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Proteome Profiler Human Phospho-Kinase Array Kit

ARY003B 178 Citations 15 Reviews Datasheet / COA / SDS
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins
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ARY003B
R&D Systems Proteome Profiler Antibody Array Kits
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Proteome Profiler Human Phospho-Kinase Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of human protein kinase phosphorylation. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 43 human kinases and total amounts of 2 related proteins simultaneously
  • Requires no specialized equipment
Human Phospho-Kinase Array Kit data example
View Data Examples
 

 

Principle of the Assay

The Proteome Profiler Human Phospho-Kinase Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Phosphorylation of captured proteins is detected with biotinylated phospho-specific detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple kinases in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 

 

Kit Contents

Each Human Phospho-Kinase Antibody Array Kit contains most of the necessary components for a ready-to-run assay without the need for specialized equipment.

  • 8 Array Membranes (4 of membrane A and 4 of membrane B)
  • 8-Well Multi-dish
  • Lysis Buffer
  • Array Buffers
  • Wash Buffer
  • Detection Antibody Cocktail A
  • Detection Antibody Cocktail B
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed product datasheet with protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2°C to 8°C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these proteins in a single sample.
Akt 1/2/3 (S473) Hck (Y411) PLC gamma-1 (Y783)
Akt 1/2/3 (T308) HSP27 (S78/S82) PRAS40 (T246)
AMPK alpha1 (T183) HSP60 Pyk2 (Y402)
AMPK alpha2 (T172) JNK 1/2/3 (T183/Y185, T221/Y223) RSK1/2/3 (S380)
beta-Catenin Lck (Y394) Src (Y419)
Chk-2 (T68) Lyn (Y397) STAT2 (Y689)
c-Jun (S63) MSK1/2 (S376/S360) STAT3 (S727)
CREB (S133) p27 (T198) STAT3 (Y705)
EGF R (Y1086) p38 alpha (T180/Y182) STAT5a (Y699)
eNOS (S1177) p53 (S15) STAT5a/b (Y699)
ERK1/2 (T202/Y204, T185/Y187) p53 (S392) STAT5b (Y699)
FAK (Y397) p53 (S46) STAT6 (Y641)
Fgr (Y412) P70 S6 Kinase (T389) TOR (S2448)
Fyn (Y420) p70 S6 Kinase (T421/S424) WNK-1 (T60)
GSK-3 alpha/beta (S21/S9) PDGF R beta (Y751) Yes (Y426)

 

Assays for analytes represented in the Human Phospho-Kinase Array Kit

 

Analyte DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA
Development Systems (Phospho)		 Quantikine®
ELISA Kits
Akt (S473)   DYC887B  
Akt (T308)      
AMPK alpha1 (T183) DYC3197 DYC3528  
AMPK alpha2 (T172)      
beta-Catenin DYC1329   DYC1329
Chk2 (T68)   DYC1626  
c-Jun (S63)      
CREB (S133)   DYC2510  
EGF R (Y1086) DYC1854   DEGFR0
eNOS (S1177)      
ERK1/2 (T202/Y204, T185/Y187)   DYC1018B  
FAK (Y397) DYC4467    
Fgr (Y412)      
Fyn (Y420)      
GSK-3 alpha/beta (S21/S9) DYC2157 DYC2630  
Hck (Y411)      
HSP27 (S78/S82) DYC1580 DYC2314  
HSP60 DYC1800    
JNK pan (T183/Y185, T221/Y223) DYC1205 DYC1387  
Lck (Y394)      
Lyn (Y397)   DYC3936  
MSK1/2 (S376/S360)      
p27 (T198) DYC2256    
p38 alpha (T180/Y182) DYC8691B DYC869B  
p53 (S15) DYC1043 DYC1839  
p53 (S46) DYC1043 DYC1489  
p53 (S392) DYC1043 DYC2996  
p70 S6 Kinase (T389)   DYC896  
p70 S6 Kinase (T421/S424) DYC8962 DYC8965  
PDGF R beta (Y751) DYC385 DYC3096  
PLC gamma-1 (Y783)      
PRAS40 (T246)   DYC6890  
PYK2 (Y402)      
RSK1/2/3 (S380/S386/S377)   DYC889B  
Src (Y419)   DYC2685  
STAT2 (Y689)      
STAT3 (S727)      
STAT3 (Y705)   DYC4607B  
STAT5a (Y694)      
STAT5a/b (Y694/Y699)      
STAT5b (Y699)      
STAT6 (Y641)      
TOR (S2448)   DYC1665  
WNK-1(T60)   DYC4720  
Yes (Y426)   DYC3929  

 

Data Examples
Figure 1.
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Figure 1. MCF-7 human breast cancer cells were either left untreated or exposed to 50 J/m2 of UV light followed by a 4 hour recovery before lysis.
Figure 2.
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Figure 2. A431 human epithelial carcinoma cells were either left untreated or treated with 200 ng/mL recombinant human (rh) EGF (Catalog # 236-EG) for 5 minutes.
Figure 3.
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Figure 3. MCF-7 human breast cancer cells were either left untreated or treated with 100 ng/mL of rhIGF-I (Catalog # 291-G1) for 1 hour.

Product Datasheets

Product Datasheet
COA
SDS

Preparation and Storage

Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Kinase Assay Kits

Protein kinases are the largest class of enzymes in the human genome. These enzymes regulate almost all cellular processes by adding phosphate groups to proteins, thereby modifying the activity, localization, and overall function of their targets. Consequently, abnormal activity of kinases underlies many diseases including cancer.

