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Proteome Profiler Human Phospho-Kinase Array Kit

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R&D Systems Proteome Profiler Antibody Array Kits
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Proteome Profiler Human Phospho-Kinase Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of human protein kinase phosphorylation. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 43 human kinases and total amounts of 2 related proteins simultaneously
  • Requires no specialized equipment
Human Phospho-Kinase Array Kit data example
View Data Examples
 

 

Principle of the Assay

The Proteome Profiler Human Phospho-Kinase Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Phosphorylation of captured proteins is detected with biotinylated phospho-specific detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple kinases in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 

 

Kit Contents

Each Human Phospho-Kinase Antibody Array Kit contains most of the necessary components for a ready-to-run assay without the need for specialized equipment.

  • 8 Array Membranes (4 of membrane A and 4 of membrane B)
  • 8-Well Multi-dish
  • Lysis Buffer
  • Array Buffers
  • Wash Buffer
  • Detection Antibody Cocktail A
  • Detection Antibody Cocktail B
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed product datasheet with protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2°C to 8°C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these proteins in a single sample.
Akt 1/2/3 (S473) Hck (Y411) PLC gamma-1 (Y783)
Akt 1/2/3 (T308) HSP27 (S78/S82) PRAS40 (T246)
AMPK alpha1 (T183) HSP60 Pyk2 (Y402)
AMPK alpha2 (T172) JNK 1/2/3 (T183/Y185, T221/Y223) RSK1/2/3 (S380)
beta-Catenin Lck (Y394) Src (Y419)
Chk-2 (T68) Lyn (Y397) STAT2 (Y689)
c-Jun (S63) MSK1/2 (S376/S360) STAT3 (S727)
CREB (S133) p27 (T198) STAT3 (Y705)
EGF R (Y1086) p38 alpha (T180/Y182) STAT5a (Y699)
eNOS (S1177) p53 (S15) STAT5a/b (Y699)
ERK1/2 (T202/Y204, T185/Y187) p53 (S392) STAT5b (Y699)
FAK (Y397) p53 (S46) STAT6 (Y641)
Fgr (Y412) P70 S6 Kinase (T389) TOR (S2448)
Fyn (Y420) p70 S6 Kinase (T421/S424) WNK-1 (T60)
GSK-3 alpha/beta (S21/S9) PDGF R beta (Y751) Yes (Y426)

 

Assays for analytes represented in the Human Phospho-Kinase Array Kit

 

Analyte DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA
Development Systems (Phospho)		 Quantikine®
ELISA Kits
Akt (S473)   DYC887B  
Akt (T308)      
AMPK alpha1 (T183) DYC3197 DYC3528  
AMPK alpha2 (T172)      
beta-Catenin DYC1329   DYC1329
Chk2 (T68)   DYC1626  
c-Jun (S63)      
CREB (S133)   DYC2510  
EGF R (Y1086) DYC1854   DEGFR0
eNOS (S1177)      
ERK1/2 (T202/Y204, T185/Y187)   DYC1018B  
FAK (Y397) DYC4467    
Fgr (Y412)      
Fyn (Y420)      
GSK-3 alpha/beta (S21/S9) DYC2157 DYC2630  
Hck (Y411)      
HSP27 (S78/S82) DYC1580 DYC2314  
HSP60 DYC1800    
JNK pan (T183/Y185, T221/Y223) DYC1205 DYC1387  
Lck (Y394)      
Lyn (Y397)   DYC3936  
MSK1/2 (S376/S360)      
p27 (T198) DYC2256    
p38 alpha (T180/Y182) DYC8691B DYC869B  
p53 (S15) DYC1043 DYC1839  
p53 (S46) DYC1043 DYC1489  
p53 (S392) DYC1043 DYC2996  
p70 S6 Kinase (T389)   DYC896  
p70 S6 Kinase (T421/S424) DYC8962 DYC8965  
PDGF R beta (Y751) DYC385 DYC3096  
PLC gamma-1 (Y783)      
PRAS40 (T246)   DYC6890  
PYK2 (Y402)      
RSK1/2/3 (S380/S386/S377)   DYC889B  
Src (Y419)   DYC2685  
STAT2 (Y689)      
STAT3 (S727)      
STAT3 (Y705)   DYC4607B  
STAT5a (Y694)      
STAT5a/b (Y694/Y699)      
STAT5b (Y699)      
STAT6 (Y641)      
TOR (S2448)   DYC1665  
WNK-1(T60)   DYC4720  
Yes (Y426)   DYC3929  

 

Data Examples
Figure 1.
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Figure 1. MCF-7 human breast cancer cells were either left untreated or exposed to 50 J/m2 of UV light followed by a 4 hour recovery before lysis.
Figure 2.
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Figure 2. A431 human epithelial carcinoma cells were either left untreated or treated with 200 ng/mL recombinant human (rh) EGF (Catalog # 236-EG) for 5 minutes.
Figure 3.
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Figure 3. MCF-7 human breast cancer cells were either left untreated or treated with 100 ng/mL of rhIGF-I (Catalog # 291-G1) for 1 hour.

Protein kinases are the largest class of enzymes in the human genome. These enzymes regulate almost all cellular processes by adding phosphate groups to proteins, thereby modifying the activity, localization, and overall function of their targets. Consequently, abnormal activity of kinases underlies many diseases including cancer.

Specifications

Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

Product Datasheets

Product Datasheet
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Citations for Proteome Profiler Human Phospho-Kinase Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

