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Proteome Profiler Human Phospho-Kinase Array Kit

ARY003B 228 Citations 22 Reviews Datasheet / COA / SDS
Newer Version Available: ARY003C

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ARY003B has been discontinued and is replaced by ARY003C.

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Citations (228)
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Reviews (22)
Summary Product Datasheets Background

Proteome Profiler Human Phospho-Kinase Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of human protein kinase phosphorylation. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 43 human kinases and total amounts of 2 related proteins simultaneously
  • Requires no specialized equipment
Human Phospho-Kinase Array Kit data example
View Data Examples
 

 

Principle of the Assay

The Proteome Profiler Human Phospho-Kinase Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Phosphorylation of captured proteins is detected with biotinylated phospho-specific detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple kinases in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 

 

Kit Contents

Each Human Phospho-Kinase Antibody Array Kit contains most of the necessary components for a ready-to-run assay without the need for specialized equipment.

  • 8 Array Membranes (4 of membrane A and 4 of membrane B)
  • 8-Well Multi-dish
  • Lysis Buffer
  • Array Buffers
  • Wash Buffer
  • Detection Antibody Cocktail A
  • Detection Antibody Cocktail B
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed product datasheet with protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2°C to 8°C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these proteins in a single sample.
Akt 1/2/3 (S473) Hck (Y411) PLC gamma-1 (Y783)
Akt 1/2/3 (T308) HSP27 (S78/S82) PRAS40 (T246)
AMPK alpha1 (T183) HSP60 Pyk2 (Y402)
AMPK alpha2 (T172) JNK 1/2/3 (T183/Y185, T221/Y223) RSK1/2/3 (S380)
beta-Catenin Lck (Y394) Src (Y419)
Chk-2 (T68) Lyn (Y397) STAT2 (Y689)
c-Jun (S63) MSK1/2 (S376/S360) STAT3 (S727)
CREB (S133) p27 (T198) STAT3 (Y705)
EGF R (Y1086) p38 alpha (T180/Y182) STAT5a (Y699)
eNOS (S1177) p53 (S15) STAT5a/b (Y699)
ERK1/2 (T202/Y204, T185/Y187) p53 (S392) STAT5b (Y699)
FAK (Y397) p53 (S46) STAT6 (Y641)
Fgr (Y412) P70 S6 Kinase (T389) TOR (S2448)
Fyn (Y420) p70 S6 Kinase (T421/S424) WNK-1 (T60)
GSK-3 alpha/beta (S21/S9) PDGF R beta (Y751) Yes (Y426)

 

Assays for analytes represented in the Human Phospho-Kinase Array Kit

 

Analyte DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA
Development Systems (Phospho)		 Quantikine®
ELISA Kits
Akt (S473)   DYC887B  
Akt (T308)      
AMPK alpha1 (T183) DYC3197 DYC3528  
AMPK alpha2 (T172)      
beta-Catenin DYC1329   DYC1329
Chk2 (T68)   DYC1626  
c-Jun (S63)      
CREB (S133)   DYC2510  
EGF R (Y1086) DYC1854   DEGFR0
eNOS (S1177)      
ERK1/2 (T202/Y204, T185/Y187)   DYC1018B  
FAK (Y397) DYC4467    
Fgr (Y412)      
Fyn (Y420)      
GSK-3 alpha/beta (S21/S9) DYC2157 DYC2630  
Hck (Y411)      
HSP27 (S78/S82) DYC1580 DYC2314  
HSP60 DYC1800    
JNK pan (T183/Y185, T221/Y223) DYC1205 DYC1387  
Lck (Y394)      
Lyn (Y397)   DYC3936  
MSK1/2 (S376/S360)      
p27 (T198) DYC2256    
p38 alpha (T180/Y182) DYC8691B DYC869B  
p53 (S15) DYC1043 DYC1839  
p53 (S46) DYC1043 DYC1489  
p53 (S392) DYC1043 DYC2996  
p70 S6 Kinase (T389)   DYC896  
p70 S6 Kinase (T421/S424) DYC8962 DYC8965  
PDGF R beta (Y751) DYC385 DYC3096  
PLC gamma-1 (Y783)      
PRAS40 (T246)   DYC6890  
PYK2 (Y402)      
RSK1/2/3 (S380/S386/S377)   DYC889B  
Src (Y419)   DYC2685  
STAT2 (Y689)      
STAT3 (S727)      
STAT3 (Y705)   DYC4607B  
STAT5a (Y694)      
STAT5a/b (Y694/Y699)      
STAT5b (Y699)      
STAT6 (Y641)      
TOR (S2448)   DYC1665  
WNK-1(T60)   DYC4720  
Yes (Y426)   DYC3929  