Alternate Names
Kinase Assay Kits

Citations for Proteome Profiler Human Phospho-Kinase Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

178 Citations: Showing 1 - 10
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  1. The Noncoding RNA nc886 Regulates PKR Signaling and Cytokine Production in Human Cells
    Authors: E Golec, L Lind, M Qayyum, AM Blom, BC King
    J. Immunol., 2018;0(0):.  2018
  2. CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1? axis to inhibit gastric tumorigenesis
    Authors: W Li, CC Wong, X Zhang, W Kang, G Nakatsu, Q Zhao, H Chen, MYY Go, PWY Chiu, X Wang, J Ji, X Li, Z Cai, EKW Ng, J Yu
    Oncogene, 2018;0(0):.  2018
  3. miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer
    Authors: U Baumgartne, F Berger, A Hashemi Gh, SS Burgener, K Monastyrsk, E Vassella
    Mol. Cancer, 2018;17(1):44.  2018
  4. WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling
    Authors: W Chen, LN Zebaze, J Dong, L Chézeau, P Inquimbert, S Hugel, S Niu, F Bihel, E Boutant, E Réal, P Villa, MP Junier, H Chneiweiss, M Hibert, J Haiech, MC Kilhoffer, M Zeniou
    Oncotarget, 2018;9(43):27197-27219.  2018
  5. Suppression of the ERK-SRF axis facilitates somatic cell reprogramming
    Authors: S Huh, HR Song, GR Jeong, H Jang, NH Seo, JH Lee, JY Yi, B Lee, HW Choi, JT Do, JS Kim, SH Lee, JW Jung, T Lee, J Shim, MK Han, TH Lee
    Exp. Mol. Med., 2018;50(2):e448.  2018
  6. JDP2 overexpression provokes cardiac dysfunction in mice
    Authors: J Heger, J Bornbaum, A Würfel, C Hill, N Brockmann, R Gáspár, J Pálóczi, ZV Varga, M Sárközy, P Bencsik, T Csont, S Török, B Kojonazaro, RT Schermuly, K Böngler, M Parahuleva, P Ferdinandy, R Schulz, G Euler
    Sci Rep, 2018;8(1):7647.  2018
  7. Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
    Authors: X Gong, JR Smith, HM Swanson, LP Rubin
    Molecules, 2018;23(4):.  2018
  8. HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis
    Authors: C Hernandez, P Huebener, JP Pradere, DJ Antoine, RA Friedman, RF Schwabe
    J. Clin. Invest., 2018;0(0):.  2018
  9. Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy
    Authors: JM Santiago-O, ES Kleinerman, MG Hollomon, A Livingston, WL Wang, JW Tsai, NB Gordon
    Oncotarget, 2018;9(2):1602-1616.  2018
  10. YM155 decreases radiation-induced invasion and reverses epithelial-mesenchymal transition by targeting STAT3 in glioblastoma
    Authors: X Zhang, X Wang, R Xu, J Ji, Y Xu, M Han, Y Wei, B Huang, A Chen, Q Zhang, W Li, J Wang, X Li, C Qiu
    J Transl Med, 2018;16(1):79.  2018
  11. Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway
    Authors: Z Fang, KH Jung, HH Yan, SJ Kim, M Rumman, JH Park, B Han, JE Lee, YW Kang, JH Lim, SS Hong
    Cell. Physiol. Biochem., 2018;47(5):1751-1768.  2018
  12. Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo
    Authors: C Li, V Rezov, E Joensuu, V Vartiainen, M Rönty, M Yin, M Myllärniem, K Koli
    Sci Rep, 2018;8(1):10070.  2018
  13. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
    Authors: PD Fan, G Narzisi, AD Jayaprakas, E Venturini, N Robine, P Smibert, S Germer, HA Yu, EJ Jordan, PK Paik, YY Janjigian, JE Chaft, L Wang, AA Jungbluth, S Middha, L Spraggon, H Qiao, CM Lovly, MG Kris, GJ Riely, K Politi, H Varmus, M Ladanyi
    Proc. Natl. Acad. Sci. U.S.A., 2018;115(26):E6030-E6038.  2018
  14. Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17
    Authors: P Urriola-Mu, R Lagos-Cabr, D Patiño-Gar, JG Reyes, RD Moreno
    Int J Mol Sci, 2018;19(8):.  2018
  15. Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds
    Authors: V Vishwakarm, J New, D Kumar, V Snyder, L Arnold, E Nissen, Q Hu, N Cheng, D Miller, AR Thomas, Y Shnayder, K Kakarala, TT Tsue, DA Girod, SM Thomas
    Sci Rep, 2018;8(1):12163.  2018
  16. Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines
    Authors: MY Gökyildiri, U Grandel, K Hattar, G Dahlem, E Schuetz, FH Leinberger, F Eberle, U Sibelius, F Grimminger, W Seeger, R Engenhart-, E Dikomey, FSB Subtil
    Oncotarget, 2018;9(48):28976-28988.  2018
  17. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
    Authors: Y Jiang, YY Jiang, JJ Xie, A Mayakonda, M Hazawa, L Chen, JF Xiao, CQ Li, ML Huang, LW Ding, QY Sun, L Xu, D Kanojia, M Jeitany, JW Deng, LD Liao, HJ Soukiasian, BP Berman, JJ Hao, LY Xu, EM Li, MR Wang, XG Bi, DC Lin, HP Koeffler
    Nat Commun, 2018;9(1):3619.  2018
  18. BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling
    Authors: K Taniuchi, M Furihata, S Naganuma, K Dabanaka, K Hanazaki, T Saibara
    Am J Cancer Res, 2018;8(3):387-404.  2018
  19. Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells
    Authors: G Tornillo, C Knowlson, H Kendrick, J Cooke, H Mirza, I Aurrekoetx, MDM Vivanco, NE Buckley, A Grigoriadi, MJ Smalley
    Cell Rep, 2018;25(13):3674-3692.e10.  2018
  20. Ruxolitinib in combination with prednisone and nilotinib exhibit synergistic effects in human cells lines and primary cells from myeloproliferative neoplasms
    Authors: A Arenas Cor, R Ayala Diaz, P Hernández-, J Gorrochate, D Primo, A Robles, ML Morales, J Ballestero, I Rapado, M Gallardo, M Linares, J Martínez-L
    Haematologica, 2018;0(0):.  2018
  21. ?-arrestin 1 regulates ?2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
    Authors: J Kim, CA Grotegut, JW Wisler, T Li, L Mao, M Chen, W Chen, PB Rosenberg, HA Rockman, RJ Lefkowitz
    Skelet Muscle, 2018;8(1):39.  2018
  22. 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease
    Authors: C Klein, G Roussel, S Brun, C Rusu, C Patte-Mens, M Maitre, AG Mensah-Nya
    Acta Neuropathol Commun, 2018;6(1):136.  2018
  23. IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells
    Authors: M Shimizu, N Tanaka
    Oncogene, 2018;0(0):.  2018
  24. Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT
    Authors: Y Zhang, G Ji, S Han, Z Shao, Z Lu, L Huo, J Zhang, R Yang, Q Feng, H Shen, H Wang, X Li
    Cell. Physiol. Biochem., 2018;50(2):612-628.  2018
  25. Establishment of keratinocyte cell lines from human hair follicles
    Authors: T Wagner, M Gschwandtn, A Strajeriu, A Elbe-Bürge, J Grillari, R Grillari-V, G Greiner, B Golabi, E Tschachler, M Mildner
    Sci Rep, 2018;8(1):13434.  2018
  26. Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines
    Authors: S Heavey, P Dowling, G Moore, MP Barr, N Kelly, SG Maher, S Cuffe, SP Finn, KJ O'Byrne, K Gately
    Sci Rep, 2018;8(1):1652.  2018