268 Citations: Showing 1 - 10
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  1. Glycosyltransferase POMGNT1 deficiency strengthens N-cadherin-mediated cell-cell adhesion
    Authors: SI Noor, M Hoffmann, N Rinis, MF Bartels, PR Winterhalt, C Hoelscher, R Hennig, N Himmelreic, C Thiel, T Ruppert, E Rapp, S Strahl
    The Journal of Biological Chemistry, 2021;0(0):100433.  2021
  2. New Treatment Strategy Targeting Galectin-1 against Thyroid Cancer
    Authors: L Gheysen, L Soumoy, A Trelcat, L Verset, F Journe, S Saussez
    Cells, 2021;10(5):.  2021
  3. Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines
    Authors: F Benedetti, S Curreli, RC Gallo, D Zella
    Journal of Translational Medicine, 2021;19(1):60.  2021
  4. mTOR modulates resistance to gemcitabine in lung cancer in an MTORC2 dependent mechanism
    Authors: MA Chawsheen, PR Dash
    Cellular Signalling, 2021;81(0):109934.  2021
  5. Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells
    Authors: H Sevim, H Çelik, L Dü?ünceli, CS Ceyhan, A Molotkova, K Nakazawa, GT Graham, JR Petro, JA Toretsky, A Üren
    PLoS ONE, 2021;16(6):e0253170.  2021
  6. Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis
    Authors: K Andelid, K Öst, A Andersson, E Mohamed, Z Jevnikar, LEGW Vanfletere, M Göransson
    Respiratory Research, 2021;22(1):172.  2021
  7. Extracellular signal-regulated kinase 1/2 is required for complement component C1q and fibronectin dependent enhancement of Fc&gamma- receptor mediated phagocytosis in mouse and human cells
    Authors: EA Willmann, V Pandurovic, A Jokinen, D Beckley, SS Bohlson
    BMC immunology, 2020;21(1):61.  2020
  8. Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL
    Authors: C Hurtz, GB Wertheim, JP Loftus, D Blumenthal, A Lehman, Y Li, A Bagashev, B Manning, KD Cummins, JK Burkhardt, AE Perl, M Carroll, SK Tasian
    J. Clin. Invest., 2020;0(0):.  2020
  9. Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells
    Authors: K Oono, K Ohtake, C Watanabe, S Shiba, T Sekiya, K Kasono
    Lipids Health Dis, 2020;19(1):15.  2020
  10. Porphyromonas gingivalis triggers the shedding of inflammatory endothelial microvesicles that act as autocrine effectors of endothelial dysfunction
    Authors: IM Bugueno, F Zobairi El, F Batool, H El Itawi, E Anglès-Can, N Benkirane-, F Toti, O Huck
    Sci Rep, 2020;10(1):1778.  2020
  11. Schistosoma mansoni eggs induce Wnt/&beta-catenin signaling and activate the protooncogene c-Jun in human and hamster colon
    Authors: J Weglage, F Wolters, L Hehr, J Lichtenber, C Wulz, F Hempel, A Baier, T Quack, K Köhler, T Longerich, G Schramm, K Irungbam, H Mueller, V von Buelow, A Tschuschne, M Odenthal, U Drebber, ME Arousy, LNZ Ramalho, K Bankov, P Wild, J Pons-Kühne, J Tschammer, CG Grevelding, E Roeb, M Roderfeld
    Scientific Reports, 2020;10(1):22373.  2020
  12. The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma
    Authors: A Reszegi, Z Horváth, K Karászi, E Reg?s, V Postniková, P Tátrai, A Kiss, Z Schaff, I Kovalszky, K Baghy
    Biomolecules, 2020;10(8):.  2020
  13. A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
    Authors: LR Kong, NAB Mohamed Sa, RW Ong, TZ Tan, NL Syn, RM Goh, CW Fhu, DSW Tan, NG Iyer, S Kannan, CS Verma, YC Lim, R Soo, J Ho, Y Huang, JSJ Lim, BJ Yan, ME Nga, SG Lim, HP Koeffler, SC Lee, D Kappei, HT Hung, BC Goh
    Nat Commun, 2020;11(1):1556.  2020
  14. LDOC1 Suppresses Microbe-Induced Production of IL-1&beta in Human Normal and Cancerous Oral Cells through the PI3K/Akt/GSK-3&beta Axis
    Authors: CH Lee, PF Hung, KJ Liu, HL Chung, WC Yang, KC Hsu, TH Fong, HJ Lo, YP Chen, JR Yang, CY Yen
    Cancers (Basel), 2020;12(11):.  2020
  15. Anticancer activities of selected Emirati Date (Phoenix dactylifera L.) varieties pits in human triple negative breast cancer MDA-MB-231 cells
    Authors: MNK Khattak, A Shanableh, MI Hussain, AA Khan, M Abdulwahab, W Radeef, MH Samreen
    Saudi journal of biological sciences, 2020;27(12):3390-3396.  2020
  16. Insight into Cisplatin-Resistance Signaling of W1 Ovarian Cancer Cells Emerges mTOR and HSP27 as Targets for Sensitization Strategies
    Authors: K Wantoch vo, P König, S Henze, M Schlesinge, P Zawierucha, R Januchowsk, G Bendas
    International Journal of Molecular Sciences, 2020;21(23):.  2020
  17. The role of TRPV1 ion channels in the suppression of gastric cancer development
    Authors: N Gao, F Yang, S Chen, H Wan, X Zhao, H Dong
    J Exp Clin Cancer Res, 2020;39(1):206.  2020
  18. FGF trapping inhibits multiple myeloma growth through c-Myc degradation-induced mitochondrial oxidative stress
    Authors: R Ronca, GC Ghedini, F Maccarinel, A Sacco, SL Locatelli, E Foglio, S Taranto, E Grillo, S Matarazzo, R Castelli, G Paganini, V Desantis, N Cattane, A Cattaneo, M Mor, C Carlo-Stel, A Belotti, A Roccaro, M Presta, A Giacomini
    Cancer Res., 2020;0(0):.  2020
  19. The Lipid Virulence Factors of Mycobacterium tuberculosis Exert Multilayered Control over Autophagy-Related Pathways in Infected Human Macrophages
    Authors: A Bah, M Sanicas, J Nigou, C Guilhot, C Astarie-De, I Vergne
    Cells, 2020;9(3):.  2020
  20. Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma
    Authors: ES Grassi, V Pantazopou, A Pietras
    Oncogene, 2020;0(0):.  2020
  21. Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma
    Authors: M Pruss, A Dwucet, M Tanriover, M Hlavac, RE Kast, KM Debatin, CR Wirtz, ME Halatsch, MD Siegelin, MA Westhoff, G Karpel-Mas
    Br. J. Cancer, 2020;0(0):.  2020
  22. The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu)
    Authors: A Alghamdi, W Aldossary, S Albahkali, B Alotaibi, BM Alrfaei
    PLoS ONE, 2020;15(11):e0241902.  2020
  23. m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling
    Authors: JW Xie, XB Huang, QY Chen, YB Ma, YJ Zhao, LC Liu, JB Wang, JX Lin, J Lu, LL Cao, M Lin, RH Tu, CH Zheng, CM Huang, P Li
    Mol. Cancer, 2020;19(1):114.  2020
  24. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
    Authors: JMD Grandjean, A Madhavan, L Cech, BO Seguinot, RJ Paxman, E Smith, L Scampavia, ET Powers, CB Cooley, L Plate, TP Spicer, JW Kelly, RL Wiseman
    Nat. Chem. Biol., 2020;0(0):.  2020
  25. FGF2 Induces Resistance to Nilotinib through MAPK Pathway Activation in KIT Mutated Melanoma
    Authors: P Tétu, J Delyon, J André, C Reger de M, M Sabbah, GE Ghanem, M Battistell, S Mourah, C Lebbé, N Dumaz
    Cancers (Basel), 2020;12(5):.  2020
  26. Circulating Neutrophils Predict Poor Survival for HCC and Promote HCC Progression Through p53 and STAT3 Signaling Pathway
    Authors: Y Wang, R Yao, D Zhang, R Chen, Z Ren, L Zhang
    J Cancer, 2020;11(13):3736-3744.  2020
  27. Immuno-metabolic impact of the multiple sclerosis patients' sera on endothelial cells of the blood-brain barrier
    Authors: MH Sheikh, SM Henson, RA Loiola, S Mercurio, A Colamatteo, GT Maniscalco, V De Rosa, S McArthur, E Solito
    J Neuroinflammation, 2020;17(1):153.  2020
  28. The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells
    Authors: A Douida, F Batista, A Robaszkiew, P Boto, A Aladdin, M Szenykiv, R Czinege, L Virág, K Tar
    J. Cell. Mol. Med., 2020;0(0):.  2020
  29. Oncogenic Potential of Bisphenol A and Common Environmental Contaminants in Human Mammary Epithelial Cells
    Authors: VA Nair, S Valo, P Peltomäki, K Bajbouj, WM Abdel-Rahm
    Int J Mol Sci, 2020;21(10):.  2020
  30. Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3&beta signalling pathway in renal cell carcinoma
    Authors: Q Zhu, AL Zhong, H Hu, JJ Zhao, DS Weng, Y Tang, QZ Pan, ZQ Zhou, MJ Song, JY Yang, JY He, Y Liu, M Li, WM Hu, CP Yang, T Xiang, MY Chen, G Ma, L Guo, JC Xia
    J Hematol Oncol, 2020;13(1):2.  2020
  31. Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling
    Authors: P Shahi Thak, M Gupta, S Singh, R Joshi, E Glasgow, A Lekan, S Agarwal, GD Luker, H Tavana
    BMC Cancer, 2020;20(1):4.  2020
  32. Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling
    Authors: B Zhou, J Liu, L Zeng, S Zhu, H Wang, TR Billiar, G Kroemer, DJ Klionsky, HJ Zeh, J Jiang, D Tang, R Kang
    Nat Microbiol, 2020;0(0):.  2020
  33. SNCG promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathway
    Authors: J Zhang, XH Liu, C Li, XX Wu, YL Chen, WW Li, X Li, F Gong, Q Tang, D Jiang
    J. Exp. Clin. Cancer Res., 2020;39(1):79.  2020
  34. IL-32&gamma potentiates tumor immunity in melanoma
    Authors: T Gruber, M Kremenovic, H Sadozai, N Rombini, L Baeriswyl, F Maibach, RL Modlin, M Gilliet, D von Werdt, RE Hunger, SM Seyed Jafa, G Parisi, G Abril-Rodr, A Ribas, M Schenk
    JCI Insight, 2020;5(18):.  2020
  35. Design, synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as anti-glioblastoma agents targeting the AKT pathway
    Authors: M Szeliga, M Karpi?ska, R Rola, A Niewiadomy
    Bioorg Chem, 2020;105(0):104362.  2020
  36. LIMD2 Regulates Key Steps of Metastasis Cascade in Papillary Thyroid Cancer Cells via MAPK Crosstalk
    Authors: RP Araldi, TC de Melo, D Levy, DM de Souza, B Maurício, GA Colozza-Ga, SP Bydlowski, H Peng, FJ Rauscher, JM Cerutti
    Cells, 2020;9(11):.  2020
  37. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling
    Authors: S Ketterer, J Mitschke, A Ketscher, M Schlimpert, W Reichardt, N Baeuerle, ME Hess, P Metzger, M Boerries, C Peters, B Kammerer, T Brummer, F Steinberg, T Reinheckel
    Nat Commun, 2020;11(1):5133.  2020
  38. Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer
    Authors: R Wang, T Yamada, K Kita, H Taniguchi, S Arai, K Fukuda, M Terashima, A Ishimura, A Nishiyama, A Tanimoto, S Takeuchi, K Ohtsubo, K Yamashita, T Yamano, A Yoshimura, K Takayama, K Kaira, Y Taniguchi, S Atagi, H Uehara, R Hanayama, I Matsumoto, X Han, K Matsumoto, W Wang, T Suzuki, S Yano
    Nat Commun, 2020;11(1):4607.  2020
  39. Downregulation of RRM2 Attenuates Retroperitoneal Liposarcoma Progression via the Akt/mTOR/4EBP1 Pathway: Clinical, Biological, and Therapeutic Significance
    Authors: S Zhang, L Yan, C Cui, Z Wang, J Wu, A Lv, M Zhao, B Dong, W Zhang, X Guan, X Tian, C Hao
    Onco Targets Ther, 2020;13(0):6523-6537.  2020
  40. Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/&beta-catenin/SLUG axis
