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Proteome Profiler Human Cytokine Array Kit

ARY005B 175 Citations 8 Reviews Datasheet / COA / SDS
Contains 4 membranes - each spotted in duplicate with 36 different cytokine antibodies
Catalog # Availability Size / Price Qty
ARY005B
The Human Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates.
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Citations (175)
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Proteome Profiler Human Cytokine Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of selected human cytokines and chemokines. Validated for analyte detection in cell culture supernates, cell lysates, tissue lysates, serum, plasma, saliva, urine, and human milk.

Troubleshooting Guide

Key Benefits

  • Detects 36 human cytokines, chemokines, and acute phase proteins simultaneously
  • Requires no specialized equipment

Principle of the Assay

The Proteome Profiler Human Cytokine Array Kit is a membrane-based sandwich immunoassay. Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2). Captured proteins are visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of analyte bound.

Why Use an Antibody Array to Detect Multiple Cytokines?

Determining the expression of multiple cytokines in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple cytokines in a single sample can be cost-effective and also save time and sample.

 

 

Kit Contents
  • Rectangular 4-Well Multi-dish
  • Human Cytokine Array, Panel A nitrocellulose membranes spotted with 36 different antibodies to human cytokines, chemokines, and acute phase proteins
  • Array Buffer 4
  • Array Buffer 5
  • Chemi Reagent 1
  • Chemi Reagent 2
  • Detection Antibody Cocktail, Human Cytokine Array
  • Streptavidin-HRP
  • Transparency Overlay Template
  • Wash Buffer Concentrate (25X)

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

 
Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample.
C5a IL-4 IL-27
CD40 Ligand IL-5 IL-32 alpha
G-CSF IL-6 CXCL10/IP-10
GM-CSF IL-8 CXCL11/I-TAC
CXCL1/GRO alpha IL-10 CCL2/MCP-1
CCL1/I-309 IL-12 p70 MIF
ICAM-1 IL-13 MIP-1 alpha/MIP-1 beta
IFN-gamma IL-16 CCL5/RANTES
IL-1 alpha IL-17 CXCL12/SDF-1
IL-1 beta IL-17E Serpin E1/PAI-1
IL-1ra IL-18 TNF-alpha
IL-2 IL-21 TREM-1

Assays for Analytes represented in the Human Cytokine Array Kit

Analyte Quantikine® ELISA Kits Quantikine® HS (High Sensitivity) ELISA Kits QuantiGlo® ELISA Kits DuoSet® ELISA Development Systems
C5a       DY2037
CD40 Ligand DCDL40     DY617
G-CSF DCS50 HSTCS0   DY214
GM-CSF DGM00 HSGM0   DY215
CXCL1/GRO alpha DGR00     DY275
CCL1/I-309       DY272
ICAM-1 DCIM00     DY720
IFN-gamma DIF50     DY285
IL-1 alpha DLA50     DY200
IL-1 beta DLB50 HSLB00C QLB00B DY201
IL-1ra DRA00B     DY280
IL-2 D2050   Q2000B DY202
IL-4 D4050 HS400   DY204
IL-5 D5000B     DY205
IL-6 D6050 HS600B Q6000B DY206
CXCL8/IL-8 D8000C HS800 Q8000B DY208
IL-10 D1000B HS100C Q1000 DY217B
IL-12 p70 D1200 HS120   DY1270
IL-13 D1300B     DY213
IL-16 D1600     DY316
IL-17 D1700     DY317
IL-17E        
IL-18 7620      
IL-21        
IL-27      

DY2526
IL-32 alpha        
CXCL10/IP-10 DIP100     DY266
CXCL11/I-TAC DCX110     DY672
CCL2/MCP-1 DCP00     DY279
MIF DMF00B     DY289
CCL3/MIP-1 alpha DMA00     DY270
CCL4/MIP-1 beta DMB00     DY271
Serpin E1/PAI-1 DSE100, DTSE100    

DY1786
CCL5/RANTES DRN00B     DY278
CXCL12/SDF-1 DSA00     DY350
TNF-alpha DTA00C HSTA00D QTA00B DY210
TREM-1 DTRM10B     DY1278B

Specifications

Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

Product Datasheets

Product Datasheet
COA
SDS

Data Example

The Human Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates. View Larger

The Human Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates. The amount of cell culture supernate used on each array and the duration of exposure to X-ray film is indicated below. Profiles of mean spot pixel density were created using a transmission-mode scanner and image analysis software. 1A: THP-1 human acute monocytic leukemia cells were untreated or treated with 1 µg/mL LPS for 4 hours, then 5mM Nigericin (Tocris, Catalog # 4312) for 1 hour (50 µL of cell culture supernate, 10 minute exposure). 1B: SW480 human colorectal adenocarcinoma cells were untreated or treated with 100 ng/mL LPS for 24 hours (500 µL of cell culture supernate, 10 minute exposure).

