Proteome Profiler Human Cytokine Array Kit
Proteome Profiler Human Cytokine Array Kit Summary
A membrane-based antibody array for the parallel determination of the relative levels of selected human cytokines and chemokines. Validated for analyte detection in cell culture supernates, cell lysates, tissue lysates, serum, plasma, saliva, urine, and human milk.
Key Benefits
- Detects 36 human cytokines, chemokines, and acute phase proteins simultaneously
- Requires no specialized equipment
Principle of the Assay
The Proteome Profiler Human Cytokine Array Kit is a membrane-based sandwich immunoassay. Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2). Captured proteins are visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of analyte bound.
Why Use an Antibody Array to Detect Multiple Cytokines?
Determining the expression of multiple cytokines in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple cytokines in a single sample can be cost-effective and also save time and sample.
- Rectangular 4-Well Multi-dish
- Human Cytokine Array, Panel A nitrocellulose membranes spotted with 36 different antibodies to human cytokines, chemokines, and acute phase proteins
- Array Buffer 4
- Array Buffer 5
- Chemi Reagent 1
- Chemi Reagent 2
- Detection Antibody Cocktail, Human Cytokine Array
- Streptavidin-HRP
- Transparency Overlay Template
- Wash Buffer Concentrate (25X)
For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.
Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample. | ||
C5a | IL-4 | IL-27 |
CD40 Ligand | IL-5 | IL-32 alpha |
G-CSF | IL-6 | CXCL10/IP-10 |
GM-CSF | IL-8 | CXCL11/I-TAC |
CXCL1/GRO alpha | IL-10 | CCL2/MCP-1 |
CCL1/I-309 | IL-12 p70 | MIF |
ICAM-1 | IL-13 | MIP-1 alpha/MIP-1 beta |
IFN-gamma | IL-16 | CCL5/RANTES |
IL-1 alpha | IL-17 | CXCL12/SDF-1 |
IL-1 beta | IL-17E | Serpin E1/PAI-1 |
IL-1ra | IL-18 | TNF-alpha |
IL-2 | IL-21 | TREM-1 |
Assays for Analytes represented in the Human Cytokine Array Kit
Analyte | Quantikine® ELISA Kits | Quantikine® HS (High Sensitivity) ELISA Kits | QuantiGlo® ELISA Kits | DuoSet® ELISA Development Systems |
C5a | DY2037 | |||
CD40 Ligand | DCDL40 | DY617 | ||
G-CSF | DCS50 | HSTCS0 | DY214 | |
GM-CSF | DGM00 | HSGM0 | DY215 | |
CXCL1/GRO alpha | DGR00 | DY275 | ||
CCL1/I-309 | DY272 | |||
ICAM-1 | DCIM00 | DY720 | ||
IFN-gamma | DIF50 | DY285 | ||
IL-1 alpha | DLA50 | DY200 | ||
IL-1 beta | DLB50 | HSLB00C | QLB00B | DY201 |
IL-1ra | DRA00B | DY280 | ||
IL-2 | D2050 | Q2000B | DY202 | |
IL-4 | D4050 | HS400 | DY204 | |
IL-5 | D5000B | DY205 | ||
IL-6 | D6050 | HS600B | Q6000B | DY206 |
CXCL8/IL-8 | D8000C | HS800 | Q8000B | DY208 |
IL-10 | D1000B | HS100C | Q1000 | DY217B |
IL-12 p70 | D1200 | HS120 | DY1270 | |
IL-13 | D1300B | DY213 | ||
IL-16 | D1600 | DY316 | ||
IL-17 | D1700 | DY317 | ||
IL-17E | ||||
IL-18 | 7620 | |||
IL-21 | ||||
IL-27 | ||||
IL-32 alpha | ||||
CXCL10/IP-10 | DIP100 | DY266 | ||
CXCL11/I-TAC | DCX110 | DY672 | ||
CCL2/MCP-1 | DCP00 | DY279 | ||
MIF | DMF00B | DY289 | ||
CCL3/MIP-1 alpha | DMA00 | DY270 | ||
CCL4/MIP-1 beta | DMB00 | DY271 | ||
Serpin E1/PAI-1 | DSE100, DTSE100 | |||
CCL5/RANTES | DRN00B | DY278 | ||
CXCL12/SDF-1 | DSA00 | DY350 | ||
TNF-alpha | DTA00C | HSTA00D | QTA00B | DY210 |
TREM-1 | DTRM10B | DY1278B |
Specifications
Product Datasheets
Data Example