 

Data Examples
Figure 1.
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Figure 1. MCF-7 human breast cancer cells were either left untreated or exposed to 50 J/m2 of UV light followed by a 4 hour recovery before lysis.
Figure 2.
View Larger Image

Figure 2. A431 human epithelial carcinoma cells were either left untreated or treated with 200 ng/mL recombinant human (rh) EGF (Catalog # 236-EG) for 5 minutes.
Figure 3.
View Larger Image

Figure 3. MCF-7 human breast cancer cells were either left untreated or treated with 100 ng/mL of rhIGF-I (Catalog # 291-G1) for 1 hour.

Protein kinases are the largest class of enzymes in the human genome. These enzymes regulate almost all cellular processes by adding phosphate groups to proteins, thereby modifying the activity, localization, and overall function of their targets. Consequently, abnormal activity of kinases underlies many diseases including cancer.

Specifications

Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

Product Datasheets

Product Datasheet
COA
SDS

Reagents Provided

Other Reagents Provided

Citations for Proteome Profiler Human Phospho-Kinase Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

228 Citations: Showing 1 - 10
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  1. Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice
    Authors: SA Scarneo, LS Eibschutz, PJ Bendele, KW Yang, J Totzke, P Hughes, DA Fox, TAJ Haystead
    Arthritis Res. Ther., 2019;21(1):292.  2019
  2. Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells
    Authors: DA Ferraro, F Patella, S Zanivan, C Donato, N Aceto, M Giannotta, E Dejana, M Diepenbruc, G Christofor, M Buess
    BMC Cancer, 2019;19(1):312.  2019
  3. Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin
    Authors: C Zalfa, P Azmoon, E Mantuano, SL Gonias
    J. Leukoc. Biol., 2019;0(0):.  2019
  4. IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states
    Authors: G Pellizzari, C Hoskin, S Crescioli, S Mele, J Gotovina, G Chiaruttin, R Bianchini, K Ilieva, HJ Bax, S Papa, KE Lacy, E Jensen-Jar, S Tsoka, DH Josephs, JF Spicer, SN Karagianni
    EBioMedicine, 2019;0(0):.  2019
  5. Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma
    Authors: R Kumar, CN Njauw, BY Reddy, Z Ji, A Rajadurai, N Klebanov, H Tsao
    Oncogene, 2019;0(0):.  2019
  6. Survival/adaptation of Bone Marrow derived Mesenchymal Stem Cells after long term starvation through selective processes
    Authors: F Ferro, R Spelat, G Shaw, N Duffy, MN Islam, PM O'Shea, D O'Toole, L Howard, M Murphy
    Stem Cells, 2019;0(0):.  2019
  7. EPHA2 is a predictive biomarker of resistance and a potential therapeutic target for improving anti-epidermal growth factor receptor therapy in colorectal cancer
    Authors: G Martini, C Cardone, PP Vitiello, V Belli, S Napolitano, T Troiani, D Ciardiello, CM Della Cort, F Morgillo, N Matrone, V Sforza, G Papaccio, V Desiderio, MC Paul, V Moreno-Vie, N Normanno, AM Rachiglio, V Tirino, E Maiello, TP Latiano, D Rizzi, G Signoriell, M Sibilia, F Ciardiello, E Martinelli
    Mol. Cancer Ther., 2019;0(0):.  2019
  8. Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis
    Authors: D Neelakanta, S Dogra, BR Devapatla, P Jaiprasart, MC Mukashyaka, R Janknecht, SKD Dwivedi, R Bhattachar, S Husain, K Ding, S Woo
    Mol. Cancer Res., 2019;0(0):.  2019
  9. E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms
    Authors: MK Jolly, KE Ware, S Xu, S Gilja, S Shetler, Y Yang, X Wang, RG Austin, D Runyambo, AJ Hish, S Bartholf D, JT George, RT Kreulen, MK Boss, AL Lazarides, DL Kerr, DG Gerber, D Sivaraj, AJ Armstrong, MW Dewhirst, WC Eward, H Levine, JA Somarelli
    Mol. Cancer Res., 2019;0(0):.  2019
  10. Signal regulatory protein ? protects podocytes through promoting autophagic activity
    Authors: L Li, Y Liu, S Li, Y Yang, C Zeng, W Rong, H Liang, M Zhang, X Zhu, K Kidder, Y Liu, Z Liu, K Zen