    Authors: S Bu, Q Wang, J Sun, X Li, T Gu, D Lai
    Cell Death Dis, 2020;11(8):644.  2020
  41. CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma
    Authors: R Xu, Y Li, H Yan, E Zhang, X Huang, Q Chen, J Chen, J Qu, Y Liu, J He, Q Yi, Z Cai
    Cell Death Dis, 2019;10(10):781.  2019
  42. Interleukin-6 mediates resistance to PI3K-pathway-targeted therapy in lymphoma
    Authors: JH Kim, WS Kim, C Park
    BMC Cancer, 2019;19(1):936.  2019
  43. CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation
    Authors: NL Cook, M Pjanic, AG Emmerich, AS Rao, S Hetty, JW Knowles, T Quertermou, C Castillejo, E Ingelsson
    BMC Endocr Disord, 2019;19(1):115.  2019
  44. Tyrosine kinase inhibition to improve anthracycline-based chemotherapy efficacy in T-cell lymphoma
    Authors: M Magni, G Biancon, S Rizzitano, A Cavanè, C Paolizzi, M Dugo, P Corradini, C Carniti
    Br. J. Cancer, 2019;0(0):.  2019
  45. Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia-reperfusion injury
    Authors: L Hummitzsch, K Zitta, R Berndt, YL Wong, R Rusch, K Hess, T Wedel, M Gruenewald, J Cremer, M Steinfath, M Albrecht
    J Transl Med, 2019;17(1):136.  2019
  46. Kinome expression profiling to target new therapeutic avenues in multiple myeloma
    Authors: H de Boussac, A Bruyer, M Jourdan, A Maes, N Robert, C Gourzones, L Vincent, A Seckinger, G Cartron, D Hose, E De Bruyne, A Kassambara, P Pasero, J Moreaux
    Haematologica, 2019;0(0):.  2019
  47. Multilevel defects in the hematopoietic niche in essential thrombocythemia
    Authors: T Sun, M Ju, X Dai, H Dong, W Gu, Y Gao, R Fu, X Liu, Y Huang, W Liu, Y Chi, W Wang, H Li, Y Zhou, L Shi, R Yang, L Zhang
    Haematologica, 2019;0(0):.  2019
  48. Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer
    Authors: MJ Jo, S Jeong, HK Yun, DY Kim, BR Kim, JL Kim, YJ Na, SH Park, YA Jeong, BG Kim, H Ashktorab, DT Smoot, JY Heo, J Han, DH Lee, SC Oh
    BMC Cancer, 2019;19(1):739.  2019
  49. Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice
    Authors: SA Scarneo, LS Eibschutz, PJ Bendele, KW Yang, J Totzke, P Hughes, DA Fox, TAJ Haystead
    Arthritis Res. Ther., 2019;21(1):292.  2019
  50. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
    Authors: SP Kennedy, JZR Han, N Portman, M Nobis, JF Hastings, KJ Murphy, SL Latham, AL Cadell, D Miladinovi, GR Marriott, YEI O'Donnell, RF Shearer, JT Williams, AG Munoz, TR Cox, DN Watkins, DN Saunders, P Timpson, E Lim, W Kolch, DR Croucher
    Breast Cancer Res., 2019;21(1):43.  2019
  51. Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin
    Authors: J Menéndez-M, F Hermida-Pr, R Granda-Día, A González, JM García-Ped, N Del-Río-Ib, A González-G, S Cos, C Alonso-Gon, C Martínez-C
    Cancers (Basel), 2019;11(7):.  2019
  52. The small GTPase ARF6 activates PI3K in melanoma to induce a pro-metastatic state
    Authors: JH Yoo, SW Brady, L Acosta-Alv, A Rogers, J Peng, LK Sorensen, RK Wolff, T Mleynek, D Shin, CP Rich, DA Kircher, A Bild, SJ Odelberg, DY Li, SL Holmen, AH Grossmann
    Cancer Res., 2019;0(0):.  2019
  53. Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach
    Authors: Z Xiao, B Sperl, S Gärtner, T Nedelko, E Stacher-Pr, A Ullrich, PG Knyazev
    Oncotarget, 2019;10(26):2546-2560.  2019
  54. UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling
    Authors: JX Lin, XS Xie, XF Weng, SL Qiu, C Yoon, NZ Lian, JW Xie, JB Wang, J Lu, QY Chen, LL Cao, M Lin, RH Tu, YH Yang, CM Huang, CH Zheng, P Li
    J. Exp. Clin. Cancer Res., 2019;38(1):410.  2019
  55. Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program
    Authors: JH Noh, KM Kim, PR Pandey, NN Hooten, R Munk, G Kundu, S De, JL Martindale, X Yang, MK Evans, K Abdelmohse, M Gorospe
    Nucleic Acids Res., 2019;0(0):.  2019
  56. A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer
    Authors: J Chen, J Bell, BT Lau, T Whittaker, D Stapleton, HP Ji
    Oncogenesis, 2019;8(5):33.  2019
  57. PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway
    Authors: Y Bai, X Liu, X Qi, X Liu, F Peng, H Li, H Fu, S Pei, L Chen, X Chi, L Zhang, X Zhu, Y Song, Y Wang, S Meng, T Jiang, S Shao
    EBioMedicine, 2019;0(0):.  2019
  58. AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
    Authors: H Taniguchi, T Yamada, R Wang, K Tanimura, Y Adachi, A Nishiyama, A Tanimoto, S Takeuchi, LH Araujo, M Boroni, A Yoshimura, S Shiotsu, I Matsumoto, S Watanabe, T Kikuchi, S Miura, H Tanaka, T Kitazaki, H Yamaguchi, H Mukae, J Uchino, H Uehara, K Takayama, S Yano
    Nat Commun, 2019;10(1):259.  2019
  59. Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus
    Authors: ME Nickol, J Ciric, SD Falcinelli, DS Chertow, J Kindrachuk
    Viruses, 2019;11(2):.  2019
  60. CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
    Authors: S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis
    JCI Insight, 2019;0(0):.  2019
  61. Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin
    Authors: C Zalfa, P Azmoon, E Mantuano, SL Gonias
    J. Leukoc. Biol., 2019;0(0):.  2019
  62. MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma
    Authors: Y Zhao, W Huang, TM Kim, Y Jung, LG Menon, H Xing, H Li, RS Carroll, PJ Park, HW Yang, MD Johnson
    J. Exp. Clin. Cancer Res., 2019;38(1):36.  2019
  63. Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway
    Authors: T van Montfo, R van der Sl, G Darcis, D Beaty, K Groen, AO Pasternak, G Pollakis, M Vink, EM Westerhout, M Hamdi, M Bakker, B van der Pu, S Jurriaans, JH Prins, R Jeeninga, AAM Thomas, D Speijer, B Berkhout
    EBioMedicine, 2019;0(0):.  2019
  64. Signal regulatory protein ? protects podocytes through promoting autophagic activity
    Authors: L Li, Y Liu, S Li, Y Yang, C Zeng, W Rong, H Liang, M Zhang, X Zhu, K Kidder, Y Liu, Z Liu, K Zen
    JCI Insight, 2019;5(0):.  2019
  65. Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib
    Authors: YC Ko, CY Hu, ZH Liu, HF Tien, DL Ou, HF Chien, LI Lin
    Int J Mol Sci, 2019;20(5):.  2019
  66. Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells
    Authors: DA Ferraro, F Patella, S Zanivan, C Donato, N Aceto, M Giannotta, E Dejana, M Diepenbruc, G Christofor, M Buess
    BMC Cancer, 2019;19(1):312.  2019
  67. E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms
    Authors: MK Jolly, KE Ware, S Xu, S Gilja, S Shetler, Y Yang, X Wang, RG Austin, D Runyambo, AJ Hish, S Bartholf D, JT George, RT Kreulen, MK Boss, AL Lazarides, DL Kerr, DG Gerber, D Sivaraj, AJ Armstrong, MW Dewhirst, WC Eward, H Levine, JA Somarelli
    Mol. Cancer Res., 2019;0(0):.  2019
  68. Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis
    Authors: D Neelakanta, S Dogra, BR Devapatla, P Jaiprasart, MC Mukashyaka, R Janknecht, SKD Dwivedi, R Bhattachar, S Husain, K Ding, S Woo
    Mol. Cancer Res., 2019;0(0):.  2019
  69. EPHA2 is a predictive biomarker of resistance and a potential therapeutic target for improving anti-epidermal growth factor receptor therapy in colorectal cancer
    Authors: G Martini, C Cardone, PP Vitiello, V Belli, S Napolitano, T Troiani, D Ciardiello, CM Della Cort, F Morgillo, N Matrone, V Sforza, G Papaccio, V Desiderio, MC Paul, V Moreno-Vie, N Normanno, AM Rachiglio, V Tirino, E Maiello, TP Latiano, D Rizzi, G Signoriell, M Sibilia, F Ciardiello, E Martinelli
    Mol. Cancer Ther., 2019;0(0):.  2019
  70. Survival/adaptation of Bone Marrow derived Mesenchymal Stem Cells after long term starvation through selective processes
    Authors: F Ferro, R Spelat, G Shaw, N Duffy, MN Islam, PM O'Shea, D O'Toole, L Howard, M Murphy
    Stem Cells, 2019;0(0):.  2019
  71. Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma
    Authors: R Kumar, CN Njauw, BY Reddy, Z Ji, A Rajadurai, N Klebanov, H Tsao
    Oncogene, 2019;0(0):.  2019
  72. IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states
    Authors: G Pellizzari, C Hoskin, S Crescioli, S Mele, J Gotovina, G Chiaruttin, R Bianchini, K Ilieva, HJ Bax, S Papa, KE Lacy, E Jensen-Jar, S Tsoka, DH Josephs, JF Spicer, SN Karagianni
    EBioMedicine, 2019;0(0):.  2019
  73. Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds
    Authors: IA Schepetkin, LN Kirpotina, AI Khlebnikov, N Balasubram, MT Quinn
    Molecules, 2019;24(9):.  2019
  74. Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma
    Authors: J Wurm, SP Behringer, VM Ravi, K Joseph, N Neidert, JP Maier, R Doria-Medi, M Follo, D Delev, D Pfeifer, J Beck, R Sankowski, O Schnell, DH Heiland
    Cancers (Basel), 2019;11(10):.  2019
  75. YM155 decreases radiation-induced invasion and reverses epithelial-mesenchymal transition by targeting STAT3 in glioblastoma
    Authors: X Zhang, X Wang, R Xu, J Ji, Y Xu, M Han, Y Wei, B Huang, A Chen, Q Zhang, W Li, J Wang, X Li, C Qiu
    J Transl Med, 2018;16(1):79.  2018
  76. Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines
    Authors: S Heavey, P Dowling, G Moore, MP Barr, N Kelly, SG Maher, S Cuffe, SP Finn, KJ O'Byrne, K Gately
    Sci Rep, 2018;8(1):1652.  2018
  77. Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells
    Authors: G Tornillo, C Knowlson, H Kendrick, J Cooke, H Mirza, I Aurrekoetx, MDM Vivanco, NE Buckley, A Grigoriadi, MJ Smalley
    Cell Rep, 2018;25(13):3674-3692.e10.  2018
  78. Ruxolitinib in combination with prednisone and nilotinib exhibit synergistic effects in human cells lines and primary cells from myeloproliferative neoplasms
    Authors: A Arenas Cor, R Ayala Diaz, P Hernández-, J Gorrochate, D Primo, A Robles, ML Morales, J Ballestero, I Rapado, M Gallardo, M Linares, J Martínez-L
    Haematologica, 2018;0(0):.  2018
  79. JDP2 overexpression provokes cardiac dysfunction in mice
    Authors: J Heger, J Bornbaum, A Würfel, C Hill, N Brockmann, R Gáspár, J Pálóczi, ZV Varga, M Sárközy, P Bencsik, T Csont, S Török, B Kojonazaro, RT Schermuly, K Böngler, M Parahuleva, P Ferdinandy, R Schulz, G Euler
    Sci Rep, 2018;8(1):7647.  2018
  80. ?-arrestin 1 regulates ?2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
    Authors: J Kim, CA Grotegut, JW Wisler, T Li, L Mao, M Chen, W Chen, PB Rosenberg, HA Rockman, RJ Lefkowitz
    Skelet Muscle, 2018;8(1):39.  2018
  81. Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo
