Proteome Profiler Human Phospho-Kinase Array Kit
Discontinued Product
ARY003B has been discontinued and is replaced by ARY003C.
Proteome Profiler Human Phospho-Kinase Array Kit Summary
A membrane-based antibody array for the parallel determination of the relative levels of human protein kinase phosphorylation. Validated for analyte detection in cell lysates.
Key Benefits
- Detects phosphorylation of 43 human kinases and total amounts of 2 related proteins simultaneously
- Requires no specialized equipment
Principle of the Assay
The Proteome Profiler Human Phospho-Kinase Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Phosphorylation of captured proteins is detected with biotinylated phospho-specific detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.
Why Use an Antibody Array to Detect Receptor Phosphorylation?
Determining the phosphorylation of multiple kinases in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.
Each Human Phospho-Kinase Antibody Array Kit contains most of the necessary components for a ready-to-run assay without the need for specialized equipment.
- 8 Array Membranes (4 of membrane A and 4 of membrane B)
- 8-Well Multi-dish
- Lysis Buffer
- Array Buffers
- Wash Buffer
- Detection Antibody Cocktail A
- Detection Antibody Cocktail B
- Streptavidin-HRP
- Chemiluminescent Detection Reagents
- Transparency Overlay Template
- Detailed product datasheet with protocol
For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.
Stability and Storage
Store the unopened kit at 2°C to 8°C. Do not use past kit expiration date.
Simultaneously detect the relative phosphorylation of these proteins in a single sample. | ||
Akt 1/2/3 (S473) | Hck (Y411) | PLC gamma-1 (Y783) |
Akt 1/2/3 (T308) | HSP27 (S78/S82) | PRAS40 (T246) |
AMPK alpha1 (T183) | HSP60 | Pyk2 (Y402) |
AMPK alpha2 (T172) | JNK 1/2/3 (T183/Y185, T221/Y223) | RSK1/2/3 (S380) |
beta-Catenin | Lck (Y394) | Src (Y419) |
Chk-2 (T68) | Lyn (Y397) | STAT2 (Y689) |
c-Jun (S63) | MSK1/2 (S376/S360) | STAT3 (S727) |
CREB (S133) | p27 (T198) | STAT3 (Y705) |
EGF R (Y1086) | p38 alpha (T180/Y182) | STAT5a (Y699) |
eNOS (S1177) | p53 (S15) | STAT5a/b (Y699) |
ERK1/2 (T202/Y204, T185/Y187) | p53 (S392) | STAT5b (Y699) |
FAK (Y397) | p53 (S46) | STAT6 (Y641) |
Fgr (Y412) | P70 S6 Kinase (T389) | TOR (S2448) |
Fyn (Y420) | p70 S6 Kinase (T421/S424) | WNK-1 (T60) |
GSK-3 alpha/beta (S21/S9) | PDGF R beta (Y751) | Yes (Y426) |
Assays for analytes represented in the Human Phospho-Kinase Array Kit
Analyte | DuoSet® IC ELISA Development Systems (Total) | DuoSet® IC ELISA Development Systems (Phospho) |
Quantikine® ELISA Kits |
Akt (S473) | DYC887B | ||
Akt (T308) | |||
AMPK alpha1 (T183) | DYC3197 | DYC3528 | |
AMPK alpha2 (T172) | |||
beta-Catenin | DYC1329 | DYC1329 | |
Chk2 (T68) | DYC1626 | ||
c-Jun (S63) | |||
CREB (S133) | DYC2510 | ||
EGF R (Y1086) | DYC1854 | DEGFR0 | |
eNOS (S1177) | |||
ERK1/2 (T202/Y204, T185/Y187) | DYC1018B | ||
FAK (Y397) | DYC4467 | ||
Fgr (Y412) | |||
Fyn (Y420) | |||
GSK-3 alpha/beta (S21/S9) | DYC2157 | DYC2630 | |
Hck (Y411) | |||
HSP27 (S78/S82) | DYC1580 | DYC2314 | |
HSP60 | DYC1800 | ||
JNK pan (T183/Y185, T221/Y223) | DYC1205 | DYC1387 | |
Lck (Y394) | |||
Lyn (Y397) | DYC3936 | ||
MSK1/2 (S376/S360) | |||
p27 (T198) | DYC2256 | ||
p38 alpha (T180/Y182) | DYC8691B | DYC869B | |
p53 (S15) | DYC1043 | DYC1839 | |
p53 (S46) | DYC1043 | DYC1489 | |
p53 (S392) | DYC1043 | DYC2996 | |
p70 S6 Kinase (T389) | DYC896 | ||
p70 S6 Kinase (T421/S424) | DYC8962 | DYC8965 | |
PDGF R beta (Y751) | DYC385 | DYC3096 | |
PLC gamma-1 (Y783) | |||
PRAS40 (T246) | DYC6890 | ||
PYK2 (Y402) | |||
RSK1/2/3 (S380/S386/S377) | DYC889B | ||
Src (Y419) | DYC2685 | ||
STAT2 (Y689) | |||
STAT3 (S727) | |||
STAT3 (Y705) | DYC4607B | ||
STAT5a (Y694) | |||
STAT5a/b (Y694/Y699) | |||
STAT5b (Y699) | |||
STAT6 (Y641) | |||
TOR (S2448) | DYC1665 | ||
WNK-1(T60) | DYC4720 | ||
Yes (Y426) | DYC3929 |
![]() View Larger Image |
Figure 1. MCF-7 human breast cancer cells were either left untreated or exposed to 50 J/m2 of UV light followed by a 4 hour recovery before lysis. |
![]() View Larger Image |
Figure 2. A431 human epithelial carcinoma cells were either left untreated or treated with 200 ng/mL recombinant human (rh) EGF (Catalog # 236-EG) for 5 minutes. |
![]() View Larger Image |
Figure 3. MCF-7 human breast cancer cells were either left untreated or treated with 100 ng/mL of rhIGF-I (Catalog # 291-G1) for 1 hour. |
Protein kinases are the largest class of enzymes in the human genome. These enzymes regulate almost all cellular processes by adding phosphate groups to proteins, thereby modifying the activity, localization, and overall function of their targets. Consequently, abnormal activity of kinases underlies many diseases including cancer.