  27. WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4
    Authors: K Taniuchi, M Furihata, S Naganuma, T Saibara
    Cancer Med, 2018;0(0):.  2018
  28. Acquired resistance to AZD9291 as an upfront treatment is dependent on ERK signaling in a preclinical model
    Authors: BM Ku, MK Choi, JM Sun, SH Lee, JS Ahn, K Park, MJ Ahn
    PLoS ONE, 2018;13(4):e0194730.  2018
  29. Olfactory receptor OR2AT4 regulates human hair growth
    Authors: J Chéret, M Bertolini, L Ponce, J Lehmann, T Tsai, M Alam, H Hatt, R Paus
    Nat Commun, 2018;9(1):3624.  2018
  30. WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
    Authors: CS Gonçalves, J Vieira de, M Pojo, EP Martins, S Queirós, E Chautard, R Taipa, MM Pires, AA Pinto, F Pardal, C Custódia, CC Faria, C Clara, RM Reis, N Sousa, BM Costa
    Theranostics, 2018;8(17):4805-4823.  2018
  31. Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors
    Authors: F Pareja, AH Brandes, T Basili, P Selenica, FC Geyer, D Fan, A Da Cruz Pa, R Kumar, DN Brown, R Gularte-Mé, B Alemar, R Bi, RS Lim, I de Bruijn, S Fujisawa, R Gardner, E Feng, A Li, EM da Silva, JR Lozada, P Blecua, L Cohen-Goul, AA Jungbluth, EA Rakha, IO Ellis, MIA Edelweiss, J Palazzo, L Norton, T Hollmann, M Edelweiss, BP Rubin, B Weigelt, JS Reis-Filho
    Nat Commun, 2018;9(1):3533.  2018
  32. Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma
    Authors: Y Mo, Y Lu, P Wang, S Huang, L He, D Li, F Li, J Huang, X Lin, X Li, S Che, Q Chen
    Tumour Biol, 2017;39(2):1010428317690.  2017
  33. Protein C receptor stimulates multiple signaling pathways in breast cancer cells
    Authors: D Wang, C Liu, J Wang, Y Jia, X Hu, H Jiang, ZM Shao, YA Zeng
    J. Biol. Chem., 2017;0(0):.  2017
  34. Galectin-3 interacts with the cell surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells
    Authors: F Colomb, W Wang, D Simpson, M Zafar, R Beynon, JM Rhodes, LG Yu
    J. Biol. Chem., 2017;0(0):.  2017
  35. The Transcription Factor HOXB7 Regulates ERK Kinase Activity and Thereby Stimulates the Motility and Invasiveness of Pancreatic Cancer Cells
    Authors: M Tsuboi, K Taniuchi, T Shimizu, M Saito, T Saibara
    J. Biol. Chem., 2017;0(0):.  2017
  36. Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene
    Authors: SA Nadeau, W An, BC Mohapatra, I Mushtaq, TA Bielecki, H Luan, N Zutshi, G Ahmad, MD Storck, M Sanada, S Ogawa, V Band, H Band
    J. Biol. Chem, 2017;292(9):3666-3682.  2017
  37. Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer
    Authors: K Kalyvianak, V Gebhart, N Peroulis, C Panagiotop, F Kiagiadaki, I Pediaditak, M Aivaliotis, E Moustou, M Tzardi, G Notas, E Castanas, M Kampa
    Sci Rep, 2017;7(0):44418.  2017
  38. Induction and Differentiation of IL-10-Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients.
    Authors: Banko Z, Pozsgay J, Szili D, Toth M, Gati T, Nagy G, Rojkovich B, Sarmay G
    J Immunol, 2017;198(4):1512-1520.  2017
  39. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension
    Authors: P Yang, C Read, RE Kuc, G Buonincont, M Southwood, R Torella, PD Upton, A Crosby, SJ Sawiak, TA Carpenter, RC Glen, NW Morrell, JJ Maguire, AP Davenport
    Circulation, 2017;135(12):1160-1173.  2017
  40. Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice
    Authors: P Kuppusamy, A Nagalingam, N Muniraj, NK Saxena, D Sharma
    Sci Rep, 2017;7(1):17943.  2017
  41. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades
    Authors: H Lee, SH Baek, JH Lee, C Kim, JH Ko, SG Lee, A Chinnatham, SA Alharbi, WM Yang, JY Um, G Sethi, KS Ahn
    Int J Mol Sci, 2017;18(5):.  2017
  42. Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells
    Authors: GM Pio, Y Xia, MM Piaseczny, JE Chu, AL Allan
    PLoS ONE, 2017;12(5):e0177640.  2017
  43. Co-targeting of MEK and PDGFR/STAT3 pathways to treat pancreatic ductal adenocar
    Authors: N Sahu, E Chan, F Chu, T Pham, H Koeppen, W Forrest, M Merchant, J Settleman
    Mol. Cancer Ther., 2017;0(0):.  2017
  44. Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes
    Authors: M Mustapic, E Eitan, JK Werner, ST Berkowitz, MP Lazaropoul, J Tran, EJ Goetzl, D Kapogianni
    Front Neurosci, 2017;11(0):278.  2017
  45. The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischemia/reperfusion independent from mitochondrial connexin 43
    Authors: K Boengler, M Bulic, R Schreckenb, KD Schlueter, R Schulz
    Br. J. Pharmacol., 2017;0(0):.  2017
  46. Resistance to the antibody-drug conjugate T-DM1 is based in a reduction in lysosomal proteolytic activity
    Authors: C Ríos-Luci, S García-Alo, E Díaz-Rodrí, M Nadal-Serr, J Arribas, A Ocaña, A Pandiella
    Cancer Res., 2017;0(0):.  2017
  47. Dysregulation of Mir-196b in Head and Neck Cancers Leads to Pleiotropic Effects in the Tumor Cells and Surrounding Stromal Fibroblasts
    Authors: S Álvarez-Te, ST Menéndez, MÁ Villaronga, JP Rodrigo, L Manterola, L de Villala, JC de Vicente, L Alonso-Dur, MP Fernández, CH Lawrie, JM García-Ped
    Sci Rep, 2017;7(1):17785.  2017
  48. Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation
    Authors: M Riera-Borr, VD Cuevas, B Alonso, MA Vega, J Joven, E Izquierdo, ÁL Corbí
    J. Immunol., 2017;0(0):.  2017
  49. WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response
    Authors: S Janczar, J Nautiyal, Y Xiao, E Curry, M Sun, E Zanini, AJ Paige, H Gabra
    Cell Death Dis, 2017;8(7):e2955.  2017
  50. Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer.
    Authors: Chang C, Yen M, Liao S, Hsu Y, Lai C, Chang K, Hsu Y
    Int J Mol Sci, 2017;18(7):.  2017
  51. The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry
    Authors: Z Zhou, L Xu, A Sennepin, C Federici, Y Ganor, D Tudor, D Damotte, N Barry Delo, M Zerbib, M Bomsel
    Mucosal Immunol, 2017;0(0):.  2017
  52. Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell
    Authors: S Chen, J Tao, F Zhong, Y Jiao, J Xu, Q Shen, H Wang, S Fan, Y Zhang
    PLoS ONE, 2017;12(5):e0176501.  2017
  53. Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17
    Authors: PC Buchanan, KL Boylan, B Walcheck, R Heinze, MA Geller, PA Argenta, AP Skubitz
    J. Biol. Chem, 2017;0(0):.  2017
  54. Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer.
    Authors: Chih-Hau Chang, Meng-Chi Yen, Ssu-Hui Liao, Yu-Ling Hsu, Chung-Sheng Lai, Kao-Ping Chang, Ya-Ling Hsu
    International Journal of Molecular Sciences, 2017;0(0):1422-0067.  2017
