Mouse IL-1 beta /IL-1F2 Antibody

RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux
Authors: LS da Costa, A Outlioua, A Anginot, K Akarid, D Arnoult
Cell Death Dis, 2019;10(5):346.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice
Authors: R Meng, L Gu, Y Lu, K Zhao, J Wu, H Wang, J Han, Y Tang, B Lu
J. Biol. Chem., 2019;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Authors: MK Akula, MX Ibrahim, EG Ivarsson, OM Khan, IT Kumar, M Erlandsson, C Karlsson, X Xu, M Brisslert, C Brakebusch, D Wang, M Bokarewa, VI Sayin, MO Bergo
Nat Commun, 2019;10(1):3975.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells
Authors: P Wang, X Qi, G Xu, J Liu, J Guo, X Li, X Ma, H Sun
Aging (Albany NY), 2019;11(18):7402-7415.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner
Authors: MR Spalinger, TS Schmidt, M Schwarzfis, L Hering, K Atrott, S Lang, C Gottier, A Geirnaert, C Lacroix, X Dai, DJ Rawlings, AC Chan, C von Mering, G Rogler, M Scharl
J. Clin. Invest., 2019;130(0):2527-2541.
Species: Mouse
Sample Types: Tissue Lysates
Applications: Western Blot

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome
Authors: P Samir, S Kesavardha, DM Patmore, S Gingras, RKS Malireddi, R Karki, CS Guy, B Briard, DE Place, A Bhattachar, BR Sharma, A Nourse, SV King, A Pitre, AR Burton, S Pelletier, RJ Gilbertson, TD Kanneganti
Nature, 2019;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
Authors: MM Hughes, A Hooftman, S Angiari, P Tummala, Z Zaslona, MC Runtsch, AF McGettrick, CE Sutton, C Diskin, M Rooke, S Takahashi, S Sundararaj, MG Casarotto, JE Dahlstrom, EM Palsson-Mc, SC Corr, KHG Mills, RJS Preston, N Neamati, Y Xie, JB Baell, PG Board, LAJ O'Neill
Cell Rep, 2019;29(1):151-161.e5.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Gasdermin D Drives the Nonexosomal Secretion of Galectin-3, an Insulin Signal Antagonist
Authors: Y Chen, H Wang, J Shen, R Deng, X Yao, Q Guo, A Lu, B Sun, Y Zhang, G Meng
J. Immunol., 2019;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Dicer regulates activation of the NLRP3 inflammasome
Authors: DM Ojcius, A Jafari, L Yeruva, CW Schindler, AA Abdul-Sate
PLoS ONE, 2019;14(4):e0215689.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury
Authors: Z Zhang, X Shao, N Jiang, S Mou, L Gu, S Li, Q Lin, Y He, M Zhang, W Zhou, Z Ni
Cell Death Dis, 2018;9(10):983.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
Authors: H He, H Jiang, Y Chen, J Ye, A Wang, C Wang, Q Liu, G Liang, X Deng, W Jiang, R Zhou
Nat Commun, 2018;9(1):2550.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Interleukin-1? Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion
Authors: M Monteleone, AC Stanley, KW Chen, DL Brown, JS Bezbradica, JB von Pein, CL Holley, D Boucher, MR Shakespear, R Kapetanovi, V Rolfes, MJ Sweet, JL Stow, K Schroder
Cell Rep, 2018;24(6):1425-1433.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis
Authors: C Marchetti, B Swartzwelt, MI Koenders, T Azam, IW Tengesdal, N Powers, DM de Graaf, CA Dinarello, LAB Joosten
Arthritis Res. Ther., 2018;20(1):169.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation
Authors: SB Kwak, S Koppula, EJ In, X Sun, YK Kim, MK Kim, KH Lee, TB Kang
Mediators Inflamm., 2018;2018(0):6054069.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration
Authors: E Lee, I Hwang, S Park, S Hong, B Hwang, Y Cho, J Son, JW Yu
Cell Death Differ., 2018;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation
Authors: RG Carroll, Z Zas?ona, S Galván-Peñ, EL Koppe, DC Sévin, S Angiari, M Triantafil, K Triantafil, LK Modis, LA O'Neill
J. Biol. Chem., 2018;293(15):5509-5521.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

HMGB1/IL-1? complexes in plasma microvesicles modulate immune responses to burn injury
Authors: LG Coleman, R Maile, SW Jones, BA Cairns, FT Crews
PLoS ONE, 2018;13(3):e0195335.
Species: Mouse
Sample Types: Protein
Applications: Western Blot

Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis
Authors: M Shahid, MY Lee, A Yeon, E Cho, V Sairam, L Valdiviez, S You, J Kim
Sci Rep, 2018;8(1):10859.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

Tranilast directly targets NLRP3 to treat inflammasome-driven diseases
Authors: Y Huang, H Jiang, Y Chen, X Wang, Y Yang, J Tao, X Deng, G Liang, H Zhang, W Jiang, R Zhou
EMBO Mol Med, 2018;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
Authors: L Kasper, A König, PA Koenig, MS Gresnigt, J Westman, RA Drummond, MS Lionakis, O Gro beta, J Ruland, JR Naglik, B Hube
Nat Commun, 2018;9(1):4260.

Inhibitory Effect and Mechanism ofArctium lappaExtracton NLRP3Inflammasome Activation
Authors: YK Kim, S Koppula, DW Shim, EJ In, SB Kwak, MK Kim, SH Yu, KH Lee, TB Kang
Evid Based Complement Alternat Med, 2018;2018(0):6346734.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ
Authors: Y Chen, X He, X Yuan, J Hong, O Bhat, G Li, PL Li, J Guo
Oxid Med Cell Longev, 2018;2018(0):2901871.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy
Authors: D Sharma, A Malik, C Guy, P Vogel, TD Kanneganti
J. Clin. Invest., 2018;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Cutting Edge: IL-1? and Not IL-1? Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality
Authors: JT Benjamin, DJ Moore, C Bennett, R van der Me, A Royce, R Loveland, JL Wynn
J. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss
Authors: W Zhuang, C Wang, X Shi, S Qiu, S Zhang, B Xu, M Chen, W Jiang, H Dong, Y Qiao
Int. J. Mol. Med., 2018;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia
Authors: C Widmann, C Gandin, A Petit-Pait, M Lazdunski, C Heurteaux
Sci Rep, 2018;8(1):18062.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1? Activation
Authors: JE Vince, D De Nardo, W Gao, AJ Vince, C Hall, K McArthur, D Simpson, S Vijayaraj, LM Lindqvist, P Bouillet, MA Rizzacasa, SM Man, J Silke, SL Masters, G Lessene, DCS Huang, DHD Gray, BT Kile, F Shao, KE Lawlor
Cell Rep, 2018;25(9):2339-2353.e4.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling
Authors: B Koch, AA Barugahare, TL Lo, C Huang, RB Schittenhe, DR Powell, TH Beilharz, A Traven
Cell Rep, 2018;25(8):2244-2258.e7.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation
Authors: JC Santos, MS Dick, B Lagrange, D Degrandi, K Pfeffer, M Yamamoto, E Meunier, P Pelczar, T Henry, P Broz
EMBO J., 2018;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
Authors: D Boucher, M Monteleone, RC Coll, KW Chen, CM Ross, JL Teo, GA Gomez, CL Holley, D Bierschenk, KJ Stacey, AS Yap, JS Bezbradica, K Schroder
J. Exp. Med., 2018;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

REV-ERB? integrates colon clock with experimental colitis through regulation of NF-?B/NLRP3 axis
Authors: S Wang, Y Lin, X Yuan, F Li, L Guo, B Wu
Nat Commun, 2018;9(1):4246.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury
Authors: JL Ross, LF Queme, JE Lamb, KJ Green, MP Jankowski
Biol Sex Differ, 2018;9(1):2.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome
Authors: A Mathur, S Feng, JA Hayward, C Ngo, D Fox, II Atmosukart, JD Price, K Schauer, E Märtlbauer, AAB Robertson, G Burgio, EM Fox, SH Leppla, NO Kaakoush, SM Man
Nat Microbiol, 2018;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
Authors: LH Chu, M Indramohan, RA Ratsimandr, A Gangopadhy, EP Morris, DM Monack, A Dorfleutne, C Stehlik
Nat Commun, 2018;9(1):996.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis
Authors: C Cochain, E Vafadarnej, P Arampatzi, P Jaroslav, H Winkels, K Ley, D Wolf, AE Saliba, A Zernecke
Circ. Res., 2018;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation
Authors: M Tsugita, N Morimoto, M Tashiro, K Kinoshita, M Nakayama
Cell Rep, 2017;18(5):1298-1311.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1?
Authors: Q Zhu, TD Kanneganti
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects
Authors: MK Choo, Y Sano, C Kim, K Yasuda, XD Li, X Lin, M Stenzel-Po, L Alexopoulo, S Ghosh, E Latz, IR Rifkin, ZJ Chen, GC Stewart, H Chong, JM Park
J. Exp. Med., 2017;214(5):1297-1311.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

A new approach for ratiometric in vivo calcium imaging of microglia
Authors: B Brawek, Y Liang, D Savitska, K Li, N Fomin-Thun, Y Kovalchuk, E Zirdum, J Jakobsson, O Garaschuk
Sci Rep, 2017;7(1):6030.

