Proteome Profiler Human Phospho-Kinase Array Kit

Newer Version Available: ARY003C
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Discontinued Product

ARY003B has been discontinued and is replaced by ARY003C.

R&D Systems Proteome Profiler Antibody Array Kits
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Proteome Profiler Human Phospho-Kinase Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of human protein kinase phosphorylation. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 43 human kinases and total amounts of 2 related proteins simultaneously
  • Requires no specialized equipment
 

 

Principle of the Assay

The Proteome Profiler Human Phospho-Kinase Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Phosphorylation of captured proteins is detected with biotinylated phospho-specific detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple kinases in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 

 

Kit Contents

Each Human Phospho-Kinase Antibody Array Kit contains most of the necessary components for a ready-to-run assay without the need for specialized equipment.

  • 8 Array Membranes (4 of membrane A and 4 of membrane B)
  • 8-Well Multi-dish
  • Lysis Buffer
  • Array Buffers
  • Wash Buffer
  • Detection Antibody Cocktail A
  • Detection Antibody Cocktail B
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed product datasheet with protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2°C to 8°C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these proteins in a single sample.
Akt 1/2/3 (S473) Hck (Y411) PLC gamma-1 (Y783)
Akt 1/2/3 (T308) HSP27 (S78/S82) PRAS40 (T246)
AMPK alpha1 (T183) HSP60 Pyk2 (Y402)
AMPK alpha2 (T172) JNK 1/2/3 (T183/Y185, T221/Y223) RSK1/2/3 (S380)
beta-Catenin Lck (Y394) Src (Y419)
Chk-2 (T68) Lyn (Y397) STAT2 (Y689)
c-Jun (S63) MSK1/2 (S376/S360) STAT3 (S727)
CREB (S133) p27 (T198) STAT3 (Y705)
EGF R (Y1086) p38 alpha (T180/Y182) STAT5a (Y699)
eNOS (S1177) p53 (S15) STAT5a/b (Y699)
ERK1/2 (T202/Y204, T185/Y187) p53 (S392) STAT5b (Y699)
FAK (Y397) p53 (S46) STAT6 (Y641)
Fgr (Y412) P70 S6 Kinase (T389) TOR (S2448)
Fyn (Y420) p70 S6 Kinase (T421/S424) WNK-1 (T60)
GSK-3 alpha/beta (S21/S9) PDGF R beta (Y751) Yes (Y426)

 

Assays for analytes represented in the Human Phospho-Kinase Array Kit

 

Analyte DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA
Development Systems (Phospho)
Quantikine®
ELISA Kits
Akt (S473)   DYC887B  
Akt (T308)      
AMPK alpha1 (T183) DYC3197 DYC3528  
AMPK alpha2 (T172)      
beta-Catenin DYC1329   DYC1329
Chk2 (T68)   DYC1626  
c-Jun (S63)      
CREB (S133)   DYC2510  
EGF R (Y1086) DYC1854   DEGFR0
eNOS (S1177)      
ERK1/2 (T202/Y204, T185/Y187)   DYC1018B  
FAK (Y397) DYC4467    
Fgr (Y412)      
Fyn (Y420)      
GSK-3 alpha/beta (S21/S9) DYC2157 DYC2630  
Hck (Y411)      
HSP27 (S78/S82) DYC1580 DYC2314  
HSP60 DYC1800    
JNK pan (T183/Y185, T221/Y223) DYC1205 DYC1387  
Lck (Y394)      
Lyn (Y397)   DYC3936  
MSK1/2 (S376/S360)      
p27 (T198) DYC2256    
p38 alpha (T180/Y182) DYC8691B DYC869B  
p53 (S15) DYC1043 DYC1839  
p53 (S46) DYC1043 DYC1489  
p53 (S392) DYC1043 DYC2996  
p70 S6 Kinase (T389)   DYC896  
p70 S6 Kinase (T421/S424) DYC8962 DYC8965  
PDGF R beta (Y751) DYC385 DYC3096  
PLC gamma-1 (Y783)      
PRAS40 (T246)   DYC6890  
PYK2 (Y402)      
RSK1/2/3 (S380/S386/S377)   DYC889B  
Src (Y419)   DYC2685  
STAT2 (Y689)      
STAT3 (S727)      
STAT3 (Y705)   DYC4607B  
STAT5a (Y694)      
STAT5a/b (Y694/Y699)      
STAT5b (Y699)      
STAT6 (Y641)      
TOR (S2448)   DYC1665  
WNK-1(T60)   DYC4720  
Yes (Y426)   DYC3929  

 

Data Examples
Figure 1.
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Figure 1. MCF-7 human breast cancer cells were either left untreated or exposed to 50 J/m2 of UV light followed by a 4 hour recovery before lysis.