  55. JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non-small cell lung cancer
    Authors: K Shien, VA Papadimitr, D Ruder, C Behrens, L Shen, N Kalhor, J Song, JJ Lee, J Wang, X Tang, RS Herbst, S Toyooka, L Girard, JD Minna, JM Kurie, II Wistuba, JG Izzo
    Mol. Cancer Ther., 2017;0(0):.  2017
  56. Disruption of Aneuploidy and Senescence induced by Aurora inhibition promotes intrinsic Apoptosis in double hit or double expressor Diffuse Large B-cell Lymphomas
    Authors: D Mahadevan, S Islam, W Qi, C Morales, L Cooke, C Spier, E Weterings
    Mol. Cancer Ther., 2017;0(0):.  2017
  57. Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway
    Authors: TO Cri?an, MCP Cleophas, B Novakovic, K Erler, FL van de Vee, HG Stunnenber, MG Netea, CA Dinarello, LAB Joosten
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.  2017
  58. Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN
    Authors: A Cavazzoni, S La Monica, R Alfieri, A Ravelli, N Van Der St, R Sciarrillo, D Madeddu, CAM Lagrasta, F Quaini, M Bonelli, C Fumarola, D Cretella, G Digiacomo, M Tiseo, GJ Peters, A Ardizzoni, PG Petronini, E Giovannett
    Oncotarget, 2017;0(0):.  2017
  59. Activation of p38 and Erk Mitogen-Activated Protein Kinases Signaling in Ocular Rosacea
    Authors: EJ Wladis, S Swamy, A Herrmann, J Yang, JA Carlson, AP Adam
    Invest. Ophthalmol. Vis. Sci, 2017;58(2):843-848.  2017
  60. Ras-MEK Signaling Mediates a Critical Chk1-dependent DNA Damage Response in Cancer Cells
    Authors: HJ Lee, Y Cao, V Pham, E Blackwood, C Wilson, M Evangelist, C Klijn, D Stokoe, J Settleman
    Mol. Cancer Ther, 2017;0(0):.  2017
  61. Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation
    Authors: S Curcic, M Holzer, L Pasterk, E Knuplez, TO Eichmann, S Frank, R Zimmermann, R Schicho, A Heinemann, G Marsche
    Sci Rep, 2017;7(1):8030.  2017
  62. Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas
    Authors: MV Carriero, K Bifulco, V Ingangi, S Costantini, G Botti, C Ragone, M Minopoli, ML Motti, D Rea, G Scognamigl, G Botti, C Arra, G Ciliberto, A Pessi
    Sci Rep, 2017;7(1):1312.  2017
  63. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2�
    Authors: II Kuan, KH Liang, YP Wang, TW Kuo, YJ Meir, SC Wu, SC Yang, J Lu, HC Wu
    Sci Rep, 2017;7(0):41852.  2017
  64. FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation
    Authors: FR Teixeira, AO Manfiolli, NA Vieira, AC Medeiros, PO Coelho, D Santiago G, D Schechtman, MD Gomes
    Arch. Biochem. Biophys., 2017;0(0):.  2017
  65. Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer
    Authors: CH Chang, MC Yen, SH Liao, YL Hsu, CS Lai, KP Chang, YL Hsu
    Int J Mol Sci, 2017;18(7):.  2017
  66. Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis
    Authors: S Keller, J Kneissl, V Grabher-Me, S Heindl, J Hasenauer, D Maier, J Mattes, P Winter, B Luber
    BMC Cancer, 2017;17(1):845.  2017
  67. Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer
    Oncotarget, 2016;0(0):.  2016
  68. Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase
    Authors: Raymond B Birge
    Cell Commun. Signal, 2016;14(1):19.  2016
  69. A Small Molecule Inhibitor of PDK1/PLC?1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion
    Authors: C Raimondi, V Calleja, R Ferro, A Fantin, AM Riley, BV Potter, CH Brennan, T Maffucci, B Larijani, M Falasca
    Sci Rep, 2016;6(0):26142.  2016
  70. Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance
    Acta Pharmacol. Sin., 2016;0(0):.  2016
  71. Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells.
    Authors: Skolekova S, Matuskova M, Bohac M, Toro L, Demkova L, Gursky J, Kucerova L
    Cell Commun Signal, 2016;14(1):4.  2016
  72. New insights into the Shwachman-Diamond Syndrome-related haematological disorder: hyper-activation of mTOR and STAT3 in leukocytes
    Sci Rep, 2016;6(0):33165.  2016
  73. Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling
    Authors: L Bénard, JG Oh, M Cacheux, A Lee, M Nonnenmach, DS Matasic, E Kohlbrenne, C Kho, C Pavoine, RJ Hajjar, JS Hulot
    Circulation, 2016;133(15):1458-71; disc.  2016
  74. Metabolism regulates cellular functions of bone marrow-derived cells used for cardiac therapy
    Stem Cells, 2016;0(0):.  2016
  75. Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line
    Authors: Benjamin Kalbe
    Eur. J. Cell Biol, 2016;0(0):.  2016
  76. Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs
    Authors: Nader Alaridah
    J Innate Immun, 2016;0(0):.  2016
  77. Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells
    Sci Rep, 2016;6(0):33132.  2016
  78. The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2
    Authors: Nicola M Heller
    J. Biol. Chem., 2016;291(48):24922-24930.  2016
  79. CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells
    Oncogene, 2016;0(0):.  2016
  80. Necrotic cells influence migration and invasion of glioblastoma via NF-?B/AP-1-mediated IL-8 regulation
    Authors: SH Ahn, H Park, YH Ahn, S Kim, MS Cho, JL Kang, YH Choi
    Sci Rep, 2016;6(0):24552.  2016
  81. Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions.
    Authors: Purushothaman A, Bandari S, Liu J, Mobley J, Brown E, Sanderson R
    J Biol Chem, 2016;291(4):1652-63.  2016
  82. Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection
    MBio, 2016;7(6):.  2016
  83. Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18
    Sci Rep, 2016;6(0):32255.  2016
  84. BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine
    Authors: Yuexi Gu
    Sci Rep, 2016;6(0):28217.  2016
  85. CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells
    Authors: Aki Tanouchi
    J. Exp. Clin. Cancer Res, 2016;35(1):190.  2016
  86. Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells
    J Cancer, 2016;7(13):1824-1832.  2016
  87. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism
    Proc Natl Acad Sci USA, 2016;0(0):.  2016
  88. Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
    Oncotarget, 2016;7(26):40531-40545.  2016
  89. The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes.
    Authors: Hansen F, Kalle-Brune M, van der Plas M, Stromdahl A, Malmsten M, Morgelin M, Schmidtchen A
    J Immunol, 2015;194(11):5397-406.  2015
  90. Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.
    Authors: Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, Kim Y, Adam J, Lichter P, Solary E, Berchem G, Moussay E
    Blood, 2015;126(9):1106-17.  2015