    JCI Insight, 2019;5(0):.  2019
  11. A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer
    Authors: J Chen, J Bell, BT Lau, T Whittaker, D Stapleton, HP Ji
    Oncogenesis, 2019;8(5):33.  2019
  12. PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway
    Authors: Y Bai, X Liu, X Qi, X Liu, F Peng, H Li, H Fu, S Pei, L Chen, X Chi, L Zhang, X Zhu, Y Song, Y Wang, S Meng, T Jiang, S Shao
    EBioMedicine, 2019;0(0):.  2019
  13. Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway
    Authors: T van Montfo, R van der Sl, G Darcis, D Beaty, K Groen, AO Pasternak, G Pollakis, M Vink, EM Westerhout, M Hamdi, M Bakker, B van der Pu, S Jurriaans, JH Prins, R Jeeninga, AAM Thomas, D Speijer, B Berkhout
    EBioMedicine, 2019;0(0):.  2019
  14. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer
    Authors: SP Kennedy, JZR Han, N Portman, M Nobis, JF Hastings, KJ Murphy, SL Latham, AL Cadell, D Miladinovi, GR Marriott, YEI O'Donnell, RF Shearer, JT Williams, AG Munoz, TR Cox, DN Watkins, DN Saunders, P Timpson, E Lim, W Kolch, DR Croucher
    Breast Cancer Res., 2019;21(1):43.  2019
  15. Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program
    Authors: JH Noh, KM Kim, PR Pandey, NN Hooten, R Munk, G Kundu, S De, JL Martindale, X Yang, MK Evans, K Abdelmohse, M Gorospe
    Nucleic Acids Res., 2019;0(0):.  2019
  16. AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
    Authors: H Taniguchi, T Yamada, R Wang, K Tanimura, Y Adachi, A Nishiyama, A Tanimoto, S Takeuchi, LH Araujo, M Boroni, A Yoshimura, S Shiotsu, I Matsumoto, S Watanabe, T Kikuchi, S Miura, H Tanaka, T Kitazaki, H Yamaguchi, H Mukae, J Uchino, H Uehara, K Takayama, S Yano
    Nat Commun, 2019;10(1):259.  2019
  17. Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus
    Authors: ME Nickol, J Ciric, SD Falcinelli, DS Chertow, J Kindrachuk
    Viruses, 2019;11(2):.  2019
  18. CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
    Authors: S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis
    JCI Insight, 2019;0(0):.  2019
  19. Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds
    Authors: IA Schepetkin, LN Kirpotina, AI Khlebnikov, N Balasubram, MT Quinn
    Molecules, 2019;24(9):.  2019
  20. Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib
    Authors: YC Ko, CY Hu, ZH Liu, HF Tien, DL Ou, HF Chien, LI Lin
    Int J Mol Sci, 2019;20(5):.  2019
  21. Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia-reperfusion injury
    Authors: L Hummitzsch, K Zitta, R Berndt, YL Wong, R Rusch, K Hess, T Wedel, M Gruenewald, J Cremer, M Steinfath, M Albrecht
    J Transl Med, 2019;17(1):136.  2019
  22. Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach
    Authors: Z Xiao, B Sperl, S Gärtner, T Nedelko, E Stacher-Pr, A Ullrich, PG Knyazev
    Oncotarget, 2019;10(26):2546-2560.  2019
  23. CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation
    Authors: NL Cook, M Pjanic, AG Emmerich, AS Rao, S Hetty, JW Knowles, T Quertermou, C Castillejo, E Ingelsson
    BMC Endocr Disord, 2019;19(1):115.  2019
  24. CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma
    Authors: R Xu, Y Li, H Yan, E Zhang, X Huang, Q Chen, J Chen, J Qu, Y Liu, J He, Q Yi, Z Cai
    Cell Death Dis, 2019;10(10):781.  2019
  25. Interleukin-6 mediates resistance to PI3K-pathway-targeted therapy in lymphoma
    Authors: JH Kim, WS Kim, C Park
    BMC Cancer, 2019;19(1):936.  2019
  26. Tyrosine kinase inhibition to improve anthracycline-based chemotherapy efficacy in T-cell lymphoma
    Authors: M Magni, G Biancon, S Rizzitano, A Cavanè, C Paolizzi, M Dugo, P Corradini, C Carniti
    Br. J. Cancer, 2019;0(0):.  2019
  27. Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma
    Authors: J Wurm, SP Behringer, VM Ravi, K Joseph, N Neidert, JP Maier, R Doria-Medi, M Follo, D Delev, D Pfeifer, J Beck, R Sankowski, O Schnell, DH Heiland