The Human Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates. The amount of cell culture supernate used on each array and the duration of exposure to X-ray film is indicated below. Profiles of mean spot pixel density were created using a transmission-mode scanner and image analysis software. 1A: THP-1 human acute monocytic leukemia cells were untreated or treated with 1 µg/mL LPS for 4 hours, then 5mM Nigericin (Tocris, Catalog # 4312) for 1 hour (50 µL of cell culture supernate, 10 minute exposure). 1B: SW480 human colorectal adenocarcinoma cells were untreated or treated with 100 ng/mL LPS for 24 hours (500 µL of cell culture supernate, 10 minute exposure).
The Human Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell lysates. The amount of cell lysate used on each array and the duration of exposure to X-ray film is indicated below. Profiles of mean spot pixel density were created using a transmission-mode scanner and image analysis software. 2A: SW1353 human chondrosarcoma cells were untreated or treated with 5 ng/mL recombinant human IL-1 alpha (R&D Systems, Catalog # 200-LA) and 10 ng/mL recombinant human OSM (R&D Systems, Catalog # 295-OM) for 24 hours (200 µg of cell lysate, 5 minute exposure). 2B: THP-1 human acute monocytic leukemia cells were untreated or treated with 1 µg/mL recombinant human IFN-gamma (R&D Systems, Catalog # 285-IF) for 8 hours, then 1 µg/mL LPS for 16 hours (200 µg of cell lysate, 5 minute exposure).
The Human Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in tissue lysate samples.
200 µg of tissue lysate was run on each array. Data shown are from a 5 minute exposure to X-ray film.
1. ICAM-1/CD54
2. MIF
3. Complment Component C5/C5a
4. CXCL1/GRO alpha
5. IL-8
6. IL-16
7. IL-18
8. CCL5/RANTES
9. IL-1ra/IL-1F3
10. Serpin E1/PAI-1
Citations for Proteome Profiler Human Cytokine Array Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Inhibiting Monocyte Recruitment to Prevent the Pro-Tumoral Activity of Tumor-Associated Macrophages in Chondrosarcoma
Authors: M Minopoli, S Sarno, G Di Carlucc, R Azzaro, S Costantini, F Fazioli, M Gallo, G Apice, L Cannella, D Rea, MP Stoppelli, D Boraschi, A Budillon, K Scotlandi, A De Chiara, MV Carriero
Cells, 2020;9(4):. 2020
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A functional genetic screen defines the AKT-induced senescence signaling network
Authors: KT Chan, S Blake, H Zhu, J Kang, AS Trigos, PB Madhamshet, J Diesch, L Paavolaine, P Horvath, RD Hannan, AJ George, E Sanij, KM Hannan, KJ Simpson, RB Pearson
Cell Death Differ., 2020;27(2):725-741. 2020
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Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer
Authors: PM Witschen, TS Chaffee, NJ Brady, DN Huggins, TP Knutson, RS LaRue, SA Munro, L Tiegs, JB McCarthy, AC Nelson, KL Schwertfeg
Cancers (Basel), 2020;12(5):. 2020
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Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
Authors: F Pelon, B Bourachot, Y Kieffer, I Magagna, F Mermet-Mei, I Bonnet, A Costa, AM Givel, Y Attieh, J Barbazan, C Bonneau, L Fuhrmann, S Descroix, D Vignjevic, P Silberzan, MC Parrini, A Vincent-Sa, F Mechta-Gri
Nat Commun, 2020;11(1):404. 2020
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Impaired microRNA processing in neutrophils from rheumatoid arthritis patients confers their pathogenic profile. Modulation by biological therapies
Authors: I Arias de l, C Perez-Sanc, P Ruiz-Limon, A Patiño-Tri, C Torres-Gra, Y Jimenez-Go, MDC Abalos-Agu, I Cecchi, R Ortega, MA Caracuel, J Calvo-Guti, A Escudero-C, E Collantes-, C Lopez-Pedr, N Barbarroja
Haematologica, 2020;0(0):. 2020
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STAT3 Relays a Differential Response to Melanoma-Associated NRAS Mutations
Authors: J Kim, D Novak, C Sachpekidi, J Utikal, L Larribère
Cancers (Basel), 2020;12(1):. 2020