  91. A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D.
    Authors: Eggink L, Spyroulias G, Jones N, Hanson C, Hoober J
    PLoS ONE, 2015;10(6):e0130532.  2015
  92. Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes.
    Authors: Sento S, Sasabe E, Yamamoto T
    PLoS ONE, 2015;11(2):e0148454.  2015
  93. Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells.
    Authors: Singh A, Ruan Y, Tippett T, Narendran A
    J Exp Clin Cancer Res, 2015;34(0):104.  2015
  94. Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma.
    Authors: Yamada T, Amann J, Fukuda K, Takeuchi S, Fujita N, Uehara H, Iwakiri S, Itoi K, Shilo K, Yano S, Carbone D
    Cancer Res, 2015;75(19):4188-97.  2015
  95. YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway.
    Authors: Chang B, Johnson K, LaTocha D, Rowley J, Bryant J, Burke R, Smith R, Loriaux M, Muschen M, Mullighan C, Druker B, Tyner J
    J Hematol Oncol, 2015;8(0):39.  2015
  96. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5promotes angiogenesis and vasorelaxation.
    Authors: Cho Y, Hur S, Kim J, Kim J, Lee D, Choe J, Won M, Ha K, Jeoung D, Han S, Ryoo S, Lee H, Min J, Kwon Y, Kim D, Kim Y
    J Biol Chem, 2015;290(1):467-77.  2015
  97. Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma.
    Authors: Atefi M, Titz B, Avramis E, Ng C, Wong D, Lassen A, Cerniglia M, Escuin-Ordinas H, Foulad D, Comin-Anduix B, Graeber T, Ribas A
    Mol Cancer, 2015;14(0):27.  2015
  98. A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
    Authors: Bajpe, P K, Prahallad, A, Horlings, H, Nagtegaal, I, Beijersbergen, R, Bernards, R
    Oncogene, 2015;34(4):531-6.  2015
  99. Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling.
    Authors: Man J, Shoemake J, Ma T, Rizzo A, Godley A, Wu Q, Mohammadi A, Bao S, Rich J, Yu J
    Cancer Res, 2015;75(8):1760-9.  2015
  100. Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.
    Authors: Mailly L, Xiao F, Lupberger J, Wilson G, Aubert P, Duong F, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lutgehetmann M, Volz T, Davis C, Harris H, Mee C, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim M, Neunlist M, Zeisel M, Dandri M, McKeating J, Robinet E, Baumert T
    Nat Biotechnol, 2015;33(5):549-54.  2015
  101. Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.
    Authors: Laukkanen, Mikko O, Cammarota, Francesc, Esposito, Tiziana, Salvatore, Marco, Castellone, Maria D
    PLoS ONE, 2015;10(3):e0121441.  2015
  102. Loss of DGKepsilon induces endothelial cell activation and death independently of complement activation.
    Authors: Bruneau S, Neel M, Roumenina L, Frimat M, Laurent L, Fremeaux-Bacchi V, Fakhouri F
    Blood, 2015;125(6):1038-46.  2015
  103. Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation.
    Authors: Zhao D, Besser A, Wander S, Sun J, Zhou W, Wang B, Ince T, Durante M, Guo W, Mills G, Theodorescu D, Slingerland J
    Oncogene, 2015;34(43):5447-59.  2015
  104. EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line.
    Authors: Ranayhossaini D, Lu J, Mabus J, Gervais A, Lingham R, Fursov N
    Int J Mol Sci, 2014;15(10):17686-704.  2014
  105. Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells.
    Authors: Victoni T, Gleonnec F, Lanzetti M, Tenor H, Valenca S, Porto L, Lagente V, Boichot E
    PLoS ONE, 2014;9(1):e85243.  2014
  106. The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells.
    Authors: Kim, Ji Hye, Kim, Wang-Kyu, Sung, Young Kw, Kwack, Mi Hee, Song, Seung Yo, Choi, Joon-Seo, Park, Sang Gyu, Yi, TacGhee, Lee, Hyun-Joo, Kim, Dae-Duk, Seo, Hyun Min, Song, Sun U, Sung, Jong-Hyu
    Stem Cells Dev, 2014;23(12):1364-76.  2014
  107. Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.
    Authors: Ray, K C, Moss, M E, Franklin, J L, Weaver, C J, Higginbotham, J, Song, Y, Revetta, F L, Blaine, S A, Bridges, L R, Guess, K E, Coffey, R J, Crawford, H C, Washington, M K, Means, A L
    Oncogene, 2014;33(7):823-31.  2014
  108. Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naive to primed cell transition.
    Authors: Speakman C, Domke T, Wongpaiboonwattana W, Sanders K, Mudaliar M, van Aalten D, Barton G, Stavridis M
    Stem Cells, 2014;32(10):2605-15.  2014
  109. Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells.
    Authors: Raimondi C, Fantin A, Lampropoulou A, Denti L, Chikh A, Ruhrberg C
    J Exp Med, 2014;211(6):1167-83.  2014
  110. Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.
    Authors: Lin Z, Zhang C, Zhang M, Xu D, Fang Y, Zhou Z, Chen X, Qin N, Zhang X
    PLoS ONE, 2014;9(1):e85296.  2014
  111. An increase in integrin-linked kinase non-canonically confers NF- inverted question markB-mediated growth advantages to gastric cancer cells by activating ERK1/2.
    Authors: Tseng P, Chen C, Shan Y, Chang W, Liu H, Hong T, Hsieh C, Lin S, Lin C
    Cell Commun Signal, 2014;12(1):69.  2014
  112. Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response.
    Authors: Lutay N, Hakansson G, Alaridah N, Hallgren O, Westergren-Thorsson G, Godaly G
    PLoS ONE, 2014;9(1):e86466.  2014
  113. JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer.
    Authors: Song W, Ma Y, Wang J, Brantley-Sieders D, Chen J
    Cancer Res, 2014;74(9):2444-54.  2014
  114. Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer.
    Authors: Nagalingam A, Kuppusamy P, Singh S, Sharma D, Saxena N
    Cancer Res, 2014;74(9):2617-29.  2014
  115. Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling.
    Authors: Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, Limame R, Mestdagh P, Vandesompele J, Vanhove C, Maynard D, Lehuede C, Muller C, Valet P, Gespach C, Bracke M, Cocquyt V, Denys H, De Wever O
    Cancer Res, 2014;74(23):6806-19.  2014
  116. Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML.
    Authors: Kampen, K R, Ter Elst, A, Mahmud, H, Scherpen, F J G, Diks, S H, Peppelenbosch, M P, de Haas, V, Guryev, V, de Bont, E S J M
    Leukemia, 2014;28(3):589-99.  2014
  117. Soft matrix is a natural stimulator for cellular invasiveness.
    Authors: Gu, Zhizhan, Liu, Fei, Tonkova, Elina A, Lee, Soo Youn, Tschumperlin, Daniel J, Brenner, Michael
    Mol Biol Cell, 2014;25(4):457-69.  2014
  118. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.
    Authors: Sinkevicius, Kerstin, Kriegel, Christin, Bellaria, Kelly J, Lee, Jaewon, Lau, Allison, Leeman, Kristen, Zhou, Pengchen, Beede, Alexande, Fillmore, Christin, Caswell, Deborah, Barrios, Juliana, Wong, Kwok-Kin, Sholl, Lynette, Schlaeger, Thorsten, Bronson, Roderick, Chirieac, Lucian R, Winslow, Monte M, Haigis, Marcia C, Kim, Carla F
