Proteome Profiler Mouse Cytokine Array Kit, Panel A (ARY006): R&D Systems

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Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of selected mouse cytokines and chemokines. Validated for analyte detection in cell culture supernates, cell lysates, tissue lysates, serum, and plasma.

Key Benefits

  • Detects 40 mouse cytokines, chemokines, and acute phase proteins simultaneously
  • Requires no specialized equipment
  • Compatible with LI-COR and chemiluminescence detection

ARY006 Data Examples
View Data Examples

LI-COR Data Examples for Mouse Cytokine Array, Panel A
 

Principle of the Assay

The Proteome Profiler Mouse Cytokine Array Kit, Panel A is a membrane-based sandwich immunoassay. Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2). Captured proteins are visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of analyte bound.

Why Use an Antibody Array to Detect Multiple Cytokines?

Determining the expression of multiple cytokines in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple cytokines in a single sample can be cost-effective and also save time and sample.

 

 

Kit Contents
  • Rectangular 4-Well Multi-dish
  • 4 Mouse Cytokine Array, Panel A nitrocellulose membranes spotted with 40 different antibodies to mouse cytokines, chemokines, and acute phase proteins
  • Array Buffer 4
  • Array Buffer 6
  • Chemi Reagent 1
  • Chemi Reagent 2
  • Detection Antibody Cocktail, Mouse Cytokine Array, Panel A
  • Streptavidin-HRP
  • Transparency Overlay Template
  • Wash Buffer Concentrate (25X)

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.  

 
Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample.
CXCL13/BLC/BCA-1 IL-5 M-CSF
C5a IL-6 CCL2/JE/MCP-1
G-CSF IL-7 CCL12/MCP-5
GM-CSF IL-10 CXCL9/MIG
CCL1/I-309 IL-12 p70 CCL3/MIP-1 alpha
CCL11/Eotaxin IL-13 CCL4/MIP-1 beta
ICAM-1 IL-16 CXCL2/MIP-2
IFN-gamma IL-17 CCL5/RANTES
IL-1 alpha/IL-1F1 IL-23 CXCL12/SDF-1
IL-1 beta/IL-1F2 IL-27 CCL17/TARC
IL-1ra/IL-1F3 CXCL10/IP-10 TIMP-1
IL-2 CXCL11/I-TAC TNF-alpha
IL-3 CXCL1/KC TREM-1
IL-4    

 

Assays for Analytes represented in the Mouse Cytokine Array Kit, Panel A

Analyte Quantikine® ELISA Kits DuoSet® ELISA Development Systems
CXCL13/BLC/BCA-1 MCX130 DY470
C5a   DY2150
G-CSF MCS00 DY414
GM-CSF MGM00 DY415
CCL1/I-309/TCA-3   DY845
CCL11/Eotaxin MME00 DY420
ICAM-1 MIC100 DY796
IFN-gamma MIF00 DY485
IL-1 alpha MLA00 DY400
IL-1 beta MLB00B DY401
IL-1ra MRA00 DY480
IL-2 M2000 DY402
IL-3 M3000 DY403
IL-4 M4000B DY404
IL-5 M5000 DY405
IL-6 M6000B DY406
IL-7 M7000 DY407
IL-10 M1000b DY417
IL-12 p70 M1270 DY419
IL-13 M1300CB DY413
IL-16    
IL-17 M1700 DY421
IL-23 M2300 DY1887
IL-27 M2728  
CXCL10/IP-10/CRG-2 MCX100 DY466
CXCL11/I-TAC   DY572
CXCL1/KC MKC00B DY453
M-CSF MMC00 DY416
CCL2/MCP-1/JE MJE00 DY479
CCL12/MCP-5 MCC120 DY428
CXCL9/MIG MCX900 DY492
CCL3/MIP-1 alpha MMA00 DY450
CCL4/MIP-1 beta MMB00 DY451
CXCL2/MIP-2 MM200 DY452
CCL5/RANTES MMR00 DY478
CXCL12/SDF-1 MCX120 DY460
CCL17/TARC   DY529
TIMP-1 MTM100 DY980
TNF-alpha MTA00 DY410
TREM-1 MTRM10 DY1187

 

 
Data Examples
R&D Systems Mouse Cytokine Array, Panel A
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The Mouse Cytokine Array, Panel A utilizes capture antibodies spotted onto a nitrocellulose membrane to allow high-throughput multi-analyte profiling of 40 cytokines, chemokines, and more in a single sample. Mouse splenocytes treated with 100 ng/mL LPS for 20 hours were mixed with a cocktail of biotinylated detection antibodies, and then incubated with the Mouse Cytokine Array. The array was then incubated with streptavidin-horseradish peroxidase followed by chemiluminescent detection. After detection, the array data were quantitated to generate a protein profile (histogram). The table shows the analytes detected and their location on the membrane.
Preparation and Storage
  • Stability & Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