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Relation of Macrophage Migration Inhibitory Factor to Pulmonary Hemodynamics and Vascular Structure and Carbamyl-Phosphate Synthetase I Genetic Variations in Pediatric Patients with Congenital Cardiac Shunts
Authors: NY Maeda, VD Aiello, PC Santos, AM Thomaz, LJ Kajita, SP Bydlowski, AA Lopes
Mediators Inflamm., 2019;2019(0):7305028. 2019
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Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase
Authors: PG Jobin, N Solis, Y Machado, PA Bell, NH Kwon, S Kim, CM Overall, GS Butler
J. Biol. Chem., 2019;0(0):. 2019
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Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts
Authors: MA Eckert, F Coscia, A Chryplewic, JW Chang, KM Hernandez, S Pan, SM Tienda, DA Nahotko, G Li, I Blaženovi?, RR Lastra, M Curtis, SD Yamada, R Perets, SM McGregor, J Andrade, O Fiehn, RE Moellering, M Mann, E Lengyel
Nature, 2019;0(0):. 2019
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Loss of zinc-finger protein 143 contributes to tumour progression by interleukin-8-CXCR axis in colon cancer
Authors: V Verma, AR Paek, BK Choi, EK Hong, HJ You
J. Cell. Mol. Med., 2019;0(0):. 2019
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Lysosomal trapping of palbociclib and its functional implications
Authors: S Llanos, D Megias, C Blanco-Apa, E Hernández-, M Rovira, F Pietrocola, M Serrano
Oncogene, 2019;0(0):. 2019
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Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner
Authors: J Nehls, R Businger, M Hoffmann, C Brinkmann, B Fehrenbach, M Schaller, B Maurer, C Schönfeld, D Kramer, S Hailfinger, S Pöhlmann, M Schindler
Cell Rep, 2019;26(7):1841-1853.e6. 2019
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Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor
Authors: A Gartung, J Yang, VP Sukhatme, DR Bielenberg, D Fernandes, J Chang, BA Schmidt, SH Hwang, D Zurakowski, S Huang, MW Kieran, BD Hammock, D Panigrahy
Proc. Natl. Acad. Sci. U.S.A., 2019;116(5):1698-1703. 2019
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Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
Authors: I Kurelac, L Iommarini, R Vatrinet, LB Amato, M De Luise, G Leone, G Girolimett, N Umesh Gane, VL Bridgeman, L Ombrato, M Columbaro, M Ragazzi, L Gibellini, M Sollazzo, RG Feichtinge, S Vidali, M Baldassarr, S Foriel, M Vidone, A Cossarizza, D Grifoni, B Kofler, I Malanchi, AM Porcelli, G Gasparre
Nat Commun, 2019;10(1):903. 2019
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Transient Mitomycin C-treatment of human corneal epithelial cells and fibroblasts alters cell migration, cytokine secretion, and matrix accumulation
Authors: S Pal-Ghosh, G Tadvalkar, VR Lieberman, X Guo, JD Zieske, A Hutcheon, MA Stepp
Sci Rep, 2019;9(1):13905. 2019
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Anti ?-enolase antibody is a novel autoimmune biomarker for unexplained recurrent miscarriages
Authors: Y Ye, C Kuhn, M Kösters, GJ Arnold, H Ishikawa-A, C Schulz, N Rogenhofer, CJ Thaler, S Mahner, T Fröhlich, U Jeschke, V von Schönf
EBioMedicine, 2019;0(0):. 2019
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1?,25(OH)2D3 attenuates IL-6 and IL-1?-mediated inflammatory responses in macrophage conditioned medium-stimulated human white preadipocytes by modulating p44/42 MAPK and NF-?B signaling pathways
Authors: J Zhu, C Bing, JPH Wilding
Diabetol Metab Syndr, 2019;11(0):9. 2019
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Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity
Authors: M Dall, SAJ Trammell, M Asping, AS Hassing, M Agerholm, SG Vienberg, MP Gillum, S Larsen, JT Treebak
J. Biol. Chem., 2019;0(0):. 2019
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KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis
Authors: MC Wu, HH Cheng, TS Yeh, YC Li, TJ Chen, WY Sit, CP Chuu, HJ Kung, S Chien, WC Wang
Cell Death Dis, 2019;10(2):68. 2019
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Fundamental differences in patterns of retinal ageing between primates and mice
Authors: JH Kam, TW Weinrich, H Shinhmar, MB Powner, NW Roberts, A Aboelnour, G Jeffery
Sci Rep, 2019;9(1):12574. 2019
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The efficacy of conditioned medium released by tonsil-derived mesenchymal stem cells in a chronic murine colitis model
Authors: KE Lee, SA Jung, YH Joo, EM Song, CM Moon, SE Kim, I Jo
PLoS ONE, 2019;14(12):e0225739. 2019
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Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes
Authors: R Riise, L Odqvist, J Mattsson, S Monkley, SM Abdillahi, C Tyrchan, D Muthas, LF Yrlid
Sci Rep, 2019;9(1):20407. 2019
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Ginsenoside Rh2 Ameliorates Atopic Dermatitis in NC/Nga Mice by Suppressing NF-kappaB-Mediated Thymic Stromal Lymphopoietin Expression and T Helper Type 2 Differentiation
Authors: E Ko, S Park, JH Lee, CH Cui, J Hou, MH Kim, SC Kim
Int J Mol Sci, 2019;20(24):. 2019
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Neutrophil Activities in Human Ocular Toxoplasmosis: An In Vitro Study With Human Cells
Authors: LM Ashander, S Lie, Y Ma, E Rochet, JM Washington, JM Furtado, B Appukuttan, JR Smith
Invest. Ophthalmol. Vis. Sci., 2019;60(14):4652-4660. 2019
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A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma
Authors: I Kurelac, A Abarrategi, M Ragazzi, L Iommarini, N Umesh Gane, T Snoeks, D Bonnet, AM Porcelli, I Malanchi, G Gasparre
J Clin Med, 2019;8(12):. 2019
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Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice
Authors: SA Scarneo, LS Eibschutz, PJ Bendele, KW Yang, J Totzke, P Hughes, DA Fox, TAJ Haystead
Arthritis Res. Ther., 2019;21(1):292. 2019
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Therapeutic effect of mesenchymal stem cells derived from human umbilical cord in rabbit temporomandibular joint model of osteoarthritis
Authors: H Kim, G Yang, J Park, J Choi, E Kang, BK Lee
Sci Rep, 2019;9(1):13854. 2019
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Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
Authors: H Maekawa, T Inoue, H Ouchi, TM Jao, R Inoue, H Nishi, R Fujii, F Ishidate, T Tanaka, Y Tanaka, N Hirokawa, M Nangaku, R Inagi
Cell Rep, 2019;29(5):1261-1273.e6. 2019
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NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARgamma
Authors: P Luan, W Jian, X Xu, W Kou, Q Yu, H Hu, D Li, W Wang, MW Feinberg, J Zhuang, Y Xu, W Peng
Nat Commun, 2019;10(1):2882. 2019
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SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells
Authors: CA Valenzuela, R Quintanill, A Olate-Brio, W Venturini, D Mancilla, A Cayo, R Moore-Carr, NE Brown
Int J Mol Sci, 2019;20(21):. 2019
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Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3
Authors: SA Greenall, J Donoghue, TG Johns, TE Adams
Transl Oncol, 2018;11(4):971-978. 2018