    Proc Natl Acad Sci U S A, 2014;111(28):10299-304.  2014
  119. Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation.
    Authors: Huck, Bettina, Duss, Stephan, Hausser, Angelika, Olayioye, Monilola
    J Biol Chem, 2014;289(6):3138-47.  2014
  120. Adenosine inhibits tumor cell invasion via receptor-independent mechanisms.
    Authors: Virtanen S, Kukkonen-Macchi A, Vainio M, Elima K, Harkonen P, Jalkanen S, Yegutkin G
    Mol Cancer Res, 2014;12(12):1863-74.  2014
  121. Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells.
    Authors: Li, Wenjuan, Liu, Joan, Jackson, Kasey, Shi, Runhua, Zhao, Yunfeng
    PLoS ONE, 2014;9(4):e94079.  2014
  122. Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy.
    Authors: Iida, Mari, Brand, Toni M, Starr, Megan M, Huppert, Evan J, Luthar, Neha, Bahrar, Harsh, Coan, John P, Pearson, Hannah E, Salgia, Ravi, Wheeler, Deric L
    Mol Cancer, 2014;13(0):242.  2014
  123. Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner.
    Authors: Polajeva J, Bergstrom T, Edqvist P, Lundequist A, Sjosten A, Nilsson G, Smits A, Bergqvist M, Ponten F, Westermark B, Pejler G, Forsberg Nilsson K, Tchougounova E
    Mol Oncol, 2014;8(1):50-8.  2014
  124. Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells.
    Authors: Golubkov V, Strongin A
    Cell Commun Signal, 2014;12(0):15.  2014
  125. Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 in hypopharyngeal carcinoma cells.
    Authors: Wang L, Chen P, Hsu L, Hsu W, Liu D, Chang C, Hsu Y, Lee J
    Am J Pathol, 2014;184(2):418-30.  2014
  126. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
    Authors: Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A
    Nat Commun, 2014;5(0):4715.  2014
  127. Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo.
    Authors: Naspi A, Panasiti V, Abbate F, Roberti V, Devirgiliis V, Curzio M, Borghi M, Lozupone F, Carotti S, Morini S, Gaudio E, Calvieri S, Londei P
    PLoS ONE, 2014;9(6):e98641.  2014
  128. Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.
    Authors: Jokela T, Karna R, Makkonen K, Laitinen J, Tammi R, Tammi M
    J Biol Chem, 2014;289(26):18569-81.  2014
  129. IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers.
    Authors: Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle-Cezar F, Watkins J, Rashid M, De Rinaldis E, Hessey S, Gazinska P, Hayday A, Tutt A
    Cancer Res, 2014;74(17):4908-21.  2014
  130. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.
    Authors: Large M, Wetendorf M, Lanz R, Hartig S, Creighton C, Mancini M, Kovanci E, Lee K, Threadgill D, Lydon J, Jeong J, DeMayo F
    , 2014;0(0):.  2014
  131. Histamine contributes to tissue remodeling via periostin expression.
    Authors: Yang, Lingli, Murota, Hiroyuki, Serada, Satoshi, Fujimoto, Minoru, Kudo, Akira, Naka, Tetsuji, Katayama, Ichiro
    J Invest Dermatol, 2014;134(8):2105-13.  2014
  132. Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation.
    Authors: Spary L, Al-Taei S, Salimu J, Cook A, Ager A, Watson H, Clayton A, Staffurth J, Mason M, Tabi Z
    J Immunol, 2014;192(7):3101-10.  2014
  133. Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein.
    Authors: Szalmas A, Gyongyosi E, Ferenczi A, Laszlo B, Karosi T, Csomor P, Gergely L, Veress G, Konya J
    Virol J, 2013;10(0):79.  2013
  134. CALHM1 controls the Ca(2)(+)-dependent MEK, ERK, RSK and MSK signaling cascade in neurons.
    Authors: Dreses-Werringloer U, Vingtdeux V, Zhao H, Chandakkar P, Davies P, Marambaud P
    J Cell Sci, 2013;126(0):1199-206.  2013
  135. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
    Authors: Haas D, Bala K, Busche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Ruckert J, Varga Z, Keri G, Schulz T
    PLoS Pathog, 2013;9(11):e1003737.  2013
  136. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
    Authors: Shimizu A, Nakayama H, Wang P, Konig C, Akino T, Sandlund J, Coma S, Italiano J, Mammoto A, Bielenberg D, Klagsbrun M
    J Biol Chem, 2013;288(4):2210-22.  2013
  137. Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines.
    Authors: Stegeman H, Kaanders J, Verheijen M, Peeters W, Wheeler D, Iida M, Grenman R, van der Kogel A, Span P, Bussink J
    Mol Cancer, 2013;12(1):133.  2013
  138. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer.
    Authors: Davies, Kurtis D, Mahale, Sakshi, Astling, David P, Aisner, Dara L, Le, Anh T, Hinz, Trista K, Vaishnavi, Aria, Bunn, Paul A J, Heasley, Lynn E, Tan, Aik-Choo, Camidge, D Ross, Varella-Garcia, Marileil, Doebele, Robert C
    PLoS ONE, 2013;8(12):e82236.  2013
  139. Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy.
    Authors: Mir, Shakeel, Schwarze, Steven R, Jin, Ling, Zhang, Jinling, Friend, Woodrow, Miriyala, Sumitra, St Clair, Daret, Craven, Rolf J
    Autophagy, 2013;9(10):1566-78.  2013
  140. The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
    Authors: Lekawanvijit S, Kumfu S, Wang B, Manabe M, Nishijima F, Kelly D, Krum H, Kompa A
    PLoS ONE, 2013;8(12):e83687.  2013
  141. Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584.
    Authors: Weidenaar A, Ter Elst A, Kampen K, Meeuwsen-de Boer T, Kamps W, Schuringa J, de Bont E
    Mol Cancer Res, 2013;11(4):339-48.  2013
  142. Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets.
    Authors: Drake J, Graham N, Lee J, Stoyanova T, Faltermeier C, Sud S, Titz B, Huang J, Pienta K, Graeber T, Witte O
    Proc Natl Acad Sci U S A, 2013;110(49):E4762-9.  2013
  143. Sunlight UV-induced skin cancer relies upon activation of the p38alpha signaling pathway.
    Authors: Liu K, Yu D, Cho Y, Bode A, Ma W, Yao K, Li S, Li J, Bowden G, Dong Z, Dong Z
    Cancer Res, 2013;73(7):2181-8.  2013
  144. Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ss-estradiol-BSA.
    Authors: Cheng W, Chen L, Yang S, Han J, Zhai D, Ni J, Yu C, Cai Z
    PLoS ONE, 2012;7(9):e45529.  2012
  145. Concomitant targeting of EGF receptor, tgf-Beta and SRC points to a novel therapeutic approach in pancreatic cancer.
    Authors: Deharvengt S, Marmarelis M, Korc M
    PLoS ONE, 2012;7(6):e39684.  2012
  146. Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y.
    Authors: Olszewski U, Deally A, Tacke M, Hamilton G
    Neoplasia, 2012;14(9):813-22.  2012
