Compounds for Embryonic Stem Cell Research: Products

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For many stem cell experiments, especially those with therapeutic applications, it is important to culture embryonic stem (ES) cells under defined conditions in order to reduce experimental variability. The addition of small molecules to ES cell culture media can aid in the optimization of ES cell survival, proliferation, and maintenance of pluripotency. Under certain conditions, the use of bioactive small molecules may serve as a substitute for undefined culture media. The undifferentiated and pluripotent state of ES cells can be enhanced by activation of the Wnt signaling pathway and by the addition of indole derivatives, such as ID 8. In addition, Tocris biochemicals and compounds can be used to induce the differentiation of ES cells into specialized cell types. For example, alkyl hydrazone derivatives, such as IDE-1, can activate TGF-beta signaling and induce the differentiation of ES cells into definitive endoderm.

"Compounds for Embryonic Stem Cell Research" has 29 results in Products.
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Y-27632 dihydrochloride

Selective p160ROCK inhibitor

IWP 2

PORCN inhibitor; inhibits Wnt processing and secretion

XAV 939

Potent tankyrase inhibitor

endo-IWR 1

Wnt/β-catenin signaling inhibitor; axin stabilizer

LY 294002 hydrochloride

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

PD 98059

MEK inhibitor

Cyclopamine

Inhibitor of Hedgehog (Hh) signaling

IWP 4

Potent inhibitor of Wnt/β-catenin signaling

Tranylcypromine hydrochloride

Irreversible inhibitor of LSD1; also inhibits MAO

HLM 006474

E2F transcription factor inhibitor

SB 216763

Potent, selective GSK-3 inhibitor

BIO

Potent, selective GSK-3 inhibitor

IDE 1

Induces definitive endoderm formation in mouse and human ESCs

KY 02111

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Theanine

Glutamate receptor ligand

Sinomenine hydrochloride

Anti-inflammatory; causes mast cell degranulation and histamine release

Sodium butyrate

Histone deacetylase inhibitor

IDE 2

Induces definitive endoderm formation in mouse and human ESCs

A 939572

Potent SCD-1 inhibitor

ID 8

Sustains self-renewal and pluripotency of ESCs

QS 11

ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling

SR 3677 dihydrochloride

Potent, selective Rho-kinase (ROCK) inhibitor

Stauprimide

Inhibits NME2 nuclear translocation; primes ESCs for differentiation

Gatifloxacin

Antibiotic; inhibits bacterial type II topoisomerase

Cardiogenol C hydrochloride

Induces cardiomyocyte differentiation in ESCs

Pluripotin

Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal

Cardionogen 1

Inhibitor of Wnt/β-catenin signaling

PluriSln 1

SCD-1 inhibitor

CKI 7 dihydrochloride

CK1 inhibitor
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