    Cancers (Basel), 2019;11(10):.  2019
  28. UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling
    Authors: JX Lin, XS Xie, XF Weng, SL Qiu, C Yoon, NZ Lian, JW Xie, JB Wang, J Lu, QY Chen, LL Cao, M Lin, RH Tu, YH Yang, CM Huang, CH Zheng, P Li
    J. Exp. Clin. Cancer Res., 2019;38(1):410.  2019
  29. Kinome expression profiling to target new therapeutic avenues in multiple myeloma
    Authors: H de Boussac, A Bruyer, M Jourdan, A Maes, N Robert, C Gourzones, L Vincent, A Seckinger, G Cartron, D Hose, E De Bruyne, A Kassambara, P Pasero, J Moreaux
    Haematologica, 2019;0(0):.  2019
  30. Multilevel defects in the hematopoietic niche in essential thrombocythemia
    Authors: T Sun, M Ju, X Dai, H Dong, W Gu, Y Gao, R Fu, X Liu, Y Huang, W Liu, Y Chi, W Wang, H Li, Y Zhou, L Shi, R Yang, L Zhang
    Haematologica, 2019;0(0):.  2019
  31. MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma
    Authors: Y Zhao, W Huang, TM Kim, Y Jung, LG Menon, H Xing, H Li, RS Carroll, PJ Park, HW Yang, MD Johnson
    J. Exp. Clin. Cancer Res., 2019;38(1):36.  2019
  32. Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer
    Authors: MJ Jo, S Jeong, HK Yun, DY Kim, BR Kim, JL Kim, YJ Na, SH Park, YA Jeong, BG Kim, H Ashktorab, DT Smoot, JY Heo, J Han, DH Lee, SC Oh
    BMC Cancer, 2019;19(1):739.  2019
  33. Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin
    Authors: J Menéndez-M, F Hermida-Pr, R Granda-Día, A González, JM García-Ped, N Del-Río-Ib, A González-G, S Cos, C Alonso-Gon, C Martínez-C
    Cancers (Basel), 2019;11(7):.  2019
  34. The small GTPase ARF6 activates PI3K in melanoma to induce a pro-metastatic state
    Authors: JH Yoo, SW Brady, L Acosta-Alv, A Rogers, J Peng, LK Sorensen, RK Wolff, T Mleynek, D Shin, CP Rich, DA Kircher, A Bild, SJ Odelberg, DY Li, SL Holmen, AH Grossmann
    Cancer Res., 2019;0(0):.  2019
  35. WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4
    Authors: K Taniuchi, M Furihata, S Naganuma, T Saibara
    Cancer Med, 2018;0(0):.  2018
  36. IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells
    Authors: M Shimizu, N Tanaka
    Oncogene, 2018;0(0):.  2018
  37. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
    Authors: Y Jiang, YY Jiang, JJ Xie, A Mayakonda, M Hazawa, L Chen, JF Xiao, CQ Li, ML Huang, LW Ding, QY Sun, L Xu, D Kanojia, M Jeitany, JW Deng, LD Liao, HJ Soukiasian, BP Berman, JJ Hao, LY Xu, EM Li, MR Wang, XG Bi, DC Lin, HP Koeffler
    Nat Commun, 2018;9(1):3619.  2018
  38. Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy
    Authors: JM Santiago-O, ES Kleinerman, MG Hollomon, A Livingston, WL Wang, JW Tsai, NB Gordon
    Oncotarget, 2018;9(2):1602-1616.  2018
  39. Olfactory receptor OR2AT4 regulates human hair growth
    Authors: J Chéret, M Bertolini, L Ponce, J Lehmann, T Tsai, M Alam, H Hatt, R Paus
    Nat Commun, 2018;9(1):3624.  2018
  40. Establishment of keratinocyte cell lines from human hair follicles
    Authors: T Wagner, M Gschwandtn, A Strajeriu, A Elbe-Bürge, J Grillari, R Grillari-V, G Greiner, B Golabi, E Tschachler, M Mildner
    Sci Rep, 2018;8(1):13434.  2018
  41. Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors
    Authors: F Pareja, AH Brandes, T Basili, P Selenica, FC Geyer, D Fan, A Da Cruz Pa, R Kumar, DN Brown, R Gularte-Mé, B Alemar, R Bi, RS Lim, I de Bruijn, S Fujisawa, R Gardner, E Feng, A Li, EM da Silva, JR Lozada, P Blecua, L Cohen-Goul, AA Jungbluth, EA Rakha, IO Ellis, MIA Edelweiss, J Palazzo, L Norton, T Hollmann, M Edelweiss, BP Rubin, B Weigelt, JS Reis-Filho
    Nat Commun, 2018;9(1):3533.  2018
  42. WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
    Authors: CS Gonçalves, J Vieira de, M Pojo, EP Martins, S Queirós, E Chautard, R Taipa, MM Pires, AA Pinto, F Pardal, C Custódia, CC Faria, C Clara, RM Reis, N Sousa, BM Costa