Specifications
Product Datasheets
Citations for Proteome Profiler Human Phospho-Kinase Array Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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FGF2 Induces Resistance to Nilotinib through MAPK Pathway Activation in KIT Mutated Melanoma
Authors: P Tétu, J Delyon, J André, C Reger de M, M Sabbah, GE Ghanem, M Battistell, S Mourah, C Lebbé, N Dumaz
Cancers (Basel), 2020;12(5):. 2020
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Circulating Neutrophils Predict Poor Survival for HCC and Promote HCC Progression Through p53 and STAT3 Signaling Pathway
Authors: Y Wang, R Yao, D Zhang, R Chen, Z Ren, L Zhang
J Cancer, 2020;11(13):3736-3744. 2020
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Immuno-metabolic impact of the multiple sclerosis patients' sera on endothelial cells of the blood-brain barrier
Authors: MH Sheikh, SM Henson, RA Loiola, S Mercurio, A Colamatteo, GT Maniscalco, V De Rosa, S McArthur, E Solito
J Neuroinflammation, 2020;17(1):153. 2020
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The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells
Authors: A Douida, F Batista, A Robaszkiew, P Boto, A Aladdin, M Szenykiv, R Czinege, L Virág, K Tar
J. Cell. Mol. Med., 2020;0(0):. 2020
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Oncogenic Potential of Bisphenol A and Common Environmental Contaminants in Human Mammary Epithelial Cells
Authors: VA Nair, S Valo, P Peltomäki, K Bajbouj, WM Abdel-Rahm
Int J Mol Sci, 2020;21(10):. 2020
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SNCG promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathway
Authors: J Zhang, XH Liu, C Li, XX Wu, YL Chen, WW Li, X Li, F Gong, Q Tang, D Jiang
J. Exp. Clin. Cancer Res., 2020;39(1):79. 2020
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Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3&beta signalling pathway in renal cell carcinoma
Authors: Q Zhu, AL Zhong, H Hu, JJ Zhao, DS Weng, Y Tang, QZ Pan, ZQ Zhou, MJ Song, JY Yang, JY He, Y Liu, M Li, WM Hu, CP Yang, T Xiang, MY Chen, G Ma, L Guo, JC Xia
J Hematol Oncol, 2020;13(1):2. 2020
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Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling
Authors: P Shahi Thak, M Gupta, S Singh, R Joshi, E Glasgow, A Lekan, S Agarwal, GD Luker, H Tavana
BMC Cancer, 2020;20(1):4. 2020
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Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis
Authors: D Neelakanta, S Dogra, BR Devapatla, P Jaiprasart, MC Mukashyaka, R Janknecht, SKD Dwivedi, R Bhattachar, S Husain, K Ding, S Woo
Mol. Cancer Res., 2019;0(0):. 2019
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Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib
Authors: YC Ko, CY Hu, ZH Liu, HF Tien, DL Ou, HF Chien, LI Lin
Int J Mol Sci, 2019;20(5):. 2019
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IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states
Authors: G Pellizzari, C Hoskin, S Crescioli, S Mele, J Gotovina, G Chiaruttin, R Bianchini, K Ilieva, HJ Bax, S Papa, KE Lacy, E Jensen-Jar, S Tsoka, DH Josephs, JF Spicer, SN Karagianni
EBioMedicine, 2019;0(0):. 2019
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MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma
Authors: Y Zhao, W Huang, TM Kim, Y Jung, LG Menon, H Xing, H Li, RS Carroll, PJ Park, HW Yang, MD Johnson
J. Exp. Clin. Cancer Res., 2019;38(1):36. 2019
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Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma
Authors: R Kumar, CN Njauw, BY Reddy, Z Ji, A Rajadurai, N Klebanov, H Tsao
Oncogene, 2019;0(0):. 2019
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Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin
Authors: C Zalfa, P Azmoon, E Mantuano, SL Gonias
J. Leukoc. Biol., 2019;0(0):. 2019
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Survival/adaptation of Bone Marrow derived Mesenchymal Stem Cells after long term starvation through selective processes
Authors: F Ferro, R Spelat, G Shaw, N Duffy, MN Islam, PM O'Shea, D O'Toole, L Howard, M Murphy
Stem Cells, 2019;0(0):. 2019
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EPHA2 is a predictive biomarker of resistance and a potential therapeutic target for improving anti-epidermal growth factor receptor therapy in colorectal cancer
Authors: G Martini, C Cardone, PP Vitiello, V Belli, S Napolitano, T Troiani, D Ciardiello, CM Della Cort, F Morgillo, N Matrone, V Sforza, G Papaccio, V Desiderio, MC Paul, V Moreno-Vie, N Normanno, AM Rachiglio, V Tirino, E Maiello, TP Latiano, D Rizzi, G Signoriell, M Sibilia, F Ciardiello, E Martinelli
Mol. Cancer Ther., 2019;0(0):. 2019
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Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway
Authors: T van Montfo, R van der Sl, G Darcis, D Beaty, K Groen, AO Pasternak, G Pollakis, M Vink, EM Westerhout, M Hamdi, M Bakker, B van der Pu, S Jurriaans, JH Prins, R Jeeninga, AAM Thomas, D Speijer, B Berkhout
EBioMedicine, 2019;0(0):. 2019
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E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms
Authors: MK Jolly, KE Ware, S Xu, S Gilja, S Shetler, Y Yang, X Wang, RG Austin, D Runyambo, AJ Hish, S Bartholf D, JT George, RT Kreulen, MK Boss, AL Lazarides, DL Kerr, DG Gerber, D Sivaraj, AJ Armstrong, MW Dewhirst, WC Eward, H Levine, JA Somarelli
Mol. Cancer Res., 2019;0(0):. 2019
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Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells
Authors: DA Ferraro, F Patella, S Zanivan, C Donato, N Aceto, M Giannotta, E Dejana, M Diepenbruc, G Christofor, M Buess
BMC Cancer, 2019;19(1):312. 2019
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Signal regulatory protein ? protects podocytes through promoting autophagic activity
Authors: L Li, Y Liu, S Li, Y Yang, C Zeng, W Rong, H Liang, M Zhang, X Zhu, K Kidder, Y Liu, Z Liu, K Zen
JCI Insight, 2019;5(0):. 2019
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PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway
Authors: Y Bai, X Liu, X Qi, X Liu, F Peng, H Li, H Fu, S Pei, L Chen, X Chi, L Zhang, X Zhu, Y Song, Y Wang, S Meng, T Jiang, S Shao
EBioMedicine, 2019;0(0):. 2019
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A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer
Authors: J Chen, J Bell, BT Lau, T Whittaker, D Stapleton, HP Ji
Oncogenesis, 2019;8(5):33. 2019
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Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
Authors: SP Kennedy, JZR Han, N Portman, M Nobis, JF Hastings, KJ Murphy, SL Latham, AL Cadell, D Miladinovi, GR Marriott, YEI O'Donnell, RF Shearer, JT Williams, AG Munoz, TR Cox, DN Watkins, DN Saunders, P Timpson, E Lim, W Kolch, DR Croucher
Breast Cancer Res., 2019;21(1):43. 2019
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Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program
Authors: JH Noh, KM Kim, PR Pandey, NN Hooten, R Munk, G Kundu, S De, JL Martindale, X Yang, MK Evans, K Abdelmohse, M Gorospe
Nucleic Acids Res., 2019;0(0):. 2019
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AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
Authors: H Taniguchi, T Yamada, R Wang, K Tanimura, Y Adachi, A Nishiyama, A Tanimoto, S Takeuchi, LH Araujo, M Boroni, A Yoshimura, S Shiotsu, I Matsumoto, S Watanabe, T Kikuchi, S Miura, H Tanaka, T Kitazaki, H Yamaguchi, H Mukae, J Uchino, H Uehara, K Takayama, S Yano
Nat Commun, 2019;10(1):259. 2019
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Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus
Authors: ME Nickol, J Ciric, SD Falcinelli, DS Chertow, J Kindrachuk
Viruses, 2019;11(2):. 2019
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Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds
Authors: IA Schepetkin, LN Kirpotina, AI Khlebnikov, N Balasubram, MT Quinn
Molecules, 2019;24(9):. 2019
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The small GTPase ARF6 activates PI3K in melanoma to induce a pro-metastatic state
Authors: JH Yoo, SW Brady, L Acosta-Alv, A Rogers, J Peng, LK Sorensen, RK Wolff, T Mleynek, D Shin, CP Rich, DA Kircher, A Bild, SJ Odelberg, DY Li, SL Holmen, AH Grossmann
Cancer Res., 2019;0(0):. 2019
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Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia-reperfusion injury
Authors: L Hummitzsch, K Zitta, R Berndt, YL Wong, R Rusch, K Hess, T Wedel, M Gruenewald, J Cremer, M Steinfath, M Albrecht
J Transl Med, 2019;17(1):136. 2019
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Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach
Authors: Z Xiao, B Sperl, S Gärtner, T Nedelko, E Stacher-Pr, A Ullrich, PG Knyazev
Oncotarget, 2019;10(26):2546-2560. 2019
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Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice
Authors: SA Scarneo, LS Eibschutz, PJ Bendele, KW Yang, J Totzke, P Hughes, DA Fox, TAJ Haystead
Arthritis Res. Ther., 2019;21(1):292. 2019