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The impact of circulating preeclampsia-associated extracellular vesicles on the migratory activity and phenotype of THP-1 monocytic cells
Authors: ÁF Kovács, O Láng, L Turiák, A Ács, L K?hidai, N Fekete, B Alasztics, T Mészáros, EI Buzás, J Rigó, É Pállinger
Sci Rep, 2018;8(1):5426. 2018
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Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases
Authors: B Gril, AN Paranjape, S Woditschka, E Hua, EL Dolan, J Hanson, X Wu, W Kloc, E Izycka-Swi, R Duchnowska, R P?ksa, W Biernat, J Jassem, N Nayyar, PK Brastianos, OM Hall, CJ Peer, WD Figg, GT Pauly, C Robinson, S Difilippan, E Bialecki, P Metellus, JP Schneider, PS Steeg
Psychoneuroendocrinology, 2018;9(1):2705. 2018
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HSP90 inhibition alters the chemotherapy-driven rearrangement of the oncogenic secretome
Authors: S di Martino, CA Amoreo, B Nuvoli, R Galati, S Strano, F Facciolo, G Alessandri, HI Pass, G Ciliberto, G Blandino, R De Maria, M Cioce
Oncogene, 2018;0(0):. 2018
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Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations
Authors: JA Fraser, S Kemp, L Young, M Ross, M Prach, GR Hutchison, E Malone
Sci Rep, 2018;8(1):7506. 2018
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Endothelial Protein C-Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells
Authors: A Arta, AZ Eriksen, F Melander, P Kempen, M Larsen, TL Andresen, AJ Urquhart
Invest. Ophthalmol. Vis. Sci., 2018;59(5):2119-2132. 2018
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Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
Authors: DJ McGrail, L Federico, Y Li, H Dai, Y Lu, GB Mills, S Yi, SY Lin, N Sahni
Nat Commun, 2018;9(1):1317. 2018
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Cytokine MIF Enhances Blood-Brain Barrier Permeability: Impact for Therapy in Ischemic Stroke
Authors: YC Liu, YH Tsai, SC Tang, HC Liou, KH Kang, HH Liou, JS Jeng, WM Fu
Sci Rep, 2018;8(1):743. 2018
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Overexpression of Rab11-FIP2 in colorectal cancer cells promotes tumor migration and angiogenesis through increasing secretion of PAI-1
Authors: W Dong, X Wu
Cancer Cell Int., 2018;18(0):35. 2018
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IL-6 mediates platinum-induced enrichment of ovarian cancer stem cells
Authors: Y Wang, X Zong, S Mitra, AK Mitra, D Matei, KP Nephew
JCI Insight, 2018;3(23):. 2018
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Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer
Authors: S Srinivasan, T Totiger, C Shi, J Castellano, P Lamichhane, AR Dosch, F Messaggio, N Kashikar, K Honnenahal, Y Ban, NB Merchant, MN VanSaun, NS Nagathihal
Cancer Res., 2018;0(0):. 2018
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Modulating bone marrow hematopoietic lineage potential to prevent bone metastasis in breast cancer
Authors: JM Ubellacker, N Baryawno, N Severe, MJ DeCristo, J Sceneay, JN Hutchinson, MT Haider, CS Rhee, Y Qin, WM Gregory, AC Garrido-Ca, I Holen, JE Brown, RE Coleman, DT Scadden, SS McAllister
Cancer Res., 2018;0(0):. 2018
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EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes
Authors: A Rutkowska, DR Shimshek, AW Sailer, KK Dev
Neuropharmacology, 2018;133(0):121-128. 2018
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Effects of Graphene Oxide Nanoparticles on the Immune System Biomarkers Produced by RAW 264.7 and Human Whole Blood Cell Cultures
Authors: K Lategan, H Alghadi, M Bayati, MF de Cortale, E Pool
