhang, C Liu, X Mo, H Shi, S Li
    Oncol Lett, 2018;15(2):1771-1776.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  15. CXCR4/CXCL12 Signaling and Protumor Macrophages in Primary Tumors and Sentinel Lymph Nodes Are Involved in Luminal B Breast Cancer Progression
    Authors: C Raschioni, G Bottai, A Sagona, V Errico, A Testori, W Gatzemeier, F Corsi, C Tinterri, M Roncalli, L Santarpia, L Di Tommaso
    Dis. Markers, 2018;2018(0):5018671.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  16. Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay
    Authors: H Pierce, D Zhang, C Magnon, D Lucas, JR Christin, M Huggins, GJ Schwartz, PS Frenette
    Cell Stem Cell, 2017;0(0):.
    Species: Mouse
    Sample Types: Bone Marrow Fluid
    Applications: ELISA Development (Capture)
  17. SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy
    Authors: C De-Colle, D Mönnich, S Welz, S Boeke, B Sipos, F Fend, PS Mauz, I Tinhofer, V Budach, JA Jawad, M Stuschke, P Balermpas, C Rödel, AL Grosu, A Abdollahi, J Debus, C Bayer, C Belka, S Pigorsch, SE Combs, F Lohaus, A Linge, M Krause, M Baumann, D Zips, A Menegakis
    Clin Transl Radiat Oncol, 2017;5(0):28-36.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  18. Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells
    Authors: N Guidi, M Sacma, L Ständker, K Soller, G Marka, K Eiwen, JM Weiss, F Kirchhoff, T Weil, JA Cancelas, MC Florian, H Geiger
    EMBO J, 2017;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development (Capture)
  19. A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies
    Authors: DI Bromage, S Taferner, M Pillai, DM Yellon, SM Davidson
    PLoS ONE, 2017;12(4):e0174447.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Functional Assay
  20. Increasing tumor-infiltrating T cells through inhibition of CXCL12 with NOX-A12 synergizes with PD-1 blockade
    Authors: D Zboralski, K Hoehlig, D Eulberg, A Froemming, A Vater
    Cancer Immunol Res, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  21. Dipeptidyl Peptidase-4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1?(1-67) in Patients With Type 2 Diabetes
    Authors: JA Lovshin, H Rajasekera, Y Lytvyn, LE Lovblom, S Khan, R Alemu, A Locke, V Lai, H He, L Hittle, W Wang, DJ Drucker, DZI Cherney
    Diabetes Care, 2017;0(0):.
    Species: Human
    Sample Types: Plasma
    Applications: Mass Spectrometry
  22. The chronically inflamed central nervous system provides niches for long-lived plasma cells
    Authors: K Pollok, R Mothes, C Ulbricht, A Liebheit, JD Gerken, S Uhlmann, F Paul, R Niesner, H Radbruch, AE Hauser
    Acta Neuropathol Commun, 2017;5(1):88.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  23. Hypoxia-Inducible Factor 1? Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury
    Authors: J McClendon, NL Jansing, EF Redente, A Gandjeva, Y Ito, SP Colgan, A Ahmad, DWH Riches, HA Chapman, RJ Mason, RM Tuder, RL Zemans
    Am. J. Pathol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  24. Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells
    Authors: A Venkatesh, H Nandigam, M Muccioli, M Singh, T Loftus, D Lewis, M Pate, F Benencia
    Immunobiology, 2017;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development (Capture)
  25. Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin
    Authors: SH Omland, EE Wettergren, S Mollerup, M Asplund, T Mourier, AJ Hansen, R Gniadecki
    BMC Cancer, 2017;17(1):675.
  26. Expression and function of CXCL12/CXCR4/CXCR7 in thyroid cancer
    Authors: X Zhu, Q Bai, Y Lu, Y Lu, L Zhu, X Zhou, L Wu
    Int J Oncol, 2016;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  27. CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney.
    Authors: Siddiqi, Ferhan S, Chen, Li-Hao, Advani, Suzanne, Thai, Kerri, Batchu, Sri N, Alghamdi, Tamadher, White, Kathryn, Sood, Manish M, Gibson, Ian W, Connelly, Kim A, Marsden, Philip A, Advani, Andrew
    Endocrinology, 2015;156(3):1121-32.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC-P
  28. SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease.
    Authors: Chen L, Advani S, Thai K, Kabir M, Sood M, Gibson I, Yuen D, Connelly K, Marsden P, Kelly D, Gilbert R, Advani A
    PLoS ONE, 2014;9(3):e92227.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  29. CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro.
    Authors: Hu, Weidong, Liu, Yue, Zhou, Wenhui, Si, Lianlian, Ren, Liang
    PLoS ONE, 2014;9(6):e99056.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  30. Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats.
    Authors: Walters, M J, Ebsworth, K, Berahovich, R D, Penfold, M E T, Liu, S-C, Al Omran, R, Kioi, M, Chernikova, S B, Tseng, D, Mulkearns-Hubert, E E, Sinyuk, M, Ransohoff, R M, Lathia, J D, Karamchandani, J, Kohrt, H E K, Zhang, P, Powers, J P, Jaen, J C, Schall, T J, Merchant, M, Recht, L, Brown, J M
    Br J Cancer, 2014;110(5):1179-88.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  31. CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
    Authors: Geherin, Skye A, Wilson, R Paul, Jennrich, Silke, Debes, Gudrun F
    PLoS ONE, 2014;9(4):e95626.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  32. A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients.