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CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation
Authors: NL Cook, M Pjanic, AG Emmerich, AS Rao, S Hetty, JW Knowles, T Quertermou, C Castillejo, E Ingelsson
BMC Endocr Disord, 2019;19(1):115. 2019
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CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma
Authors: R Xu, Y Li, H Yan, E Zhang, X Huang, Q Chen, J Chen, J Qu, Y Liu, J He, Q Yi, Z Cai
Cell Death Dis, 2019;10(10):781. 2019
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Interleukin-6 mediates resistance to PI3K-pathway-targeted therapy in lymphoma
Authors: JH Kim, WS Kim, C Park
BMC Cancer, 2019;19(1):936. 2019
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Tyrosine kinase inhibition to improve anthracycline-based chemotherapy efficacy in T-cell lymphoma
Authors: M Magni, G Biancon, S Rizzitano, A Cavanè, C Paolizzi, M Dugo, P Corradini, C Carniti
Br. J. Cancer, 2019;0(0):. 2019
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Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma
Authors: J Wurm, SP Behringer, VM Ravi, K Joseph, N Neidert, JP Maier, R Doria-Medi, M Follo, D Delev, D Pfeifer, J Beck, R Sankowski, O Schnell, DH Heiland
Cancers (Basel), 2019;11(10):. 2019
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UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling
Authors: JX Lin, XS Xie, XF Weng, SL Qiu, C Yoon, NZ Lian, JW Xie, JB Wang, J Lu, QY Chen, LL Cao, M Lin, RH Tu, YH Yang, CM Huang, CH Zheng, P Li
J. Exp. Clin. Cancer Res., 2019;38(1):410. 2019
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Kinome expression profiling to target new therapeutic avenues in multiple myeloma
Authors: H de Boussac, A Bruyer, M Jourdan, A Maes, N Robert, C Gourzones, L Vincent, A Seckinger, G Cartron, D Hose, E De Bruyne, A Kassambara, P Pasero, J Moreaux
Haematologica, 2019;0(0):. 2019
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Multilevel defects in the hematopoietic niche in essential thrombocythemia
Authors: T Sun, M Ju, X Dai, H Dong, W Gu, Y Gao, R Fu, X Liu, Y Huang, W Liu, Y Chi, W Wang, H Li, Y Zhou, L Shi, R Yang, L Zhang
Haematologica, 2019;0(0):. 2019
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Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer
Authors: MJ Jo, S Jeong, HK Yun, DY Kim, BR Kim, JL Kim, YJ Na, SH Park, YA Jeong, BG Kim, H Ashktorab, DT Smoot, JY Heo, J Han, DH Lee, SC Oh
BMC Cancer, 2019;19(1):739. 2019
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Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin
Authors: J Menéndez-M, F Hermida-Pr, R Granda-Día, A González, JM García-Ped, N Del-Río-Ib, A González-G, S Cos, C Alonso-Gon, C Martínez-C
Cancers (Basel), 2019;11(7):. 2019
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CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
Authors: S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis
JCI Insight, 2019;0(0):. 2019
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Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors
Authors: F Pareja, AH Brandes, T Basili, P Selenica, FC Geyer, D Fan, A Da Cruz Pa, R Kumar, DN Brown, R Gularte-Mé, B Alemar, R Bi, RS Lim, I de Bruijn, S Fujisawa, R Gardner, E Feng, A Li, EM da Silva, JR Lozada, P Blecua, L Cohen-Goul, AA Jungbluth, EA Rakha, IO Ellis, MIA Edelweiss, J Palazzo, L Norton, T Hollmann, M Edelweiss, BP Rubin, B Weigelt, JS Reis-Filho
Nat Commun, 2018;9(1):3533. 2018
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Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT
Authors: Y Zhang, G Ji, S Han, Z Shao, Z Lu, L Huo, J Zhang, R Yang, Q Feng, H Shen, H Wang, X Li
Cell. Physiol. Biochem., 2018;50(2):612-628. 2018
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WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4
Authors: K Taniuchi, M Furihata, S Naganuma, T Saibara
Cancer Med, 2018;0(0):. 2018
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WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
Authors: CS Gonçalves, J Vieira de, M Pojo, EP Martins, S Queirós, E Chautard, R Taipa, MM Pires, AA Pinto, F Pardal, C Custódia, CC Faria, C Clara, RM Reis, N Sousa, BM Costa
Theranostics, 2018;8(17):4805-4823. 2018
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Olfactory receptor OR2AT4 regulates human hair growth
Authors: J Chéret, M Bertolini, L Ponce, J Lehmann, T Tsai, M Alam, H Hatt, R Paus
Nat Commun, 2018;9(1):3624. 2018
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IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells
Authors: M Shimizu, N Tanaka
Oncogene, 2018;0(0):. 2018
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Establishment of keratinocyte cell lines from human hair follicles
Authors: T Wagner, M Gschwandtn, A Strajeriu, A Elbe-Bürge, J Grillari, R Grillari-V, G Greiner, B Golabi, E Tschachler, M Mildner
Sci Rep, 2018;8(1):13434. 2018
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Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy
Authors: JM Santiago-O, ES Kleinerman, MG Hollomon, A Livingston, WL Wang, JW Tsai, NB Gordon
Oncotarget, 2018;9(2):1602-1616. 2018
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Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
Authors: Y Jiang, YY Jiang, JJ Xie, A Mayakonda, M Hazawa, L Chen, JF Xiao, CQ Li, ML Huang, LW Ding, QY Sun, L Xu, D Kanojia, M Jeitany, JW Deng, LD Liao, HJ Soukiasian, BP Berman, JJ Hao, LY Xu, EM Li, MR Wang, XG Bi, DC Lin, HP Koeffler
Nat Commun, 2018;9(1):3619. 2018
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YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
Authors: PD Fan, G Narzisi, AD Jayaprakas, E Venturini, N Robine, P Smibert, S Germer, HA Yu, EJ Jordan, PK Paik, YY Janjigian, JE Chaft, L Wang, AA Jungbluth, S Middha, L Spraggon, H Qiao, CM Lovly, MG Kris, GJ Riely, K Politi, H Varmus, M Ladanyi
Proc. Natl. Acad. Sci. U.S.A., 2018;115(26):E6030-E6038. 2018
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CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1? axis to inhibit gastric tumorigenesis
Authors: W Li, CC Wong, X Zhang, W Kang, G Nakatsu, Q Zhao, H Chen, MYY Go, PWY Chiu, X Wang, J Ji, X Li, Z Cai, EKW Ng, J Yu
Oncogene, 2018;0(0):. 2018
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Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds
Authors: V Vishwakarm, J New, D Kumar, V Snyder, L Arnold, E Nissen, Q Hu, N Cheng, D Miller, AR Thomas, Y Shnayder, K Kakarala, TT Tsue, DA Girod, SM Thomas
Sci Rep, 2018;8(1):12163. 2018
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Suppression of the ERK-SRF axis facilitates somatic cell reprogramming
Authors: S Huh, HR Song, GR Jeong, H Jang, NH Seo, JH Lee, JY Yi, B Lee, HW Choi, JT Do, JS Kim, SH Lee, JW Jung, T Lee, J Shim, MK Han, TH Lee
Exp. Mol. Med., 2018;50(2):e448. 2018
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Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17
Authors: P Urriola-Mu, R Lagos-Cabr, D Patiño-Gar, JG Reyes, RD Moreno
Int J Mol Sci, 2018;19(8):. 2018
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Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines
Authors: MY Gökyildiri, U Grandel, K Hattar, G Dahlem, E Schuetz, FH Leinberger, F Eberle, U Sibelius, F Grimminger, W Seeger, R Engenhart-, E Dikomey, FSB Subtil
Oncotarget, 2018;9(48):28976-28988. 2018
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?-arrestin 1 regulates ?2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
Authors: J Kim, CA Grotegut, JW Wisler, T Li, L Mao, M Chen, W Chen, PB Rosenberg, HA Rockman, RJ Lefkowitz
Skelet Muscle, 2018;8(1):39. 2018
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Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo
Authors: C Li, V Rezov, E Joensuu, V Vartiainen, M Rönty, M Yin, M Myllärniem, K Koli
Sci Rep, 2018;8(1):10070. 2018
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Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway
Authors: Z Fang, KH Jung, HH Yan, SJ Kim, M Rumman, JH Park, B Han, JE Lee, YW Kang, JH Lim, SS Hong
Cell. Physiol. Biochem., 2018;47(5):1751-1768. 2018
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HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis
Authors: C Hernandez, P Huebener, JP Pradere, DJ Antoine, RA Friedman, RF Schwabe
J. Clin. Invest., 2018;0(0):. 2018
-
JDP2 overexpression provokes cardiac dysfunction in mice
Authors: J Heger, J Bornbaum, A Würfel, C Hill, N Brockmann, R Gáspár, J Pálóczi, ZV Varga, M Sárközy, P Bencsik, T Csont, S Török, B Kojonazaro, RT Schermuly, K Böngler, M Parahuleva, P Ferdinandy, R Schulz, G Euler
Sci Rep, 2018;8(1):7647. 2018
-
WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling
Authors: W Chen, LN Zebaze, J Dong, L Chézeau, P Inquimbert, S Hugel, S Niu, F Bihel, E Boutant, E Réal, P Villa, MP Junier, H Chneiweiss, M Hibert, J Haiech, MC Kilhoffer, M Zeniou
Oncotarget, 2018;9(43):27197-27219. 2018
-
5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease
Authors: C Klein, G Roussel, S Brun, C Rusu, C Patte-Mens, M Maitre, AG Mensah-Nya
Acta Neuropathol Commun, 2018;6(1):136. 2018
-
Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.