Targeting IRE1 with small molecules counteracts progression of atherosclerosis
Authors: O Tufanli, P Telkoparan, D Acosta-Alv, B Kocaturk, UI Onat, SM Hamid, I €imen, P Walter, C Weber, E Erbay
Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation
Authors: S Yoon, A Kovalenko, K Bogdanov, D Wallach
Immunity, 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Distinct Kinase-Independent Role of RIPK3 in CD11c(+) Mononuclear Phagocytes in Cytokine-Induced Tissue Repair
Authors: K Moriwaki, S Balaji, J Bertin, PJ Gough, FK Chan
Cell Rep, 2017;18(10):2441-2451.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner
Authors: K Zenke, M Muroi, KI Tanamoto
Cell. Signal., 2017;43(0):32-39.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

MTG16 is a tumor suppressor in colitis-associated carcinoma
Authors: EM McDonough, CW Barrett, B Parang, MK Mittal, JJ Smith, AM Bradley, YA Choksi, LA Coburn, SP Short, JJ Thompson, B Zhang, SV Poindexter, MA Fischer, X Chen, J Li, FL Revetta, R Naik, MK Washington, MJ Rosen, SW Hiebert, KT Wilson, CS Williams
JCI Insight, 2017;2(16):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production
Authors: H Ahn, E Jeon, JC Kim, SG Kang, SI Yoon, HJ Ko, PH Kim, GS Lee
Sci Rep, 2017;7(1):1314.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKC�
Authors: HJ Koh, YR Kim, JS Kim, JS Yun, K Jang, CS Yang
PLoS Pathog, 2017;13(1):e1006126.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of Apc(Min/+) mice
Authors: Z Zhong, Y Zhai, P Bu, S Shah, L Qiao
Nat Commun, 2017;8(0):15004.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling
Authors: T Wu, J Zhang, M Geng, SJ Tang, W Zhang, J Shu
Sci Rep, 2017;7(1):4117.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression
Authors: S Ghosh, C Wallerath, S Covarrubia, V Hornung, S Carpenter, KA Fitzgerald
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Interleukin-1 and estrogen protect against disseminating dentoalveolar infections
Authors: H Youssef, P Stashenko
Int J Oral Sci, 2017;9(1):16-23.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

IL-1? transcriptionally activates hepcidin by inducing C/EBP? expression in hepatocytes
Authors: Y Kanamori, M Murakami, M Sugiyama, O Hashimoto, T Matsui, M Funaba
J. Biol. Chem., 2017;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

The P2X7 Receptor Primes IL-1? and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain
Authors: F Albalawi, W Lu, JM Beckel, JC Lim, SA McCaughey, CH Mitchell
Front Cell Neurosci, 2017;11(0):227.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis
Authors: TP Domiciano, D Wakita, HD Jones, TR Crother, WA Verri, M Arditi, K Shimada
Sci Rep, 2017;7(0):41539.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina
Authors: JC Rivera, B Noueihed, A Madaan, I Lahaie, J Pan, J Belik, S Chemtob
J Neuroinflammation, 2017;14(1):181.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome
Authors: R Domingo-Fe, RC Coll, J Kearney, S Breit, LA O'Neill
J. Biol. Chem., 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
Authors: L Freeman, H Guo, CN David, WJ Brickey, S Jha, JP Ting
J. Exp. Med., 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome
Authors: V Neudecker, M Haneklaus, O Jensen, L Khailova, JC Masterson, H Tye, K Biette, P Jedlicka, KS Brodsky, ME Gerich, M Mack, AAB Robertson, MA Cooper, GT Furuta, CA Dinarello, LA O'Neill, HK Eltzschig, SL Masters, EN McNamee
J. Exp. Med., 2017;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants.
Authors: Marty-Roix R, Vladimer G, Pouliot K, Weng D, Buglione-Corbett R, West K, Macmicking J, Chee J, Wang S, Lu S, Lien E
J Biol Chem, 2016;291(3):1123-36.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury
Authors: Jeremy S Duffield
J. Clin. Invest., 2016;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS
Authors: Yong Hwan Park
Nat Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation
PLoS Pathog, 2016;12(12):e1006052.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells
J Leukoc Biol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization

HIF-1? Is an Essential Mediator of IFN-?-Dependent Immunity to Mycobacterium tuberculosis
J Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

TNF?-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury
Proc. Natl. Acad. Sci. U.S.A., 2016;113(50):E8151-E8158.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Lymphatic vessels regulate immune microenvironments in human and murine melanoma
J Clin Invest, 2016;0(0):.
Species: Human
Sample Types: Tissue Homogenates
Applications: Western Blot

The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation
Authors: X Wang, DK Shaw, OS Sakhon, GA Snyder, EJ Sundberg, L Santambrog, FS Sutterwala, JS Dumler, KA Shirey, DJ Perkins, K Richard, AC Chagas, E Calvo, J Kopecký, M Kotsyfakis, JH Pedra
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

CARD9 negatively regulates NLRP3-induced IL-1? production on Salmonella infection of macrophages
Nat Commun, 2016;7(0):12874.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression
Authors: Gang Hu
Int. J. Neuropsychopharmacol., 2016;19(9):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis
Sci Rep, 2016;6(0):39257.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

C13orf31 (FAMIN) is a central regulator of immunometabolic function
Nat Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Enzymatically inactive procaspase-1 stabilizes the ASC-pyroptosome and supports pyroptosome spreading during cell division
J Biol Chem, 2016;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Bead-based Immunoassay

Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection
Oncotarget, 2016;7(26):39316-39331.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

Methylsulfonylmethane inhibits NLRP3 inflammasome activation.
Authors: Ahn H, Kim J, Lee M, Kim Y, Cho Y, Lee G
Cytokine, 2015;71(2):223-31.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.
Authors: Denes A, Coutts G, Lenart N, Cruickshank S, Pelegrin P, Skinner J, Rothwell N, Allan S, Brough D
Proc Natl Acad Sci U S A, 2015;112(13):4050-5.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr

Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules.
Authors: Sadeghi H, Lockmann A, Hund A, Samavedam U, Pipi E, Vafia K, Hauenschild E, Kalies K, Pas H, Jonkman M, Iwata H, Recke A, Schon M, Zillikens D, Schmidt E, Ludwig R
J Immunol, 2015;194(8):3656-63.

Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2.
Authors: Sitaras N, Rivera J, Noueihed B, Bien-Aime M, Zaniolo K, Omri S, Hamel D, Zhu T, Hardy P, Sapieha P, Joyal J, Chemtob S
Am J Pathol, 2015;185(2):581-95.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
Authors: Lawlor K, Khan N, Mildenhall A, Gerlic M, Croker B, D'Cruz A, Hall C, Kaur Spall S, Anderton H, Masters S, Rashidi M, Wicks I, Alexander W, Mitsuuchi Y, Benetatos C, Condon S, Wong W, Silke J, Vaux D, Vince J
Nat Commun, 2015;6(0):6282.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Local immunosuppressive microenvironment enhances migration of melanoma cells to lungs in DJ-1 knockout mice.
Authors: Chien C, Lee M, Liou H, Liou H, Fu W
PLoS ONE, 2015;10(2):e0115827.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice.
Authors: Sester D, Sagulenko V, Thygesen S, Cridland J, Loi Y, Cridland S, Masters S, Genske U, Hornung V, Andoniou C, Sweet M, Degli-Esposti M, Schroder K, Stacey K
J Immunol, 2015;195(3):1233-41.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome.
Authors: Yang C, Kim J, Kim T, Lee P, Kim S, Lee H, Shin D, Nguyen L, Lee M, Jin H, Kim K, Lee C, Kim M, Park S, Kim J, Choi H, Jo E
Nat Commun, 2015;6(0):6115.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.
Authors: Maier N, Leppla S, Moayeri M
J Immunol, 2015;194(6):2776-85.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
Authors: Meunier E, Wallet P, Dreier R, Costanzo S, Anton L, Ruhl S, Dussurgey S, Dick M, Kistner A, Rigard M, Degrandi D, Pfeffer K, Yamamoto M, Henry T, Broz P
, 2015;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.
Authors: Li B, Gurung P, Malireddi R, Vogel P, Kanneganti T, Geiger T
Nat Commun, 2015;6(0):6131.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