    Theranostics, 2018;8(17):4805-4823.  2018
  43. CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1? axis to inhibit gastric tumorigenesis
    Authors: W Li, CC Wong, X Zhang, W Kang, G Nakatsu, Q Zhao, H Chen, MYY Go, PWY Chiu, X Wang, J Ji, X Li, Z Cai, EKW Ng, J Yu
    Oncogene, 2018;0(0):.  2018
  44. Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT
    Authors: Y Zhang, G Ji, S Han, Z Shao, Z Lu, L Huo, J Zhang, R Yang, Q Feng, H Shen, H Wang, X Li
    Cell. Physiol. Biochem., 2018;50(2):612-628.  2018
  45. Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines
    Authors: MY Gökyildiri, U Grandel, K Hattar, G Dahlem, E Schuetz, FH Leinberger, F Eberle, U Sibelius, F Grimminger, W Seeger, R Engenhart-, E Dikomey, FSB Subtil
    Oncotarget, 2018;9(48):28976-28988.  2018
  46. Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds
    Authors: V Vishwakarm, J New, D Kumar, V Snyder, L Arnold, E Nissen, Q Hu, N Cheng, D Miller, AR Thomas, Y Shnayder, K Kakarala, TT Tsue, DA Girod, SM Thomas
    Sci Rep, 2018;8(1):12163.  2018
  47. Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17
    Authors: P Urriola-Mu, R Lagos-Cabr, D Patiño-Gar, JG Reyes, RD Moreno
    Int J Mol Sci, 2018;19(8):.  2018
  48. ?-arrestin 1 regulates ?2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
    Authors: J Kim, CA Grotegut, JW Wisler, T Li, L Mao, M Chen, W Chen, PB Rosenberg, HA Rockman, RJ Lefkowitz
    Skelet Muscle, 2018;8(1):39.  2018
  49. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
    Authors: PD Fan, G Narzisi, AD Jayaprakas, E Venturini, N Robine, P Smibert, S Germer, HA Yu, EJ Jordan, PK Paik, YY Janjigian, JE Chaft, L Wang, AA Jungbluth, S Middha, L Spraggon, H Qiao, CM Lovly, MG Kris, GJ Riely, K Politi, H Varmus, M Ladanyi
    Proc. Natl. Acad. Sci. U.S.A., 2018;115(26):E6030-E6038.  2018
  50. Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo
    Authors: C Li, V Rezov, E Joensuu, V Vartiainen, M Rönty, M Yin, M Myllärniem, K Koli
    Sci Rep, 2018;8(1):10070.  2018
  51. Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway
    Authors: Z Fang, KH Jung, HH Yan, SJ Kim, M Rumman, JH Park, B Han, JE Lee, YW Kang, JH Lim, SS Hong
    Cell. Physiol. Biochem., 2018;47(5):1751-1768.  2018
  52. Suppression of the ERK-SRF axis facilitates somatic cell reprogramming
    Authors: S Huh, HR Song, GR Jeong, H Jang, NH Seo, JH Lee, JY Yi, B Lee, HW Choi, JT Do, JS Kim, SH Lee, JW Jung, T Lee, J Shim, MK Han, TH Lee
    Exp. Mol. Med., 2018;50(2):e448.  2018
  53. HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis
    Authors: C Hernandez, P Huebener, JP Pradere, DJ Antoine, RA Friedman, RF Schwabe
    J. Clin. Invest., 2018;0(0):.  2018
  54. JDP2 overexpression provokes cardiac dysfunction in mice
    Authors: J Heger, J Bornbaum, A Würfel, C Hill, N Brockmann, R Gáspár, J Pálóczi, ZV Varga, M Sárközy, P Bencsik, T Csont, S Török, B Kojonazaro, RT Schermuly, K Böngler, M Parahuleva, P Ferdinandy, R Schulz, G Euler
    Sci Rep, 2018;8(1):7647.  2018
  55. WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling
    Authors: W Chen, LN Zebaze, J Dong, L Chézeau, P Inquimbert, S Hugel, S Niu, F Bihel, E Boutant, E Réal, P Villa, MP Junier, H Chneiweiss, M Hibert, J Haiech, MC Kilhoffer, M Zeniou
    Oncotarget, 2018;9(43):27197-27219.  2018
  56. miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer
    Authors: U Baumgartne, F Berger, A Hashemi Gh, SS Burgener, K Monastyrsk, E Vassella
    Mol. Cancer, 2018;17(1):44.  2018
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Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 08/08/2019
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 06/26/2019
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 06/05/2019
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 06/02/2019