  147. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
    EMBO J., 2012;31(17):3513-23.  2012
  148. Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia.
    BMC Cancer, 2012;12(0):431.  2012
  149. Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy.
    Authors: Joshi, Avadhut, Loilome, Watchari, Siu, I-Mei, Tyler, Betty, Gallia, Gary L, Riggins, Gregory
    PLoS ONE, 2012;7(10):e44372.  2012
  150. A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer.
    Authors: Dumitru CA, Fechner MK, Hoffmann TK
    J. Leukoc. Biol., 2012;91(4):591-8.  2012
  151. Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab.
    Authors: Dunn EF, Iida M, Myers RA, Campbell DA, Hintz KA, Armstrong EA, Li C, Wheeler DL
    Oncogene, 2011;30(5):561-74.  2011
  152. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.
    Authors: Chandarlapaty, Sarat, Sawai, Ayana, Scaltriti, Maurizio, Rodrik-Outmezguine, Vanessa, Grbovic-Huezo, Olivera, Serra, Violeta, Majumder, Pradip K, Baselga, Jose, Rosen, Neal
    Cancer Cell, 2011;19(1):58-71.  2011
  153. Influence of leucine on protein metabolism, phosphokinase expression, and cell proliferation in human duodenum1,3.
    Authors: Coeffier M, Claeyssens S, Bensifi M, Lecleire S, Boukhettala N, Maurer B, Donnadieu N, Lavoinne A, Cailleux AF, Dechelotte P
    Am. J. Clin. Nutr., 2011;93(6):1255-62.  2011
  154. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways.
    Authors: Li J, Cho YY, Langfald A
    Cancer Prev Res (Phila), 2011;4(8):1190-7.  2011
  155. Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling.
    Authors: Wei Q, Jiang H, Xiao Z
    Proc. Natl. Acad. Sci. U.S.A., 2011;108(17):7004-9.  2011
  156. Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation.
    Authors: Vingtdeux V, Chandakkar P, Zhao H, d'Abramo C, Davies P, Marambaud P
    FASEB J., 2011;25(1):219-31.  2011
  157. BH3 mimetics activate multiple pro-autophagic pathways.
    Authors: Malik SA, Orhon I, Morselli E, Criollo A, Shen S, Marino G, BenYounes A, Benit P, Rustin P, Maiuri MC, Kroemer G
    Oncogene, 2011;30(37):3918-29.  2011
  158. Proteome profiling reveals potential toxicity and detoxification pathways following exposure of BEAS-2B cells to engineered nanoparticle titanium dioxide.
    Authors: Ge Y, Bruno M, Wallace K, Winnik W, Prasad RY
    Proteomics, 2011;11(12):2406-22.  2011
  159. IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis.
    Authors: Martins AS, Ordonez JL, Amaral AT, Prins F, Floris G, Debiec-Rychter M, Hogendoorn PC, de Alava E
    PLoS ONE, 2011;6(5):e19846.  2011
  160. Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer.
    Authors: Li A, King J, Moro A, Sugi MD, Dawson DW, Kaplan J, Li G, Lu X, Strieter RM, Burdick M, Go VL, Reber HA, Eibl G, Hines OJ
    Am. J. Pathol., 2011;178(3):1340-9.  2011
  161. EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes.
    Authors: Maddigan A, Truitt L, Arsenault R
    J. Immunol., 2011;187(11):5983-94.  2011
  162. Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome.
    Authors: Guo T, Lee SS, Ng WH
    Cell. Mol. Life Sci., 2011;68(11):1983-2002.  2011
  163. DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma.
    Authors: Singhal G, Akhter MZ, Stern DF
    Cancer Gene Ther., 2011;18(7):520-30.  2011
  164. Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells.
    Authors: Shih YR, Tseng KF, Lai HY, Lin CH, Lee OK
    J. Bone Miner. Res., 2011;26(4):730-8.  2011
  165. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
    Authors: Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, Garcia-Echeverria C, Bardeesy N, Sharpless NE, Hayes ND, Kim WY, Engelman JA, Wong KK
    Cancer Cell, 2010;17(0):547-59.  2010
  166. Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation.
    Authors: Zhang H, Fagan DH, Zeng X
    Oncogene, 2010;29(17):2517-27.  2010
  167. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).
    Authors: Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villen J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ
    Proc. Natl. Acad. Sci. U.S.A., 2010;107(34):15299-304.  2010
  168. Coactivated platelet-derived growth factor receptor alpha and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma.
    Authors: Dewaele B, Floris G, Finalet-Ferreiro J, Fletcher CD, Coindre JM, Guillou L, Hogendoorn PC, Wozniak A, Vanspauwen V, Schoffski P, Marynen P, Vandenberghe P, Sciot R, Debiec-Rychter M
    Cancer Res., 2010;70(18):7304-14.  2010
  169. Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice.
    Authors: Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avances C, Allory Y, de la Taille A, Culine S, Blancou H, Cristol JP, Michel F, Sardet C, Fajas L
    Mol. Cancer Ther., 2010;9(0):1740-54.  2010
  170. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.
    Authors: Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon JE, Janle EM, Lobo J, Ferruzzi MG, Davies P, Marambaud P
    J. Biol. Chem., 2010;285(12):9100-13.  2010
  171. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation.
    Authors: Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R
    J. Clin. Invest., 2010;120(12):4353-65.  2010
  172. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
    Authors: Tomlinson DC, Knowles MA
    Am. J. Pathol., 2010;177(5):2379-86.  2010
  173. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
    Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES
    Eur. J. Cancer, 2010;46(5):974-82.  2010
  174. Kaposi's sarcoma-associated herpesvirus-G protein-coupled receptor-expressing endothelial cells exhibit reduced migration and stimulated chemotaxis by chemokine inverse agonists.
    Authors: Couty JP, Lupu-Meiri M, Oron Y, Gershengorn MC
    J. Pharmacol. Exp. Ther., 2009;329(3):1142-7.  2009
  175. The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1.
    Authors: Smith NJ, Stoddart LA, Devine NM, Jenkins L, Milligan G
    J. Biol. Chem., 2009;284(26):17527-39.  2009
  176. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.
    Authors: Cailleteau C, Liagre B, Beneytout JL
    J. Cell. Biochem., 2009;107(4):785-96.  2009
  177. Neutrophils support lung colonization of metastasis-initiating breast cancer cells.
    Authors: Wculek S, Malanchi I
    Nature, 0;528(7582):413-7.  0
  178. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation.
    Authors: Barquilla A, Lamberto I, Heynen-Genel S, Brill L, Pasquale E
    Mol Biol Cell, 0;27(17):2757-70.  0