Critical role of aquaporins in interleukin 1beta (IL-1beta)-induced inflammation.
Authors: Rabolli V, Wallemme L, Lo Re S, Uwambayinema F, Palmai-Pallag M, Thomassen L, Tyteca D, Octave J, Marbaix E, Lison D, Devuyst O, Huaux F
J Biol Chem, 2014;289(20):13937-47.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes.
Authors: Lim, Yu-Mi, Lim, Hyejin, Hur, Kyu Yeon, Quan, Wenying, Lee, Hae-Youn, Cheon, Hwanju, Ryu, Dongryeo, Koo, Seung-Ho, Kim, Hong Lim, Kim, Jin, Komatsu, Masaaki, Lee, Myung-Sh
Nat Commun, 2014;5(0):4934.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

Critical role for IL-1beta in DNA damage-induced mucositis.
Authors: Kanarek N, Grivennikov S, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul Y, Stachler M, Voronov E, Apte R, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y
Proc Natl Acad Sci U S A, 2014;111(6):E702-11.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

Activation of NLRP3 inflammasome by crystalline structures via cell surface contact.
Authors: Hari A, Zhang Y, Tu Z, Detampel P, Stenner M, Ganguly A, Shi Y
Sci Rep, 2014;4(0):7281.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines.
Authors: Asrat S, Dugan A, Isberg R
PLoS Pathog, 2014;10(7):e1004229.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation.
Authors: Zhao C, Gillette D, Li X, Zhang Z, Wen H
J Biol Chem, 2014;289(24):17020-9.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Endothelial NLRP3 inflammasome activation and enhanced neointima formation in mice by adipokine visfatin.
Authors: Xia M, Boini K, Abais J, Xu M, Zhang Y, Li P
Am J Pathol, 2014;184(5):1617-28.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1beta production in response to beta-glucans and the fungal pathogen, Candida albicans.
Authors: Ganesan S, Rathinam V, Bossaller L, Army K, Kaiser W, Mocarski E, Dillon C, Green D, Mayadas T, Levitz S, Hise A, Silverman N, Fitzgerald K
J Immunol, 2014;193(5):2519-30.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

A critical role for human caspase-4 in endotoxin sensitivity.
Authors: Kajiwara Y, Schiff T, Voloudakis G, Gama Sosa M, Elder G, Bozdagi O, Buxbaum J
J Immunol, 2014;193(1):335-43.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.
Authors: Meunier E, Dick M, Dreier R, Schurmann N, Kenzelmann Broz D, Warming S, Roose-Girma M, Bumann D, Kayagaki N, Takeda K, Yamamoto M, Broz P
Nature, 2014;509(7500):366-70.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes.
Authors: Maier N, Crown D, Liu J, Leppla S, Moayeri M
J Immunol, 2014;192(2):763-70.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

Signaling pathways in murine dendritic cells that regulate the response to vesicular stomatitis virus vectors that express flagellin.
Authors: Smedberg J, Westcott M, Ahmed M, Lyles D
J Virol, 2014;88(2):777-85.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

3,4-methylenedioxy-beta-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.
Authors: He Y, Varadarajan S, Munoz-Planillo R, Burberry A, Nakamura Y, Nunez G
J Biol Chem, 2014;289(2):1142-50.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis.
Authors: Nieto-Torres J, DeDiego M, Verdia-Baguena C, Jimenez-Guardeno J, Regla-Nava J, Fernandez-Delgado R, Castano-Rodriguez C, Alcaraz A, Torres J, Aguilella V, Enjuanes L
PLoS Pathog, 2014;10(5):e1004077.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

RNA and beta-hemolysin of group B Streptococcus induce interleukin-1beta (IL-1beta) by activating NLRP3 inflammasomes in mouse macrophages.
Authors: Gupta R, Ghosh S, Monks B, DeOliveira R, Tzeng T, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock D
J Biol Chem, 2014;289(20):13701-5.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome.
Authors: Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, Akira S
Nat Immunol, 2013;14(5):454-60.
Species: Mouse
Sample Types: Peritoneal Fluid
Applications: Western Blot

Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.
Authors: El-Zaatari M, Kao J, Tessier A, Bai L, Hayes M, Fontaine C, Eaton K, Merchant J
PLoS ONE, 2013;8(3):e58935.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways.
Authors: Li B, Shi Y, Shu J, Gao J, Wu P, Tang S
J Biol Chem, 2013;288(19):13610-9.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

