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Proteome Profiler Human Phospho-Kinase Array Kit

ARY003B 193 Citations 17 Reviews Datasheet / COA / SDS
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 43 different kinases and 2 related total proteins
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ARY003B
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Citations (193)
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Reviews (17)
Summary Background Product Datasheets Related Research Areas

Proteome Profiler Human Phospho-Kinase Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of human protein kinase phosphorylation. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 43 human kinases and total amounts of 2 related proteins simultaneously
  • Requires no specialized equipment
Human Phospho-Kinase Array Kit data example
View Data Examples
 

 

Principle of the Assay

The Proteome Profiler Human Phospho-Kinase Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Phosphorylation of captured proteins is detected with biotinylated phospho-specific detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple kinases in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 

 

Kit Contents

Each Human Phospho-Kinase Antibody Array Kit contains most of the necessary components for a ready-to-run assay without the need for specialized equipment.

  • 8 Array Membranes (4 of membrane A and 4 of membrane B)
  • 8-Well Multi-dish
  • Lysis Buffer
  • Array Buffers
  • Wash Buffer
  • Detection Antibody Cocktail A
  • Detection Antibody Cocktail B
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed product datasheet with protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2°C to 8°C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these proteins in a single sample.
Akt 1/2/3 (S473) Hck (Y411) PLC gamma-1 (Y783)
Akt 1/2/3 (T308) HSP27 (S78/S82) PRAS40 (T246)
AMPK alpha1 (T183) HSP60 Pyk2 (Y402)
AMPK alpha2 (T172) JNK 1/2/3 (T183/Y185, T221/Y223) RSK1/2/3 (S380)
beta-Catenin Lck (Y394) Src (Y419)
Chk-2 (T68) Lyn (Y397) STAT2 (Y689)
c-Jun (S63) MSK1/2 (S376/S360) STAT3 (S727)
CREB (S133) p27 (T198) STAT3 (Y705)
EGF R (Y1086) p38 alpha (T180/Y182) STAT5a (Y699)
eNOS (S1177) p53 (S15) STAT5a/b (Y699)
ERK1/2 (T202/Y204, T185/Y187) p53 (S392) STAT5b (Y699)
FAK (Y397) p53 (S46) STAT6 (Y641)
Fgr (Y412) P70 S6 Kinase (T389) TOR (S2448)
Fyn (Y420) p70 S6 Kinase (T421/S424) WNK-1 (T60)
GSK-3 alpha/beta (S21/S9) PDGF R beta (Y751) Yes (Y426)

 

Assays for analytes represented in the Human Phospho-Kinase Array Kit

 

Analyte DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA
Development Systems (Phospho)		 Quantikine®
ELISA Kits
Akt (S473)   DYC887B  
Akt (T308)      
AMPK alpha1 (T183) DYC3197 DYC3528  
AMPK alpha2 (T172)      
beta-Catenin DYC1329   DYC1329
Chk2 (T68)   DYC1626  
c-Jun (S63)      
CREB (S133)   DYC2510  
EGF R (Y1086) DYC1854   DEGFR0
eNOS (S1177)      
ERK1/2 (T202/Y204, T185/Y187)   DYC1018B  
FAK (Y397) DYC4467    
Fgr (Y412)      
Fyn (Y420)      
GSK-3 alpha/beta (S21/S9) DYC2157 DYC2630  
Hck (Y411)      
HSP27 (S78/S82) DYC1580 DYC2314  
HSP60 DYC1800    
JNK pan (T183/Y185, T221/Y223) DYC1205 DYC1387  
Lck (Y394)      
Lyn (Y397)   DYC3936  
MSK1/2 (S376/S360)      
p27 (T198) DYC2256    
p38 alpha (T180/Y182) DYC8691B DYC869B  
p53 (S15) DYC1043 DYC1839  
p53 (S46) DYC1043 DYC1489  
p53 (S392) DYC1043 DYC2996  
p70 S6 Kinase (T389)   DYC896  
p70 S6 Kinase (T421/S424) DYC8962 DYC8965  
PDGF R beta (Y751) DYC385 DYC3096  
PLC gamma-1 (Y783)      
PRAS40 (T246)   DYC6890  
PYK2 (Y402)      
RSK1/2/3 (S380/S386/S377)   DYC889B  
Src (Y419)   DYC2685  
STAT2 (Y689)      
STAT3 (S727)      
STAT3 (Y705)   DYC4607B  
STAT5a (Y694)      
STAT5a/b (Y694/Y699)      
STAT5b (Y699)      
STAT6 (Y641)      
TOR (S2448)   DYC1665  
WNK-1(T60)   DYC4720  
Yes (Y426)   DYC3929  