Nanomaterials (Basel), 2018;8(2):. 2018
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Safety, pharmacokinetics, and biomarkers of F-652, a recombinant human interleukin-22 dimer, in healthy subjects
Authors: KY Tang, J Lickliter, ZH Huang, ZS Xian, HY Chen, C Huang, C Xiao, YP Wang, Y Tan, LF Xu, YL Huang, XQ Yan
Cell. Mol. Immunol., 2018;0(0):. 2018
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Early loss of Histone H2B monoubiquitylation alters chromatin accessibility and activates key immune pathways that facilitate progression of ovarian cancer
Authors: J Hooda, M Novak, MP Salomon, C Matsuba, RI Ramos, E MacDuffie, M Song, MS Hirsch, J Lester, V Parkash, BY Karlan, M Oren, DS Hoon, R Drapkin
Cancer Res., 2018;0(0):. 2018
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A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease
Authors: J Park, I Wetzel, I Marriott, D Dréau, C D'Avanzo, DY Kim, RE Tanzi, H Cho
Nat. Neurosci., 2018;21(7):941-951. 2018
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Peri-foci adipose-derived stem cells promote chemoresistance in breast cancer
Authors: WL Yeh, CF Tsai, DR Chen
Stem Cell Res Ther, 2017;8(1):177. 2017
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Cancer-Associated Fibroblasts Share Characteristics and Pro-tumorigenic Activity with Mesenchymal Stromal Cells
Authors: L Borriello, R Nakata, MA Sheard, GE Fernandez, R Sposto, J Malvar, L Blavier, H Shimada, S Asgharzade, RC Seeger, YA DeClerck
Cancer Res., 2017;0(0):. 2017
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Disruption of outer blood-retinal barrier by Toxoplasma gondii-infected monocytes is mediated by paracrinely activated FAK signaling
Authors: HB Song, HO Jun, JH Kim, YH Lee, MH Choi, JH Kim
PLoS ONE, 2017;12(4):e0175159. 2017
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Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells
Authors: A Gabrielyan, E Neumann, M Gelinsky, A Rösen-Wolf
Stem Cell Res Ther, 2017;8(1):212. 2017
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Human adipose-derived mesenchymal stem cell-secreted CXCL1 and CXCL8 facilitate breast tumor growth by promoting angiogenesis
Authors: Y Wang, J Liu, Q Jiang, J Deng, F Xu, X Chen, F Cheng, Y Zhang, Y Yao, Z Xia, X Xu, X Su, M Huang, L Dai, Y Yang, S Zhang, D Yu, RC Zhao, Y Wei, H Deng
Stem Cells, 2017;0(0):. 2017
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NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy
Authors: Q Wu, A Allouch, A Paoletti, C Leteur, C Mirjolet, I Martins, L Voisin, F Law, H Dakhli, E Mintet, M Thoreau, Z Muradova, M Gauthier, O Caron, F Milliat, DM Ojcius, F Rosselli, E Solary, N Modjtahedi, E Deutsch, JL Perfettini
Cell Death Differ., 2017;0(0):. 2017
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Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
Authors: L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He
Autophagy, 2017;0(0):0. 2017
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miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A
Authors: A Bott, N Erdem, S Lerrer, A Hotz-Wagen, C Breunig, K Abnaof, A Wörner, H Wilhelm, E Münsterman, A Ben-Baruch, S Wiemann
Oncotarget, 2017;8(27):43897-43914. 2017
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Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells
Authors: JH Kim, JW Shim, DY Eum, SD Kim, SH Choi, K Yang, K Heo, MT Park
Sci Rep, 2017;7(1):2798. 2017
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Isolation and Molecular Characterization of Amniotic Fluid-Derived Mesenchymal Stem Cells Obtained from Caesarean Sections