Figure 2.
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Figure 2. A431 human epithelial carcinoma cells were either left untreated or treated with 200 ng/mL recombinant human (rh) EGF (Catalog # 236-EG) for 5 minutes.

Figure 3.
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Figure 3. MCF-7 human breast cancer cells were either left untreated or treated with 100 ng/mL of rhIGF-I (Catalog # 291-G1) for 1 hour.

Specifications

Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

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Citations for Proteome Profiler Human Phospho-Kinase Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

367 Citations: Showing 1 - 10
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  1. Fenretinide induces apoptosis and synergises the apoptosis inducing effect of gemcitabine through inhibition of key signalling molecules involved in A549 cell survival in in silico and in vitro analyses
    Authors: Al-Bustany, HA;Muhammad, HA;Chawsheen, MA;Dash, PR;
    Cellular signalling  2023-09-11
  2. Outside-in signaling through the major histocompatibility complex class-I cytoplasmic tail modulates glutamate receptor expression in neurons
    Authors: Eyford, BA;Lazarczyk, MJ;Choi, KB;Varghese, M;Arora, H;Kari, S;Munro, L;Pfeifer, CG;Sowa, A;Dickstein, DR;Dickstein, DL;Jefferies, WA;
    Scientific reports  2023-08-11
  3. ?-aminobutyric acid B2 receptor: A potential therapeutic target for cholangiocarcinoma in patients with diabetes mellitus
    Authors: Saengboonmee, C;Sorin, S;Sangkhamanon, S;Chomphoo, S;Indramanee, S;Seubwai, W;Thithuan, K;Chiu, CF;Okada, S;Gingras, MC;Wongkham, S;
    World journal of gastroenterology  2023-07-28
  4. Tissue Inhibitor of Metalloproteinases-1 Interacts with CD74 to Promote AKT Signaling, Monocyte Recruitment Responses, and Vascular Smooth Muscle Cell Proliferation
    Authors: Ebert, S;Zang, L;Ismail, N;Otabil, M;Fröhlich, A;Egea, V;Ács, S;Hoeberg, M;Berres, ML;Weber, C;Moreira, JMA;Ries, C;Bernhagen, J;El Bounkari, O;
    Cells  2023-07-20
  5. Mucin 4 Confers Gemcitabine Resistance and an Unfavorable Prognosis in Patients with Cholangiocarcinoma via AKT Activation
    Authors: Pan, YR;Wu, CE;Jung, SM;Huang, SC;Lin, SH;Chou, WC;Chang, YC;Chen, MH;Hung, TH;Yu, AL;Huang, WK;Yeh, CN;
    International journal of biological sciences  2023-05-21
  6. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis
    Authors: W Lin, R Niu, SM Park, Y Zou, SS Kim, X Xia, S Xing, Q Yang, X Sun, Z Yuan, S Zhou, D Zhang, HJ Kwon, S Park, C Il Kim, H Koo, Y Liu, H Wu, M Zheng, H Yoo, B Shi, JB Park, J Yin
    Nature Communications, 2023-03-22;14(1):1578.  2023-03-22
  7. Venetoclax-Resistant T-ALL Cells Display Distinct Cancer Stem Cell Signatures and Enrichment of Cytokine Signaling
    Authors: K Shah, L Al Ashiri, A Nasimian, M Ahmed, JU Kazi
    International Journal of Molecular Sciences, 2023-03-05;24(5):.  2023-03-05
  8. EGFR and Lyn inhibition augments regorafenib induced cell death in sorafenib resistant 3D tumor spheroid model
    Authors: E Sar?yar, O Karpat, S Sezan, SM Baylan, A K?pçak, K Guven, E Erdal, ZF Karagonlar
    Cellular Signalling, 2023-01-21;0(0):110608.  2023-01-21
  9. Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade
    Authors: CH Chang, BJ Lin, CH Chen, NL Nguyen, TH Hsieh, JH Su, MC Chen
    Marine Drugs, 2023-01-21;21(2):.  2023-01-21
  10. HIF-1alpha accumulation in response to transient hypoglycemia may worsen diabetic eye disease
    Authors: C Guo, M Deshpande, Y Niu, I Kachwala, M Flores-Bel, H Megarity, T Nuse, S Babapoor-F, M Ramada, J Sanchez, N Inamdar, TV Johnson, MV Canto-Sole, S Montaner, A Sodhi
    Cell Reports, 2023-01-10;42(1):111976.  2023-01-10
  11. Sustaining the Activation of EGFR Signal by Inflammatory Cytokine IL17A Prompts Cell Proliferation and EGFR-TKI Resistance in Lung Cancer