The role of IL-1beta in the early tumor cell-induced angiogenic response.
Authors: Carmi Y, Dotan S, Rider P, Kaplanov I, White M, Baron R, Abutbul S, Huszar M, Dinarello C, Apte R, Voronov E
J Immunol, 2013;190(7):3500-9.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice.
Authors: Tanaka S, Ishii A, Ohtaki H, Shioda S, Yoshida T, Numazawa S
J Neuroinflammation, 2013;10(0):143.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.
Authors: Broz P, Ruby T, Belhocine K, Bouley D, Kayagaki N, Dixit V, Monack D
Nature, 2012;490(7419):288-91.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Authors: Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J
Nature, 2012;492(7427):123-7.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.
Authors: Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, Steele C
Infect. Immun., 2012;80(1):410-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization

Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis.
Authors: Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, Voronov E, Apte RN
J. Immunol., 2011;186(6):3462-71.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

Coordinated Host Responses during Pyroptosis: Caspase-1-Dependent Lysosome Exocytosis and Inflammatory Cytokine Maturation.
Authors: Bergsbaken T, Fink SL, den Hartigh AB, Loomis WP, Cookson BT
J. Immunol., 2011;187(5):2748-54.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

Toll-like receptor 2 contributes to chemokine gene expression and macrophage infiltration in the dorsal root ganglia after peripheral nerve injury.
Authors: Kim D, You B, Lim H, Lee SJ
Mol Pain, 2011;7(0):74.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC

IL-1alpha and IL-1beta recruit different myeloid cells and promote different stages of sterile inflammation.
Authors: Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN
J. Immunol., 2011;187(9):4835-43.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
Authors: Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS
J. Clin. Invest., 2011;121(10):3846-59.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages.
Authors: McCoy AJ, Koizumi Y, Toma C, Higa N, Dixit V, Taniguchi S, Tschopp J, Suzuki T
Eur. J. Immunol., 2010;40(10):2797-803.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes.
Authors: Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA
Nat. Immunol., 2010;11(10):897-904.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Tyrosine kinase 2 controls IL-1beta production at the translational level.
Authors: Radwan M, Stiefvater R, Grunert T, Sharif O, Miller I, Marchetti-Deschmann M, Allmaier G, Gemeiner M, Knapp S, Kovarik P, Muller M, Strobl B
J. Immunol., 2010;185(6):3544-53.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis.
Authors: Yoshida H, Russell J, Senchenkova EY, Almeida Paula LD, Granger DN
Am. J. Pathol., 2010;177(6):2774-81.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.
Authors: Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA
J. Immunol., 2009;183(6):4021-30.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice.
Authors: Hyvarinen K, Tuomainen AM, Laitinen S, Bykov IL, Tormakangas L, Lindros K, Käkelä R, Alfthan G, Salminen I, Jauhiainen M, Kovanen PT, Leinonen M, Saikku P, Pussinen PJ
Infect. Immun., 2009;77(8):3442-9.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Authors: Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L
Nat. Med., 2009;15(10):1170-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.
Authors: Maelfait J, Vercammen E, Janssens S, Schotte P, Haegman M, Magez S, Beyaert R
J. Exp. Med., 2008;205(9):1967-73.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death.
Authors: Das S, Mishra MK, Ghosh J, Basu A
J. Neuroimmunol., 2008;195(1):60-72.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi.
Authors: Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonca-Previato L, Nobrega A, Bellio M
J. Leukoc. Biol., 2007;82(3):488-96.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice.
Authors: Pozsgai G, Sandor K, Perkecz A, Szolcsanyi J, Helyes Z, Brain SD, Pinter E
Inflamm. Res., 2007;56(11):459-67.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo.
Authors: Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL
J. Immunol., 2007;179(10):6933-42.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1beta.
Authors: Ogiso T, Nagaki M, Takai S, Tsukada Y, Mukai T, Kimura K, Moriwaki H
J. Hepatol., 2007;47(6):816-25.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
Authors: Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI
Genes Dev., 2006;20(18):2527-38.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization

Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration.
Authors: Perrin FE, Lacroix S, Aviles-Trigueros M, David S
Brain, 2005;128(0):854-66.
Species: Mouse
Sample Types:
Applications: Neutralization

Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum.
Authors: Banks WA, Farr SA, La Scola ME
J. Pharmacol. Exp. Ther., 2001;299(2):536-41.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization

Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
Authors: Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Schaefer R, Grone HJ, Schaefer L
J Biol Chem, 0;284(36):24035-48.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P