Authors: LS Spitzhorn, MS Rahman, L Schwindt, HT Ho, W Wruck, M Bohndorf, S Wehrmeyer, A Ncube, I Beyer, C Hagenbeck, P Balan, T Fehm, J Adjaye
Stem Cells Int, 2017;2017(0):5932706. 2017
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Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced Microenvironment
Authors: JP Vernot, X Bonilla, V Rodriguez-, NP Vanegas
Int J Mol Sci, 2017;18(2):. 2017
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Surface-bound galectin-4 regulates gene transcription and secretion of chemokines in human colorectal cancer cell lines
Authors: US Rao, PS Rao
Tumour Biol, 2017;39(3):1010428317691. 2017
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Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification
Authors: B Yu, A Hafiane, G Thanassoul, L Ott, N Filwood, M Cerruti, O Gourgas, D Shum-Tim, H Al Kindi, B de Varenne, A Alsheikh-A, J Genest, A Schwertani
JACC Basic Transl Sci, 2017;2(4):358-371. 2017
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Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation
Authors: CA Nold-Petry, MF Nold, O Levy, Y Kliger, A Oren, I Borukhov, C Becker, S Wirtz, MK Sandhu, M Neurath, CA Dinarello
Front Immunol, 2017;8(0):1531. 2017
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Orai and TRPC channel characterization in Fc?RI-mediated calcium signaling and mediator secretion in human mast cells
Authors: HE Wajdner, J Farrington, C Barnard, PT Peachell, CG Schnackenb, JP Marino, X Xu, K Affleck, M Begg, EP Seward
Physiol Rep, 2017;5(5):. 2017
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Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System
Authors: S Santaguida, A Richardson, DR Iyer, O M'Saad, L Zasadil, KA Knouse, YL Wong, N Rhind, A Desai, A Amon
Dev. Cell, 2017;41(6):638-651.e5. 2017
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The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2
Authors: T Hartwig, A Montinaro, S von Karste, A Sevko, S Surinova, A Chakravart, L Taraborrel, P Draber, E Lafont, F Arce Varga, MA El-Bahrawy, SA Quezada, H Walczak
Mol. Cell, 2017;65(4):730-742.e5. 2017
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Serum cytokine/chemokine profiles in patients with dengue fever (DF) and dengue hemorrhagic fever (FHD) by using protein array
Authors: RA Oliveira, MT Cordeiro, PM Moura, PN Baptista F, UM Braga-Neto, ET Marques, LH Gil
J. Clin. Virol, 2017;89(0):39-45. 2017
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A Proinflammatory Secretome Mediates the Impaired Immunopotency of Human Mesenchymal Stromal Cells in Elderly Patients with Atherosclerosis
Authors: Ö Kizilay Ma, M Lora, D Shum-Tim, S Nadeau, F Rodier, I Colmegna
Stem Cells Transl Med, 2017;6(4):1132-1140. 2017
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Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells
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Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease.
Authors: Smith AM, Rahman FZ, Hayee B, Graham SJ, Marks DJ, Sewell GW, Palmer CD, Wilde J, Foxwell BM, Gloger IS, Sweeting T, Marsh M, Walker AP, Bloom SL, Segal AW
J. Exp. Med., 2009;206(9):1883-97. 2009
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Co-cultures of multiple cell types mimic pulmonary cell communication in response to urban PM10.
Authors: Alfaro-Moreno E, Nawrot TS, Vanaudenaerde BM, Hoylaerts MF, Vanoirbeek JA, Nemery B, Hoet PH
Eur. Respir. J., 2008;32(5):1184-94. 2008
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Endogenous IL-32 controls cytokine and HIV-1 production.