The Human Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell lysates. View Larger

The Human Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell lysates. The amount of cell lysate used on each array and the duration of exposure to X-ray film is indicated below. Profiles of mean spot pixel density were created using a transmission-mode scanner and image analysis software. 2A: SW1353 human chondrosarcoma cells were untreated or treated with 5 ng/mL recombinant human IL-1 alpha (R&D Systems, Catalog # 200-LA) and 10 ng/mL recombinant human OSM (R&D Systems, Catalog # 295-OM) for 24 hours (200 µg of cell lysate, 5 minute exposure). 2B: THP-1 human acute monocytic leukemia cells were untreated or treated with 1 µg/mL recombinant human IFN-gamma (R&D Systems, Catalog # 285-IF) for 8 hours, then 1 µg/mL LPS for 16 hours (200 µg of cell lysate, 5 minute exposure).

The Human Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in tissue lysate samples. View Larger

The Human Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in tissue lysate samples. 200 µg of tissue lysate was run on each array. Data shown are from a 5 minute exposure to X-ray film.

1. ICAM-1/CD54
2. MIF
3. Complment Component C5/C5a
4. CXCL1/GRO alpha
5. IL-8
6. IL-16
7. IL-18
8. CCL5/RANTES
9. IL-1ra/IL-1F3
10. Serpin E1/PAI-1

Reagents Provided

Citations for Proteome Profiler Human Cytokine Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

