Compounds for Embryonic Stem Cell Research: Products

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For many stem cell experiments, especially those with therapeutic applications, it is important to culture embryonic stem (ES) cells under defined conditions in order to reduce experimental variability. The addition of small molecules to ES cell culture media can aid in the optimization of ES cell survival, proliferation, and maintenance of pluripotency. Under certain conditions, the use of bioactive small molecules may serve as a substitute for undefined culture media. The undifferentiated and pluripotent state of ES cells can be enhanced by activation of the Wnt signaling pathway and by the addition of indole derivatives, such as ID 8. In addition, Tocris biochemicals and compounds can be used to induce the differentiation of ES cells into specialized cell types. For example, alkyl hydrazone derivatives, such as IDE-1, can activate TGF-beta signaling and induce the differentiation of ES cells into definitive endoderm.

"Compounds for Embryonic Stem Cell Research" has 30 results in Products.
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Y-27632 dihydrochloride 

Selective p160ROCK inhibitor

IWP 2 

PORCN inhibitor; inhibits Wnt processing and secretion

XAV 939 

Potent tankyrase inhibitor

endo-IWR 1 

Wnt/β-catenin signaling inhibitor; axin stabilizer

PD 98059 

MEK inhibitor

LY 294002 hydrochloride 

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Cyclopamine 

Inhibitor of Hedgehog (Hh) signaling

IWP 4 

Potent inhibitor of Wnt/β-catenin signaling

SB 216763 

Potent, selective GSK-3 inhibitor

BIO 

Potent GSK-3 inhibitor; also inhibits cdks

Tranylcypromine hydrochloride 

Irreversible inhibitor of LSD1; also inhibits MAO

IDE 2 

Induces definitive endoderm formation in mouse and human ESCs

HLM 006474 

E2F transcription factor inhibitor

KY 02111 

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

SR 3677 dihydrochloride 

Potent, selective Rho-kinase (ROCK) inhibitor

Theanine 

Glutamate receptor ligand

Sinomenine hydrochloride 

Anti-inflammatory; causes mast cell degranulation and histamine release

Sodium butyrate 

Histone deacetylase inhibitor

IDE 1 

Induces definitive endoderm formation in mouse and human ESCs

QS 11 

ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling

Stauprimide 

Inhibits NME2 nuclear translocation; primes ESCs for differentiation

Gatifloxacin 

Antibiotic; inhibits bacterial type II topoisomerase

Cardiogenol C hydrochloride 

Induces cardiomyocyte differentiation in ESCs

Pluripotin 

Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal

Cardionogen 1 

Inhibitor of Wnt/β-catenin signaling

A 939572 

Potent SCD-1 inhibitor

PluriSln 1 

SCD-1 inhibitor

CKI 7 dihydrochloride 

CK1 inhibitor

ID 8 

Sustains self-renewal and pluripotency of ESCs

Y-27632 dihydrochloride 

Y-27632 synthesized to cGMP guidelines
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