    Authors: Lee, K;Lai, T;Lee, W;Chen, Y;Ho, K;Hung, W;Yang, Y;Chan, M;Hsieh, F;Chung, C;Chang, J;Chien, M;
    Cancers  2023-01-01
  12. CCL4 Regulates Eosinophil Activation in Eosinophilic Airway Inflammation
    Authors: HH Chu, Y Kobayashi, DV Bui, Y Yun, LM Nguyen, A Mitani, K Suzuki, M Asako, A Kanda, H Iwai
    International Journal of Molecular Sciences, 2022-12-18;23(24):.  2022-12-18
  13. Oxidized Proteins Differentially Affect Maturation and Activation of Human Monocyte-Derived Cells
    Authors: R Clemen, K Arlt, L Miebach, T von Woedtk, S Bekeschus
    Cells, 2022-11-18;11(22):.  2022-11-18
  14. BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes
    Authors: H Takahashi, WM Kühtreiber, RC Keefe, AH Lee, A Aristarkho, HF Dias, N Ng, KJ Nelson, S Bien, D Scheffey, DL Faustman
    Science Advances, 2022-11-16;8(46):eabq7240.  2022-11-16
  15. Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation
    Authors: M Schmitt, F Ceteci, J Gupta, M Pesic, TW Böttger, AM Nicolas, KB Kennel, E Engel, M Schewe, A Callak Kir, V Petrocelli, Y Dabiri, J Varga, M Ramakrishn, M Karimova, A Ablasser, T Sato, MC Arkan, FJ de Sauvage, FR Greten
    Nature, 2022-11-16;0(0):.  2022-11-16
  16. Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells
    Authors: T Chernova, S Grosso, XM Sun, AR Tenor, JZ Cabeza, A Craxton, EL Self, A Nakas, K Cain, M MacFarlane, AE Willis
    International Journal of Molecular Sciences, 2022-10-18;23(20):.  2022-10-18
  17. Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion
    Authors: J Ablain, A Al Mahi, H Rothschild, M Prasad, S Aires, S Yang, ME Dokukin, S Xu, M Dang, I Sokolov, CG Lian, LI Zon
    Nature Genetics, 2022-10-13;0(0):.  2022-10-13
  18. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation
    Authors: P Marona, J Górka, O Kwapisz, J Jura, J Rys, RM Hoffman, K Miekus
    Cell Death & Disease, 2022-09-22;13(9):814.  2022-09-22
  19. Targeting Microtubule-Associated Protein Tau in Chemotherapy-Resistant Models of High-Grade Serous Ovarian Carcinoma
    Authors: MV Barbolina
    Cancers, 2022-09-19;14(18):.  2022-09-19
  20. Post-translational dysregulation of glucose uptake during exhaustive cycling exercise in vastus lateralis muscle of healthy homozygous carriers of the ACE deletion allele
    Authors: M Flück, D Vaughan, J Rittweger, MN Giraud
    Frontiers in Physiology, 2022-09-06;13(0):933792.  2022-09-06
  21. An in vivo model of glioblastoma radiation resistance identifies long non-coding RNAs and targetable kinases
    Authors: CT Stackhouse, JC Anderson, Z Yue, T Nguyen, NJ Eustace, CP Langford, J Wang, JR Rowland Iv, C Xing, FM Mikhail, X Cui, H Alrefai, RE Bash, KJ Lee, ES Yang, AB Hjelmeland, CR Miller, JY Chen, GY Gillespie, CD Willey
    JCI Insight, 2022-08-22;0(0):.  2022-08-22
  22. Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice
    Authors: W Jiang, C Ma, J Bai, X Du
    Redox Biology, 2022-08-13;56(0):102432.  2022-08-13
  23. PTEN inhibits AMPK to control collective migration
    Authors: F Peglion, L Capuana, I Perfettini, L Boucontet, B Braithwait, E Colucci-Gu, E Quissac, K Forsberg-N, F Llense, S Etienne-Ma
    Nature Communications, 2022-08-11;13(1):4528.  2022-08-11
  24. p38 MAPK-dependent phosphorylation of transcription factor SOX2 promotes an adaptive response to BRAF inhibitors in melanoma cells
    Authors: S Pietrobono, R De Paolo, D Mangiameli, A Marranci, I Battisti, C Franchin, G Arrigoni, D Melisi, L Poliseno, B Stecca
    The Journal of Biological Chemistry, 2022-08-07;298(9):102353.  2022-08-07
  25. Angiotensin II Exaggerates SARS-CoV-2 Specific T-Cell Response in Convalescent Individuals following COVID-19
    Authors: M Almutlaq, FA Mansour, J Alghamdi, Y Alhendi, AA Alamro, AA Alghamdi, HS Alamri, F Alroqi, T Barhoumi