 

Data Examples
Figure 1.
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Figure 1. MCF-7 human breast cancer cells were either left untreated or exposed to 50 J/m2 of UV light followed by a 4 hour recovery before lysis.
Figure 2.
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Figure 2. A431 human epithelial carcinoma cells were either left untreated or treated with 200 ng/mL recombinant human (rh) EGF (Catalog # 236-EG) for 5 minutes.
Figure 3.
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Figure 3. MCF-7 human breast cancer cells were either left untreated or treated with 100 ng/mL of rhIGF-I (Catalog # 291-G1) for 1 hour.

Product Datasheets

Product Datasheet
COA
SDS

Preparation and Storage

Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Kinase Assay Kits

Protein kinases are the largest class of enzymes in the human genome. These enzymes regulate almost all cellular processes by adding phosphate groups to proteins, thereby modifying the activity, localization, and overall function of their targets. Consequently, abnormal activity of kinases underlies many diseases including cancer.

Alternate Names
Kinase Assay Kits

Citations for Proteome Profiler Human Phospho-Kinase Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

193 Citations: Showing 1 - 10
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  1. Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program
    Authors: JH Noh, KM Kim, PR Pandey, NN Hooten, R Munk, G Kundu, S De, JL Martindale, X Yang, MK Evans, K Abdelmohse, M Gorospe
    Nucleic Acids Res., 2019;0(0):.  2019
  2. Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus
    Authors: ME Nickol, J Ciric, SD Falcinelli, DS Chertow, J Kindrachuk
    Viruses, 2019;11(2):.  2019
  3. Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin
    Authors: C Zalfa, P Azmoon, E Mantuano, SL Gonias
    J. Leukoc. Biol., 2019;0(0):.  2019
  4. CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
    Authors: S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis
    JCI Insight, 2019;0(0):.  2019
  5. MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma
    Authors: Y Zhao, W Huang, TM Kim, Y Jung, LG Menon, H Xing, H Li, RS Carroll, PJ Park, HW Yang, MD Johnson
    J. Exp. Clin. Cancer Res., 2019;38(1):36.  2019
  6. AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
    Authors: H Taniguchi, T Yamada, R Wang, K Tanimura, Y Adachi, A Nishiyama, A Tanimoto, S Takeuchi, LH Araujo, M Boroni, A Yoshimura, S Shiotsu, I Matsumoto, S Watanabe, T Kikuchi, S Miura, H Tanaka, T Kitazaki, H Yamaguchi, H Mukae, J Uchino, H Uehara, K Takayama, S Yano
    Nat Commun, 2019;10(1):259.  2019
  7. The Noncoding RNA nc886 Regulates PKR Signaling and Cytokine Production in Human Cells
    Authors: E Golec, L Lind, M Qayyum, AM Blom, BC King
    J. Immunol., 2018;0(0):.  2018
  8. Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells
    Authors: G Tornillo, C Knowlson, H Kendrick, J Cooke, H Mirza, I Aurrekoetx, MDM Vivanco, NE Buckley, A Grigoriadi, MJ Smalley
    Cell Rep, 2018;25(13):3674-3692.e10.  2018
  9. Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo
    Authors: C Li, V Rezov, E Joensuu, V Vartiainen, M Rönty, M Yin, M Myllärniem, K Koli
    Sci Rep, 2018;8(1):10070.  2018
  10. Ruxolitinib in combination with prednisone and nilotinib exhibit synergistic effects in human cells lines and primary cells from myeloproliferative neoplasms
    Authors: A Arenas Cor, R Ayala Diaz, P Hernández-, J Gorrochate, D Primo, A Robles, ML Morales, J Ballestero, I Rapado, M Gallardo, M Linares, J Martínez-L
    Haematologica, 2018;0(0):.  2018
  11. Suppression of the ERK-SRF axis facilitates somatic cell reprogramming
