Proteases

Proteases (also known as peptidases or proteinases) are a subgroup of hydrolase enzymes that catalyze the cleavage of peptide bonds within proteins. There are two main subtypes of proteases: exoproteases, which hydrolyze peptide bonds at the terminus of polypeptide chains; and endoproteases, which act internally. Proteases are involved in a vast array of physiological processes, from simple digestion of food to complex signaling cascades such as the apoptotic caspase-activated cascade.

Protease Research Areas

Discover more protease products from R&D Systems:

Aspartic Proteases and Regulators	Cysteine Proteases and Regulators	Metalloproteases and Regulators
Serine Proteases and Regulators	Ubiquitin Proteasome System

Protease Targets

γ-Secretase (γ-Secretase) γ-Secretase Inhibitors γ-Secretase Modulators	Dipeptidyl Peptidase IV (DPPIV/CD26) DPPIV/CD26 Inhibitors
3C and 3CL Proteases (3CL Protease) 3C and 3CL Protease Compounds 3C and 3CL Protease Inhibitors	Elastases (Elastase, ELA2) Synthetic Elastase Inhibitors
ACE2 (ACE2) ACE2 Compounds ACE2 Inhibitors ACE2 Substrates	Furin (Furin) Furin Inhibitors
ADAM (View All) ADAM Inhibitors	HIV Protease (HIV-1 Protease) HIV Protease Inhibitors
Aminopeptidases (View All) Aminopeptidase Inhibitors	Papain-like Proteases (PLpro) Papain-like Protease Inhibitors
Angiotensin-Converting Enzyme (ACE) ACE Compounds	Plasminogen Activator Inhibitor-1 (PAI-1) PAI-1 Inhibitors
Calpains (View All) Calpain Inhibitors	TMPRSS2 (TMPRSS2) TMPRSS2 Inhibitors
Carboxypeptidases (View All) Carboxypeptidase Inhibitors	Urokinase (uPA) Urokinase Inhibitors
Caspases (View All) Caspase Activators Caspase Compounds Caspase Inhibitors	Other Proteases Additional Synthetic Protease Inhibitors
Cathepsin (View All) Synthetic Cathepsin Inhibitors