Mouse IL-1 beta /IL-1F2 Antibody

Tranilast directly targets NLRP3 to treat inflammasome-driven diseases
Authors: Y Huang, H Jiang, Y Chen, X Wang, Y Yang, J Tao, X Deng, G Liang, H Zhang, W Jiang, R Zhou
EMBO Mol Med, 2018;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

HMGB1/IL-1? complexes in plasma microvesicles modulate immune responses to burn injury
Authors: LG Coleman, R Maile, SW Jones, BA Cairns, FT Crews
PLoS ONE, 2018;13(3):e0195335.
Species: Mouse
Sample Types: Protein
Applications: WB

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration
Authors: E Lee, I Hwang, S Park, S Hong, B Hwang, Y Cho, J Son, JW Yu
Cell Death Differ., 2018;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation
Authors: M Tsugita, N Morimoto, M Tashiro, K Kinoshita, M Nakayama
Cell Rep, 2017;18(5):1298-1311.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

IL-1? transcriptionally activates hepcidin by inducing C/EBP? expression in hepatocytes
Authors: Y Kanamori, M Murakami, M Sugiyama, O Hashimoto, T Matsui, M Funaba
J. Biol. Chem., 2017;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1?
Authors: Q Zhu, TD Kanneganti
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Distinct Kinase-Independent Role of RIPK3 in CD11c(+) Mononuclear Phagocytes in Cytokine-Induced Tissue Repair
Authors: K Moriwaki, S Balaji, J Bertin, PJ Gough, FK Chan
Cell Rep, 2017;18(10):2441-2451.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production
Authors: H Ahn, E Jeon, JC Kim, SG Kang, SI Yoon, HJ Ko, PH Kim, GS Lee
Sci Rep, 2017;7(1):1314.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation
Authors: S Yoon, A Kovalenko, K Bogdanov, D Wallach
Immunity, 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of Apc(Min/+) mice
Authors: Z Zhong, Y Zhai, P Bu, S Shah, L Qiao
Nat Commun, 2017;8(0):15004.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner
Authors: K Zenke, M Muroi, KI Tanamoto
Cell. Signal., 2017;43(0):32-39.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Interleukin-1 and estrogen protect against disseminating dentoalveolar infections
Authors: H Youssef, P Stashenko
Int J Oral Sci, 2017;9(1):16-23.
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKC�
Authors: HJ Koh, YR Kim, JS Kim, JS Yun, K Jang, CS Yang
PLoS Pathog, 2017;13(1):e1006126.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis
Authors: TP Domiciano, D Wakita, HD Jones, TR Crother, WA Verri, M Arditi, K Shimada
Sci Rep, 2017;7(0):41539.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

A new approach for ratiometric in vivo calcium imaging of microglia
Authors: B Brawek, Y Liang, D Savitska, K Li, N Fomin-Thun, Y Kovalchuk, E Zirdum, J Jakobsson, O Garaschuk
Sci Rep, 2017;7(1):6030.

The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression
Authors: S Ghosh, C Wallerath, S Covarrubia, V Hornung, S Carpenter, KA Fitzgerald
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Targeting IRE1 with small molecules counteracts progression of atherosclerosis
Authors: O Tufanli, P Telkoparan, D Acosta-Alv, B Kocaturk, UI Onat, SM Hamid, I €imen, P Walter, C Weber, E Erbay
Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

The P2X7 Receptor Primes IL-1? and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain
Authors: F Albalawi, W Lu, JM Beckel, JC Lim, SA McCaughey, CH Mitchell
Front Cell Neurosci, 2017;11(0):227.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome
Authors: V Neudecker, M Haneklaus, O Jensen, L Khailova, JC Masterson, H Tye, K Biette, P Jedlicka, KS Brodsky, ME Gerich, M Mack, AAB Robertson, MA Cooper, GT Furuta, CA Dinarello, LA O'Neill, HK Eltzschig, SL Masters, EN McNamee
J. Exp. Med., 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