Authors: Charalambos Kaittanis, Chrysafis Andreou, Haley Hieronymu, Ninghui Mao, Catherine A Foss, Matthias Eiber, Gregor Weirich, Palak Panchal, Anuradha Gopalan, Juan Zurita, Samuel Achilefu, Gabriela Chiosis, Vladimir Ponomarev, Markus Schwaiger, Brett S Carver, Martin G Pomper, Jan Grimm
The Journal of Experimental Medicine, 2018;0(0):1540-9538. 2018
-
Ruxolitinib in combination with prednisone and nilotinib exhibit synergistic effects in human cells lines and primary cells from myeloproliferative neoplasms
Authors: A Arenas Cor, R Ayala Diaz, P Hernández-, J Gorrochate, D Primo, A Robles, ML Morales, J Ballestero, I Rapado, M Gallardo, M Linares, J Martínez-L
Haematologica, 2018;0(0):. 2018
-
Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
Authors: TM Totiger, S Srinivasan, VR Jala, P Lamichhane, AR Dosch, AA Gaidarski, C Joshi, S Rangappa, J Castellano, PK Vemula, X Chen, D Kwon, N Kashikar, M VanSaun, NB Merchant, NS Nagathihal
Mol. Cancer Ther., 2018;0(0):. 2018
-
BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling
Authors: K Taniuchi, M Furihata, S Naganuma, K Dabanaka, K Hanazaki, T Saibara
Am J Cancer Res, 2018;8(3):387-404. 2018
-
Acquired resistance to AZD9291 as an upfront treatment is dependent on ERK signaling in a preclinical model
Authors: BM Ku, MK Choi, JM Sun, SH Lee, JS Ahn, K Park, MJ Ahn
PLoS ONE, 2018;13(4):e0194730. 2018
-
Low-molecular weight keratins with anti-skin aging activity produced by anaerobic digestion of poultry feathers with Fervidobacterium islandicum AW-1
Authors: I Yeo, YJ Lee, K Song, HS Jin, JE Lee, D Kim, DW Lee, NJ Kang
J. Biotechnol., 2018;0(0):. 2018
-
B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies
Authors: G Xiao, LN Chan, L Klemm, D Braas, Z Chen, H Geng, QC Zhang, A Aghajanire, KN Cosgun, T Sadras, J Lee, T Mirzapoiaz, R Salgia, T Ernst, A Hochhaus, H Jumaa, X Jiang, DM Weinstock, TG Graeber, M Müschen
Cell, 2018;0(0):. 2018
-
Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation
Authors: V Pandey, B Wang, CD Mohan, AR Raquib, S Rangappa, V Srinivasa, JE Fuchs, KS Girish, T Zhu, A Bender, L Ma, Z Yin, Basappa, KS Rangappa, PE Lobie
Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):. 2018
-
Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells
Authors: G Tornillo, C Knowlson, H Kendrick, J Cooke, H Mirza, I Aurrekoetx, MDM Vivanco, NE Buckley, A Grigoriadi, MJ Smalley
Cell Rep, 2018;25(13):3674-3692.e10. 2018
-
K-Ras lysine-42 is crucial for its signaling, cell migration and invasion
Authors: BH Choi, MR Philips, Y Chen, L Lu, W Dai
J. Biol. Chem., 2018;0(0):. 2018
-
The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors
Authors: X Wang, J Ai, H Liu, X Peng, H Chen, Y Chen, Y Su, A Shen, X Huang, J Ding, M Geng
Mol. Cancer Ther., 2018;0(0):. 2018
-
Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
Authors: X Gong, JR Smith, HM Swanson, LP Rubin
Molecules, 2018;23(4):. 2018
-
Lorlatinib treatment elicits multiple on- and off-target mechanisms of resistance in ALK-driven cancer
Authors: S Redaelli, M Ceccon, M Zappa, GG Sharma, C Mastini, M Mauri, M Nigoghossi, L Massimino, N Cordani, F Farina, R Piazza, C Gambacorti, L Mologni
Cancer Res., 2018;0(0):. 2018
-
Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines
Authors: S Heavey, P Dowling, G Moore, MP Barr, N Kelly, SG Maher, S Cuffe, SP Finn, KJ O'Byrne, K Gately
Sci Rep, 2018;8(1):1652. 2018
-
Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist
Authors: W Miao, K Sakai, N Ozawa, T Nishiuchi, Y Suzuki, K Ito, T Morioka, M Umitsu, J Takagi, H Suga, K Matsumoto
Sci Rep, 2018;8(1):16492. 2018
-
The Noncoding RNA nc886 Regulates PKR Signaling and Cytokine Production in Human Cells
Authors: E Golec, L Lind, M Qayyum, AM Blom, BC King
J. Immunol., 2018;0(0):. 2018
-
Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1
Authors: TY Wong, WC Juang, CT Tsai, CJ Tseng, WH Lee, SN Chang, PW Cheng
J Clin Med, 2018;7(11):. 2018
-
Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin
Authors: E Narvi, K Vaparanta, A Karrila, D Chakrobort, S Knuutila, A Pulliainen, M Sundvall, K Elenius
Sci Rep, 2018;8(1):16579. 2018
-
miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer
Authors: U Baumgartne, F Berger, A Hashemi Gh, SS Burgener, K Monastyrsk, E Vassella
Mol. Cancer, 2018;17(1):44. 2018
-
Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer
Authors: MH Kubala, V Punj, VR Placencio-, H Fang, GE Fernandez, R Sposto, YA DeClerck
Cell Rep, 2018;25(8):2177-2191.e7. 2018
-
NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway
Authors: L Deng, X Gao, B Liu, X He, J Xu, J Qiang, Q Wu, S Liu
Cell Death Dis, 2018;9(12):1143. 2018
-
YM155 decreases radiation-induced invasion and reverses epithelial-mesenchymal transition by targeting STAT3 in glioblastoma
Authors: X Zhang, X Wang, R Xu, J Ji, Y Xu, M Han, Y Wei, B Huang, A Chen, Q Zhang, W Li, J Wang, X Li, C Qiu
J Transl Med, 2018;16(1):79. 2018
-
Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes
Authors: M Mustapic, E Eitan, JK Werner, ST Berkowitz, MP Lazaropoul, J Tran, EJ Goetzl, D Kapogianni
Front Neurosci, 2017;11(0):278. 2017
-
The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischemia/reperfusion independent from mitochondrial connexin 43
Authors: K Boengler, M Bulic, R Schreckenb, KD Schlueter, R Schulz
Br. J. Pharmacol., 2017;0(0):. 2017
-
Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation.
Authors: Benjamin Y Owusu, Shantasia Thomas, Phanindra Venukadas, Zhenfu Han, James W Janetka, Robert A Galemmo, Lidija Klampfer
Oncotarget, 2017;0(0):1949-2553. 2017
-
Resistance to the antibody-drug conjugate T-DM1 is based in a reduction in lysosomal proteolytic activity
Authors: C Ríos-Luci, S García-Alo, E Díaz-Rodrí, M Nadal-Serr, J Arribas, A Ocaña, A Pandiella
Cancer Res., 2017;0(0):. 2017
-
Dysregulation of Mir-196b in Head and Neck Cancers Leads to Pleiotropic Effects in the Tumor Cells and Surrounding Stromal Fibroblasts
Authors: S Álvarez-Te, ST Menéndez, MÁ Villaronga, JP Rodrigo, L Manterola, L de Villala, JC de Vicente, L Alonso-Dur, MP Fernández, CH Lawrie, JM García-Ped
Sci Rep, 2017;7(1):17785. 2017
-
Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer.