Prostae cancer cell lines were used and 200 ug lysate for each samples per membrane was applied.

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/11/2019

2xce arrays purchased circa Jan 2018

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/05/2019
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/05/2019
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/31/2019
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 11/29/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 09/13/2018

Great tool for evaluating cell signaling changes. We used this kit with LS174T cells. Kit protocol was easy to follow, and after imaging the resulting spots were very clear and easy to analyze. Phosphorylation of one of the identified signaling proteins was verified using an independent western blot. I would recommend this product

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 07/18/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/18/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/05/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/22/2018
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/20/2017
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 02/13/2017

Great kit and ok value for money considering the amount of data you get!

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 02/12/2017

Used with human samples. Image shown was at 1 minute. Other 'dots' appeared at increased exposure. Kit very good overall. Good quality result and easy to use

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/03/2017

This array is an excellent tool for screening potential phospho-kinases and related targets. However, it would be nice that if the total level of non-phosphorylated proteins be visualized at the same time on the membrane. In this case, the phosphorylated signals can be normalized.

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/28/2016

Antibodies could not be sourced to validate some of the targets.

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/14/2016
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 08/09/2016
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/26/2015
Sample Tested: Cell Lysates

This was control and didnt show any non specific bindings.
Specificity: Specific
Sensitivity: Sensitive
Buffer: BSA
Dilution: 1:1000

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B