MTG16 is a tumor suppressor in colitis-associated carcinoma
Authors: EM McDonough, CW Barrett, B Parang, MK Mittal, JJ Smith, AM Bradley, YA Choksi, LA Coburn, SP Short, JJ Thompson, B Zhang, SV Poindexter, MA Fischer, X Chen, J Li, FL Revetta, R Naik, MK Washington, MJ Rosen, SW Hiebert, KT Wilson, CS Williams
JCI Insight, 2017;2(16):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
Authors: L Freeman, H Guo, CN David, WJ Brickey, S Jha, JP Ting
J. Exp. Med., 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome
Authors: R Domingo-Fe, RC Coll, J Kearney, S Breit, LA O'Neill
J. Biol. Chem., 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina
Authors: JC Rivera, B Noueihed, A Madaan, I Lahaie, J Pan, J Belik, S Chemtob
J Neuroinflammation, 2017;14(1):181.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling
Authors: T Wu, J Zhang, M Geng, SJ Tang, W Zhang, J Shu
Sci Rep, 2017;7(1):4117.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects
Authors: MK Choo, Y Sano, C Kim, K Yasuda, XD Li, X Lin, M Stenzel-Po, L Alexopoulo, S Ghosh, E Latz, IR Rifkin, ZJ Chen, GC Stewart, H Chong, JM Park
J. Exp. Med., 2017;214(5):1297-1311.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression
Authors: Gang Hu
Int. J. Neuropsychopharmacol., 2016;19(9):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: WB

Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation
PLoS Pathog, 2016;12(12):e1006052.
Species: Human
Sample Types: Cell Lysates
Applications: WB

Lymphatic vessels regulate immune microenvironments in human and murine melanoma
J Clin Invest, 2016;0(0):.
Species: Human
Sample Types: Tissue Homogenates
Applications: WB

TNF?-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury
Proc. Natl. Acad. Sci. U.S.A., 2016;113(50):E8151-E8158.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells
J Leukoc Biol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neut

C13orf31 (FAMIN) is a central regulator of immunometabolic function
Nat Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection
Oncotarget, 2016;7(26):39316-39331.
Species: Mouse
Sample Types: Whole Tissue
Applications: IF

HIF-1? Is an Essential Mediator of IFN-?-Dependent Immunity to Mycobacterium tuberculosis
J Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Enzymatically inactive procaspase-1 stabilizes the ASC-pyroptosome and supports pyroptosome spreading during cell division
J Biol Chem, 2016;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Bead-based Immunoassay

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants.
Authors: Marty-Roix R, Vladimer G, Pouliot K, Weng D, Buglione-Corbett R, West K, Macmicking J, Chee J, Wang S, Lu S, Lien E
J Biol Chem, 2016;291(3):1123-36.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation
Authors: X Wang, DK Shaw, OS Sakhon, GA Snyder, EJ Sundberg, L Santambrog, FS Sutterwala, JS Dumler, KA Shirey, DJ Perkins, K Richard, AC Chagas, E Calvo, J Kopecký, M Kotsyfakis, JH Pedra
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS
Authors: Yong Hwan Park
Nat Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

CARD9 negatively regulates NLRP3-induced IL-1? production on Salmonella infection of macrophages
Nat Commun, 2016;7(0):12874.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis
Sci Rep, 2016;6(0):39257.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury
Authors: Jeremy S Duffield
J. Clin. Invest., 2016;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome.
Authors: Yang C, Kim J, Kim T, Lee P, Kim S, Lee H, Shin D, Nguyen L, Lee M, Jin H, Kim K, Lee C, Kim M, Park S, Kim J, Choi H, Jo E
Nat Commun, 2015;6(0):6115.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.
Authors: Denes A, Coutts G, Lenart N, Cruickshank S, Pelegrin P, Skinner J, Rothwell N, Allan S, Brough D
Proc Natl Acad Sci U S A, 2015;112(13):4050-5.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC Frozen

Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2.
Authors: Sitaras N, Rivera J, Noueihed B, Bien-Aime M, Zaniolo K, Omri S, Hamel D, Zhu T, Hardy P, Sapieha P, Joyal J, Chemtob S
Am J Pathol, 2015;185(2):581-95.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
Authors: Meunier E, Wallet P, Dreier R, Costanzo S, Anton L, Ruhl S, Dussurgey S, Dick M, Kistner A, Rigard M, Degrandi D, Pfeffer K, Yamamoto M, Henry T, Broz P
, 2015;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.
Authors: Li B, Gurung P, Malireddi R, Vogel P, Kanneganti T, Geiger T
Nat Commun, 2015;6(0):6131.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules.
Authors: Sadeghi H, Lockmann A, Hund A, Samavedam U, Pipi E, Vafia K, Hauenschild E, Kalies K, Pas H, Jonkman M, Iwata H, Recke A, Schon M, Zillikens D, Schmidt E, Ludwig R
J Immunol, 2015;194(8):3656-63.

Methylsulfonylmethane inhibits NLRP3 inflammasome activation.
Authors: Ahn H, Kim J, Lee M, Kim Y, Cho Y, Lee G
Cytokine, 2015;71(2):223-31.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: WB

Local immunosuppressive microenvironment enhances migration of melanoma cells to lungs in DJ-1 knockout mice.
Authors: Chien C, Lee M, Liou H, Liou H, Fu W
PLoS ONE, 2015;10(2):e0115827.
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
Authors: Lawlor K, Khan N, Mildenhall A, Gerlic M, Croker B, D'Cruz A, Hall C, Kaur Spall S, Anderton H, Masters S, Rashidi M, Wicks I, Alexander W, Mitsuuchi Y, Benetatos C, Condon S, Wong W, Silke J, Vaux D, Vince J
Nat Commun, 2015;6(0):6282.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.
Authors: Sester D, Sagulenko V, Thygesen S, Cridland J, Loi Y, Cridland S, Masters S, Genske U, Hornung V, Andoniou C, Sweet M, Degli-Esposti M, Schroder K, Stacey K
J Immunol, 2015;195(3):1233-41.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: WB

The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.
Authors: Maier N, Leppla S, Moayeri M
J Immunol, 2015;194(6):2776-85.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Activation of NLRP3 inflammasome by crystalline structures via cell surface contact.
Authors: Hari A, Zhang Y, Tu Z, Detampel P, Stenner M, Ganguly A, Shi Y
Sci Rep, 2014;4(0):7281.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Critical role for IL-1beta in DNA damage-induced mucositis.
Authors: Kanarek N, Grivennikov S, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul Y, Stachler M, Voronov E, Apte R, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y
Proc Natl Acad Sci U S A, 2014;111(6):E702-11.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

RNA and beta-hemolysin of group B Streptococcus induce interleukin-1beta (IL-1beta) by activating NLRP3 inflammasomes in mouse macrophages.
Authors: Gupta R, Ghosh S, Monks B, DeOliveira R, Tzeng T, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock D
J Biol Chem, 2014;289(20):13701-5.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: WB

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.
Authors: Meunier E, Dick M, Dreier R, Schurmann N, Kenzelmann Broz D, Warming S, Roose-Girma M, Bumann D, Kayagaki N, Takeda K, Yamamoto M, Broz P
Nature, 2014;509(7500):366-70.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: WB

Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis.
Authors: Nieto-Torres J, DeDiego M, Verdia-Baguena C, Jimenez-Guardeno J, Regla-Nava J, Fernandez-Delgado R, Castano-Rodriguez C, Alcaraz A, Torres J, Aguilella V, Enjuanes L
PLoS Pathog, 2014;10(5):e1004077.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1beta production in response to beta-glucans and the fungal pathogen, Candida albicans.
Authors: Ganesan S, Rathinam V, Bossaller L, Army K, Kaiser W, Mocarski E, Dillon C, Green D, Mayadas T, Levitz S, Hise A, Silverman N, Fitzgerald K
J Immunol, 2014;193(5):2519-30.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