Authors: Chih-Hau Chang, Meng-Chi Yen, Ssu-Hui Liao, Yu-Ling Hsu, Chung-Sheng Lai, Kao-Ping Chang, Ya-Ling Hsu
International Journal of Molecular Sciences, 2017;0(0):1422-0067. 2017
-
Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation
Authors: M Riera-Borr, VD Cuevas, B Alonso, MA Vega, J Joven, E Izquierdo, ÁL Corbí
J. Immunol., 2017;0(0):. 2017
-
Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer.
Authors: Chang C, Yen M, Liao S, Hsu Y, Lai C, Chang K, Hsu Y
Int J Mol Sci, 2017;18(7):. 2017
-
Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades
Authors: H Lee, SH Baek, JH Lee, C Kim, JH Ko, SG Lee, A Chinnatham, SA Alharbi, WM Yang, JY Um, G Sethi, KS Ahn
Int J Mol Sci, 2017;18(5):. 2017
-
Co-targeting of MEK and PDGFR/STAT3 pathways to treat pancreatic ductal adenocar
Authors: N Sahu, E Chan, F Chu, T Pham, H Koeppen, W Forrest, M Merchant, J Settleman
Mol. Cancer Ther., 2017;0(0):. 2017
-
Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell
Authors: S Chen, J Tao, F Zhong, Y Jiao, J Xu, Q Shen, H Wang, S Fan, Y Zhang
PLoS ONE, 2017;12(5):e0176501. 2017
-
Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17
Authors: PC Buchanan, KL Boylan, B Walcheck, R Heinze, MA Geller, PA Argenta, AP Skubitz
J. Biol. Chem, 2017;0(0):. 2017
-
Human Epididymis Protein 4 Promotes Events Associated with Metastatic Ovarian CancerviaRegulation of the Extracelluar Matrix
Authors: JR Ribeiro, HM Gaudet, M Khan, C Schorl, NE James, MT Oliver, PA DiSilvestr, RG Moore, N Yano
Front Oncol, 2017;7(0):332. 2017
-
The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry
Authors: Z Zhou, L Xu, A Sennepin, C Federici, Y Ganor, D Tudor, D Damotte, N Barry Delo, M Zerbib, M Bomsel
Mucosal Immunol, 2017;0(0):. 2017
-
WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response
Authors: S Janczar, J Nautiyal, Y Xiao, E Curry, M Sun, E Zanini, AJ Paige, H Gabra
Cell Death Dis, 2017;8(7):e2955. 2017
-
Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells
Authors: GM Pio, Y Xia, MM Piaseczny, JE Chu, AL Allan
PLoS ONE, 2017;12(5):e0177640. 2017
-
Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN
Authors: A Cavazzoni, S La Monica, R Alfieri, A Ravelli, N Van Der St, R Sciarrillo, D Madeddu, CAM Lagrasta, F Quaini, M Bonelli, C Fumarola, D Cretella, G Digiacomo, M Tiseo, GJ Peters, A Ardizzoni, PG Petronini, E Giovannett
Oncotarget, 2017;0(0):. 2017
-
Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma
Authors: Y Mo, Y Lu, P Wang, S Huang, L He, D Li, F Li, J Huang, X Lin, X Li, S Che, Q Chen
Tumour Biol, 2017;39(2):1010428317690. 2017
-
Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis
Authors: S Keller, J Kneissl, V Grabher-Me, S Heindl, J Hasenauer, D Maier, J Mattes, P Winter, B Luber
BMC Cancer, 2017;17(1):845. 2017
-
Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation
Authors: S Curcic, M Holzer, L Pasterk, E Knuplez, TO Eichmann, S Frank, R Zimmermann, R Schicho, A Heinemann, G Marsche
Sci Rep, 2017;7(1):8030. 2017
-
EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2�
Authors: II Kuan, KH Liang, YP Wang, TW Kuo, YJ Meir, SC Wu, SC Yang, J Lu, HC Wu
Sci Rep, 2017;7(0):41852. 2017
-
Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas
Authors: MV Carriero, K Bifulco, V Ingangi, S Costantini, G Botti, C Ragone, M Minopoli, ML Motti, D Rea, G Scognamigl, G Botti, C Arra, G Ciliberto, A Pessi
Sci Rep, 2017;7(1):1312. 2017
-
Ras-MEK Signaling Mediates a Critical Chk1-dependent DNA Damage Response in Cancer Cells
Authors: HJ Lee, Y Cao, V Pham, E Blackwood, C Wilson, M Evangelist, C Klijn, D Stokoe, J Settleman
Mol. Cancer Ther, 2017;0(0):. 2017
-
Activation of p38 and Erk Mitogen-Activated Protein Kinases Signaling in Ocular Rosacea
Authors: EJ Wladis, S Swamy, A Herrmann, J Yang, JA Carlson, AP Adam
Invest. Ophthalmol. Vis. Sci, 2017;58(2):843-848. 2017
-
FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation
Authors: FR Teixeira, AO Manfiolli, NA Vieira, AC Medeiros, PO Coelho, D Santiago G, D Schechtman, MD Gomes
Arch. Biochem. Biophys., 2017;0(0):. 2017
-
Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway
Authors: TO Cri?an, MCP Cleophas, B Novakovic, K Erler, FL van de Vee, HG Stunnenber, MG Netea, CA Dinarello, LAB Joosten
Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):. 2017
-
Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice
Authors: P Kuppusamy, A Nagalingam, N Muniraj, NK Saxena, D Sharma
Sci Rep, 2017;7(1):17943. 2017
-
JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non-small cell lung cancer
Authors: K Shien, VA Papadimitr, D Ruder, C Behrens, L Shen, N Kalhor, J Song, JJ Lee, J Wang, X Tang, RS Herbst, S Toyooka, L Girard, JD Minna, JM Kurie, II Wistuba, JG Izzo
Mol. Cancer Ther., 2017;0(0):. 2017
-
Induction and Differentiation of IL-10-Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients.
Authors: Banko Z, Pozsgay J, Szili D, Toth M, Gati T, Nagy G, Rojkovich B, Sarmay G
J Immunol, 2017;198(4):1512-1520. 2017
-
The Transcription Factor HOXB7 Regulates ERK Kinase Activity and Thereby Stimulates the Motility and Invasiveness of Pancreatic Cancer Cells
Authors: M Tsuboi, K Taniuchi, T Shimizu, M Saito, T Saibara
J. Biol. Chem., 2017;0(0):. 2017
-
Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer
Authors: CH Chang, MC Yen, SH Liao, YL Hsu, CS Lai, KP Chang, YL Hsu
Int J Mol Sci, 2017;18(7):. 2017
-
Protein C receptor stimulates multiple signaling pathways in breast cancer cells
Authors: D Wang, C Liu, J Wang, Y Jia, X Hu, H Jiang, ZM Shao, YA Zeng
J. Biol. Chem., 2017;0(0):. 2017
-
Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene
Authors: SA Nadeau, W An, BC Mohapatra, I Mushtaq, TA Bielecki, H Luan, N Zutshi, G Ahmad, MD Storck, M Sanada, S Ogawa, V Band, H Band
J. Biol. Chem, 2017;292(9):3666-3682. 2017
-
Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer
Authors: K Kalyvianak, V Gebhart, N Peroulis, C Panagiotop, F Kiagiadaki, I Pediaditak, M Aivaliotis, E Moustou, M Tzardi, G Notas, E Castanas, M Kampa
Sci Rep, 2017;7(0):44418. 2017
-
Disruption of Aneuploidy and Senescence induced by Aurora inhibition promotes intrinsic Apoptosis in double hit or double expressor Diffuse Large B-cell Lymphomas
Authors: D Mahadevan, S Islam, W Qi, C Morales, L Cooke, C Spier, E Weterings
Mol. Cancer Ther., 2017;0(0):. 2017
-
Galectin-3 interacts with the cell surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells
Authors: F Colomb, W Wang, D Simpson, M Zafar, R Beynon, JM Rhodes, LG Yu
J. Biol. Chem., 2017;0(0):. 2017
-
Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension
Authors: P Yang, C Read, RE Kuc, G Buonincont, M Southwood, R Torella, PD Upton, A Crosby, SJ Sawiak, TA Carpenter, RC Glen, NW Morrell, JJ Maguire, AP Davenport
Circulation, 2017;135(12):1160-1173. 2017
-
Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
Oncotarget, 2016;7(26):40531-40545. 2016
-
Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18
Sci Rep, 2016;6(0):32255. 2016
-
Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer.