    Authors: S Huh, HR Song, GR Jeong, H Jang, NH Seo, JH Lee, JY Yi, B Lee, HW Choi, JT Do, JS Kim, SH Lee, JW Jung, T Lee, J Shim, MK Han, TH Lee
    Exp. Mol. Med., 2018;50(2):e448.  2018
  12. YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
    Authors: PD Fan, G Narzisi, AD Jayaprakas, E Venturini, N Robine, P Smibert, S Germer, HA Yu, EJ Jordan, PK Paik, YY Janjigian, JE Chaft, L Wang, AA Jungbluth, S Middha, L Spraggon, H Qiao, CM Lovly, MG Kris, GJ Riely, K Politi, H Varmus, M Ladanyi
    Proc. Natl. Acad. Sci. U.S.A., 2018;115(26):E6030-E6038.  2018
  13. Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines
    Authors: MY Gökyildiri, U Grandel, K Hattar, G Dahlem, E Schuetz, FH Leinberger, F Eberle, U Sibelius, F Grimminger, W Seeger, R Engenhart-, E Dikomey, FSB Subtil
    Oncotarget, 2018;9(48):28976-28988.  2018
  14. Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17
    Authors: P Urriola-Mu, R Lagos-Cabr, D Patiño-Gar, JG Reyes, RD Moreno
    Int J Mol Sci, 2018;19(8):.  2018
  15. Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds
    Authors: V Vishwakarm, J New, D Kumar, V Snyder, L Arnold, E Nissen, Q Hu, N Cheng, D Miller, AR Thomas, Y Shnayder, K Kakarala, TT Tsue, DA Girod, SM Thomas
    Sci Rep, 2018;8(1):12163.  2018
  16. Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1
    Authors: TY Wong, WC Juang, CT Tsai, CJ Tseng, WH Lee, SN Chang, PW Cheng
    J Clin Med, 2018;7(11):.  2018
  17. Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
    Authors: X Gong, JR Smith, HM Swanson, LP Rubin
    Molecules, 2018;23(4):.  2018
  18. ?-arrestin 1 regulates ?2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
    Authors: J Kim, CA Grotegut, JW Wisler, T Li, L Mao, M Chen, W Chen, PB Rosenberg, HA Rockman, RJ Lefkowitz
    Skelet Muscle, 2018;8(1):39.  2018
  19. 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease
    Authors: C Klein, G Roussel, S Brun, C Rusu, C Patte-Mens, M Maitre, AG Mensah-Nya
    Acta Neuropathol Commun, 2018;6(1):136.  2018
  20. CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1? axis to inhibit gastric tumorigenesis
    Authors: W Li, CC Wong, X Zhang, W Kang, G Nakatsu, Q Zhao, H Chen, MYY Go, PWY Chiu, X Wang, J Ji, X Li, Z Cai, EKW Ng, J Yu
    Oncogene, 2018;0(0):.  2018
  21. Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway
    Authors: Z Fang, KH Jung, HH Yan, SJ Kim, M Rumman, JH Park, B Han, JE Lee, YW Kang, JH Lim, SS Hong
    Cell. Physiol. Biochem., 2018;47(5):1751-1768.  2018
  22. IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells
    Authors: M Shimizu, N Tanaka
    Oncogene, 2018;0(0):.  2018
  23. Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines
    Authors: S Heavey, P Dowling, G Moore, MP Barr, N Kelly, SG Maher, S Cuffe, SP Finn, KJ O'Byrne, K Gately
    Sci Rep, 2018;8(1):1652.  2018
  24. Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT
    Authors: Y Zhang, G Ji, S Han, Z Shao, Z Lu, L Huo, J Zhang, R Yang, Q Feng, H Shen, H Wang, X Li
    Cell. Physiol. Biochem., 2018;50(2):612-628.  2018
  25. YM155 decreases radiation-induced invasion and reverses epithelial-mesenchymal transition by targeting STAT3 in glioblastoma
    Authors: X Zhang, X Wang, R Xu, J Ji, Y Xu, M Han, Y Wei, B Huang, A Chen, Q Zhang, W Li, J Wang, X Li, C Qiu
    J Transl Med, 2018;16(1):79.  2018
  26. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
    Authors: Y Jiang, YY Jiang, JJ Xie, A Mayakonda, M Hazawa, L Chen, JF Xiao, CQ Li, ML Huang, LW Ding, QY Sun, L Xu, D Kanojia, M Jeitany, JW Deng, LD Liao, HJ Soukiasian, BP Berman, JJ Hao, LY Xu, EM Li, MR Wang, XG Bi, DC Lin, HP Koeffler
    Nat Commun, 2018;9(1):3619.  2018
  27. Establishment of keratinocyte cell lines from human hair follicles
    Authors: T Wagner, M Gschwandtn, A Strajeriu, A Elbe-Bürge, J Grillari, R Grillari-V, G Greiner, B Golabi, E Tschachler, M Mildner