175 Citations: Showing 1 - 10
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  1. Inhibiting Monocyte Recruitment to Prevent the Pro-Tumoral Activity of Tumor-Associated Macrophages in Chondrosarcoma
    Authors: M Minopoli, S Sarno, G Di Carlucc, R Azzaro, S Costantini, F Fazioli, M Gallo, G Apice, L Cannella, D Rea, MP Stoppelli, D Boraschi, A Budillon, K Scotlandi, A De Chiara, MV Carriero
    Cells, 2020;9(4):.  2020
  2. A functional genetic screen defines the AKT-induced senescence signaling network
    Authors: KT Chan, S Blake, H Zhu, J Kang, AS Trigos, PB Madhamshet, J Diesch, L Paavolaine, P Horvath, RD Hannan, AJ George, E Sanij, KM Hannan, KJ Simpson, RB Pearson
    Cell Death Differ., 2020;27(2):725-741.  2020
  3. Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer
    Authors: PM Witschen, TS Chaffee, NJ Brady, DN Huggins, TP Knutson, RS LaRue, SA Munro, L Tiegs, JB McCarthy, AC Nelson, KL Schwertfeg
    Cancers (Basel), 2020;12(5):.  2020
  4. Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
    Authors: F Pelon, B Bourachot, Y Kieffer, I Magagna, F Mermet-Mei, I Bonnet, A Costa, AM Givel, Y Attieh, J Barbazan, C Bonneau, L Fuhrmann, S Descroix, D Vignjevic, P Silberzan, MC Parrini, A Vincent-Sa, F Mechta-Gri
    Nat Commun, 2020;11(1):404.  2020
  5. Impaired microRNA processing in neutrophils from rheumatoid arthritis patients confers their pathogenic profile. Modulation by biological therapies
    Authors: I Arias de l, C Perez-Sanc, P Ruiz-Limon, A Patiño-Tri, C Torres-Gra, Y Jimenez-Go, MDC Abalos-Agu, I Cecchi, R Ortega, MA Caracuel, J Calvo-Guti, A Escudero-C, E Collantes-, C Lopez-Pedr, N Barbarroja
    Haematologica, 2020;0(0):.  2020
  6. STAT3 Relays a Differential Response to Melanoma-Associated NRAS Mutations
    Authors: J Kim, D Novak, C Sachpekidi, J Utikal, L Larribère
    Cancers (Basel), 2020;12(1):.  2020
  7. Relation of Macrophage Migration Inhibitory Factor to Pulmonary Hemodynamics and Vascular Structure and Carbamyl-Phosphate Synthetase I Genetic Variations in Pediatric Patients with Congenital Cardiac Shunts
    Authors: NY Maeda, VD Aiello, PC Santos, AM Thomaz, LJ Kajita, SP Bydlowski, AA Lopes
    Mediators Inflamm., 2019;2019(0):7305028.  2019
  8. Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase
    Authors: PG Jobin, N Solis, Y Machado, PA Bell, NH Kwon, S Kim, CM Overall, GS Butler
    J. Biol. Chem., 2019;0(0):.  2019
  9. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts
    Authors: MA Eckert, F Coscia, A Chryplewic, JW Chang, KM Hernandez, S Pan, SM Tienda, DA Nahotko, G Li, I Blaženovi?, RR Lastra, M Curtis, SD Yamada, R Perets, SM McGregor, J Andrade, O Fiehn, RE Moellering, M Mann, E Lengyel
    Nature, 2019;0(0):.  2019
  10. Loss of zinc-finger protein 143 contributes to tumour progression by interleukin-8-CXCR axis in colon cancer
    Authors: V Verma, AR Paek, BK Choi, EK Hong, HJ You
    J. Cell. Mol. Med., 2019;0(0):.  2019
  11. Lysosomal trapping of palbociclib and its functional implications
    Authors: S Llanos, D Megias, C Blanco-Apa, E Hernández-, M Rovira, F Pietrocola, M Serrano
    Oncogene, 2019;0(0):.  2019
  12. Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner
    Authors: J Nehls, R Businger, M Hoffmann, C Brinkmann, B Fehrenbach, M Schaller, B Maurer, C Schönfeld, D Kramer, S Hailfinger, S Pöhlmann, M Schindler
    Cell Rep, 2019;26(7):1841-1853.e6.  2019
  13. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor
    Authors: A Gartung, J Yang, VP Sukhatme, DR Bielenberg, D Fernandes, J Chang, BA Schmidt, SH Hwang, D Zurakowski, S Huang, MW Kieran, BD Hammock, D Panigrahy
    Proc. Natl. Acad. Sci. U.S.A., 2019;116(5):1698-1703.  2019
  14. Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
    Authors: I Kurelac, L Iommarini, R Vatrinet, LB Amato, M De Luise, G Leone, G Girolimett, N Umesh Gane, VL Bridgeman, L Ombrato, M Columbaro, M Ragazzi, L Gibellini, M Sollazzo, RG Feichtinge, S Vidali, M Baldassarr, S Foriel, M Vidone, A Cossarizza, D Grifoni, B Kofler, I Malanchi, AM Porcelli, G Gasparre
    Nat Commun, 2019;10(1):903.  2019
  15. Transient Mitomycin C-treatment of human corneal epithelial cells and fibroblasts alters cell migration, cytokine secretion, and matrix accumulation