124 Citations: Showing 1 - 10

  1. DNA damage induced by Strontium-90 exposure at low concentrations in mesenchymal stromal cells: the functional consequences
    Authors: S Musilli, N Nicolas, Z El Ali, P Orellana-M, C Grand, K Tack, S Kerdine-R”, JM Bertho
    Sci Rep, 2017;7(0):41580. 2017
  2. Importance of CD200 expression by tumor or host cells to regulation of immunotherapy in a mouse breast cancer model
    Authors: A Curry, I Khatri, O Kos, F Zhu, R Gorczynski
    PLoS ONE, 2017;12(2):e0171586. 2017
  3. Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis
    Authors: CJ Halbrook, HJ Wen, JM Ruggeri, KK Takeuchi, Y Zhang, MP di Maglian, HC Crawford
    Cell Mol Gastroenterol Hepatol, 2017;3(1):99-118. 2017
  4. Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina
    Authors: SL Roche, AC Wyse-Jacks, AM Ruiz-Lopez, AM Byrne, TG Cotter
    Sci Rep, 2017;7(0):43067. 2017
  5. Lack of ABCG2 Leads to Biventricular Dysfunction and Remodeling in Response to Hypoxia
    Authors: BM Nagy, C Nagaraj, B Egemnazaro, G Kwapiszews, RE Stauber, A Avian, H Olschewski, A Olschewski
    Front Physiol, 2017;8(0):98. 2017
  6. Impact of the Sensory Neurons on Melanoma Growth In Vivo
    PLoS ONE, 2016;11(5):e0156095. 2016
  7. Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists
    Sci Rep, 2016;6(0):34145. 2016
  8. Targeting Serglycin Prevents Metastasis in Murine Mammary Carcinoma
    PLoS ONE, 2016;11(5):e0156151. 2016
  9. The Anti-Inflammatory Effects and Mechanisms of Eupafolin in Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Macrophages
    PLoS ONE, 2016;11(7):e0158662. 2016
  10. Proatherosclerotic Effect of the ?1-Subunit of Soluble Guanylyl Cyclase by Promoting Smooth Muscle Phenotypic Switching
    Authors: Maria Segura-Pui
    Am J Pathol, 2016;0(0):. 2016
  11. Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms.
    Authors: Tsao C, Tsao P, Chen Y, Chuang Y
    PLoS ONE, 2016;11(1):e0147710. 2016
  12. Immune response characterization and vaccine potential of a recombinant chimera comprising B-cell epitope of Aeromonas hydrophila outer membrane protein C and LTB
    Vaccine, 2016;34(50):6259-6266. 2016
  13. Treatment of refractory cutaneous ulcers with mixed sheets consisting of peripheral blood mononuclear cells and fibroblasts
    Authors: Koji Ueno
    Sci Rep, 2016;6(0):28538. 2016
  14. The Thyroid Hormone Receptors Inhibit Hepatic Interleukin-6 Signaling During Endotoxemia
    Sci Rep, 2016;6(0):30990. 2016
  15. Neutrophils suppress intraluminal NK-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells
    Authors: A Spiegel, MW Brooks, S Houshyar, F Reinhardt, M Ardolino, E Fessler, MB Chen, JA Krall, J DeCock, IK Zervantona, A Iannello, Y Iwamoto, V Cortez-Ret, RD Kamm, MJ Pittet, DH Raulet, RA Weinberg
    Cancer Discov, 2016;0(0):. 2016
  16. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy
    EMBO Mol Med, 2016;0(0):. 2016
  17. Activation of IFN/STAT1 signalling predicts response to chemotherapy in oestrogen receptor-negative breast cancer
    Authors: ME Legrier, I BiŠche, J Gaston, A Beurdeley, V Yvonnet, O D‚as, A Thuleau, S Chƒteau-Jo, JL Servely, S Vacher, M Lassalle, S Depil, GC Tucker, JJ Fontaine, MF Poupon, S Roman-Roma, JG Judde, D Decaudin, S Cairo, E Marangoni
    Br. J. Cancer, 2016;114(2):177-87. 2016
  18. Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages
    Oncotarget, 2016;0(0):. 2016
  19. Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation.
    Authors: Tassoni A, Gutteridge A, Barber A, Osborne A, Martin K
    Stem Cells, 2015;33(10):3006-16. 2015
  20. Plasmacytoid Dendritic Cell Activation and IFN-alpha Production Are Prominent Features of Murine Autoimmune Pancreatitis and Human IgG4-Related Autoimmune Pancreatitis.
    Authors: Arai Y, Yamashita K, Kuriyama K, Shiokawa M, Kodama Y, Sakurai T, Mizugishi K, Uchida K, Kadowaki N, Takaori-Kondo A, Kudo M, Okazaki K, Strober W, Chiba T, Watanabe T