    Sci Rep, 2018;8(1):13434.  2018
  28. WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4
    Authors: K Taniuchi, M Furihata, S Naganuma, T Saibara
    Cancer Med, 2018;0(0):.  2018
  29. Olfactory receptor OR2AT4 regulates human hair growth
    Authors: J Chéret, M Bertolini, L Ponce, J Lehmann, T Tsai, M Alam, H Hatt, R Paus
    Nat Commun, 2018;9(1):3624.  2018
  30. Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors
    Authors: F Pareja, AH Brandes, T Basili, P Selenica, FC Geyer, D Fan, A Da Cruz Pa, R Kumar, DN Brown, R Gularte-Mé, B Alemar, R Bi, RS Lim, I de Bruijn, S Fujisawa, R Gardner, E Feng, A Li, EM da Silva, JR Lozada, P Blecua, L Cohen-Goul, AA Jungbluth, EA Rakha, IO Ellis, MIA Edelweiss, J Palazzo, L Norton, T Hollmann, M Edelweiss, BP Rubin, B Weigelt, JS Reis-Filho
    Nat Commun, 2018;9(1):3533.  2018
  31. Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy
    Authors: JM Santiago-O, ES Kleinerman, MG Hollomon, A Livingston, WL Wang, JW Tsai, NB Gordon
    Oncotarget, 2018;9(2):1602-1616.  2018
  32. Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin
    Authors: E Narvi, K Vaparanta, A Karrila, D Chakrobort, S Knuutila, A Pulliainen, M Sundvall, K Elenius
    Sci Rep, 2018;8(1):16579.  2018
  33. WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
    Authors: CS Gonçalves, J Vieira de, M Pojo, EP Martins, S Queirós, E Chautard, R Taipa, MM Pires, AA Pinto, F Pardal, C Custódia, CC Faria, C Clara, RM Reis, N Sousa, BM Costa
    Theranostics, 2018;8(17):4805-4823.  2018
  34. JDP2 overexpression provokes cardiac dysfunction in mice
    Authors: J Heger, J Bornbaum, A Würfel, C Hill, N Brockmann, R Gáspár, J Pálóczi, ZV Varga, M Sárközy, P Bencsik, T Csont, S Török, B Kojonazaro, RT Schermuly, K Böngler, M Parahuleva, P Ferdinandy, R Schulz, G Euler
    Sci Rep, 2018;8(1):7647.  2018
  35. NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway
    Authors: L Deng, X Gao, B Liu, X He, J Xu, J Qiang, Q Wu, S Liu
    Cell Death Dis, 2018;9(12):1143.  2018
  36. Acquired resistance to AZD9291 as an upfront treatment is dependent on ERK signaling in a preclinical model
    Authors: BM Ku, MK Choi, JM Sun, SH Lee, JS Ahn, K Park, MJ Ahn
    PLoS ONE, 2018;13(4):e0194730.  2018
  37. BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling
    Authors: K Taniuchi, M Furihata, S Naganuma, K Dabanaka, K Hanazaki, T Saibara
    Am J Cancer Res, 2018;8(3):387-404.  2018
  38. Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer
    Authors: MH Kubala, V Punj, VR Placencio-, H Fang, GE Fernandez, R Sposto, YA DeClerck
    Cell Rep, 2018;25(8):2177-2191.e7.  2018
  39. Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
    Authors: TM Totiger, S Srinivasan, VR Jala, P Lamichhane, AR Dosch, AA Gaidarski, C Joshi, S Rangappa, J Castellano, PK Vemula, X Chen, D Kwon, N Kashikar, M VanSaun, NB Merchant, NS Nagathihal
    Mol. Cancer Ther., 2018;0(0):.  2018
  40. WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling
    Authors: W Chen, LN Zebaze, J Dong, L Chézeau, P Inquimbert, S Hugel, S Niu, F Bihel, E Boutant, E Réal, P Villa, MP Junier, H Chneiweiss, M Hibert, J Haiech, MC Kilhoffer, M Zeniou
    Oncotarget, 2018;9(43):27197-27219.  2018
  41. miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer
    Authors: U Baumgartne, F Berger, A Hashemi Gh, SS Burgener, K Monastyrsk, E Vassella
    Mol. Cancer, 2018;17(1):44.  2018
  42. Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist
    Authors: W Miao, K Sakai, N Ozawa, T Nishiuchi, Y Suzuki, K Ito, T Morioka, M Umitsu, J Takagi, H Suga, K Matsumoto
    Sci Rep, 2018;8(1):16492.  2018
  43. HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis
    Authors: C Hernandez, P Huebener, JP Pradere, DJ Antoine, RA Friedman, RF Schwabe
    J. Clin. Invest., 2018;0(0):.  2018
  44. Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.
    Authors: Charalambos Kaittanis, Chrysafis Andreou, Haley Hieronymu, Ninghui Mao, Catherine A Foss, Matthias Eiber, Gregor Weirich, Palak Panchal, Anuradha Gopalan, Juan Zurita, Samuel Achilefu, Gabriela Chiosis, Vladimir Ponomarev, Markus Schwaiger, Brett S Carver, Martin G Pomper, Jan Grimm
    The Journal of Experimental Medicine, 2018;0(0):1540-9538.  2018
  45. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades
    Authors: H Lee, SH Baek, JH Lee, C Kim, JH Ko, SG Lee, A Chinnatham, SA Alharbi, WM Yang, JY Um, G Sethi, KS Ahn
    Int J Mol Sci, 2017;18(5):.  2017
  46. WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response
    Authors: S Janczar, J Nautiyal, Y Xiao, E Curry, M Sun, E Zanini, AJ Paige, H Gabra
    Cell Death Dis, 2017;8(7):e2955.  2017
  47. Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation
    Authors: M Riera-Borr, VD Cuevas, B Alonso, MA Vega, J Joven, E Izquierdo, ÁL Corbí
    J. Immunol., 2017;0(0):.  2017
  48. The Transcription Factor HOXB7 Regulates ERK Kinase Activity and Thereby Stimulates the Motility and Invasiveness of Pancreatic Cancer Cells
    Authors: M Tsuboi, K Taniuchi, T Shimizu, M Saito, T Saibara
    J. Biol. Chem., 2017;0(0):.  2017
  49. Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene
    Authors: SA Nadeau, W An, BC Mohapatra, I Mushtaq, TA Bielecki, H Luan, N Zutshi, G Ahmad, MD Storck, M Sanada, S Ogawa, V Band, H Band
    J. Biol. Chem, 2017;292(9):3666-3682.  2017
  50. Dysregulation of Mir-196b in Head and Neck Cancers Leads to Pleiotropic Effects in the Tumor Cells and Surrounding Stromal Fibroblasts
    Authors: S Álvarez-Te, ST Menéndez, MÁ Villaronga, JP Rodrigo, L Manterola, L de Villala, JC de Vicente, L Alonso-Dur, MP Fernández, CH Lawrie, JM García-Ped
    Sci Rep, 2017;7(1):17785.  2017
  51. Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer.
    Authors: Chang C, Yen M, Liao S, Hsu Y, Lai C, Chang K, Hsu Y
    Int J Mol Sci, 2017;18(7):.  2017
  52. Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma
    Authors: Y Mo, Y Lu, P Wang, S Huang, L He, D Li, F Li, J Huang, X Lin, X Li, S Che, Q Chen
    Tumour Biol, 2017;39(2):1010428317690.  2017
  53. Resistance to the antibody-drug conjugate T-DM1 is based in a reduction in lysosomal proteolytic activity
    Authors: C Ríos-Luci, S García-Alo, E Díaz-Rodrí, M Nadal-Serr, J Arribas, A Ocaña, A Pandiella
    Cancer Res., 2017;0(0):.  2017
  54. Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer
    Authors: K Kalyvianak, V Gebhart, N Peroulis, C Panagiotop, F Kiagiadaki, I Pediaditak, M Aivaliotis, E Moustou, M Tzardi, G Notas, E Castanas, M Kampa
    Sci Rep, 2017;7(0):44418.  2017
  55. Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17
    Authors: PC Buchanan, KL Boylan, B Walcheck, R Heinze, MA Geller, PA Argenta, AP Skubitz
    J. Biol. Chem, 2017;0(0):.  2017
  56. The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry
    Authors: Z Zhou, L Xu, A Sennepin, C Federici, Y Ganor, D Tudor, D Damotte, N Barry Delo, M Zerbib, M Bomsel
    Mucosal Immunol, 2017;0(0):.  2017
  57. Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell
    Authors: S Chen, J Tao, F Zhong, Y Jiao, J Xu, Q Shen, H Wang, S Fan, Y Zhang
    PLoS ONE, 2017;12(5):e0176501.  2017
  58. The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischemia/reperfusion independent from mitochondrial connexin 43
    Authors: K Boengler, M Bulic, R Schreckenb, KD Schlueter, R Schulz
    Br. J. Pharmacol., 2017;0(0):.  2017
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Reviews for Proteome Profiler Human Phospho-Kinase Array Kit