    Authors: C Li, V Rezov, E Joensuu, V Vartiainen, M Rönty, M Yin, M Myllärniem, K Koli
    Sci Rep, 2018;8(1):10070.  2018
  82. IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells
    Authors: M Shimizu, N Tanaka
    Oncogene, 2018;0(0):.  2018
  83. HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis
    Authors: C Hernandez, P Huebener, JP Pradere, DJ Antoine, RA Friedman, RF Schwabe
    J. Clin. Invest., 2018;0(0):.  2018
  84. Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT
    Authors: Y Zhang, G Ji, S Han, Z Shao, Z Lu, L Huo, J Zhang, R Yang, Q Feng, H Shen, H Wang, X Li
    Cell. Physiol. Biochem., 2018;50(2):612-628.  2018
  85. Low-molecular weight keratins with anti-skin aging activity produced by anaerobic digestion of poultry feathers with Fervidobacterium islandicum AW-1
    Authors: I Yeo, YJ Lee, K Song, HS Jin, JE Lee, D Kim, DW Lee, NJ Kang
    J. Biotechnol., 2018;0(0):.  2018
  86. WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4
    Authors: K Taniuchi, M Furihata, S Naganuma, T Saibara
    Cancer Med, 2018;0(0):.  2018
  87. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies
    Authors: G Xiao, LN Chan, L Klemm, D Braas, Z Chen, H Geng, QC Zhang, A Aghajanire, KN Cosgun, T Sadras, J Lee, T Mirzapoiaz, R Salgia, T Ernst, A Hochhaus, H Jumaa, X Jiang, DM Weinstock, TG Graeber, M Müschen
    Cell, 2018;0(0):.  2018
  88. Olfactory receptor OR2AT4 regulates human hair growth
    Authors: J Chéret, M Bertolini, L Ponce, J Lehmann, T Tsai, M Alam, H Hatt, R Paus
    Nat Commun, 2018;9(1):3624.  2018
  89. WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
    Authors: CS Gonçalves, J Vieira de, M Pojo, EP Martins, S Queirós, E Chautard, R Taipa, MM Pires, AA Pinto, F Pardal, C Custódia, CC Faria, C Clara, RM Reis, N Sousa, BM Costa
    Theranostics, 2018;8(17):4805-4823.  2018
  90. WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling
    Authors: W Chen, LN Zebaze, J Dong, L Chézeau, P Inquimbert, S Hugel, S Niu, F Bihel, E Boutant, E Réal, P Villa, MP Junier, H Chneiweiss, M Hibert, J Haiech, MC Kilhoffer, M Zeniou
    Oncotarget, 2018;9(43):27197-27219.  2018
  91. Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation
    Authors: V Pandey, B Wang, CD Mohan, AR Raquib, S Rangappa, V Srinivasa, JE Fuchs, KS Girish, T Zhu, A Bender, L Ma, Z Yin, Basappa, KS Rangappa, PE Lobie
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.  2018
  92. Lorlatinib treatment elicits multiple on- and off-target mechanisms of resistance in ALK-driven cancer
    Authors: S Redaelli, M Ceccon, M Zappa, GG Sharma, C Mastini, M Mauri, M Nigoghossi, L Massimino, N Cordani, F Farina, R Piazza, C Gambacorti, L Mologni
    Cancer Res., 2018;0(0):.  2018
  93. Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors
    Authors: F Pareja, AH Brandes, T Basili, P Selenica, FC Geyer, D Fan, A Da Cruz Pa, R Kumar, DN Brown, R Gularte-Mé, B Alemar, R Bi, RS Lim, I de Bruijn, S Fujisawa, R Gardner, E Feng, A Li, EM da Silva, JR Lozada, P Blecua, L Cohen-Goul, AA Jungbluth, EA Rakha, IO Ellis, MIA Edelweiss, J Palazzo, L Norton, T Hollmann, M Edelweiss, BP Rubin, B Weigelt, JS Reis-Filho
    Nat Commun, 2018;9(1):3533.  2018
  94. K-Ras lysine-42 is crucial for its signaling, cell migration and invasion
    Authors: BH Choi, MR Philips, Y Chen, L Lu, W Dai
    J. Biol. Chem., 2018;0(0):.  2018
  95. The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors
    Authors: X Wang, J Ai, H Liu, X Peng, H Chen, Y Chen, Y Su, A Shen, X Huang, J Ding, M Geng
    Mol. Cancer Ther., 2018;0(0):.  2018
  96. Establishment of keratinocyte cell lines from human hair follicles
    Authors: T Wagner, M Gschwandtn, A Strajeriu, A Elbe-Bürge, J Grillari, R Grillari-V, G Greiner, B Golabi, E Tschachler, M Mildner
    Sci Rep, 2018;8(1):13434.  2018
  97. Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
    Authors: X Gong, JR Smith, HM Swanson, LP Rubin
    Molecules, 2018;23(4):.  2018
  98. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
    Authors: Y Jiang, YY Jiang, JJ Xie, A Mayakonda, M Hazawa, L Chen, JF Xiao, CQ Li, ML Huang, LW Ding, QY Sun, L Xu, D Kanojia, M Jeitany, JW Deng, LD Liao, HJ Soukiasian, BP Berman, JJ Hao, LY Xu, EM Li, MR Wang, XG Bi, DC Lin, HP Koeffler
    Nat Commun, 2018;9(1):3619.  2018
  99. CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1? axis to inhibit gastric tumorigenesis
    Authors: W Li, CC Wong, X Zhang, W Kang, G Nakatsu, Q Zhao, H Chen, MYY Go, PWY Chiu, X Wang, J Ji, X Li, Z Cai, EKW Ng, J Yu
    Oncogene, 2018;0(0):.  2018
  100. Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds
    Authors: V Vishwakarm, J New, D Kumar, V Snyder, L Arnold, E Nissen, Q Hu, N Cheng, D Miller, AR Thomas, Y Shnayder, K Kakarala, TT Tsue, DA Girod, SM Thomas
    Sci Rep, 2018;8(1):12163.  2018
  101. Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17
    Authors: P Urriola-Mu, R Lagos-Cabr, D Patiño-Gar, JG Reyes, RD Moreno
    Int J Mol Sci, 2018;19(8):.  2018
  102. Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines
    Authors: MY Gökyildiri, U Grandel, K Hattar, G Dahlem, E Schuetz, FH Leinberger, F Eberle, U Sibelius, F Grimminger, W Seeger, R Engenhart-, E Dikomey, FSB Subtil
    Oncotarget, 2018;9(48):28976-28988.  2018
  103. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
    Authors: PD Fan, G Narzisi, AD Jayaprakas, E Venturini, N Robine, P Smibert, S Germer, HA Yu, EJ Jordan, PK Paik, YY Janjigian, JE Chaft, L Wang, AA Jungbluth, S Middha, L Spraggon, H Qiao, CM Lovly, MG Kris, GJ Riely, K Politi, H Varmus, M Ladanyi
    Proc. Natl. Acad. Sci. U.S.A., 2018;115(26):E6030-E6038.  2018
  104. Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy
    Authors: JM Santiago-O, ES Kleinerman, MG Hollomon, A Livingston, WL Wang, JW Tsai, NB Gordon
    Oncotarget, 2018;9(2):1602-1616.  2018
  105. 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease
    Authors: C Klein, G Roussel, S Brun, C Rusu, C Patte-Mens, M Maitre, AG Mensah-Nya
    Acta Neuropathol Commun, 2018;6(1):136.  2018
  106. The Noncoding RNA nc886 Regulates PKR Signaling and Cytokine Production in Human Cells
    Authors: E Golec, L Lind, M Qayyum, AM Blom, BC King
    J. Immunol., 2018;0(0):.  2018
  107. Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin
    Authors: E Narvi, K Vaparanta, A Karrila, D Chakrobort, S Knuutila, A Pulliainen, M Sundvall, K Elenius
    Sci Rep, 2018;8(1):16579.  2018
  108. Suppression of the ERK-SRF axis facilitates somatic cell reprogramming
    Authors: S Huh, HR Song, GR Jeong, H Jang, NH Seo, JH Lee, JY Yi, B Lee, HW Choi, JT Do, JS Kim, SH Lee, JW Jung, T Lee, J Shim, MK Han, TH Lee
    Exp. Mol. Med., 2018;50(2):e448.  2018
  109. Acquired resistance to AZD9291 as an upfront treatment is dependent on ERK signaling in a preclinical model
    Authors: BM Ku, MK Choi, JM Sun, SH Lee, JS Ahn, K Park, MJ Ahn
    PLoS ONE, 2018;13(4):e0194730.  2018
  110. Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.
    Authors: Charalambos Kaittanis, Chrysafis Andreou, Haley Hieronymu, Ninghui Mao, Catherine A Foss, Matthias Eiber, Gregor Weirich, Palak Panchal, Anuradha Gopalan, Juan Zurita, Samuel Achilefu, Gabriela Chiosis, Vladimir Ponomarev, Markus Schwaiger, Brett S Carver, Martin G Pomper, Jan Grimm
    The Journal of Experimental Medicine, 2018;0(0):1540-9538.  2018
  111. BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling
    Authors: K Taniuchi, M Furihata, S Naganuma, K Dabanaka, K Hanazaki, T Saibara
    Am J Cancer Res, 2018;8(3):387-404.  2018
  112. Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
    Authors: TM Totiger, S Srinivasan, VR Jala, P Lamichhane, AR Dosch, AA Gaidarski, C Joshi, S Rangappa, J Castellano, PK Vemula, X Chen, D Kwon, N Kashikar, M VanSaun, NB Merchant, NS Nagathihal
    Mol. Cancer Ther., 2018;0(0):.  2018
  113. Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer
    Authors: MH Kubala, V Punj, VR Placencio-, H Fang, GE Fernandez, R Sposto, YA DeClerck
    Cell Rep, 2018;25(8):2177-2191.e7.  2018
  114. NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway
    Authors: L Deng, X Gao, B Liu, X He, J Xu, J Qiang, Q Wu, S Liu
    Cell Death Dis, 2018;9(12):1143.  2018
  115. Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist
    Authors: W Miao, K Sakai, N Ozawa, T Nishiuchi, Y Suzuki, K Ito, T Morioka, M Umitsu, J Takagi, H Suga, K Matsumoto
    Sci Rep, 2018;8(1):16492.  2018
  116. Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway
    Authors: Z Fang, KH Jung, HH Yan, SJ Kim, M Rumman, JH Park, B Han, JE Lee, YW Kang, JH Lim, SS Hong
    Cell. Physiol. Biochem., 2018;47(5):1751-1768.  2018
  117. miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer
    Authors: U Baumgartne, F Berger, A Hashemi Gh, SS Burgener, K Monastyrsk, E Vassella
    Mol. Cancer, 2018;17(1):44.  2018
  118. Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1
    Authors: TY Wong, WC Juang, CT Tsai, CJ Tseng, WH Lee, SN Chang, PW Cheng
    J Clin Med, 2018;7(11):.  2018
  119. Dysregulation of Mir-196b in Head and Neck Cancers Leads to Pleiotropic Effects in the Tumor Cells and Surrounding Stromal Fibroblasts
    Authors: S Álvarez-Te, ST Menéndez, MÁ Villaronga, JP Rodrigo, L Manterola, L de Villala, JC de Vicente, L Alonso-Dur, MP Fernández, CH Lawrie, JM García-Ped
    Sci Rep, 2017;7(1):17785.  2017
  120. Activation of p38 and Erk Mitogen-Activated Protein Kinases Signaling in Ocular Rosacea
    Authors: EJ Wladis, S Swamy, A Herrmann, J Yang, JA Carlson, AP Adam
    Invest. Ophthalmol. Vis. Sci, 2017;58(2):843-848.  2017
  121. Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells
    Authors: GM Pio, Y Xia, MM Piaseczny, JE Chu, AL Allan
    PLoS ONE, 2017;12(5):e0177640.  2017
  122. Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma
    Authors: Y Mo, Y Lu, P Wang, S Huang, L He, D Li, F Li, J Huang, X Lin, X Li, S Che, Q Chen
    Tumour Biol, 2017;39(2):1010428317690.  2017
  123. The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry
    Authors: Z Zhou, L Xu, A Sennepin, C Federici, Y Ganor, D Tudor, D Damotte, N Barry Delo, M Zerbib, M Bomsel