A critical role for human caspase-4 in endotoxin sensitivity.
Authors: Kajiwara Y, Schiff T, Voloudakis G, Gama Sosa M, Elder G, Bozdagi O, Buxbaum J
J Immunol, 2014;193(1):335-43.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation.
Authors: Zhao C, Gillette D, Li X, Zhang Z, Wen H
J Biol Chem, 2014;289(24):17020-9.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

3,4-methylenedioxy-beta-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.
Authors: He Y, Varadarajan S, Munoz-Planillo R, Burberry A, Nakamura Y, Nunez G
J Biol Chem, 2014;289(2):1142-50.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines.
Authors: Asrat S, Dugan A, Isberg R
PLoS Pathog, 2014;10(7):e1004229.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes.
Authors: Maier N, Crown D, Liu J, Leppla S, Moayeri M
J Immunol, 2014;192(2):763-70.
Species: Human
Sample Types: Cell Lysates
Applications: WB

Endothelial NLRP3 inflammasome activation and enhanced neointima formation in mice by adipokine visfatin.
Authors: Xia M, Boini K, Abais J, Xu M, Zhang Y, Li P
Am J Pathol, 2014;184(5):1617-28.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

Signaling pathways in murine dendritic cells that regulate the response to vesicular stomatitis virus vectors that express flagellin.
Authors: Smedberg J, Westcott M, Ahmed M, Lyles D
J Virol, 2014;88(2):777-85.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes.
Authors: Lim, Yu-Mi, Lim, Hyejin, Hur, Kyu Yeon, Quan, Wenying, Lee, Hae-Youn, Cheon, Hwanju, Ryu, Dongryeo, Koo, Seung-Ho, Kim, Hong Lim, Kim, Jin, Komatsu, Masaaki, Lee, Myung-Sh
Nat Commun, 2014;5(0):4934.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

Critical role of aquaporins in interleukin 1beta (IL-1beta)-induced inflammation.
Authors: Rabolli V, Wallemme L, Lo Re S, Uwambayinema F, Palmai-Pallag M, Thomassen L, Tyteca D, Octave J, Marbaix E, Lison D, Devuyst O, Huaux F
J Biol Chem, 2014;289(20):13937-47.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice.
Authors: Tanaka S, Ishii A, Ohtaki H, Shioda S, Yoshida T, Numazawa S
J Neuroinflammation, 2013;10(0):143.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC Frozen

Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.
Authors: El-Zaatari M, Kao J, Tessier A, Bai L, Hayes M, Fontaine C, Eaton K, Merchant J
PLoS ONE, 2013;8(3):e58935.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC Fluorescence

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome.
Authors: Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, Akira S
Nat Immunol, 2013;14(5):454-60.
Species: Mouse
Sample Types: Peritoneal Fluid
Applications: WB

Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways.
Authors: Li B, Shi Y, Shu J, Gao J, Wu P, Tang S
J Biol Chem, 2013;288(19):13610-9.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

The role of IL-1beta in the early tumor cell-induced angiogenic response.
Authors: Carmi Y, Dotan S, Rider P, Kaplanov I, White M, Baron R, Abutbul S, Huszar M, Dinarello C, Apte R, Voronov E
J Immunol, 2013;190(7):3500-9.
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Authors: Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J
Nature, 2012;492(7427):123-7.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: WB

Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.
Authors: Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, Steele C
Infect. Immun., 2012;80(1):410-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Neut

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.
Authors: Broz P, Ruby T, Belhocine K, Bouley D, Kayagaki N, Dixit V, Monack D
Nature, 2012;490(7419):288-91.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: WB