    Authors: D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento F, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli R, Scala S
    Int J Cancer, 2014;135(2):379-90.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  33. Immunohistochemical evaluation of CXCL12-CXCR4 axis and VEGFR3 expression in primary urothelial cancer and its recurrence.
    Authors: Batsi O, Giannopoulou I, Nesseris I, Valavanis C, Gakiopoulou H, Patsouris E, Arapandoni-Dadioti P, Lazaris A
    Anticancer Res, 2014;34(7):3537-42.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  34. Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
    Authors: Pinto S, Martinez-Romero A, O'Connor J, Gil-Benso R, San-Miguel T, Terradez L, Monteagudo C, Callaghan R
    BMC Cancer, 2014;14(0):118.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  35. Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies.
    Authors: Sangaletti, Sabina, Tripodo, Claudio, Portararo, Paola, Dugo, Matteo, Vitali, Caterina, Botti, Laura, Guarnotta, Carla, Cappetti, Barbara, Gulino, Alessand, Torselli, Ilaria, Casalini, Patrizia, Chiodoni, Claudia, Colombo, Mario P
    Oncoimmunology, 2014;3(0):e28989.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  36. Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease.
    Authors: Zhang W, He L, Shi X, Wu S, Zhang B, Mei L, Xu Y, Zhang Z, Zhao J, Zhang H
    Respir Res, 2014;15(0):33.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC-P
  37. CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis.
    Authors: Roy, Ishan, Zimmerman, Noah P, Mackinnon, A Craig, Tsai, Susan, Evans, Douglas, Dwinell, Michael
    PLoS ONE, 2014;9(3):e90400.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development (Capture)
  38. CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice.
    Authors: Akhtar S, Gremse F, Kiessling F, Weber C, Schober A
    Arterioscler Thromb Vasc Biol, 2013;33(4):679-86.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  39. The SDF-1α/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells.
    Authors: Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC
    PLoS ONE, 2012;7(6):e38721.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  40. A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment.
    Authors: Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill FR
    Cancer Res., 2012;72(1):66-75.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  41. Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma.
    Authors: Liberman J, Sartelet H, Flahaut M, Muhlethaler-Mottet A, Coulon A, Nyalendo C, Vassal G, Joseph J, Gross N
    PLoS ONE, 2012;7(8):e43665.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  42. VEGF-DdeltaNdeltaC mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits.
    Authors: Roy H, Bhardwaj S, Babu M, Lahteenvuo JE, Yla-Herttuala S
    Eur. J. Clin. Invest., 2010;40(5):422-32.
    Species: Rabbit
    Sample Types: Whole Tissue
    Applications: IHC-P
  43. Comprehensive assessment of chemokine expression profiles by flow cytometry.
    Authors: Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D
    J. Clin. Invest., 2010;120(3):907-23.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  44. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
    Authors: Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C
    FASEB J., 2009;23(9):2928-41.
    Species: Feline
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  45. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
    Authors: Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S
    J. Exp. Med., 2009;206(1):249-58.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  46. Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents.
    Authors: Gilbert DC, Chandler I, McIntyre A, Goddard NC, Gabe R, Huddart RA, Shipley J
    J. Pathol., 2009;217(1):94-102.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  47. Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss.
    Authors: Diamond P, Labrinidis A, Martin SK, Farrugia AN, Gronthos S, To LB, Fujii N, O'Loughlin PD, Evdokiou A, Zannettino AC
    J. Bone Miner. Res., 2009;24(7):1150-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  48. Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes.
    Authors: Sayyed SG, Hagele H, Kulkarni OP, Endlich K, Segerer S, Eulberg D, Klussmann S, Anders HJ
    Diabetologia, 2009;52(11):2445-54.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  49. Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4.
    Authors: Struyf S, Noppen S, Loos T, Mortier A, Gouwy M, Verbeke H, Huskens D, Luangsay S, Parmentier M, Geboes K, Schols D, Van Damme J, Proost P
    J. Immunol., 2009;182(1):666-74.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  50. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
    Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
    AIDS Res. Hum. Retroviruses, 2008;24(3):453-62.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Luminex Development
  51. pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma.
    Authors: Struckmann K, Mertz K, Steu S, Storz M, Staller P, Krek W, Schraml P, Moch H