Authors: Astrid Escudero-E, Michael Bartosche, Chrysostomi Gialeli, Marcin Okroj, Sioned Owen, Karin Jirström, Akira Orimo, Wen G Jiang, Kristian Pietras, Anna M Blom
Oncotarget, 2016;0(0):1949-2553. 2016
-
Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells
J Cancer, 2016;7(13):1824-1832. 2016
-
The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2
Authors: Nicola M Heller
J. Biol. Chem., 2016;291(48):24922-24930. 2016
-
Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase
Authors: Raymond B Birge
Cell Commun. Signal, 2016;14(1):19. 2016
-
A Small Molecule Inhibitor of PDK1/PLC?1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion
Authors: C Raimondi, V Calleja, R Ferro, A Fantin, AM Riley, BV Potter, CH Brennan, T Maffucci, B Larijani, M Falasca
Sci Rep, 2016;6(0):26142. 2016
-
Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions.
Authors: Purushothaman A, Bandari S, Liu J, Mobley J, Brown E, Sanderson R
J Biol Chem, 2016;291(4):1652-63. 2016
-
Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance
Acta Pharmacol. Sin., 2016;0(0):. 2016
-
BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine
Authors: Yuexi Gu
Sci Rep, 2016;6(0):28217. 2016
-
CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells
Authors: Aki Tanouchi
J. Exp. Clin. Cancer Res, 2016;35(1):190. 2016
-
Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line
Authors: Benjamin Kalbe
Eur. J. Cell Biol, 2016;0(0):. 2016
-
Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection
MBio, 2016;7(6):. 2016
-
Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs
Authors: Nader Alaridah
J Innate Immun, 2016;0(0):. 2016
-
Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells
Sci Rep, 2016;6(0):33132. 2016
-
Necrotic cells influence migration and invasion of glioblastoma via NF-?B/AP-1-mediated IL-8 regulation
Authors: SH Ahn, H Park, YH Ahn, S Kim, MS Cho, JL Kang, YH Choi
Sci Rep, 2016;6(0):24552. 2016
-
Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism
Proc Natl Acad Sci USA, 2016;0(0):. 2016
-
Metabolism regulates cellular functions of bone marrow-derived cells used for cardiac therapy
Stem Cells, 2016;0(0):. 2016
-
Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells.
Authors: Skolekova S, Matuskova M, Bohac M, Toro L, Demkova L, Gursky J, Kucerova L
Cell Commun Signal, 2016;14(1):4. 2016
-
Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling
Authors: L Bénard, JG Oh, M Cacheux, A Lee, M Nonnenmach, DS Matasic, E Kohlbrenne, C Kho, C Pavoine, RJ Hajjar, JS Hulot
Circulation, 2016;133(15):1458-71; disc. 2016
-
CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells
Oncogene, 2016;0(0):. 2016
-
Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer
Oncotarget, 2016;0(0):. 2016
-
New insights into the Shwachman-Diamond Syndrome-related haematological disorder: hyper-activation of mTOR and STAT3 in leukocytes
Sci Rep, 2016;6(0):33165. 2016
-
A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D.
Authors: Eggink L, Spyroulias G, Jones N, Hanson C, Hoober J
PLoS ONE, 2015;10(6):e0130532. 2015
-
Loss of DGKepsilon induces endothelial cell activation and death independently of complement activation.
Authors: Bruneau S, Neel M, Roumenina L, Frimat M, Laurent L, Fremeaux-Bacchi V, Fakhouri F
Blood, 2015;125(6):1038-46. 2015
-
Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation.
Authors: Zhao D, Besser A, Wander S, Sun J, Zhou W, Wang B, Ince T, Durante M, Guo W, Mills G, Theodorescu D, Slingerland J
Oncogene, 2015;34(43):5447-59. 2015
-
Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes.
Authors: Sento S, Sasabe E, Yamamoto T
PLoS ONE, 2015;11(2):e0148454. 2015
-
YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway.
Authors: Chang B, Johnson K, LaTocha D, Rowley J, Bryant J, Burke R, Smith R, Loriaux M, Muschen M, Mullighan C, Druker B, Tyner J
J Hematol Oncol, 2015;8(0):39. 2015
-
Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma.
Authors: Atefi M, Titz B, Avramis E, Ng C, Wong D, Lassen A, Cerniglia M, Escuin-Ordinas H, Foulad D, Comin-Anduix B, Graeber T, Ribas A
Mol Cancer, 2015;14(0):27. 2015
-
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.
Authors: Mailly L, Xiao F, Lupberger J, Wilson G, Aubert P, Duong F, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lutgehetmann M, Volz T, Davis C, Harris H, Mee C, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim M, Neunlist M, Zeisel M, Dandri M, McKeating J, Robinet E, Baumert T
Nat Biotechnol, 2015;33(5):549-54. 2015
-
Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5promotes angiogenesis and vasorelaxation.
Authors: Cho Y, Hur S, Kim J, Kim J, Lee D, Choe J, Won M, Ha K, Jeoung D, Han S, Ryoo S, Lee H, Min J, Kwon Y, Kim D, Kim Y
J Biol Chem, 2015;290(1):467-77. 2015
-
Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.
Authors: Laukkanen, Mikko O, Cammarota, Francesc, Esposito, Tiziana, Salvatore, Marco, Castellone, Maria D
PLoS ONE, 2015;10(3):e0121441. 2015
-
A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
Authors: Bajpe, P K, Prahallad, A, Horlings, H, Nagtegaal, I, Beijersbergen, R, Bernards, R
Oncogene, 2015;34(4):531-6. 2015
-
Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma.
Authors: Yamada T, Amann J, Fukuda K, Takeuchi S, Fujita N, Uehara H, Iwakiri S, Itoi K, Shilo K, Yano S, Carbone D
Cancer Res, 2015;75(19):4188-97. 2015
-
The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes.
Authors: Hansen F, Kalle-Brune M, van der Plas M, Stromdahl A, Malmsten M, Morgelin M, Schmidtchen A
J Immunol, 2015;194(11):5397-406. 2015
-
Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.
Authors: Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, Kim Y, Adam J, Lichter P, Solary E, Berchem G, Moussay E
Blood, 2015;126(9):1106-17. 2015
-
Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling.
Authors: Man J, Shoemake J, Ma T, Rizzo A, Godley A, Wu Q, Mohammadi A, Bao S, Rich J, Yu J
Cancer Res, 2015;75(8):1760-9. 2015
-
Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells.
Authors: Singh A, Ruan Y, Tippett T, Narendran A
J Exp Clin Cancer Res, 2015;34(0):104. 2015
-
Adenosine inhibits tumor cell invasion via receptor-independent mechanisms.
Authors: Virtanen S, Kukkonen-Macchi A, Vainio M, Elima K, Harkonen P, Jalkanen S, Yegutkin G
Mol Cancer Res, 2014;12(12):1863-74. 2014
-
Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells.
Authors: Raimondi C, Fantin A, Lampropoulou A, Denti L, Chikh A, Ruhrberg C
J Exp Med, 2014;211(6):1167-83. 2014
-
EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line.
Authors: Ranayhossaini D, Lu J, Mabus J, Gervais A, Lingham R, Fursov N
Int J Mol Sci, 2014;15(10):17686-704. 2014
-
Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.
Authors: Jokela T, Karna R, Makkonen K, Laitinen J, Tammi R, Tammi M
J Biol Chem, 2014;289(26):18569-81. 2014
-
Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner.
Authors: Polajeva J, Bergstrom T, Edqvist P, Lundequist A, Sjosten A, Nilsson G, Smits A, Bergqvist M, Ponten F, Westermark B, Pejler G, Forsberg Nilsson K, Tchougounova E
Mol Oncol, 2014;8(1):50-8. 2014
-
Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo.
Authors: Naspi A, Panasiti V, Abbate F, Roberti V, Devirgiliis V, Curzio M, Borghi M, Lozupone F, Carotti S, Morini S, Gaudio E, Calvieri S, Londei P
PLoS ONE, 2014;9(6):e98641. 2014
-
An increase in integrin-linked kinase non-canonically confers NF- inverted question markB-mediated growth advantages to gastric cancer cells by activating ERK1/2.
