Compounds for Embryonic Stem Cell Research: Products

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For many stem cell experiments, especially those with therapeutic applications, it is important to culture embryonic stem (ES) cells under defined conditions in order to reduce experimental variability. The addition of small molecules to ES cell culture media can aid in the optimization of ES cell survival, proliferation, and maintenance of pluripotency. Under certain conditions, the use of bioactive small molecules may serve as a substitute for undefined culture media. The undifferentiated and pluripotent state of ES cells can be enhanced by activation of the Wnt signaling pathway and by the addition of indole derivatives, such as ID 8. In addition, Tocris biochemicals and compounds can be used to induce the differentiation of ES cells into specialized cell types. For example, alkyl hydrazone derivatives, such as IDE-1, can activate TGF-beta signaling and induce the differentiation of ES cells into definitive endoderm.

"Compounds for Embryonic Stem Cell Research" has 23 results in Products.
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Y-27632 dihydrochloride 

Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component

Y-27632 dihydrochloride 

Y-27632 synthesized to cGMP guidelines

IWP 2 

PORCN inhibitor; inhibits Wnt processing and secretion

XAV 939 

Potent tankyrase inhibitor

endo-IWR 1 

Wnt/β-catenin signaling inhibitor; axin stabilizer

Chroman 1 

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogeneisis

LY 294002 hydrochloride 

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Cyclopamine 

Inhibitor of Hedgehog (Hh) signaling

Sodium butyrate 

Histone deacetylase inhibitor

PD 98059 

MEK inhibitor

IWP 4 

Potent inhibitor of Wnt/β-catenin signaling

XAV 939 

XAV 939 synthesized to cGMP guidelines

CKI 7 dihydrochloride 

CK1 inhibitor

SB 216763 

Potent, selective GSK-3 inhibitor

BIO 

Potent GSK-3 inhibitor; also inhibits cdks

Tranylcypromine hydrochloride 

Irreversible inhibitor of LSD1; also inhibits MAO

IDE 1 

Induces definitive endoderm formation in mouse and human ESCs

KY 02111 

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

QS 11 

ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling

SR 3677 dihydrochloride 

Potent, selective Rho-kinase (ROCK) inhibitor

A 939572 

Potent SCD-1 inhibitor

PluriSln 1 

SCD-1 inhibitor

HLM 006474 

E2F transcription factor inhibitor
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