    J Immunol, 2015;195(7):3033-44. 2015
  21. Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.
    Authors: Westman J, Papareddy P, Dahlgren M, Chakrakodi B, Norrby-Teglund A, Smeds E, Linder A, Morgelin M, Johansson-Lindbom B, Egesten A, Herwald H
    PLoS Pathog, 2015;11(12):e1005319. 2015
  22. Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease.
    Authors: Valera E, Mante M, Anderson S, Rockenstein E, Masliah E
    J Neuroinflammation, 2015;12(0):93. 2015
  23. Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components.
    Authors: Lin T, Lin H, Chang W, Mitapalli S P, Hsiao P, Yin S, Yang N
    Mol Cancer, 2015;14(0):174. 2015
  24. EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer.
    Authors: Subramanian N, Kanwar J, Kanwar R, Sreemanthula J, Biswas J, Khetan V, Krishnakumar S
    PLoS ONE, 2015;10(7):e0132407. 2015
  25. Frostbite protection in mice expressing an antifreeze glycoprotein.
    Authors: Heisig, Martin, Mattessich, Sarah, Rembisz, Alison, Acar, Ali, Shapiro, Martin, Booth, Carmen J, Neelakanta, Girish, Fikrig, Erol
    PLoS ONE, 2015;10(2):e0116562. 2015
  26. Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction.
    Authors: Park E, Choi S, Shin B, Yu J, Yu J, Hwang J, Yun H, Chung Y, Choi J, Choi Y, Rho J
    J Biol Chem, 2015;290(15):9660-73. 2015
  27. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.
    Authors: Bonapace L, Coissieux M, Wyckoff J, Mertz K, Varga Z, Junt T, Bentires-Alj M
    Nature, 2015;515(7525):130-3. 2015
  28. Supernatants of tumours treated with chemotherapy can alter tumour growth and development in vivo.
    Authors: Liu W, Scott K, Dalgleish A
    Anticancer Res, 2015;35(3):1499-508. 2015
  29. Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases.
    Authors: Sottnik J, Dai J, Zhang H, Campbell B, Keller E
    Cancer Res, 2015;75(11):2151-8. 2015
  30. Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study.
    Authors: Altara R, Gu Y, Struijker-Boudier H, Thijs L, Staessen J, Blankesteijn W
    PLoS ONE, 2015;10(10):e0141394. 2015
  31. Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease.
    Authors: Grande M, Sanchez-Laorden B, Lopez-Blau C, De Frutos C, Boutet A, Arevalo M, Rowe R, Weiss S, Lopez-Novoa J, Nieto M
    Nat Med, 2015;21(9):989-97. 2015
  32. F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.
    Authors: Yumimoto, Kanae, Akiyoshi, Sayuri, Ueo, Hiroki, Sagara, Yasuaki, Onoyama, Ichiro, Ueo, Hiroaki, Ohno, Shinji, Mori, Masaki, Mimori, Koshi, Nakayama, Keiichi
    J Clin Invest, 2015;125(2):621-35. 2015
  33. Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice.
    Authors: Lalani A, Moore C, Luo C, Kreider B, Liu Y, Morse H, Xie P
    J Immunol, 2015;194(1):334-48. 2015
  34. Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion.
    Authors: Fu X, Xiao J, Wei Y, Li S, Liu Y, Yin J, Sun K, Sun H, Wang H, Zhang Z, Zhang B, Sheng C, Wang H, Hu P
    Cell Res, 2015;25(6):655-73. 2015
  35. Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites.
    Authors: Wang Q, Ren Y, Mu J, Egilmez N, Zhuang X, Deng Z, Zhang L, Yan J, Miller D, Zhang H
    Cancer Res, 2015;75(12):2520-9. 2015
  36. mRNA-transfected Dendritic Cells Expressing Polypeptides That Link MHC-I Presentation to Constitutive TLR4 Activation Confer Tumor Immunity.
    Authors: Cafri G, Sharbi-Yunger A, Tzehoval E, Alteber Z, Gross T, Vadai E, Margalit A, Gross G, Eisenbach L
    Mol Ther, 2015;23(8):1391-400. 2015
  37. Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation.
    Authors: McKelvey R, Berta T, Old E, Ji R, Fitzgerald M
    J Neurosci, 2015;35(2):457-66. 2015
  38. Specific medicinal plant polysaccharides effectively enhance the potency of a DC-based vaccine against mouse mammary tumor metastasis.
    Authors: Chang, Wei Ting, Lai, Tzung Hs, Chyan, Yau Jan, Yin, Shu Yi, Chen, Yung Hsi, Wei, Wen Chi, Yang, Ning-Sun
