Compounds for Neural Stem Cell Research: Products


Neural stem cells (NSCs) are a population of adult cells with self-renewal and differentiation capacities. A major focus for NSC researchers is investigating the use of NSCs to combat age-related neurological disorders. Studies have shown that cell death associated with neurodegenerative diseases like Parkinsons disease may be ameliorated by promoting the proliferation and differentiation of endogenous NSCs. As for other stem cell types, the addition of small molecules, available from Tocris, to culture media can enhance NSC proliferation or induce differentiation. For example, the compound SB 203580 selectively inhibits p38 MAPK activity and stimulates neural stem cell proliferation. In addition, 1-Oleoyl lysophosphatidic acid (LPA) sodium salt, an agonist of LPA receptors, inhibits human embryonic stem cell-derived NSC differentiation. The use of small molecules can also enhance stem cell differentiation into cells of neuronal and glial lineages. For example, mesenchymal stem cells differentiate into cells of the neural lineage and express increased levels of the neuronal markers beta-III Tubulin and Enolase-2 when treated with the synthetic compound, C18H17N3O3.

"Compounds for Neural Stem Cell Research" has 36 results in Products.
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Y-27632 dihydrochloride

Selective p160ROCK inhibitor

SB 431542

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

CHIR 99021

Highly selective GSK-3 inhibitor

A 83-01

Selective inhibitor of TGF-βRI, ALK4 and ALK7


Adenylyl cyclase activator


γ-secretase inhibitor

Dorsomorphin dihydrochloride

Potent AMPK inhibitor

Metformin hydrochloride

Activator of LKB1/AMPK; antidiabetic agent


Selective ALK2 inhibitor

Retinoic acid

Endogenous retinoic acid receptor agonist

SB 203580

Selective inhibitor of p38 MAPK

SU 5402

Potent FGFR and VEGFR inhibitor

Valproic acid, sodium salt

Histone deacetylase inhibitor

1-Oleoyl lysophosphatidic acid sodium salt

Endogenous agonist of LPA1 and LPA2

Fluoxetine hydrochloride

5-HT reuptake inhibitor


Inhibitor of Hedgehog (Hh) signaling


Selective Hsp90 inhibitor


Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation

PD 173074

FGFR1 and -3 inhibitor


Potent, selective GSK-3 inhibitor


Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

Ciliobrevin A

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

Pifithrin-α hydrobromide

p53 inhibitor. Also aryl hydrocarbon receptor agonist

TCS 2210

Inducer of neuronal differentiation in MSCs

Amiodarone hydrochloride

Broad spectrum ion channel blocker; antiarrhythmic


NAMPT activator; also proneurogenic and neuroprotective


Inhibitor of 20S proteasome; immunosuppressant


Induces neurogenesis in mature skeletal muscle cells

TWS 119

GSK-3β inhibitor; induces neuronal differentiation in ESCs

EC 23

Synthetic retinoid; induces differentiation of stem cells

KHS 101 hydrochloride

Selective inducer of neuronal differentiation in hippocampal neural progenitors


DYRK1A/B inhibitor


Selective inducer of neuronal differentiation in hippocampal neural progenitors


Group III mGlu agonist

SB 431542

SB 431542 synthesized to cGMP guidelines


DAPT synthesized to cGMP guidelines
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