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Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/05/2019
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/05/2019
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/31/2019
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 11/29/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 09/13/2018

Great tool for evaluating cell signaling changes. We used this kit with LS174T cells. Kit protocol was easy to follow, and after imaging the resulting spots were very clear and easy to analyze. Phosphorylation of one of the identified signaling proteins was verified using an independent western blot. I would recommend this product

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 07/18/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/18/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 04/05/2018
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/22/2018
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/20/2017
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 02/13/2017

Great kit and ok value for money considering the amount of data you get!

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 02/12/2017

Used with human samples. Image shown was at 1 minute. Other 'dots' appeared at increased exposure. Kit very good overall. Good quality result and easy to use

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/03/2017

This array is an excellent tool for screening potential phospho-kinases and related targets. However, it would be nice that if the total level of non-phosphorylated proteins be visualized at the same time on the membrane. In this case, the phosphorylated signals can be normalized.

Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/28/2016

Antibodies could not be sourced to validate some of the targets.

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/14/2016
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 08/09/2016
Proteome Profiler Human Phospho-Kinase Array Kit ARY003B
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 10/26/2015
Sample Tested: Cell Lysates

This was control and didnt show any non specific bindings.
Specificity: Specific
Sensitivity: Sensitive
Buffer: BSA
Dilution: 1:1000

Proteome Profiler Human Phospho-Kinase Array Kit ARY003B