25 results for "Autophagy Inhibitors" in Products

Autophagy Inhibitors

Autophagy is a process by which a cell breaks down macromolecules in response to starvation or stress signals. While it is closely linked with apoptosis, autophagy is primarily characterized as a catabolic mechanism by which cellular energy homeostasis is maintained, and by which cellular organelles and proteins are degraded.

Autophagy also occurs in response to similar stresses to those which induce apoptosis and several proapoptotic signals also induce autophagy - for example, ...

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Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Chemical Name: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity: ≥99%
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
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H+-ATPase (vacuolar) inhibitor

Chemical Name: (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
Purity: ≥95%
H+-ATPase (vacuolar) inhibitor
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Promotes assembly and inhibits disassembly of microtubules

Alternate Names: Paclitaxel
Chemical Name: [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Purity: ≥98%
Promotes assembly and inhibits disassembly of microtubules
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Selective and high affinity cathepsin D inhibitor

Purity: ≥95%
Selective and high affinity cathepsin D inhibitor
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Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1

Alternate Names: SL-2052
Chemical Name: (1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione
Purity: ≥98%
Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1
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Selective farnesoid X receptor (FXR) agonist

Chemical Name: 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid
Purity: ≥97%
Selective farnesoid X receptor (FXR) agonist
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Microtubule inhibitor

Chemical Name: [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester
Purity: ≥95%
Microtubule inhibitor
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Antimalarial; inhibits apoptosis and autophagy

Chemical Name: N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Purity: ≥98%
Antimalarial; inhibits apoptosis and autophagy
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Cathepsin inhibitor; interferes with autolysosomal digestion

Chemical Name: (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic acid ethyl ester
Purity: ≥98%
Cathepsin inhibitor; interferes with autolysosomal digestion
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H+-ATPase (vacuolar) inhibitor

Alternate Names: Folimycin
Chemical Name: (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one
Purity: ≥90%
H+-ATPase (vacuolar) inhibitor
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CaV1.x activator

Chemical Name: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Purity: ≥98%
CaV1.x activator
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HMG-CoA reductase inhibitor

Chemical Name: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate
Purity: ≥98%
HMG-CoA reductase inhibitor
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Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation

Alternate Names: CP 62993
Chemical Name: 13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
Purity: ≥98%
Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation
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Class III PI 3-kinase inhibitor; also inhibits autophagy

Alternate Names: 3-MA
Chemical Name: 3-Methyl-3H-purin-6-amine
Purity: ≥98%
Class III PI 3-kinase inhibitor; also inhibits autophagy
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Disrupts microtubules

Chemical Name: Vincaleukoblastine
Purity: ≥95%
Disrupts microtubules
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Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

Chemical Name: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Purity: ≥98%
Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis
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USP10 and USP13 inhibitor; inhibits autophagy

Chemical Name: 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine
Purity: ≥98%
USP10 and USP13 inhibitor; inhibits autophagy
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Autophagy inhibitor; also TLR9 inhibitor

Chemical Name: 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate
Purity: ≥98%
Autophagy inhibitor; also TLR9 inhibitor
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Potent and selective p97 ATPase (VCP) allosteric inhibitor

Chemical Name: 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine
Purity: ≥98%
Potent and selective p97 ATPase (VCP) allosteric inhibitor
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Potent TBK inhibitor

Chemical Name: N-[3-[[5-Cyclopropyl-2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide hydrochloride
Purity: ≥98%
Potent TBK inhibitor
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Salt inducible kinase (SIK) inhibitor; also ULK1 and 2 inhibitor

Chemical Name: N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
Purity: ≥98%
Salt inducible kinase (SIK) inhibitor; also ULK1 and 2 inhibitor
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ATP-competitive inhibitor of p97 ATPase

Chemical Name: 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
Purity: ≥98%
ATP-competitive inhibitor of p97 ATPase
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Potent and selective Foxo1 inhibitor; orally bioavailable

Chemical Name: 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Purity: ≥98%
Potent and selective Foxo1 inhibitor; orally bioavailable
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ULK inhibitor

Chemical Name: N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
Purity: ≥98%
ULK inhibitor
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Potent VPS34 inhibitor

Chemical Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
Purity: ≥98%
Potent VPS34 inhibitor
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