Compounds for iPSC Dedifferentiation: Products

SB 431542 synthesized to cGMP guidelines

EZH2 histone methyltransferase inhibitor

Highly selective GSK-3 inhibitor; acts as Wnt activator

Potent and selective inhibitor of TGF-βRI

Enhances the generation of iPSCs; increases reprogramming efficiency

Potent inhibitor of MEK1/2

ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs

Histone deacetylase inhibitor

γ-secretase inhibitor; inhibits Notch pathway

Retinoic acid analog; RAR agonist

Potent histone deacetylase inhibitor

3-Deazaneplanocin A hydrochloride synthesized to Ancillary Material Grade

CaV1.x activator

Irreversible inhibitor of LSD1; also inhibits MAO

DNA methyltransferase inhibitor

Media supplement to boost cell growth; used as component of CEPT cocktail to enhance stem cell viability

GSK-3β inhibitor; also inhibits cdks

Inhibitor of p53-mitochondrial binding

Non-nucleoside DNA methyltransferase inhibitor

GLP and G9a inhibitor

DBZ synthesized to Ancillary Material Grade