Authors: Tseng P, Chen C, Shan Y, Chang W, Liu H, Hong T, Hsieh C, Lin S, Lin C
Cell Commun Signal, 2014;12(1):69. 2014
-
Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer.
Authors: Nagalingam A, Kuppusamy P, Singh S, Sharma D, Saxena N
Cancer Res, 2014;74(9):2617-29. 2014
-
Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy.
Authors: Iida, Mari, Brand, Toni M, Starr, Megan M, Huppert, Evan J, Luthar, Neha, Bahrar, Harsh, Coan, John P, Pearson, Hannah E, Salgia, Ravi, Wheeler, Deric L
Mol Cancer, 2014;13(0):242. 2014
-
Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML.
Authors: Kampen, K R, Ter Elst, A, Mahmud, H, Scherpen, F J G, Diks, S H, Peppelenbosch, M P, de Haas, V, Guryev, V, de Bont, E S J M
Leukemia, 2014;28(3):589-99. 2014
-
Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.
Authors: Sinkevicius, Kerstin, Kriegel, Christin, Bellaria, Kelly J, Lee, Jaewon, Lau, Allison, Leeman, Kristen, Zhou, Pengchen, Beede, Alexande, Fillmore, Christin, Caswell, Deborah, Barrios, Juliana, Wong, Kwok-Kin, Sholl, Lynette, Schlaeger, Thorsten, Bronson, Roderick, Chirieac, Lucian R, Winslow, Monte M, Haigis, Marcia C, Kim, Carla F
Proc Natl Acad Sci U S A, 2014;111(28):10299-304. 2014
-
Soft matrix is a natural stimulator for cellular invasiveness.
Authors: Gu, Zhizhan, Liu, Fei, Tonkova, Elina A, Lee, Soo Youn, Tschumperlin, Daniel J, Brenner, Michael
Mol Biol Cell, 2014;25(4):457-69. 2014
-
Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naive to primed cell transition.
Authors: Speakman C, Domke T, Wongpaiboonwattana W, Sanders K, Mudaliar M, van Aalten D, Barton G, Stavridis M
Stem Cells, 2014;32(10):2605-15. 2014
-
Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells.
Authors: Li, Wenjuan, Liu, Joan, Jackson, Kasey, Shi, Runhua, Zhao, Yunfeng
PLoS ONE, 2014;9(4):e94079. 2014
-
JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer.
Authors: Song W, Ma Y, Wang J, Brantley-Sieders D, Chen J
Cancer Res, 2014;74(9):2444-54. 2014
-
Histamine contributes to tissue remodeling via periostin expression.
Authors: Yang, Lingli, Murota, Hiroyuki, Serada, Satoshi, Fujimoto, Minoru, Kudo, Akira, Naka, Tetsuji, Katayama, Ichiro
J Invest Dermatol, 2014;134(8):2105-13. 2014
-
Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response.
Authors: Lutay N, Hakansson G, Alaridah N, Hallgren O, Westergren-Thorsson G, Godaly G
PLoS ONE, 2014;9(1):e86466. 2014
-
Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells.
Authors: Victoni T, Gleonnec F, Lanzetti M, Tenor H, Valenca S, Porto L, Lagente V, Boichot E
PLoS ONE, 2014;9(1):e85243. 2014
-
Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation.
Authors: Huck, Bettina, Duss, Stephan, Hausser, Angelika, Olayioye, Monilola
J Biol Chem, 2014;289(6):3138-47. 2014
-
Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.
Authors: Lin Z, Zhang C, Zhang M, Xu D, Fang Y, Zhou Z, Chen X, Qin N, Zhang X
PLoS ONE, 2014;9(1):e85296. 2014
-
Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling.
Authors: Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, Limame R, Mestdagh P, Vandesompele J, Vanhove C, Maynard D, Lehuede C, Muller C, Valet P, Gespach C, Bracke M, Cocquyt V, Denys H, De Wever O
Cancer Res, 2014;74(23):6806-19. 2014
-
The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.
Authors: Large M, Wetendorf M, Lanz R, Hartig S, Creighton C, Mancini M, Kovanci E, Lee K, Threadgill D, Lydon J, Jeong J, DeMayo F
, 2014;0(0):. 2014
-
Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.
Authors: Ray, K C, Moss, M E, Franklin, J L, Weaver, C J, Higginbotham, J, Song, Y, Revetta, F L, Blaine, S A, Bridges, L R, Guess, K E, Coffey, R J, Crawford, H C, Washington, M K, Means, A L
Oncogene, 2014;33(7):823-31. 2014
-
IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers.
Authors: Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle-Cezar F, Watkins J, Rashid M, De Rinaldis E, Hessey S, Gazinska P, Hayday A, Tutt A
Cancer Res, 2014;74(17):4908-21. 2014
-
Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 in hypopharyngeal carcinoma cells.
Authors: Wang L, Chen P, Hsu L, Hsu W, Liu D, Chang C, Hsu Y, Lee J
Am J Pathol, 2014;184(2):418-30. 2014
-
Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation.
Authors: Spary L, Al-Taei S, Salimu J, Cook A, Ager A, Watson H, Clayton A, Staffurth J, Mason M, Tabi Z
J Immunol, 2014;192(7):3101-10. 2014
-
Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells.
Authors: Golubkov V, Strongin A
Cell Commun Signal, 2014;12(0):15. 2014
-
The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells.
Authors: Kim, Ji Hye, Kim, Wang-Kyu, Sung, Young Kw, Kwack, Mi Hee, Song, Seung Yo, Choi, Joon-Seo, Park, Sang Gyu, Yi, TacGhee, Lee, Hyun-Joo, Kim, Dae-Duk, Seo, Hyun Min, Song, Sun U, Sung, Jong-Hyu
Stem Cells Dev, 2014;23(12):1364-76. 2014
-
Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
Authors: Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A
Nat Commun, 2014;5(0):4715. 2014
-
Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy.
Authors: Mir, Shakeel, Schwarze, Steven R, Jin, Ling, Zhang, Jinling, Friend, Woodrow, Miriyala, Sumitra, St Clair, Daret, Craven, Rolf J
Autophagy, 2013;9(10):1566-78. 2013
-
Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
Authors: Shimizu A, Nakayama H, Wang P, Konig C, Akino T, Sandlund J, Coma S, Italiano J, Mammoto A, Bielenberg D, Klagsbrun M
J Biol Chem, 2013;288(4):2210-22. 2013
-
Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer.
Authors: Davies, Kurtis D, Mahale, Sakshi, Astling, David P, Aisner, Dara L, Le, Anh T, Hinz, Trista K, Vaishnavi, Aria, Bunn, Paul A J, Heasley, Lynn E, Tan, Aik-Choo, Camidge, D Ross, Varella-Garcia, Marileil, Doebele, Robert C
PLoS ONE, 2013;8(12):e82236. 2013
-
Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein.
Authors: Szalmas A, Gyongyosi E, Ferenczi A, Laszlo B, Karosi T, Csomor P, Gergely L, Veress G, Konya J
Virol J, 2013;10(0):79. 2013
-
Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets.
Authors: Drake J, Graham N, Lee J, Stoyanova T, Faltermeier C, Sud S, Titz B, Huang J, Pienta K, Graeber T, Witte O
Proc Natl Acad Sci U S A, 2013;110(49):E4762-9. 2013
-
CALHM1 controls the Ca(2)(+)-dependent MEK, ERK, RSK and MSK signaling cascade in neurons.
Authors: Dreses-Werringloer U, Vingtdeux V, Zhao H, Chandakkar P, Davies P, Marambaud P
J Cell Sci, 2013;126(0):1199-206. 2013
-
Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines.
Authors: Stegeman H, Kaanders J, Verheijen M, Peeters W, Wheeler D, Iida M, Grenman R, van der Kogel A, Span P, Bussink J
Mol Cancer, 2013;12(1):133. 2013
-
The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.
Authors: Haas D, Bala K, Busche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Ruckert J, Varga Z, Keri G, Schulz T
PLoS Pathog, 2013;9(11):e1003737. 2013
-
Sunlight UV-induced skin cancer relies upon activation of the p38alpha signaling pathway.
