34 results for "NMDA Receptor Antagonists" in Products

NMDA Receptor Antagonists

NMDA receptors are expressed alongside AMPA receptors on the postsynaptic membrane of excitatory synapses, where they initiate a two-component excitatory postsynaptic potential (EPSP). The activation of AMPA receptors produces a current that has rapid onset and decay, while activation of NMDA receptors leads to a current with slower onset and decay. The slow decay of NMDA-mediated currents is due to the slow dissociation of glutamate from NMDA receptors, compared with AMPA receptors. Unlike ...

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Potent and selective NMDA receptor antagonist; more active form of DL-AP5

Alternate Names: 2-APV,D-APV,D-2-amino-5-phosphonovalerate
Chemical Name: D-(-)-2-Amino-5-phosphonopentanoic acid
Purity: ≥98%
Potent and selective NMDA receptor antagonist; more active form of DL-AP5
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Potent and selective NMDA antagonist

Alternate Names: DL-APV
Chemical Name: DL-2-Amino-5-phosphonopentanoic acid
Purity: ≥98%
Potent and selective NMDA antagonist
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Non-competitive NMDA antagonist; acts at ion channel site

Alternate Names: Dizocilpine
Chemical Name: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate
Purity: ≥98%
Non-competitive NMDA antagonist; acts at ion channel site
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Potent and selective non-NMDA iGluR antagonist

Alternate Names: Cyanquixaline
Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione
Purity: ≥98%
Potent and selective non-NMDA iGluR antagonist
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Potent and selective NMDA antagonist; sodium salt of DL-AP5

Chemical Name: DL-2-Amino-5-phosphonopentanoic acid sodium salt
Purity: ≥98%
Potent and selective NMDA antagonist; sodium salt of DL-AP5
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GluN2B-selective NMDA antagonist

Chemical Name: RS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
Purity: ≥98%
GluN2B-selective NMDA antagonist
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NMDA antagonist; acts at ion channel site

Chemical Name: 3,5-Dimethyl-tricyclo[3.3.1.13,7]decan-1-amine hydrochloride
NMDA antagonist; acts at ion channel site
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Potent kynurenine 3-monooxygenase (KMO) inhibitor

Chemical Name: 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide
Purity: ≥98%
Potent kynurenine 3-monooxygenase (KMO) inhibitor
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Non-competitive NMDA antagonist; also σ ligand

Chemical Name: (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate
Purity: ≥98%
Non-competitive NMDA antagonist; also σ ligand
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Potent competitive inhibitor of L-glutamate uptake

Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid
Purity: ≥98%
Potent competitive inhibitor of L-glutamate uptake
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Highly potent NMDA antagonist

Chemical Name: trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
Purity: ≥98%
Highly potent NMDA antagonist
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Potent NMDA antagonist; more active enantiomer of (RS)-CPP

Chemical Name: 3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Potent NMDA antagonist; more active enantiomer of (RS)-CPP
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GluN1/GluN2A-selective NMDA antagonist

Chemical Name: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
Purity: ≥98%
GluN1/GluN2A-selective NMDA antagonist
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NMDA antagonist; less active enantiomer of (+)-MK 801

Chemical Name: (5R,10S)-(-)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cylcohepten-5,10-imine maleate
Purity: ≥98%
NMDA antagonist; less active enantiomer of (+)-MK 801
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Potent and selective NMDA antagonist; less active form of DL-AP5

Chemical Name: L-(+)-2-Amino-5-phosphonopentanoic acid
Purity: ≥98%
Potent and selective NMDA antagonist; less active form of DL-AP5
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Potent NMDA antagonist

Chemical Name: (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Potent NMDA antagonist
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NMDA antagonist; acts at glycine site

Chemical Name: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
Purity: ≥98%
NMDA antagonist; acts at glycine site
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Potent competitive NMDA antagonist

Chemical Name: cis-4-[Phosphomethyl]-piperidine-2-carboxylic acid
Potent competitive NMDA antagonist
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Potent and selective NMDA antagonist; acts at glycine site

Alternate Names: PAMQX
Chemical Name: [(1S)-1-[[(7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonic acid hydrochloride
Purity: ≥98%
Potent and selective NMDA antagonist; acts at glycine site
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Potent competitive NMDA antagonist

Alternate Names: Midafotel,SDZ EAA 494
Chemical Name: D-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid
Potent competitive NMDA antagonist
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Potent and selective NMDA antagonist

Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid
Purity: ≥98%
Potent and selective NMDA antagonist
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Potent and selective NMDA antagonist; acts at the glycine site

Alternate Names: GV 150526A
Chemical Name: 4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Purity: ≥98%
Potent and selective NMDA antagonist; acts at the glycine site
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GluN2B-selective NMDA antagonist

Alternate Names: PD 174494,Ro 63-1908
Chemical Name: 1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol hydrochloride
Purity: ≥98%
GluN2B-selective NMDA antagonist
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GluN2C/GluN2D-selective NMDA antagonist

Chemical Name: (2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid
Purity: ≥98%
GluN2C/GluN2D-selective NMDA antagonist
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KV7 channel activator; also GABAA modulator and indirect NMDA antagonist

Alternate Names: D 9998
Chemical Name: N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate
Purity: ≥98%
KV7 channel activator; also GABAA modulator and indirect NMDA antagonist
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