    International Journal of Molecular Sciences, 2022-08-04;23(15):.  2022-08-04
  26. Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion
    Authors: A Jouida, M O'Callagha, C Mc Carthy, A Fabre, P Nadarajan, MP Keane
    Cancers, 2022-08-03;14(15):.  2022-08-03
  27. Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma
    Authors: C Xu, L Yan, X Guan, Z Wang, J Wu, A Lv, D Liu, F Liu, B Dong, M Zhao, L Jia, X Tian, C Hao
    International journal of biological sciences, 2022-08-01;18(13):5038-5055.  2022-08-01
  28. The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells
    Authors: D Ávila-Gonz, W Portillo, CP Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz
    Elife, 2022-07-11;11(0):.  2022-07-11
  29. Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells
    Authors: C He, C Wang, H Liu, B Shan
    BMC Cancer, 2022-07-02;22(1):724.  2022-07-02
  30. Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer
    Authors: K Kamat, V Krishnan, O Dorigo
    British Journal of Cancer, 2022-06-24;0(0):.  2022-06-24
  31. Peroxiredoxin IV plays a critical role in cancer cell growth and radioresistance through the activation of the Akt/GSK3 signaling pathways
    Authors: N Ding, H Jiang, P Thapa, Y Hao, A Alshahrani, D Allison, T Izumi, VM Rangnekar, X Liu, Q Wei
    The Journal of Biological Chemistry, 2022-06-10;0(0):102123.  2022-06-10
  32. GSK3beta palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis
    Authors: C Zhao, H Yu, X Fan, W Niu, J Fan, S Sun, M Gong, B Zhao, Z Fang, X Chen
    Oncogenesis, 2022-05-23;11(1):28.  2022-05-23
  33. m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer
    Authors: JX Lin, NZ Lian, YX Gao, QL Zheng, YH Yang, YB Ma, ZS Xiu, QZ Qiu, HG Wang, CH Zheng, P Li, JW Xie, J Lu, QY Chen, LL Cao, M Lin, JB Wang, CM Huang
    Cell Death & Disease, 2022-05-14;13(5):463.  2022-05-14
  34. Idelalisib activates AKT via increased recruitment of PI3Kdelta/PI3Kbeta to BCR signalosome while reducing PDK1 in post-therapy CLL cells
    Authors: MK Mamidi, H Mahmud, GP Maiti, MT Mendez, SM Fernandes, SK Vesely, J Holter-Cha, JR Brown, AK Ghosh
    Leukemia, 2022-05-14;0(0):.  2022-05-14
  35. Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer
    Authors: M Kakarla, S ChallaSiva, MF Dufficy, V Gil, Y Filipovich, R Vickman, SE Crawford, SW Hayward, OE Franco
    Cancers, 2022-05-09;14(9):.  2022-05-09
  36. Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells
    Authors: C Alonso-Gon, C González-A, J Menéndez-M, A González-G, V Álvarez-Ga, A González-C, C Martínez-C, S Cos
    Biomedicines, 2022-05-07;10(5):.  2022-05-07
  37. Non-canonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia
    Authors: T Braun, J Stachelsch, N Bley, S Oberbeck, M Otte, TA Müller, L Wahnschaff, M Gla beta, K Ommer, M Franitza, B Gathof, J Altmüller, M Hallek, D Auguin, S Hüttelmaie, A Schrader, M Herling
    Cancer Research, 2022-05-03;0(0):.  2022-05-03
  38. ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer
    Authors: EJ Lim, JH Kang, YJ Kim, S Kim, SJ Lee
    Cell Death & Disease, 2022-04-29;13(4):417.  2022-04-29
  39. The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway
    Authors: S Bini, V Pecce, A Di Costanz, L Polito, A Ghadiri, I Minicocci, F Tambaro, S Covino, M Arca, L D'Erasmo
    Biomolecules, 2022-04-16;12(4):.  2022-04-16
  40. Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
    Authors: Y Huang, E Motta, C Nanvuma, LD Kuhrt, Y Yuan, P Xia, M Lubas, S Zhu, M Schnauss, N Qazi, F Hu, H Zhang, T Lei, M Synowitz, C Flüh, H Kettenmann
    Cell Reports, 2022-04-12;39(2):110670.  2022-04-12
  41. Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion
    Authors: C Gaiteiro, J Soares, M Relvas-San, A Peixoto, D Ferreira, P Paulo, A Brandão, E Fernandes, R Azevedo, C Palmeira, R Freitas, A Miranda, H Osório, J Prieto, L Lima, AMN Silva, LL Santos, JA Ferreira
