Post-translational Modifications

Background | Products

Post-translational modifications are chemical changes to a protein that occur after translation. They widen the range of functions of the final protein. Many of these protein modifications occur in the rough endoplasmic reticulum (RER). There are five types of post-translational modifications:

  1. Formation of disulfide bridges
  2. Proper folding
  3. Addition and processing of carbohydrates
  4. Specific proteolytic cleavage
  5. Assembly into multimeric proteins

Examples of specific post-translational modifications include phosphorylation, sumolyation, ubiquitination, acetylation, methylation, glycosylation, hydroxylation, oxidation and deamination (conversion of arginine to citrulline). As all proteins begin with methionine, many have this first amino acid cleaved off during post-translational modification. This process occurs predominantly in the ER, Golgi and secretory vesicles.

Products for Post-Translational Modification Research

Post-Translational Modification Inhibitors

Cat. No.Product NameActivity
3084Anacardic acidInhibits SUMOylation; also inhibits histone acetyltransferase
1744Bay 11-7821E2 ubiquitin (Ub) conjugating enzymes inhibitor
5646EML 425Reversible and non-competitive p300/CBP inhibitor
2430GGTI 298Geranylgeranyltransferase I (GGTase I) inhibitor
6265LonafarnibPotent farnesyl transferase inhibitor
4993NSC 624206Ubiquitin-activating enzyme (E1) inhibitor
4903NU 9056Inhibitor of KAT5 (Tip60) histone acetyltransferase
2978PYR 41Ubiquitin-activating enzyme (E1) inhibitor

Other

7932Ac4GalN6yneAlkyne containing monosaccharide building block; used in BOCTAG
8035Ac4GalNAlkMetabolic chemical reporter for studying glycosylation and glycoproteins
7750Ac4GlcNAlkMetabolic chemical reporter for studying glycosylation and glycoproteins
7479Ac4ManNAzAzide-containing monosaccharide building block; used as glycoprotein, glycolipid and glycoRNA probe
7553Ac4ManNDAzPhoto-crosslinking probe for studying glycoproteins and glycolipids
77511-Hex-GlcNAlkMetabolic chemical reporter for studying glycosylation and glycoproteins
7234NitazoxanideStabilizes peptidyl arginine deiminase 2 (PAD2); inhibits Wnt signaling; broad spectrum anti-infective

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