    Mucosal Immunol, 2017;0(0):.  2017
  124. Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell
    Authors: S Chen, J Tao, F Zhong, Y Jiao, J Xu, Q Shen, H Wang, S Fan, Y Zhang
    PLoS ONE, 2017;12(5):e0176501.  2017
  125. Co-targeting of MEK and PDGFR/STAT3 pathways to treat pancreatic ductal adenocar
    Authors: N Sahu, E Chan, F Chu, T Pham, H Koeppen, W Forrest, M Merchant, J Settleman
    Mol. Cancer Ther., 2017;0(0):.  2017
  126. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension
    Authors: P Yang, C Read, RE Kuc, G Buonincont, M Southwood, R Torella, PD Upton, A Crosby, SJ Sawiak, TA Carpenter, RC Glen, NW Morrell, JJ Maguire, AP Davenport
    Circulation, 2017;135(12):1160-1173.  2017
  127. The Transcription Factor HOXB7 Regulates ERK Kinase Activity and Thereby Stimulates the Motility and Invasiveness of Pancreatic Cancer Cells
    Authors: M Tsuboi, K Taniuchi, T Shimizu, M Saito, T Saibara
    J. Biol. Chem., 2017;0(0):.  2017
  128. Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation
    Authors: M Riera-Borr, VD Cuevas, B Alonso, MA Vega, J Joven, E Izquierdo, ÁL Corbí
    J. Immunol., 2017;0(0):.  2017
  129. The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischemia/reperfusion independent from mitochondrial connexin 43
    Authors: K Boengler, M Bulic, R Schreckenb, KD Schlueter, R Schulz
    Br. J. Pharmacol., 2017;0(0):.  2017
  130. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2�
    Authors: II Kuan, KH Liang, YP Wang, TW Kuo, YJ Meir, SC Wu, SC Yang, J Lu, HC Wu
    Sci Rep, 2017;7(0):41852.  2017
  131. FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation
    Authors: FR Teixeira, AO Manfiolli, NA Vieira, AC Medeiros, PO Coelho, D Santiago G, D Schechtman, MD Gomes
    Arch. Biochem. Biophys., 2017;0(0):.  2017
  132. Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation
    Authors: S Curcic, M Holzer, L Pasterk, E Knuplez, TO Eichmann, S Frank, R Zimmermann, R Schicho, A Heinemann, G Marsche
    Sci Rep, 2017;7(1):8030.  2017
  133. Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer
    Authors: K Kalyvianak, V Gebhart, N Peroulis, C Panagiotop, F Kiagiadaki, I Pediaditak, M Aivaliotis, E Moustou, M Tzardi, G Notas, E Castanas, M Kampa
    Sci Rep, 2017;7(0):44418.  2017
  134. Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis
    Authors: S Keller, J Kneissl, V Grabher-Me, S Heindl, J Hasenauer, D Maier, J Mattes, P Winter, B Luber
    BMC Cancer, 2017;17(1):845.  2017
  135. Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17
    Authors: PC Buchanan, KL Boylan, B Walcheck, R Heinze, MA Geller, PA Argenta, AP Skubitz
    J. Biol. Chem, 2017;0(0):.  2017
  136. Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN
    Authors: A Cavazzoni, S La Monica, R Alfieri, A Ravelli, N Van Der St, R Sciarrillo, D Madeddu, CAM Lagrasta, F Quaini, M Bonelli, C Fumarola, D Cretella, G Digiacomo, M Tiseo, GJ Peters, A Ardizzoni, PG Petronini, E Giovannett
    Oncotarget, 2017;0(0):.  2017
  137. Disruption of Aneuploidy and Senescence induced by Aurora inhibition promotes intrinsic Apoptosis in double hit or double expressor Diffuse Large B-cell Lymphomas
    Authors: D Mahadevan, S Islam, W Qi, C Morales, L Cooke, C Spier, E Weterings
    Mol. Cancer Ther., 2017;0(0):.  2017
  138. Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway
    Authors: TO Cri?an, MCP Cleophas, B Novakovic, K Erler, FL van de Vee, HG Stunnenber, MG Netea, CA Dinarello, LAB Joosten
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.  2017
  139. Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation.
    Authors: Benjamin Y Owusu, Shantasia Thomas, Phanindra Venukadas, Zhenfu Han, James W Janetka, Robert A Galemmo, Lidija Klampfer
    Oncotarget, 2017;0(0):1949-2553.  2017
  140. WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response
    Authors: S Janczar, J Nautiyal, Y Xiao, E Curry, M Sun, E Zanini, AJ Paige, H Gabra
    Cell Death Dis, 2017;8(7):e2955.  2017
  141. Resistance to the antibody-drug conjugate T-DM1 is based in a reduction in lysosomal proteolytic activity
    Authors: C Ríos-Luci, S García-Alo, E Díaz-Rodrí, M Nadal-Serr, J Arribas, A Ocaña, A Pandiella
    Cancer Res., 2017;0(0):.  2017
  142. Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer
    Authors: CH Chang, MC Yen, SH Liao, YL Hsu, CS Lai, KP Chang, YL Hsu
    Int J Mol Sci, 2017;18(7):.  2017
  143. Induction and Differentiation of IL-10-Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients.
    Authors: Banko Z, Pozsgay J, Szili D, Toth M, Gati T, Nagy G, Rojkovich B, Sarmay G
    J Immunol, 2017;198(4):1512-1520.  2017
  144. Protein C receptor stimulates multiple signaling pathways in breast cancer cells
    Authors: D Wang, C Liu, J Wang, Y Jia, X Hu, H Jiang, ZM Shao, YA Zeng
    J. Biol. Chem., 2017;0(0):.  2017
  145. Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer.
    Authors: Chih-Hau Chang, Meng-Chi Yen, Ssu-Hui Liao, Yu-Ling Hsu, Chung-Sheng Lai, Kao-Ping Chang, Ya-Ling Hsu
    International Journal of Molecular Sciences, 2017;0(0):1422-0067.  2017
  146. Galectin-3 interacts with the cell surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells
    Authors: F Colomb, W Wang, D Simpson, M Zafar, R Beynon, JM Rhodes, LG Yu
    J. Biol. Chem., 2017;0(0):.  2017
  147. Human Epididymis Protein 4 Promotes Events Associated with Metastatic Ovarian CancerviaRegulation of the Extracelluar Matrix
    Authors: JR Ribeiro, HM Gaudet, M Khan, C Schorl, NE James, MT Oliver, PA DiSilvestr, RG Moore, N Yano
    Front Oncol, 2017;7(0):332.  2017
  148. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades
    Authors: H Lee, SH Baek, JH Lee, C Kim, JH Ko, SG Lee, A Chinnatham, SA Alharbi, WM Yang, JY Um, G Sethi, KS Ahn
    Int J Mol Sci, 2017;18(5):.  2017
  149. Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer.
    Authors: Chang C, Yen M, Liao S, Hsu Y, Lai C, Chang K, Hsu Y
    Int J Mol Sci, 2017;18(7):.  2017
  150. Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice
    Authors: P Kuppusamy, A Nagalingam, N Muniraj, NK Saxena, D Sharma
    Sci Rep, 2017;7(1):17943.  2017
  151. Ras-MEK Signaling Mediates a Critical Chk1-dependent DNA Damage Response in Cancer Cells
    Authors: HJ Lee, Y Cao, V Pham, E Blackwood, C Wilson, M Evangelist, C Klijn, D Stokoe, J Settleman
    Mol. Cancer Ther, 2017;0(0):.  2017
  152. Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes
    Authors: M Mustapic, E Eitan, JK Werner, ST Berkowitz, MP Lazaropoul, J Tran, EJ Goetzl, D Kapogianni
    Front Neurosci, 2017;11(0):278.  2017
  153. JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non-small cell lung cancer
    Authors: K Shien, VA Papadimitr, D Ruder, C Behrens, L Shen, N Kalhor, J Song, JJ Lee, J Wang, X Tang, RS Herbst, S Toyooka, L Girard, JD Minna, JM Kurie, II Wistuba, JG Izzo
    Mol. Cancer Ther., 2017;0(0):.  2017
  154. Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene
    Authors: SA Nadeau, W An, BC Mohapatra, I Mushtaq, TA Bielecki, H Luan, N Zutshi, G Ahmad, MD Storck, M Sanada, S Ogawa, V Band, H Band
    J. Biol. Chem, 2017;292(9):3666-3682.  2017
  155. Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas
    Authors: MV Carriero, K Bifulco, V Ingangi, S Costantini, G Botti, C Ragone, M Minopoli, ML Motti, D Rea, G Scognamigl, G Botti, C Arra, G Ciliberto, A Pessi
    Sci Rep, 2017;7(1):1312.  2017
  156. A Small Molecule Inhibitor of PDK1/PLC?1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion
    Authors: C Raimondi, V Calleja, R Ferro, A Fantin, AM Riley, BV Potter, CH Brennan, T Maffucci, B Larijani, M Falasca
    Sci Rep, 2016;6(0):26142.  2016
  157. Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer.
    Authors: Astrid Escudero-E, Michael Bartosche, Chrysostomi Gialeli, Marcin Okroj, Sioned Owen, Karin Jirström, Akira Orimo, Wen G Jiang, Kristian Pietras, Anna M Blom
    Oncotarget, 2016;0(0):1949-2553.  2016
  158. Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line
    Authors: Benjamin Kalbe
    Eur. J. Cell Biol, 2016;0(0):.  2016
  159. Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells
    Sci Rep, 2016;6(0):33132.  2016
  160. Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling
    Authors: L Bénard, JG Oh, M Cacheux, A Lee, M Nonnenmach, DS Matasic, E Kohlbrenne, C Kho, C Pavoine, RJ Hajjar, JS Hulot
    Circulation, 2016;133(15):1458-71; disc.  2016
  161. Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions.
    Authors: Purushothaman A, Bandari S, Liu J, Mobley J, Brown E, Sanderson R
    J Biol Chem, 2016;291(4):1652-63.  2016
  162. Metabolism regulates cellular functions of bone marrow-derived cells used for cardiac therapy
    Stem Cells, 2016;0(0):.  2016
  163. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism
    Proc Natl Acad Sci USA, 2016;0(0):.  2016
  164. Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells.
    Authors: Skolekova S, Matuskova M, Bohac M, Toro L, Demkova L, Gursky J, Kucerova L
    Cell Commun Signal, 2016;14(1):4.  2016
  165. CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells
    Oncogene, 2016;0(0):.  2016
  166. Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection
    MBio, 2016;7(6):.  2016
  167. Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance
    Acta Pharmacol. Sin., 2016;0(0):.  2016
  168. CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells
    Authors: Aki Tanouchi
    J. Exp. Clin. Cancer Res, 2016;35(1):190.  2016
  169. Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs
    Authors: Nader Alaridah
    J Innate Immun, 2016;0(0):.  2016
  170. Necrotic cells influence migration and invasion of glioblastoma via NF-?B/AP-1-mediated IL-8 regulation
    Authors: SH Ahn, H Park, YH Ahn, S Kim, MS Cho, JL Kang, YH Choi
    Sci Rep, 2016;6(0):24552.  2016
  171. Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
    Oncotarget, 2016;7(26):40531-40545.  2016
  172. The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2
    Authors: Nicola M Heller
    J. Biol. Chem., 2016;291(48):24922-24930.  2016
  173. New insights into the Shwachman-Diamond Syndrome-related haematological disorder: hyper-activation of mTOR and STAT3 in leukocytes
