Compounds for Neural Stem Cell Research: Products

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Neural stem cells (NSCs) are a population of adult cells with self-renewal and differentiation capacities. A major focus for NSC researchers is investigating the use of NSCs to combat age-related neurological disorders. Studies have shown that cell death associated with neurodegenerative diseases like Parkinsons disease may be ameliorated by promoting the proliferation and differentiation of endogenous NSCs. As for other stem cell types, the addition of small molecules, available from Tocris, to culture media can enhance NSC proliferation or induce differentiation. For example, the compound SB 203580 selectively inhibits p38 MAPK activity and stimulates neural stem cell proliferation. In addition, 1-Oleoyl lysophosphatidic acid (LPA) sodium salt, an agonist of LPA receptors, inhibits human embryonic stem cell-derived NSC differentiation. The use of small molecules can also enhance stem cell differentiation into cells of neuronal and glial lineages. For example, mesenchymal stem cells differentiate into cells of the neural lineage and express increased levels of the neuronal markers beta-III Tubulin and Enolase-2 when treated with the synthetic compound, C18H17N3O3.

"Compounds for Neural Stem Cell Research" has 39 results in Products.
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Y-27632 dihydrochloride 

Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component

Y-27632 dihydrochloride 

Y-27632 synthesized to cGMP guidelines

SB 431542 

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

SB 431542 

SB 431542 synthesized to cGMP guidelines

CHIR 99021 

Highly selective GSK-3 inhibitor; acts as Wnt activator

CHIR 99021 

CHIR 99021 synthesized to cGMP guidelines

A 83-01 

Selective inhibitor of TGF-βRI, ALK4 and ALK7

DAPT 

Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

Forskolin 

Adenylyl cyclase activator

Dorsomorphin dihydrochloride 

Potent AMPK inhibitor; also BMP type I receptor inhibitor

DMH-1 

Selective ALK2 inhibitor

Retinoic acid 

Endogenous retinoic acid receptor agonist

SB 203580 

Selective inhibitor of p38 MAPK

Valproic acid, sodium salt 

Histone deacetylase inhibitor

1-Oleoyl lysophosphatidic acid sodium salt 

Endogenous agonist of LPA1 and LPA2

Fluoxetine hydrochloride 

5-HT reuptake inhibitor

Metformin hydrochloride 

Activator of LKB1/AMPK; antidiabetic agent

Cyclopamine 

Inhibitor of Hedgehog (Hh) signaling

SU 5402 

Potent FGFR and VEGFR inhibitor

PD 173074 

FGFR1 and -3 inhibitor

20(S)-Hydroxycholesterol 

Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation

DAPT 

DAPT synthesized to Ancillary Material Grade

Pifithrin-α hydrobromide 

p53 inhibitor. Also aryl hydrocarbon receptor agonist

17-AAG 

Selective Hsp90 inhibitor

BIO 

Potent GSK-3 inhibitor; also inhibits cdks

EC 23 

Synthetic retinoid; induces differentiation of stem cells

ISX 9 

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

Neurodazine 

Induces neurogenesis in mature skeletal muscle cells

TCS 2210 

Inducer of neuronal differentiation in MSCs

Amiodarone hydrochloride 

Broad spectrum ion channel blocker; antiarrhythmic

KHS 101 hydrochloride 

Selective inducer of neuronal differentiation in hippocampal neural progenitors

INDY 

DYRK1A/B inhibitor

Neuropathiazol 

Selective inducer of neuronal differentiation in hippocampal neural progenitors

P7C3 

NAMPT activator; also proneurogenic and neuroprotective

Ciliobrevin A 

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

ML 184 

Selective GPR55 agonist; also promotes NSC proliferation and differentiation

A 83-01 

A 83-01 synthesized to Ancillary Material Grade

ISX 9 

ISX 9 synthesized to Ancillary Material Grade

T3 

T3 synthesized to Ancillary Material Grade
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