Authors: Nold MF, Nold-Petry CA, Pott GB, Zepp JA, Saavedra MT, Kim SH, Dinarello CA
J. Immunol., 2008;181(1):557-65. 2008
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Soluble CD40 ligand as a biomarker for storage-related preanalytic variations of human serum.
Authors: Lengelle J, Panopoulos E, Betsou F
Cytokine, 2008;44(2):275-82. 2008
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Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection.
Authors: Feld M, Shpacovitch VM, Ehrhardt C, Kerkhoff C, Hollenberg MD, Vergnolle N, Ludwig S, Steinhoff M
J. Immunol., 2008;180(10):6903-10. 2008
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Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.
Authors: Marcondes AM, Mhyre AJ, Stirewalt DL, Kim SH, Dinarello CA, Deeg HJ
Proc. Natl. Acad. Sci. U.S.A., 2008;105(8):2865-70. 2008
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Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation.
Authors: Schade AE, Schieven GL, Townsend R, Jankowska AM, Susulic V, Zhang R, Szpurka H, Maciejewski JP
Blood, 2007;111(3):1366-77. 2007
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Induction of host chemotactic response by Encephalitozoon spp.
Authors: Fischer J, West J, Agochukwu N, Suire C, Hale-Donze H
Infect. Immun., 2007;75(4):1619-25. 2007
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Annexin A2 is a soluble mediator of macrophage activation.
Authors: Swisher JF, Khatri U, Feldman GM
J. Leukoc. Biol., 2007;82(5):1174-84. 2007
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A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes.
Authors: Vinall SL, Townsend ER, Pettipher R
Immunology, 2007;121(4):577-84. 2007
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IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells.
Authors: Yang HT, Cohen P, Rousseau S
Cell. Signal., 2007;20(2):375-80. 2007
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High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFkappaB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts.
Authors: Rudisch A, Dewhurst M, Horga L, Kramer N, Harrer N, Dong M, van der Kuip H, Wernitznig A, Bernthaler A, Dolznig H, Sommergruber W
PLoS ONE, 0;10(4):e0124283. 0
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Human CD4- 8- T cells are a distinctive immunoregulatory subset.
Authors: Huang MC, Patel K, Taub DD, Longo DL, Goetzl EJ
FASEB J, 0;24(7):2558-66. 0
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Soluble CD54 induces human endothelial cells ex vivo expansion useful for cardiovascular regeneration and tissue engineering application.
Authors: Malara N, Trunzo V, Musolino G, Aprigliano S, Rotta G, Macrina L, Limongi T, Gratteri S, Di Fabrizio E, Renzulli A, Fini M, Mollace V
Int J Cardiol Heart Vasc, 0;6(0):48-53. 0
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MSC from fetal and adult lungs possess lung-specific properties compared to bone marrow-derived MSC.
Authors: Rolandsson Enes S, Andersson Sjoland A, Skog I, Hansson L, Larsson H, Le Blanc K, Eriksson L, Bjermer L, Scheding S, Westergren-Thorsson G
Sci Rep, 0;6(0):29160. 0
FAQs
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Will the Array identification number stamped on the Array membrane interfere with detection if it is not cut-off before the membrane is blocked?
The dye used for printing the Array identification number on the membranes will fluoresce and interfere with the LI-COR detection. It is critical that the number is cut off before beginning the experiment.
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Tested condition media of MSCs from the umbilical cord co-cultured with NK cells. The goal of this experiments was to detect chages in inflammatory factors in the system when MSCs were cultured with NK cells. The lack of detected secreted proteins is promising because this suggests that MSCs do not up-regulate large inflammatory proteins following immune cell activation.
Left image : MSC cultured in RPMI media (Control)
Right image: MSC co-cultured with NK cells in same RPMI media