    Sci Rep, 2016;6(0):33165.  2016
  174. Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer
    Oncotarget, 2016;0(0):.  2016
  175. Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells
    J Cancer, 2016;7(13):1824-1832.  2016
  176. Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18
    Sci Rep, 2016;6(0):32255.  2016
  177. BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine
    Authors: Yuexi Gu
    Sci Rep, 2016;6(0):28217.  2016
  178. Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase
    Authors: Raymond B Birge
    Cell Commun. Signal, 2016;14(1):19.  2016
  179. Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.
    Authors: Laukkanen, Mikko O, Cammarota, Francesc, Esposito, Tiziana, Salvatore, Marco, Castellone, Maria D
    PLoS ONE, 2015;10(3):e0121441.  2015
  180. The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes.
    Authors: Hansen F, Kalle-Brune M, van der Plas M, Stromdahl A, Malmsten M, Morgelin M, Schmidtchen A
    J Immunol, 2015;194(11):5397-406.  2015
  181. Loss of DGKepsilon induces endothelial cell activation and death independently of complement activation.
    Authors: Bruneau S, Neel M, Roumenina L, Frimat M, Laurent L, Fremeaux-Bacchi V, Fakhouri F
    Blood, 2015;125(6):1038-46.  2015
  182. Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.
    Authors: Mailly L, Xiao F, Lupberger J, Wilson G, Aubert P, Duong F, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lutgehetmann M, Volz T, Davis C, Harris H, Mee C, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim M, Neunlist M, Zeisel M, Dandri M, McKeating J, Robinet E, Baumert T
    Nat Biotechnol, 2015;33(5):549-54.  2015
  183. Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma.
    Authors: Atefi M, Titz B, Avramis E, Ng C, Wong D, Lassen A, Cerniglia M, Escuin-Ordinas H, Foulad D, Comin-Anduix B, Graeber T, Ribas A
    Mol Cancer, 2015;14(0):27.  2015
  184. Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling.
    Authors: Man J, Shoemake J, Ma T, Rizzo A, Godley A, Wu Q, Mohammadi A, Bao S, Rich J, Yu J
    Cancer Res, 2015;75(8):1760-9.  2015
  185. YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway.
    Authors: Chang B, Johnson K, LaTocha D, Rowley J, Bryant J, Burke R, Smith R, Loriaux M, Muschen M, Mullighan C, Druker B, Tyner J
    J Hematol Oncol, 2015;8(0):39.  2015
  186. Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation.
    Authors: Zhao D, Besser A, Wander S, Sun J, Zhou W, Wang B, Ince T, Durante M, Guo W, Mills G, Theodorescu D, Slingerland J
    Oncogene, 2015;34(43):5447-59.  2015
  187. Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells.
    Authors: Singh A, Ruan Y, Tippett T, Narendran A
    J Exp Clin Cancer Res, 2015;34(0):104.  2015
  188. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5promotes angiogenesis and vasorelaxation.
    Authors: Cho Y, Hur S, Kim J, Kim J, Lee D, Choe J, Won M, Ha K, Jeoung D, Han S, Ryoo S, Lee H, Min J, Kwon Y, Kim D, Kim Y
    J Biol Chem, 2015;290(1):467-77.  2015
  189. A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D.
    Authors: Eggink L, Spyroulias G, Jones N, Hanson C, Hoober J
    PLoS ONE, 2015;10(6):e0130532.  2015
  190. Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma.
    Authors: Yamada T, Amann J, Fukuda K, Takeuchi S, Fujita N, Uehara H, Iwakiri S, Itoi K, Shilo K, Yano S, Carbone D
    Cancer Res, 2015;75(19):4188-97.  2015
  191. A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
    Authors: Bajpe, P K, Prahallad, A, Horlings, H, Nagtegaal, I, Beijersbergen, R, Bernards, R
    Oncogene, 2015;34(4):531-6.  2015
  192. Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes.
    Authors: Sento S, Sasabe E, Yamamoto T
    PLoS ONE, 2015;11(2):e0148454.  2015
  193. Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.
    Authors: Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, Kim Y, Adam J, Lichter P, Solary E, Berchem G, Moussay E
    Blood, 2015;126(9):1106-17.  2015
  194. Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells.
    Authors: Li, Wenjuan, Liu, Joan, Jackson, Kasey, Shi, Runhua, Zhao, Yunfeng
    PLoS ONE, 2014;9(4):e94079.  2014
  195. Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling.
    Authors: Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, Limame R, Mestdagh P, Vandesompele J, Vanhove C, Maynard D, Lehuede C, Muller C, Valet P, Gespach C, Bracke M, Cocquyt V, Denys H, De Wever O
    Cancer Res, 2014;74(23):6806-19.  2014
  196. Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo.
    Authors: Naspi A, Panasiti V, Abbate F, Roberti V, Devirgiliis V, Curzio M, Borghi M, Lozupone F, Carotti S, Morini S, Gaudio E, Calvieri S, Londei P
    PLoS ONE, 2014;9(6):e98641.  2014
  197. Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation.
    Authors: Spary L, Al-Taei S, Salimu J, Cook A, Ager A, Watson H, Clayton A, Staffurth J, Mason M, Tabi Z
    J Immunol, 2014;192(7):3101-10.  2014
  198. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
    Authors: Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A
    Nat Commun, 2014;5(0):4715.  2014
  199. Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells.
    Authors: Golubkov V, Strongin A
    Cell Commun Signal, 2014;12(0):15.  2014
  200. IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers.
    Authors: Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle-Cezar F, Watkins J, Rashid M, De Rinaldis E, Hessey S, Gazinska P, Hayday A, Tutt A
    Cancer Res, 2014;74(17):4908-21.  2014
  201. Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 in hypopharyngeal carcinoma cells.
    Authors: Wang L, Chen P, Hsu L, Hsu W, Liu D, Chang C, Hsu Y, Lee J
    Am J Pathol, 2014;184(2):418-30.  2014
  202. Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy.
    Authors: Iida, Mari, Brand, Toni M, Starr, Megan M, Huppert, Evan J, Luthar, Neha, Bahrar, Harsh, Coan, John P, Pearson, Hannah E, Salgia, Ravi, Wheeler, Deric L
    Mol Cancer, 2014;13(0):242.  2014
  203. Adenosine inhibits tumor cell invasion via receptor-independent mechanisms.
    Authors: Virtanen S, Kukkonen-Macchi A, Vainio M, Elima K, Harkonen P, Jalkanen S, Yegutkin G
    Mol Cancer Res, 2014;12(12):1863-74.  2014
  204. Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner.
    Authors: Polajeva J, Bergstrom T, Edqvist P, Lundequist A, Sjosten A, Nilsson G, Smits A, Bergqvist M, Ponten F, Westermark B, Pejler G, Forsberg Nilsson K, Tchougounova E
    Mol Oncol, 2014;8(1):50-8.  2014
  205. Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.
    Authors: Jokela T, Karna R, Makkonen K, Laitinen J, Tammi R, Tammi M
    J Biol Chem, 2014;289(26):18569-81.  2014
  206. Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.
    Authors: Ray, K C, Moss, M E, Franklin, J L, Weaver, C J, Higginbotham, J, Song, Y, Revetta, F L, Blaine, S A, Bridges, L R, Guess, K E, Coffey, R J, Crawford, H C, Washington, M K, Means, A L
    Oncogene, 2014;33(7):823-31.  2014
  207. Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells.
    Authors: Raimondi C, Fantin A, Lampropoulou A, Denti L, Chikh A, Ruhrberg C
    J Exp Med, 2014;211(6):1167-83.  2014
  208. An increase in integrin-linked kinase non-canonically confers NF- inverted question markB-mediated growth advantages to gastric cancer cells by activating ERK1/2.
    Authors: Tseng P, Chen C, Shan Y, Chang W, Liu H, Hong T, Hsieh C, Lin S, Lin C
    Cell Commun Signal, 2014;12(1):69.  2014
  209. Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML.
    Authors: Kampen, K R, Ter Elst, A, Mahmud, H, Scherpen, F J G, Diks, S H, Peppelenbosch, M P, de Haas, V, Guryev, V, de Bont, E S J M
    Leukemia, 2014;28(3):589-99.  2014
  210. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.
    Authors: Sinkevicius, Kerstin, Kriegel, Christin, Bellaria, Kelly J, Lee, Jaewon, Lau, Allison, Leeman, Kristen, Zhou, Pengchen, Beede, Alexande, Fillmore, Christin, Caswell, Deborah, Barrios, Juliana, Wong, Kwok-Kin, Sholl, Lynette, Schlaeger, Thorsten, Bronson, Roderick, Chirieac, Lucian R, Winslow, Monte M, Haigis, Marcia C, Kim, Carla F
    Proc Natl Acad Sci U S A, 2014;111(28):10299-304.  2014
  211. Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naive to primed cell transition.
    Authors: Speakman C, Domke T, Wongpaiboonwattana W, Sanders K, Mudaliar M, van Aalten D, Barton G, Stavridis M
    Stem Cells, 2014;32(10):2605-15.  2014
  212. Soft matrix is a natural stimulator for cellular invasiveness.
    Authors: Gu, Zhizhan, Liu, Fei, Tonkova, Elina A, Lee, Soo Youn, Tschumperlin, Daniel J, Brenner, Michael
    Mol Biol Cell, 2014;25(4):457-69.  2014
  213. Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer.
    Authors: Nagalingam A, Kuppusamy P, Singh S, Sharma D, Saxena N
    Cancer Res, 2014;74(9):2617-29.  2014
  214. EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line.
    Authors: Ranayhossaini D, Lu J, Mabus J, Gervais A, Lingham R, Fursov N
    Int J Mol Sci, 2014;15(10):17686-704.  2014
  215. Histamine contributes to tissue remodeling via periostin expression.
    Authors: Yang, Lingli, Murota, Hiroyuki, Serada, Satoshi, Fujimoto, Minoru, Kudo, Akira, Naka, Tetsuji, Katayama, Ichiro
    J Invest Dermatol, 2014;134(8):2105-13.  2014
  216. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.
    Authors: Large M, Wetendorf M, Lanz R, Hartig S, Creighton C, Mancini M, Kovanci E, Lee K, Threadgill D, Lydon J, Jeong J, DeMayo F
    , 2014;0(0):.  2014
  217. Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.
    Authors: Lin Z, Zhang C, Zhang M, Xu D, Fang Y, Zhou Z, Chen X, Qin N, Zhang X
    PLoS ONE, 2014;9(1):e85296.  2014
  218. The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells.
    Authors: Kim, Ji Hye, Kim, Wang-Kyu, Sung, Young Kw, Kwack, Mi Hee, Song, Seung Yo, Choi, Joon-Seo, Park, Sang Gyu, Yi, TacGhee, Lee, Hyun-Joo, Kim, Dae-Duk, Seo, Hyun Min, Song, Sun U, Sung, Jong-Hyu
    Stem Cells Dev, 2014;23(12):1364-76.  2014
  219. Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response.
    Authors: Lutay N, Hakansson G, Alaridah N, Hallgren O, Westergren-Thorsson G, Godaly G
