Compounds for Neural Stem Cell Research: Products


Neural stem cells (NSCs) are a population of adult cells with self-renewal and differentiation capacities. A major focus for NSC researchers is investigating the use of NSCs to combat age-related neurological disorders. Studies have shown that cell death associated with neurodegenerative diseases like Parkinsons disease may be ameliorated by promoting the proliferation and differentiation of endogenous NSCs. As for other stem cell types, the addition of small molecules, available from Tocris, to culture media can enhance NSC proliferation or induce differentiation. For example, the compound SB 203580 selectively inhibits p38 MAPK activity and stimulates neural stem cell proliferation. In addition, 1-Oleoyl lysophosphatidic acid (LPA) sodium salt, an agonist of LPA receptors, inhibits human embryonic stem cell-derived NSC differentiation. The use of small molecules can also enhance stem cell differentiation into cells of neuronal and glial lineages. For example, mesenchymal stem cells differentiate into cells of the neural lineage and express increased levels of the neuronal markers beta-III Tubulin and Enolase-2 when treated with the synthetic compound, C18H17N3O3.

"Compounds for Neural Stem Cell Research" has 40 results in Products.
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Y-27632 dihydrochloride 

Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component

Y-27632 dihydrochloride 

Y-27632 synthesized to cGMP guidelines

SB 431542 

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

SB 431542 

SB 431542 synthesized to cGMP guidelines

CHIR 99021 

Highly selective GSK-3 inhibitor; acts as Wnt activator

CHIR 99021 

CHIR 99021 synthesized to cGMP guidelines

A 83-01 

Selective inhibitor of TGF-βRI, ALK4 and ALK7


Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling


Adenylyl cyclase activator


Selective ALK2 inhibitor

Dorsomorphin dihydrochloride 

Potent AMPK inhibitor; also BMP type I receptor inhibitor

SB 203580 

Selective inhibitor of p38 MAPK

Retinoic acid 

Endogenous retinoic acid receptor agonist

1-Oleoyl lysophosphatidic acid sodium salt 

Endogenous agonist of LPA1 and LPA2


DAPT synthesized to Ancillary Material Grade

Valproic acid, sodium salt 

Histone deacetylase inhibitor

SU 5402 

Potent FGFR and VEGFR inhibitor

Fluoxetine hydrochloride 

5-HT reuptake inhibitor


Inhibitor of Hedgehog (Hh) signaling

Metformin hydrochloride 

Activator of LKB1/AMPK; antidiabetic agent

PD 173074 

FGFR1 and -3 inhibitor


Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation

Pifithrin-α hydrobromide 

p53 inhibitor. Also aryl hydrocarbon receptor agonist


Selective Hsp90 inhibitor


Potent GSK-3 inhibitor; also inhibits cdks

EC 23 

Synthetic retinoid; induces differentiation of stem cells

ISX 9 

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

Ciliobrevin A 

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein


T3 synthesized to Ancillary Material Grade


Induces neurogenesis in mature skeletal muscle cells

Amiodarone hydrochloride 

Broad spectrum ion channel blocker; antiarrhythmic

KHS 101 hydrochloride 

Selective inducer of neuronal differentiation in hippocampal neural progenitors


DYRK1A/B inhibitor


Selective inducer of neuronal differentiation in hippocampal neural progenitors


NAMPT activator; also proneurogenic and neuroprotective

ML 184 

Selective GPR55 agonist; also promotes NSC proliferation and differentiation

A 83-01 

A 83-01 synthesized to Ancillary Material Grade

ISX 9 

ISX 9 synthesized to Ancillary Material Grade

WS 6 

Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons


Potent and high affinity Smo receptor agonist
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