    Authors: S Pal-Ghosh, G Tadvalkar, VR Lieberman, X Guo, JD Zieske, A Hutcheon, MA Stepp
    Sci Rep, 2019;9(1):13905.  2019
  16. Anti ?-enolase antibody is a novel autoimmune biomarker for unexplained recurrent miscarriages
    Authors: Y Ye, C Kuhn, M Kösters, GJ Arnold, H Ishikawa-A, C Schulz, N Rogenhofer, CJ Thaler, S Mahner, T Fröhlich, U Jeschke, V von Schönf
    EBioMedicine, 2019;0(0):.  2019
  17. 1?,25(OH)2D3 attenuates IL-6 and IL-1?-mediated inflammatory responses in macrophage conditioned medium-stimulated human white preadipocytes by modulating p44/42 MAPK and NF-?B signaling pathways
    Authors: J Zhu, C Bing, JPH Wilding
    Diabetol Metab Syndr, 2019;11(0):9.  2019
  18. Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity
    Authors: M Dall, SAJ Trammell, M Asping, AS Hassing, M Agerholm, SG Vienberg, MP Gillum, S Larsen, JT Treebak
    J. Biol. Chem., 2019;0(0):.  2019
  19. KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis
    Authors: MC Wu, HH Cheng, TS Yeh, YC Li, TJ Chen, WY Sit, CP Chuu, HJ Kung, S Chien, WC Wang
    Cell Death Dis, 2019;10(2):68.  2019
  20. Fundamental differences in patterns of retinal ageing between primates and mice
    Authors: JH Kam, TW Weinrich, H Shinhmar, MB Powner, NW Roberts, A Aboelnour, G Jeffery
    Sci Rep, 2019;9(1):12574.  2019
  21. The efficacy of conditioned medium released by tonsil-derived mesenchymal stem cells in a chronic murine colitis model
    Authors: KE Lee, SA Jung, YH Joo, EM Song, CM Moon, SE Kim, I Jo
    PLoS ONE, 2019;14(12):e0225739.  2019
  22. Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes
    Authors: R Riise, L Odqvist, J Mattsson, S Monkley, SM Abdillahi, C Tyrchan, D Muthas, LF Yrlid
    Sci Rep, 2019;9(1):20407.  2019
  23. Ginsenoside Rh2 Ameliorates Atopic Dermatitis in NC/Nga Mice by Suppressing NF-kappaB-Mediated Thymic Stromal Lymphopoietin Expression and T Helper Type 2 Differentiation
    Authors: E Ko, S Park, JH Lee, CH Cui, J Hou, MH Kim, SC Kim
    Int J Mol Sci, 2019;20(24):.  2019
  24. Neutrophil Activities in Human Ocular Toxoplasmosis: An In Vitro Study With Human Cells
    Authors: LM Ashander, S Lie, Y Ma, E Rochet, JM Washington, JM Furtado, B Appukuttan, JR Smith
    Invest. Ophthalmol. Vis. Sci., 2019;60(14):4652-4660.  2019
  25. A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma
    Authors: I Kurelac, A Abarrategi, M Ragazzi, L Iommarini, N Umesh Gane, T Snoeks, D Bonnet, AM Porcelli, I Malanchi, G Gasparre
    J Clin Med, 2019;8(12):.  2019
  26. Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice
    Authors: SA Scarneo, LS Eibschutz, PJ Bendele, KW Yang, J Totzke, P Hughes, DA Fox, TAJ Haystead
    Arthritis Res. Ther., 2019;21(1):292.  2019
  27. Therapeutic effect of mesenchymal stem cells derived from human umbilical cord in rabbit temporomandibular joint model of osteoarthritis
    Authors: H Kim, G Yang, J Park, J Choi, E Kang, BK Lee
    Sci Rep, 2019;9(1):13854.  2019
  28. Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
    Authors: H Maekawa, T Inoue, H Ouchi, TM Jao, R Inoue, H Nishi, R Fujii, F Ishidate, T Tanaka, Y Tanaka, N Hirokawa, M Nangaku, R Inagi
    Cell Rep, 2019;29(5):1261-1273.e6.  2019
  29. NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARgamma
    Authors: P Luan, W Jian, X Xu, W Kou, Q Yu, H Hu, D Li, W Wang, MW Feinberg, J Zhuang, Y Xu, W Peng
    Nat Commun, 2019;10(1):2882.  2019
  30. SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells
    Authors: CA Valenzuela, R Quintanill, A Olate-Brio, W Venturini, D Mancilla, A Cayo, R Moore-Carr, NE Brown
    Int J Mol Sci, 2019;20(21):.  2019
  31. Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3
    Authors: SA Greenall, J Donoghue, TG Johns, TE Adams
    Transl Oncol, 2018;11(4):971-978.  2018
  32. The impact of circulating preeclampsia-associated extracellular vesicles on the migratory activity and phenotype of THP-1 monocytic cells
    Authors: ÁF Kovács, O Láng, L Turiák, A Ács, L K?hidai, N Fekete, B Alasztics, T Mészáros, EI Buzás, J Rigó, É Pállinger
    Sci Rep, 2018;8(1):5426.  2018
  33. Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases
    Authors: B Gril, AN Paranjape, S Woditschka, E Hua, EL Dolan, J Hanson, X Wu, W Kloc, E Izycka-Swi, R Duchnowska, R P?ksa, W Biernat, J Jassem, N Nayyar, PK Brastianos, OM Hall, CJ Peer, WD Figg, GT Pauly, C Robinson, S Difilippan, E Bialecki, P Metellus, JP Schneider, PS Steeg
    Psychoneuroendocrinology, 2018;9(1):2705.  2018
  34. HSP90 inhibition alters the chemotherapy-driven rearrangement of the oncogenic secretome
    Authors: S di Martino, CA Amoreo, B Nuvoli, R Galati, S Strano, F Facciolo, G Alessandri, HI Pass, G Ciliberto, G Blandino, R De Maria, M Cioce
    Oncogene, 2018;0(0):.  2018
  35. Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations
    Authors: JA Fraser, S Kemp, L Young, M Ross, M Prach, GR Hutchison, E Malone
    Sci Rep, 2018;8(1):7506.  2018
  36. Endothelial Protein C-Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells
    Authors: A Arta, AZ Eriksen, F Melander, P Kempen, M Larsen, TL Andresen, AJ Urquhart
    Invest. Ophthalmol. Vis. Sci., 2018;59(5):2119-2132.  2018
  37. Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
    Authors: DJ McGrail, L Federico, Y Li, H Dai, Y Lu, GB Mills, S Yi, SY Lin, N Sahni
    Nat Commun, 2018;9(1):1317.  2018
  38. Cytokine MIF Enhances Blood-Brain Barrier Permeability: Impact for Therapy in Ischemic Stroke
    Authors: YC Liu, YH Tsai, SC Tang, HC Liou, KH Kang, HH Liou, JS Jeng, WM Fu
    Sci Rep, 2018;8(1):743.  2018
  39. Overexpression of Rab11-FIP2 in colorectal cancer cells promotes tumor migration and angiogenesis through increasing secretion of PAI-1
    Authors: W Dong, X Wu
    Cancer Cell Int., 2018;18(0):35.  2018
  40. IL-6 mediates platinum-induced enrichment of ovarian cancer stem cells
    Authors: Y Wang, X Zong, S Mitra, AK Mitra, D Matei, KP Nephew
    JCI Insight, 2018;3(23):.  2018
  41. Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer
    Authors: S Srinivasan, T Totiger, C Shi, J Castellano, P Lamichhane, AR Dosch, F Messaggio, N Kashikar, K Honnenahal, Y Ban, NB Merchant, MN VanSaun, NS Nagathihal
    Cancer Res., 2018;0(0):.  2018
  42. Modulating bone marrow hematopoietic lineage potential to prevent bone metastasis in breast cancer
    Authors: JM Ubellacker, N Baryawno, N Severe, MJ DeCristo, J Sceneay, JN Hutchinson, MT Haider, CS Rhee, Y Qin, WM Gregory, AC Garrido-Ca, I Holen, JE Brown, RE Coleman, DT Scadden, SS McAllister
    Cancer Res., 2018;0(0):.  2018
  43. EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes
    Authors: A Rutkowska, DR Shimshek, AW Sailer, KK Dev
    Neuropharmacology, 2018;133(0):121-128.  2018
  44. Effects of Graphene Oxide Nanoparticles on the Immune System Biomarkers Produced by RAW 264.7 and Human Whole Blood Cell Cultures
    Authors: K Lategan, H Alghadi, M Bayati, MF de Cortale, E Pool
    Nanomaterials (Basel), 2018;8(2):.  2018
  45. Safety, pharmacokinetics, and biomarkers of F-652, a recombinant human interleukin-22 dimer, in healthy subjects
    Authors: KY Tang, J Lickliter, ZH Huang, ZS Xian, HY Chen, C Huang, C Xiao, YP Wang, Y Tan, LF Xu, YL Huang, XQ Yan
    Cell. Mol. Immunol., 2018;0(0):.  2018
  46. Early loss of Histone H2B monoubiquitylation alters chromatin accessibility and activates key immune pathways that facilitate progression of ovarian cancer
    Authors: J Hooda, M Novak, MP Salomon, C Matsuba, RI Ramos, E MacDuffie, M Song, MS Hirsch, J Lester, V Parkash, BY Karlan, M Oren, DS Hoon, R Drapkin
    Cancer Res., 2018;0(0):.  2018
  47. A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease
    Authors: J Park, I Wetzel, I Marriott, D Dréau, C D'Avanzo, DY Kim, RE Tanzi, H Cho
    Nat. Neurosci., 2018;21(7):941-951.  2018
  48. Peri-foci adipose-derived stem cells promote chemoresistance in breast cancer
    Authors: WL Yeh, CF Tsai, DR Chen
    Stem Cell Res Ther, 2017;8(1):177.  2017
  49. Cancer-Associated Fibroblasts Share Characteristics and Pro-tumorigenic Activity with Mesenchymal Stromal Cells
    Authors: L Borriello, R Nakata, MA Sheard, GE Fernandez, R Sposto, J Malvar, L Blavier, H Shimada, S Asgharzade, RC Seeger, YA DeClerck
    Cancer Res., 2017;0(0):.  2017
  50. Disruption of outer blood-retinal barrier by Toxoplasma gondii-infected monocytes is mediated by paracrinely activated FAK signaling
    Authors: HB Song, HO Jun, JH Kim, YH Lee, MH Choi, JH Kim
    PLoS ONE, 2017;12(4):e0175159.  2017