    PLoS ONE, 2014;9(1):e86466.  2014
  220. Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation.
    Authors: Huck, Bettina, Duss, Stephan, Hausser, Angelika, Olayioye, Monilola
    J Biol Chem, 2014;289(6):3138-47.  2014
  221. JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer.
    Authors: Song W, Ma Y, Wang J, Brantley-Sieders D, Chen J
    Cancer Res, 2014;74(9):2444-54.  2014
  222. Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells.
    Authors: Victoni T, Gleonnec F, Lanzetti M, Tenor H, Valenca S, Porto L, Lagente V, Boichot E
    PLoS ONE, 2014;9(1):e85243.  2014
  223. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets.
    Authors: Drake J, Graham N, Lee J, Stoyanova T, Faltermeier C, Sud S, Titz B, Huang J, Pienta K, Graeber T, Witte O
    Proc Natl Acad Sci U S A, 2013;110(49):E4762-9.  2013
  224. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
    Authors: Shimizu A, Nakayama H, Wang P, Konig C, Akino T, Sandlund J, Coma S, Italiano J, Mammoto A, Bielenberg D, Klagsbrun M
    J Biol Chem, 2013;288(4):2210-22.  2013
  225. CALHM1 controls the Ca(2)(+)-dependent MEK, ERK, RSK and MSK signaling cascade in neurons.
    Authors: Dreses-Werringloer U, Vingtdeux V, Zhao H, Chandakkar P, Davies P, Marambaud P
    J Cell Sci, 2013;126(0):1199-206.  2013
  226. Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584.
    Authors: Weidenaar A, Ter Elst A, Kampen K, Meeuwsen-de Boer T, Kamps W, Schuringa J, de Bont E
    Mol Cancer Res, 2013;11(4):339-48.  2013
  227. Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein.
    Authors: Szalmas A, Gyongyosi E, Ferenczi A, Laszlo B, Karosi T, Csomor P, Gergely L, Veress G, Konya J
    Virol J, 2013;10(0):79.  2013
  228. The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
    Authors: Lekawanvijit S, Kumfu S, Wang B, Manabe M, Nishijima F, Kelly D, Krum H, Kompa A
    PLoS ONE, 2013;8(12):e83687.  2013
  229. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer.
    Authors: Davies, Kurtis D, Mahale, Sakshi, Astling, David P, Aisner, Dara L, Le, Anh T, Hinz, Trista K, Vaishnavi, Aria, Bunn, Paul A J, Heasley, Lynn E, Tan, Aik-Choo, Camidge, D Ross, Varella-Garcia, Marileil, Doebele, Robert C
    PLoS ONE, 2013;8(12):e82236.  2013
  230. Sunlight UV-induced skin cancer relies upon activation of the p38alpha signaling pathway.
    Authors: Liu K, Yu D, Cho Y, Bode A, Ma W, Yao K, Li S, Li J, Bowden G, Dong Z, Dong Z
    Cancer Res, 2013;73(7):2181-8.  2013
  231. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
    Authors: Haas D, Bala K, Busche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Ruckert J, Varga Z, Keri G, Schulz T
    PLoS Pathog, 2013;9(11):e1003737.  2013
  232. Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines.
    Authors: Stegeman H, Kaanders J, Verheijen M, Peeters W, Wheeler D, Iida M, Grenman R, van der Kogel A, Span P, Bussink J
    Mol Cancer, 2013;12(1):133.  2013
  233. Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy.
    Authors: Mir, Shakeel, Schwarze, Steven R, Jin, Ling, Zhang, Jinling, Friend, Woodrow, Miriyala, Sumitra, St Clair, Daret, Craven, Rolf J
    Autophagy, 2013;9(10):1566-78.  2013
  234. A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer.
    Authors: Dumitru CA, Fechner MK, Hoffmann TK
    J. Leukoc. Biol., 2012;91(4):591-8.  2012
  235. Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy.
    Authors: Joshi, Avadhut, Loilome, Watchari, Siu, I-Mei, Tyler, Betty, Gallia, Gary L, Riggins, Gregory
    PLoS ONE, 2012;7(10):e44372.  2012
  236. Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ss-estradiol-BSA.
    Authors: Cheng W, Chen L, Yang S, Han J, Zhai D, Ni J, Yu C, Cai Z
    PLoS ONE, 2012;7(9):e45529.  2012
  237. Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia.
    BMC Cancer, 2012;12(0):431.  2012
  238. Concomitant targeting of EGF receptor, tgf-Beta and SRC points to a novel therapeutic approach in pancreatic cancer.
    Authors: Deharvengt S, Marmarelis M, Korc M
    PLoS ONE, 2012;7(6):e39684.  2012
  239. Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y.
    Authors: Olszewski U, Deally A, Tacke M, Hamilton G
    Neoplasia, 2012;14(9):813-22.  2012
  240. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
    EMBO J., 2012;31(17):3513-23.  2012
  241. DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma.
    Authors: Singhal G, Akhter MZ, Stern DF
    Cancer Gene Ther., 2011;18(7):520-30.  2011
  242. Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells.
    Authors: Shih YR, Tseng KF, Lai HY, Lin CH, Lee OK
    J. Bone Miner. Res., 2011;26(4):730-8.  2011
  243. Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab.
    Authors: Dunn EF, Iida M, Myers RA, Campbell DA, Hintz KA, Armstrong EA, Li C, Wheeler DL
    Oncogene, 2011;30(5):561-74.  2011
  244. Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling.
    Authors: Wei Q, Jiang H, Xiao Z
    Proc. Natl. Acad. Sci. U.S.A., 2011;108(17):7004-9.  2011
  245. Proteome profiling reveals potential toxicity and detoxification pathways following exposure of BEAS-2B cells to engineered nanoparticle titanium dioxide.
    Authors: Ge Y, Bruno M, Wallace K, Winnik W, Prasad RY
    Proteomics, 2011;11(12):2406-22.  2011
  246. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.
    Authors: Chandarlapaty, Sarat, Sawai, Ayana, Scaltriti, Maurizio, Rodrik-Outmezguine, Vanessa, Grbovic-Huezo, Olivera, Serra, Violeta, Majumder, Pradip K, Baselga, Jose, Rosen, Neal
    Cancer Cell, 2011;19(1):58-71.  2011
  247. Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation.
    Authors: Vingtdeux V, Chandakkar P, Zhao H, d'Abramo C, Davies P, Marambaud P
    FASEB J., 2011;25(1):219-31.  2011
  248. IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis.
    Authors: Martins AS, Ordonez JL, Amaral AT, Prins F, Floris G, Debiec-Rychter M, Hogendoorn PC, de Alava E
    PLoS ONE, 2011;6(5):e19846.  2011
  249. BH3 mimetics activate multiple pro-autophagic pathways.
    Authors: Malik SA, Orhon I, Morselli E, Criollo A, Shen S, Marino G, BenYounes A, Benit P, Rustin P, Maiuri MC, Kroemer G
    Oncogene, 2011;30(37):3918-29.  2011
  250. Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome.
    Authors: Guo T, Lee SS, Ng WH
    Cell. Mol. Life Sci., 2011;68(11):1983-2002.  2011
  251. EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes.
    Authors: Maddigan A, Truitt L, Arsenault R
    J. Immunol., 2011;187(11):5983-94.  2011
  252. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways.
    Authors: Li J, Cho YY, Langfald A
    Cancer Prev Res (Phila), 2011;4(8):1190-7.  2011
  253. Influence of leucine on protein metabolism, phosphokinase expression, and cell proliferation in human duodenum1,3.
    Authors: Coeffier M, Claeyssens S, Bensifi M, Lecleire S, Boukhettala N, Maurer B, Donnadieu N, Lavoinne A, Cailleux AF, Dechelotte P
    Am. J. Clin. Nutr., 2011;93(6):1255-62.  2011
  254. Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer.
    Authors: Li A, King J, Moro A, Sugi MD, Dawson DW, Kaplan J, Li G, Lu X, Strieter RM, Burdick M, Go VL, Reber HA, Eibl G, Hines OJ
    Am. J. Pathol., 2011;178(3):1340-9.  2011
  255. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).
    Authors: Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villen J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ
    Proc. Natl. Acad. Sci. U.S.A., 2010;107(34):15299-304.  2010
  256. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.
    Authors: Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon JE, Janle EM, Lobo J, Ferruzzi MG, Davies P, Marambaud P
    J. Biol. Chem., 2010;285(12):9100-13.  2010
  257. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation.
    Authors: Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R
    J. Clin. Invest., 2010;120(12):4353-65.  2010
  258. Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice.
    Authors: Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avances C, Allory Y, de la Taille A, Culine S, Blancou H, Cristol JP, Michel F, Sardet C, Fajas L
    Mol. Cancer Ther., 2010;9(0):1740-54.  2010
  259. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
    Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES
    Eur. J. Cancer, 2010;46(5):974-82.  2010
  260. Coactivated platelet-derived growth factor receptor alpha and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma.
    Authors: Dewaele B, Floris G, Finalet-Ferreiro J, Fletcher CD, Coindre JM, Guillou L, Hogendoorn PC, Wozniak A, Vanspauwen V, Schoffski P, Marynen P, Vandenberghe P, Sciot R, Debiec-Rychter M
    Cancer Res., 2010;70(18):7304-14.  2010
  261. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
    Authors: Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, Garcia-Echeverria C, Bardeesy N, Sharpless NE, Hayes ND, Kim WY, Engelman JA, Wong KK
    Cancer Cell, 2010;17(0):547-59.  2010
  262. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
    Authors: Tomlinson DC, Knowles MA
    Am. J. Pathol., 2010;177(5):2379-86.  2010
  263. Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation.
    Authors: Zhang H, Fagan DH, Zeng X
    Oncogene, 2010;29(17):2517-27.  2010
  264. The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1.
    Authors: Smith NJ, Stoddart LA, Devine NM, Jenkins L, Milligan G
    J. Biol. Chem., 2009;284(26):17527-39.  2009
  265. Kaposi's sarcoma-associated herpesvirus-G protein-coupled receptor-expressing endothelial cells exhibit reduced migration and stimulated chemotaxis by chemokine inverse agonists.
    Authors: Couty JP, Lupu-Meiri M, Oron Y, Gershengorn MC
    J. Pharmacol. Exp. Ther., 2009;329(3):1142-7.  2009
  266. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.
    Authors: Cailleteau C, Liagre B, Beneytout JL
    J. Cell. Biochem., 2009;107(4):785-96.  2009
  267. Neutrophils support lung colonization of metastasis-initiating breast cancer cells.
    Authors: Wculek S, Malanchi I
    Nature, 0;528(7582):413-7.  0
  268. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation.
    Authors: Barquilla A, Lamberto I, Heynen-Genel S, Brill L, Pasquale E
    Mol Biol Cell, 0;27(17):2757-70.  0