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Reviews for Proteome Profiler Human Phospho-Kinase Array Kit

Average Rating: 4.7 (Based on 15 Reviews)

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Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/31/2019
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 11/29/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 09/13/2018

Great tool for evaluating cell signaling changes. We used this kit with LS174T cells. Kit protocol was easy to follow, and after imaging the resulting spots were very clear and easy to analyze. Phosphorylation of one of the identified signaling proteins was verified using an independent western blot. I would recommend this product

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 07/18/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/18/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/05/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/22/2018
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/20/2017
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 02/13/2017

Great kit and ok value for money considering the amount of data you get!

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 02/12/2017

Used with human samples. Image shown was at 1 minute. Other 'dots' appeared at increased exposure. Kit very good overall. Good quality result and easy to use

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/03/2017

This array is an excellent tool for screening potential phospho-kinases and related targets. However, it would be nice that if the total level of non-phosphorylated proteins be visualized at the same time on the membrane. In this case, the phosphorylated signals can be normalized.

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/28/2016

Antibodies could not be sourced to validate some of the targets.

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/14/2016
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 08/09/2016
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/26/2015
Sample Tested: Cell Lysates

This was control and didnt show any non specific bindings.
Specificity: Specific
Sensitivity: Sensitive
Buffer: BSA
Dilution: 1:1000

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B