    J. Pathol., 2008;214(4):464-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  52. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
    Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
    Blood, 2007;109(10):4272-9.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Luminex Development
  53. HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
    Authors: Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P
    AIDS, 2007;21(10):1263-72.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Luminex Development
  54. Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts.
    Authors: Tait LR, Pauley RJ, Santner SJ, Heppner GH, Heng HH, Rak JW, Miller FR
    Int. J. Cancer, 2007;120(10):2127-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  55. Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma.
    Authors: Kleinman ME, Greives MR, Churgin SS, Blechman KM, Chang EI, Ceradini DJ, Tepper OM, Gurtner GC
    Arterioscler. Thromb. Vasc. Biol., 2007;27(12):2664-70.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  56. Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
    Authors: Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME, Suratt BT
    J. Immunol., 2007;178(12):8148-57.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  57. HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta.
    Authors: Peng H, Erdmann N, Whitney N, Dou H, Gorantla S, Gendelman HE, Ghorpade A, Zheng J
    Glia, 2006;54(6):619-29.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  58. Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.
    Authors: Yasumoto K, Koizumi K, Kawashima A, Saitoh Y, Arita Y, Shinohara K, Minami T, Nakayama T, Sakurai H, Takahashi Y, Yoshie O, Saiki I
    Cancer Res., 2006;66(4):2181-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  59. Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54.
    Authors: Lisignoli G, Cristino S, Piacentini A, Cavallo C, Caplan AI, Facchini A
    J. Cell. Physiol., 2006;207(2):364-73.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  60. Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.
    Authors: Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS
    Bone, 2006;38(4):497-508.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  61. Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF.
    Authors: Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, Minatoguchi S, Fujiwara T, Fujiwara H
    Cardiovasc. Res., 2006;71(3):455-65.
    Species: Rabbit
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  62. Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
    Authors: Marchal-Somme J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P
    J. Immunol., 2006;176(10):5735-9.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  63. Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells.
    Authors: Infantino S, Moepps B, Thelen M
    J. Immunol., 2006;176(4):2197-207.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  64. Skin homing of Sezary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV.
    Authors: Narducci MG, Scala E, Bresin A, Caprini E, Picchio MC, Remotti D, Ragone G, Nasorri F, Frontani M, Arcelli D, Volinia S, Lombardo GA, Baliva G, Napolitano M, Russo G
    Blood, 2005;107(3):1108-15.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  65. Age-associated aortic stenosis in apolipoprotein E-deficient mice.
    Authors: Tanaka K, Sata M, Fukuda D, Suematsu Y, Motomura N, Takamoto S, Hirata Y, Nagai R
    J. Am. Coll. Cardiol., 2005;46(1):134-41.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  66. Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone.
    Authors: Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY
    J. Orthop. Res., 2005;23(1):203-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  67. Thymic T cell development and progenitor localization depend on CCR7.
    Authors: Misslitz A, Pabst O, Hintzen G, Ohl L, Kremmer E, Petrie HT, Forster R
    J. Exp. Med., 2004;200(4):481-91.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  68. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands.
    Authors: Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D
    J. Immunol., 2004;173(11):6592-602.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  69. Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus.
    Authors: Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, Franitza S, Weiss I, Avniel S, Boaz P, Hanna J, Zamir G, Eid A, Mandelboim O, Spengler U, Galun E, Peled A
    Eur. J. Immunol., 2004;34(4):1164-74.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  70. Characterization of hematopoietic progenitor mobilization in protease-deficient mice.
    Authors: Levesque JP, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C, Link DC
    Blood, 2004;104(1):65-72.
    Species: Mouse
    Sample Types: Bone Marrow Fluid
    Applications: ELISA Development
  71. Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo.
    Authors: Villalba S, Salvucci O, Aoki Y, De La Luz Sierra M, Gupta G, Davis D, Wyvill K, Little R, Yarchoan R, Tosato G
    J. Leukoc. Biol., 2003;74(5):880-8.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Development