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Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/16/2020
Application:
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 08/08/2019
Application:
Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 06/26/2019
Application:
Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 06/05/2019
Application:
Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 06/02/2019
Application:

Prostae cancer cell lines were used and 200 ug lysate for each samples per membrane was applied.

Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/11/2019
Application:

2xce arrays purchased circa Jan 2018

Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/05/2019
Application:
Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/05/2019
Application:
Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/31/2019
Application:
Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 11/29/2018
Application:
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 09/13/2018
Application:

Great tool for evaluating cell signaling changes. We used this kit with LS174T cells. Kit protocol was easy to follow, and after imaging the resulting spots were very clear and easy to analyze. Phosphorylation of one of the identified signaling proteins was verified using an independent western blot. I would recommend this product

Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 07/18/2018
Application:
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/18/2018
Application:
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/05/2018
Application:
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/22/2018
Application:
Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/20/2017
Application:
Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 02/13/2017
Application:

Great kit and ok value for money considering the amount of data you get!

Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 02/12/2017
Application:

Used with human samples. Image shown was at 1 minute. Other 'dots' appeared at increased exposure. Kit very good overall. Good quality result and easy to use

Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/03/2017
Application:

This array is an excellent tool for screening potential phospho-kinases and related targets. However, it would be nice that if the total level of non-phosphorylated proteins be visualized at the same time on the membrane. In this case, the phosphorylated signals can be normalized.

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/28/2016
Application:

Antibodies could not be sourced to validate some of the targets.

Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/14/2016
Application:
Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 08/09/2016
Application:
Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/26/2015
Application: Sample Tested: Cell Lysates

This was control and didnt show any non specific bindings.
Specificity: Specific
Sensitivity: Sensitive
Buffer: BSA
Dilution: 1:1000

Serum Proteome Profiler Human Phospho-Kinase Array Kit ARY003B