Toll-like receptor 2 contributes to chemokine gene expression and macrophage infiltration in the dorsal root ganglia after peripheral nerve injury.
Authors: Kim D, You B, Lim H, Lee SJ
Mol Pain, 2011;7(0):74.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC

IL-1alpha and IL-1beta recruit different myeloid cells and promote different stages of sterile inflammation.
Authors: Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN
J. Immunol., 2011;187(9):4835-43.
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis.
Authors: Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, Voronov E, Apte RN
J. Immunol., 2011;186(6):3462-71.
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

Coordinated Host Responses during Pyroptosis: Caspase-1-Dependent Lysosome Exocytosis and Inflammatory Cytokine Maturation.
Authors: Bergsbaken T, Fink SL, den Hartigh AB, Loomis WP, Cookson BT
J. Immunol., 2011;187(5):2748-54.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: WB

IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
Authors: Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS
J. Clin. Invest., 2011;121(10):3846-59.
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.
Authors: McCoy AJ, Koizumi Y, Toma C, Higa N, Dixit V, Taniguchi S, Tschopp J, Suzuki T
Eur. J. Immunol., 2010;40(10):2797-803.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes.
Authors: Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA
Nat. Immunol., 2010;11(10):897-904.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Tyrosine kinase 2 controls IL-1beta production at the translational level.
Authors: Radwan M, Stiefvater R, Grunert T, Sharif O, Miller I, Marchetti-Deschmann M, Allmaier G, Gemeiner M, Knapp S, Kovarik P, Muller M, Strobl B
J. Immunol., 2010;185(6):3544-53.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis.
Authors: Yoshida H, Russell J, Senchenkova EY, Almeida Paula LD, Granger DN
Am. J. Pathol., 2010;177(6):2774-81.
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Authors: Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L
Nat. Med., 2009;15(10):1170-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Neut

Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.
Authors: Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA
J. Immunol., 2009;183(6):4021-30.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice.
Authors: Hyvarinen K, Tuomainen AM, Laitinen S, Bykov IL, Tormakangas L, Lindros K, Käkelä R, Alfthan G, Salminen I, Jauhiainen M, Kovanen PT, Leinonen M, Saikku P, Pussinen PJ
Infect. Immun., 2009;77(8):3442-9.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC Paraffin-embedded

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.
Authors: Maelfait J, Vercammen E, Janssens S, Schotte P, Haegman M, Magez S, Beyaert R
J. Exp. Med., 2008;205(9):1967-73.
Species: Mouse
Sample Types: Cell Lysates
Applications: WB

Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death.
Authors: Das S, Mishra MK, Ghosh J, Basu A
J. Neuroimmunol., 2008;195(1):60-72.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo.
Authors: Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL
J. Immunol., 2007;179(10):6933-42.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: WB

Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1beta.
Authors: Ogiso T, Nagaki M, Takai S, Tsukada Y, Mukai T, Kimura K, Moriwaki H
J. Hepatol., 2007;47(6):816-25.
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice.
Authors: Pozsgai G, Sandor K, Perkecz A, Szolcsanyi J, Helyes Z, Brain SD, Pinter E
Inflamm. Res., 2007;56(11):459-67.
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi.
Authors: Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonca-Previato L, Nobrega A, Bellio M
J. Leukoc. Biol., 2007;82(3):488-96.
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
Authors: Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI
Genes Dev., 2006;20(18):2527-38.
Species: Mouse
Sample Types: Whole Cells
Applications: Neut

Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration.
Authors: Perrin FE, Lacroix S, Aviles-Trigueros M, David S
Brain, 2005;128(0):854-66.
Species: Mouse
Sample Types:
Applications: In vivo

Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum.
Authors: Banks WA, Farr SA, La Scola ME
J. Pharmacol. Exp. Ther., 2001;299(2):536-41.
Species: Mouse
Sample Types: In Vivo
Applications: In vivo

Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
Authors: Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Schaefer R, Grone HJ, Schaefer L
J Biol Chem, 0;284(36):24035-48.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC Paraffin-embedded