IgA-Producing B Cells in the Intestine

An overview of intestinal IgA-B cell development is shown below.

Interactive Pathways

ProductsClose
B7-H1
B7-H1
ProductsClose
ProductsClose
B7-H2
B7-H2
ProductsClose
ProductsClose
PD-L2
PD-L2
ProductsClose
BAFF R
BAFF R
BCMA
BCMA
TACI
TACI
CD40
CD40
Lymphotoxin alpha1 /beta2
Lymphotoxin alpha1 /beta2
Integrin alpha 4 beta 1
Integrin alpha 4 beta 1
Integrin alpha 4 beta 7
Integrin alpha 4 beta 7
Integrin alpha L beta 2
Integrin alpha L beta 2
ProductsClose
CD21
CD21
ProductsClose
ProductsClose
CD35
CD35
ProductsClose
ProductsClose
CXCR5
CXCR5
ProductsClose
ProductsClose
CD84
CD84
ProductsClose
NTB-A
NTB-A
ProductsClose
PU.1
PU.1
ProductsClose
ProductsClose
Pax5
Pax5
ProductsClose
BCMA
BCMA
ProductsClose
CCR9
CCR9
ProductsClose
ProductsClose
CCR10
CCR10
ProductsClose
ProductsClose
IgA
IgA
ProductsClose
BLIMP1
BLIMP1
ProductsClose
XBP1
XBP1
ProductsClose
BCMA
BCMA
ProductsClose
CCR6
CCR6
ProductsClose
ProductsClose
TLR2
TLR2
BLIMP1
BLIMP1
IgA
IgA
ProductsClose
iNOS
iNOS
ProductsClose
TNF-alpha
TNF-alpha
ProductsClose
TLR2
TLR2
TLR4
TLR4
ProductsClose
TLR5
TLR5
ProductsClose
Fc gamma RII/CD32
Fc gamma RII/CD32
Fc gamma RIII/CD16
Fc gamma RIII/CD16
ProductsClose
CD36/SR-B3
CD36/SR-B3
ProductsClose
ProductsClose
CD35
CD35
ProductsClose
ProductsClose
CD21
CD21
ProductsClose
ICAM-1
ICAM-1
VCAM-1
VCAM-1
ProductsClose
MAdCAM-1
MAdCAM-1
ProductsClose
ProductsClose
NF kappa B1
NF kappa B1
ProductsClose
TLR9
TLR9
ProductsClose
APRIL
APRIL
BAFF
BAFF
CXCL13
CXCL13
IL-5
IL-5
IL-5
IL-5
IL-6
IL-6
ProductsClose
Retinoic Acid
Retinoic Acid
Retinoic Acid
Retinoic Acid
TGF-beta
TGF-beta
CXCL13
CXCL13
TGF-beta
TGF-beta
TGF-beta
TGF-beta
TGF-beta
TGF-beta
TGF-beta
TGF-beta
ProductsClose
BTLA
BTLA
ProductsClose
ProductsClose
CD28
CD28
ProductsClose
ProductsClose
CTLA-4
CTLA-4
ProductsClose
ProductsClose
ICOS
ICOS
ProductsClose
ProductsClose
PD-1
PD-1
ProductsClose
ProductsClose
CD84
CD84
ProductsClose
NTB-A
NTB-A
ProductsClose
SLAM
SLAM
ProductsClose
OX40
OX40
CD40 Ligand
CD40 Ligand
ProductsClose
CXCR5
CXCR5
ProductsClose
ProductsClose
Bcl-6
Bcl-6
ProductsClose
CXCL13
CXCL13
IL-4
IL-4
ProductsClose
IL-21
IL-21
ProductsClose
ProductsClose
BTLA
BTLA
ProductsClose
ProductsClose
CD28
CD28
ProductsClose
ProductsClose
CTLA-4
CTLA-4
ProductsClose
ProductsClose
ICOS
ICOS
ProductsClose
ProductsClose
PD-1
PD-1
ProductsClose
ProductsClose
CXCR5
CXCR5
ProductsClose
CD25/IL-2 R alpha
CD25/IL-2 R alpha
GITR
GITR
Integrin alpha E/CD103
Integrin alpha E/CD103
ProductsClose
KLRG1
KLRG1
ProductsClose
ProductsClose
Bcl-6
Bcl-6
ProductsClose
ProductsClose
FoxP3
FoxP3
ProductsClose
CXCL13
CXCL13
IL-10
IL-10
APRIL
APRIL
BAFF
BAFF
IL-4
IL-4
ProductsClose
IL-10
IL-10
IL-21
IL-21
ProductsClose
ProductsClose
ProductsClose

Overview of IgA-B Cell Pathway

IgA is the dominant class of immuoglobulins in the intestine and is key to host immunity. In the lamina propria, which lies between the intestinal epithelium and muscle wall, follicular dendritic cells (FDC) produce the chemokine CXCL13/BLC/BCA-1 to attract CXCR5-expressing B cells, T follicular helper cells (Tfh), and T follicular regulatory cells (Tfr). Immature B cells are exposed to antigen by direct contact with FDC. B cells also interact with Tfh and Tfr cells through co-stimulatory or inhibitory proteins in the B7/CD28 and SLAM families. These cell clusters constitute the immune follicles characteristic of gut-associated lymphoid tissue (GALT) and are known as Peyer’s patches. In a Peyer’s patch, the combination of cell-cell contacts and cytokines produced by FDC, Tfh, and Tfr cells induce the B cell to undergo immunoglobulin class-switching to IgA and become a rapidly-dividing plasmablast. Additional FDC-derived factors induce the plasmablast to enter the circulation, home to the intestinal mucosa (via newly upregulated Integrin alpha 4 beta 7, CCR9, and CCR10), and develop into a plasma cell. Plasma cells secrete large amounts of IgA which binds to the receptor pIgR on enterocytes for transport across the epithelium. Secretory IgA (sIgA) in the intestinal lumen is trapped in the mucous layer where it functions as a critical component of host immunity to intestinal pathogens as well as immune tolerance to commensal microbiota.

IgA-Producing B Cells in the Intestine background image 1