Authors: Liu K, Yu D, Cho Y, Bode A, Ma W, Yao K, Li S, Li J, Bowden G, Dong Z, Dong Z
Cancer Res, 2013;73(7):2181-8. 2013
-
The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
Authors: Lekawanvijit S, Kumfu S, Wang B, Manabe M, Nishijima F, Kelly D, Krum H, Kompa A
PLoS ONE, 2013;8(12):e83687. 2013
-
Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584.
Authors: Weidenaar A, Ter Elst A, Kampen K, Meeuwsen-de Boer T, Kamps W, Schuringa J, de Bont E
Mol Cancer Res, 2013;11(4):339-48. 2013
-
Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y.
Authors: Olszewski U, Deally A, Tacke M, Hamilton G
Neoplasia, 2012;14(9):813-22. 2012
-
Concomitant targeting of EGF receptor, tgf-Beta and SRC points to a novel therapeutic approach in pancreatic cancer.
Authors: Deharvengt S, Marmarelis M, Korc M
PLoS ONE, 2012;7(6):e39684. 2012
-
Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
EMBO J., 2012;31(17):3513-23. 2012
-
Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ss-estradiol-BSA.
Authors: Cheng W, Chen L, Yang S, Han J, Zhai D, Ni J, Yu C, Cai Z
PLoS ONE, 2012;7(9):e45529. 2012
-
A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer.
Authors: Dumitru CA, Fechner MK, Hoffmann TK
J. Leukoc. Biol., 2012;91(4):591-8. 2012
-
Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy.
Authors: Joshi, Avadhut, Loilome, Watchari, Siu, I-Mei, Tyler, Betty, Gallia, Gary L, Riggins, Gregory
PLoS ONE, 2012;7(10):e44372. 2012
-
Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia.
BMC Cancer, 2012;12(0):431. 2012
-
Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling.
Authors: Wei Q, Jiang H, Xiao Z
Proc. Natl. Acad. Sci. U.S.A., 2011;108(17):7004-9. 2011
-
Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome.
Authors: Guo T, Lee SS, Ng WH
Cell. Mol. Life Sci., 2011;68(11):1983-2002. 2011
-
Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer.
Authors: Li A, King J, Moro A, Sugi MD, Dawson DW, Kaplan J, Li G, Lu X, Strieter RM, Burdick M, Go VL, Reber HA, Eibl G, Hines OJ
Am. J. Pathol., 2011;178(3):1340-9. 2011
-
EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes.
Authors: Maddigan A, Truitt L, Arsenault R
J. Immunol., 2011;187(11):5983-94. 2011
-
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.
Authors: Chandarlapaty, Sarat, Sawai, Ayana, Scaltriti, Maurizio, Rodrik-Outmezguine, Vanessa, Grbovic-Huezo, Olivera, Serra, Violeta, Majumder, Pradip K, Baselga, Jose, Rosen, Neal
Cancer Cell, 2011;19(1):58-71. 2011
-
Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation.
Authors: Vingtdeux V, Chandakkar P, Zhao H, d'Abramo C, Davies P, Marambaud P
FASEB J., 2011;25(1):219-31. 2011
-
IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis.
Authors: Martins AS, Ordonez JL, Amaral AT, Prins F, Floris G, Debiec-Rychter M, Hogendoorn PC, de Alava E
PLoS ONE, 2011;6(5):e19846. 2011
-
Proteome profiling reveals potential toxicity and detoxification pathways following exposure of BEAS-2B cells to engineered nanoparticle titanium dioxide.
Authors: Ge Y, Bruno M, Wallace K, Winnik W, Prasad RY
Proteomics, 2011;11(12):2406-22. 2011
-
BH3 mimetics activate multiple pro-autophagic pathways.
Authors: Malik SA, Orhon I, Morselli E, Criollo A, Shen S, Marino G, BenYounes A, Benit P, Rustin P, Maiuri MC, Kroemer G
Oncogene, 2011;30(37):3918-29. 2011
-
Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways.
Authors: Li J, Cho YY, Langfald A
Cancer Prev Res (Phila), 2011;4(8):1190-7. 2011
-
Influence of leucine on protein metabolism, phosphokinase expression, and cell proliferation in human duodenum1,3.
Authors: Coeffier M, Claeyssens S, Bensifi M, Lecleire S, Boukhettala N, Maurer B, Donnadieu N, Lavoinne A, Cailleux AF, Dechelotte P
Am. J. Clin. Nutr., 2011;93(6):1255-62. 2011
-
Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab.
Authors: Dunn EF, Iida M, Myers RA, Campbell DA, Hintz KA, Armstrong EA, Li C, Wheeler DL
Oncogene, 2011;30(5):561-74. 2011
-
DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma.
Authors: Singhal G, Akhter MZ, Stern DF
Cancer Gene Ther., 2011;18(7):520-30. 2011
-
Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells.
Authors: Shih YR, Tseng KF, Lai HY, Lin CH, Lee OK
J. Bone Miner. Res., 2011;26(4):730-8. 2011
-
VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES
Eur. J. Cancer, 2010;46(5):974-82. 2010
-
Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
Authors: Tomlinson DC, Knowles MA
Am. J. Pathol., 2010;177(5):2379-86. 2010
-
Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation.
Authors: Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R
J. Clin. Invest., 2010;120(12):4353-65. 2010
-
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
Authors: Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, Garcia-Echeverria C, Bardeesy N, Sharpless NE, Hayes ND, Kim WY, Engelman JA, Wong KK
Cancer Cell, 2010;17(0):547-59. 2010
-
Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice.
Authors: Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avances C, Allory Y, de la Taille A, Culine S, Blancou H, Cristol JP, Michel F, Sardet C, Fajas L
Mol. Cancer Ther., 2010;9(0):1740-54. 2010
-
Coactivated platelet-derived growth factor receptor alpha and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma.
Authors: Dewaele B, Floris G, Finalet-Ferreiro J, Fletcher CD, Coindre JM, Guillou L, Hogendoorn PC, Wozniak A, Vanspauwen V, Schoffski P, Marynen P, Vandenberghe P, Sciot R, Debiec-Rychter M
Cancer Res., 2010;70(18):7304-14. 2010
-
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.
Authors: Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon JE, Janle EM, Lobo J, Ferruzzi MG, Davies P, Marambaud P
J. Biol. Chem., 2010;285(12):9100-13. 2010
-
Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).
Authors: Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villen J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ
Proc. Natl. Acad. Sci. U.S.A., 2010;107(34):15299-304. 2010
-
Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation.
Authors: Zhang H, Fagan DH, Zeng X
Oncogene, 2010;29(17):2517-27. 2010
-
A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.
Authors: Cailleteau C, Liagre B, Beneytout JL
J. Cell. Biochem., 2009;107(4):785-96. 2009
-
The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1.
Authors: Smith NJ, Stoddart LA, Devine NM, Jenkins L, Milligan G
J. Biol. Chem., 2009;284(26):17527-39. 2009
-
Kaposi's sarcoma-associated herpesvirus-G protein-coupled receptor-expressing endothelial cells exhibit reduced migration and stimulated chemotaxis by chemokine inverse agonists.
Authors: Couty JP, Lupu-Meiri M, Oron Y, Gershengorn MC
J. Pharmacol. Exp. Ther., 2009;329(3):1142-7. 2009
-
Neutrophils support lung colonization of metastasis-initiating breast cancer cells.
Authors: Wculek S, Malanchi I
Nature, 0;528(7582):413-7. 0
-
Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation.
Authors: Barquilla A, Lamberto I, Heynen-Genel S, Brill L, Pasquale E
Mol Biol Cell, 0;27(17):2757-70. 0
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Prostae cancer cell lines were used and 200 ug lysate for each samples per membrane was applied.
2xce arrays purchased circa Jan 2018
Great tool for evaluating cell signaling changes. We used this kit with LS174T cells. Kit protocol was easy to follow, and after imaging the resulting spots were very clear and easy to analyze. Phosphorylation of one of the identified signaling proteins was verified using an independent western blot. I would recommend this product
Great kit and ok value for money considering the amount of data you get!
Used with human samples. Image shown was at 1 minute. Other 'dots' appeared at increased exposure. Kit very good overall. Good quality result and easy to use
This array is an excellent tool for screening potential phospho-kinases and related targets. However, it would be nice that if the total level of non-phosphorylated proteins be visualized at the same time on the membrane. In this case, the phosphorylated signals can be normalized.
Antibodies could not be sourced to validate some of the targets.