    Theranostics, 2022-03-28;12(7):3150-3177.  2022-03-28
  42. SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway
    Authors: Z Liu, Q Wang, G Zhai, S Ke, X Yu, J Guo
    Cancer Cell International, 2022-03-19;22(1):127.  2022-03-19
  43. ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers
    Authors: J Mooz, K Riegel, H Ps, A Sadanandam, F Marini, M Klein, U Werner, W Roth, A Wilken-Sch, I Tegeder, K Rajalingam
    Science Advances, 2022-03-18;8(11):eabk1538.  2022-03-18
  44. DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6
    Authors: X Zhang, Y Hu, Y Pan, Y Xiong, Y Zhang, M Han, K Dong, J Song, H Liang, Z Ding, X Zhang, H Zhu, Q Liu, X Lu, Y Feng, X Chen, Z Zhang, B Zhang
    Oncogene, 2022-02-09;0(0):.  2022-02-09
  45. DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3
    Authors: CM Borza, G Bolas, F Bock, X Zhang, FC Akabogu, MZ Zhang, M de Caestec, M Yang, HC Yang, E Lee, L Gewin, AB Fogo, WH McDonald, R Zent, A Pozzi
    JCI Insight, 2022-02-08;0(0):.  2022-02-08
  46. Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability
    Authors: RS Smith, I Odintsov, Z Liu, AJ Lui, T Hayashi, M Vojnic, Y Suehara, L Delasos, MS Mattar, J Hmeljak, HA Ramirez, M Shaw, G Bui, AB Hartono, E Gladstone, S Kunte, H Magnan, I Khodos, E De Stanchi, MP La Quaglia, J Yao, M Laé, SB Lee, L Spraggon, CA Pratilas, M Ladanyi, R Somwar
    Disease Models & Mechanisms, 2022-01-27;0(0):.  2022-01-27
  47. Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma
    Authors: E Shimada, Y Matsumoto, M Nakagawa, Y Susuki, M Endo, N Setsu, T Fujiwara, K Iida, A Nabeshima, K Yahiro, A Kimura, T Hirose, M Kanahori, R Oyama, Y Oda, Y Nakashima
    British Journal of Cancer, 2022-01-11;0(0):.  2022-01-11
  48. Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants
    Authors: MT Khayat, AM Omar, F Ahmed, MI Khan, SM Ibrahim, YA Muhammad, AM Malebari, T Neamatalla, ME El-Araby
    Frontiers in Pharmacology, 2022-01-05;12(0):794325.  2022-01-05
  49. SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
    Authors: Y Cha, T Kim, J Jeon, Y Jang, PB Kim, C Lopes, P Leblanc, BM Cohen, KS Kim
    Cell Reports, 2021-12-28;37(13):110155.  2021-12-28
  50. Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma
    Authors: I Berestjuk, M Lecacheur, A Carminati, S Diazzi, C Rovera, V Prod'homme, M Ohanna, A Popovic, A Mallaviall, F Larbret, S Pisano, S Audebert, T Passeron, C Gaggioli, CA Girard, M Deckert, S Tartare-De
    Embo Molecular Medicine, 2021-12-27;0(0):e11814.  2021-12-27
  51. Therapeutic potential of the PI3K inhibitor LY294002 and PARP inhibitor Talazoparib combination in BRCA-deficient triple negative breast cancer cells
    Authors: G Guney Eski, M Ozturk
    Cellular Signalling, 2021-12-24;91(0):110229.  2021-12-24
  52. Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells
    Authors: K Marunaka, S Shu, M Kobayashi, M Goto, Y Katsuta, Y Yoshino, A Ikari
    International Journal of Molecular Sciences, 2021-12-22;23(1):.  2021-12-22
  53. GPR87 Promotes Metastasis through the AKT-eNOS-NO Axis in Lung Adenocarcinoma
    Authors: HM Ahn, EY Choi, YJ Kim
    Cancers, 2021-12-21;14(1):.  2021-12-21
  54. Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease
    Authors: Y Cheng, TR Hall, X Xu, I Yung, D Souza, J Zheng, F Schiele, M Hoffmann, ML Mbow, JP Garnett, J Li
    EBioMedicine, 2021-12-18;75(0):103758.  2021-12-18
  55. SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase
    Authors: Y Ounoughene, E Fourgous, Y Boublik, E Saland, N Guiraud, C Recher, S Urbach, P Fort, JE Sarry, D Fesquet, S Roche
    Cancers, 2021-12-17;13(24):.  2021-12-17
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Reviews for Proteome Profiler Human Phospho-Kinase Array Kit