  51. Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells
    Authors: A Gabrielyan, E Neumann, M Gelinsky, A Rösen-Wolf
    Stem Cell Res Ther, 2017;8(1):212.  2017
  52. Human adipose-derived mesenchymal stem cell-secreted CXCL1 and CXCL8 facilitate breast tumor growth by promoting angiogenesis
    Authors: Y Wang, J Liu, Q Jiang, J Deng, F Xu, X Chen, F Cheng, Y Zhang, Y Yao, Z Xia, X Xu, X Su, M Huang, L Dai, Y Yang, S Zhang, D Yu, RC Zhao, Y Wei, H Deng
    Stem Cells, 2017;0(0):.  2017
  53. NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy
    Authors: Q Wu, A Allouch, A Paoletti, C Leteur, C Mirjolet, I Martins, L Voisin, F Law, H Dakhli, E Mintet, M Thoreau, Z Muradova, M Gauthier, O Caron, F Milliat, DM Ojcius, F Rosselli, E Solary, N Modjtahedi, E Deutsch, JL Perfettini
    Cell Death Differ., 2017;0(0):.  2017
  54. Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
    Authors: L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He
    Autophagy, 2017;0(0):0.  2017
  55. miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A
    Authors: A Bott, N Erdem, S Lerrer, A Hotz-Wagen, C Breunig, K Abnaof, A Wörner, H Wilhelm, E Münsterman, A Ben-Baruch, S Wiemann
    Oncotarget, 2017;8(27):43897-43914.  2017
  56. Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells
    Authors: JH Kim, JW Shim, DY Eum, SD Kim, SH Choi, K Yang, K Heo, MT Park
    Sci Rep, 2017;7(1):2798.  2017
  57. Isolation and Molecular Characterization of Amniotic Fluid-Derived Mesenchymal Stem Cells Obtained from Caesarean Sections
    Authors: LS Spitzhorn, MS Rahman, L Schwindt, HT Ho, W Wruck, M Bohndorf, S Wehrmeyer, A Ncube, I Beyer, C Hagenbeck, P Balan, T Fehm, J Adjaye
    Stem Cells Int, 2017;2017(0):5932706.  2017
  58. Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced Microenvironment
    Authors: JP Vernot, X Bonilla, V Rodriguez-, NP Vanegas
    Int J Mol Sci, 2017;18(2):.  2017
  59. Surface-bound galectin-4 regulates gene transcription and secretion of chemokines in human colorectal cancer cell lines
    Authors: US Rao, PS Rao
    Tumour Biol, 2017;39(3):1010428317691.  2017
  60. Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification
    Authors: B Yu, A Hafiane, G Thanassoul, L Ott, N Filwood, M Cerruti, O Gourgas, D Shum-Tim, H Al Kindi, B de Varenne, A Alsheikh-A, J Genest, A Schwertani
    JACC Basic Transl Sci, 2017;2(4):358-371.  2017
  61. Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation
    Authors: CA Nold-Petry, MF Nold, O Levy, Y Kliger, A Oren, I Borukhov, C Becker, S Wirtz, MK Sandhu, M Neurath, CA Dinarello
    Front Immunol, 2017;8(0):1531.  2017
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FAQs

  1. Will the Array identification number stamped on the Array membrane interfere with detection if it is not cut-off before the membrane is blocked?

    • The dye used for printing the Array identification number on the membranes will fluoresce and interfere with the LI-COR detection. It is critical that the number is cut off before beginning the experiment. 

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Proteome Profiler Human Cytokine Array Kit
By Anonymous on 01/31/2020
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Serum Proteome Profiler Human Cytokine Array Kit ARY005B
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Proteome Profiler Human Cytokine Array Kit
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Proteome Profiler Human Cytokine Array Kit
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Serum Proteome Profiler Human Cytokine Array Kit ARY005B
Proteome Profiler Human Cytokine Array Kit
By Anonymous on 01/25/2017
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Tested condition media of MSCs from the umbilical cord co-cultured with NK cells. The goal of this experiments was to detect chages in inflammatory factors in the system when MSCs were cultured with NK cells. The lack of detected secreted proteins is promising because this suggests that MSCs do not up-regulate large inflammatory proteins following immune cell activation.

Left image : MSC cultured in RPMI media (Control)
Right image: MSC co-cultured with NK cells in same RPMI media

Serum Proteome Profiler Human Cytokine Array Kit ARY005B