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Human/Mouse CXCL12/SDF-1 Antibody
By Anonymous on 08/25/2020
Application: IHC Sample Tested: Tonsil tissue Species: Human

Epitope retrieval: Leica BOND ER2 (high-pH) 100C 40min
Primary Ab: 5ug/mL in BSA/TBS for 30min
Detection system: Leica BOND-RX autostainer with Leica BOND refine detection kit


Human/Mouse CXCL12/SDF-1 Antibody
By Anonymous on 06/10/2020
Application: Microarrays Sample Tested: EDTA Plasma Species: Human

Human/Mouse CXCL12/SDF-1 Antibody
By Anonymous on 02/16/2020
Application: ELISA Sample Tested: A549 human lung carcinoma cell line Species: Human

Human/Mouse CXCL12/SDF-1 Antibody
By Anonymous on 09/28/2019
Application: WB Sample Tested: Recombinant protein Species: Human

Human/Mouse CXCL12/SDF-1 Antibody
By Anonymous on 05/11/2019
Application: ICC/IF Sample Tested: Spinal cord Species: Mouse

Human/Mouse CXCL12/SDF-1 Antibody
By Anonymous on 03/05/2019
Application: IHC Sample Tested: 4T1 mouse breast cancer cell line Species: Mouse

1:100
Citrate buffer antigen retrieval
FFPE tissues


Human/Mouse CXCL12/SDF-1 Antibody
By Anonymous on 11/09/2018
Application: MiAr Sample Tested: EDTA Plasma Species: Human

Human/Mouse CXCL12/SDF-1 Antibody
By Anonymous on 11/07/2018
Application: Microarrays Sample Tested: EDTA Plasma Species: Human

Human/Mouse CXCL12/SDF-1 Antibody
By Anonymous on 04/13/2018
Application: IHC Sample Tested: E6.5 mouse embryo fixed in 4% PFA Species: Mouse