Average Rating: 4.8 (Based on 23 Reviews)

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Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/16/2020

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 08/08/2019

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 06/26/2019

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 06/05/2019

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 06/02/2019

Prostae cancer cell lines were used and 200 ug lysate for each samples per membrane was applied.


Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/11/2019

2xce arrays purchased circa Jan 2018


Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/05/2019

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/05/2019

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/31/2019

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 11/29/2018

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 09/13/2018

Great tool for evaluating cell signaling changes. We used this kit with LS174T cells. Kit protocol was easy to follow, and after imaging the resulting spots were very clear and easy to analyze. Phosphorylation of one of the identified signaling proteins was verified using an independent western blot. I would recommend this product


Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 07/18/2018

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/18/2018

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/05/2018

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/22/2018

Proteome Profiler Human Phospho-Kinase Array Kit
By Adam Guess on 10/20/2017

Proteome Profiler Human Phospho-Kinase Array Kit
By Stephanie Wareham on 02/13/2017

Great kit and ok value for money considering the amount of data you get!


Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 02/12/2017

Used with human samples. Image shown was at 1 minute. Other 'dots' appeared at increased exposure. Kit very good overall. Good quality result and easy to use


Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/03/2017

This array is an excellent tool for screening potential phospho-kinases and related targets. However, it would be nice that if the total level of non-phosphorylated proteins be visualized at the same time on the membrane. In this case, the phosphorylated signals can be normalized.


Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/28/2016

Antibodies could not be sourced to validate some of the targets.


Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/14/2016

Proteome Profiler Human Phospho-Kinase Array Kit
By Rachael Hardison on 08/09/2016

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/26/2015
Sample Tested: Cell Lysates

This was control and didnt show any non specific bindings.
Specificity: Specific
Sensitivity: Sensitive
Buffer: BSA
Dilution: 1:1000