    PLoS ONE, 2015;10(3):e0122374. 2015
  39. Lysophosphatidic acid alters the expression profiles of angiogenic factors, cytokines, and chemokines in mouse liver sinusoidal endothelial cells.
    Authors: Chou C, Lai S, Ho C, Lin W, Chen C, Lee P, Peng F, Kuo S, Wu S, Lai H
    PLoS ONE, 2015;10(3):e0122060. 2015
  40. MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells.
    Authors: Kwon Y, Kim Y, Eom S, Kim M, Park D, Kim H, Noh K, Lee H, Lee Y, Choe J, Kim Y, Jeoung D
    J Biol Chem, 2015;290(22):14245-66. 2015
  41. Novel Role of TRPML2 in the Regulation of the Innate Immune Response.
    Authors: Sun L, Hua Y, Vergarajauregui S, Diab H, Puertollano R
    J Immunol, 2015;195(10):4922-32. 2015
  42. The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling.
    Authors: Fleming B, Chandrasekaran P, Dillon L, Dalby E, Suresh R, Sarkar A, El-Sayed N, Mosser D
    J Leukoc Biol, 2015;98(3):395-407. 2015
  43. The circadian clock controls sunburn apoptosis and erythema in mouse skin.
    Authors: Gaddameedhi, Shobhan, Selby, Christop, Kemp, Michael, Ye, Rui, Sancar, Aziz
    J Invest Dermatol, 2015;135(4):1119-27. 2015
  44. Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway.
    Authors: Sha X, Meng S, Li X, Xi H, Maddaloni M, Pascual D, Shan H, Jiang X, Wang H, Yang X
    J Biol Chem, 2015;290(31):19307-18. 2015
  45. Targeted Disruption of Ig-Hepta/Gpr116 Causes Emphysema-like Symptoms That Are Associated with Alveolar Macrophage Activation.
    Authors: Ariestanti D, Ando H, Hirose S, Nakamura N
    J Biol Chem, 2015;290(17):11032-40. 2015
  46. IkappaBNS regulates murine Th17 differentiation during gut inflammation and infection.
    Authors: Annemann M, Wang Z, Plaza-Sirvent C, Glauben R, Schuster M, Ewald Sander F, Mamareli P, Kuhl A, Siegmund B, Lochner M, Schmitz I
    J Immunol, 2015;194(6):2888-98. 2015
  47. The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
    Authors: Kovacs M, Nemeth T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell C, Mocsai A
    J Exp Med, 2014;211(10):1993-2011. 2014
  48. Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle.
    Authors: Chen D, Goswami C, Burnett R, Anjanappa M, Bhat-Nakshatri P, Muller W, Nakshatri H
    Cancer Res, 2014;74(16):4270-81. 2014
  49. Dystrophic mdx mice develop severe cardiac and respiratory dysfunction following genetic ablation of the anti-inflammatory cytokine IL-10.
    Authors: Nitahara-Kasahara Y, Hayashita-Kinoh H, Chiyo T, Nishiyama A, Okada H, Takeda S, Okada T
    Hum Mol Genet, 2014;23(15):3990-4000. 2014
  50. Novel mechanisms underlying the immediate and transient global tolerization of splenic dendritic cells after vaccination with a self-antigen.
    Authors: Farkas A, Finn O
    J Immunol, 2014;192(2):658-65. 2014
  51. Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.
    Authors: Freemerman A, Johnson A, Sacks G, Milner J, Kirk E, Troester M, Macintyre A, Goraksha-Hicks P, Rathmell J, Makowski L
    J Biol Chem, 2014;289(11):7884-96. 2014
  52. Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells.
    Authors: Wang J, Hendrix A, Hernot S, Lemaire M, De Bruyne E, Van Valckenborgh E, Lahoutte T, De Wever O, Vanderkerken K, Menu E
    Blood, 2014;124(4):555-66. 2014
  53. Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-kappaB-dependent manner.
    Authors: Wang L, Zhang H, Rodriguez S, Cao L, Parish J, Mumaw C, Zollman A, Kamoka M, Mu J, Chen D, Srour E, Chitteti B, HogenEsch H, Tu X, Bellido T, Boswell H, Manshouri T, Verstovsek S, Yoder M, Kapur R, Cardoso A, Carlesso N
    Cell Stem Cell, 2014;15(1):51-65. 2014
  54. The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.
    Authors: Hall, Belinda, Hill, Kirsti, McKenna, Michael, Ogbechi, Joy, High, Stephen, Willis, Anne E, Simmonds, Rachel E
    PLoS Pathog, 2014;10(4):e1004061. 2014
  55. Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models.
    Authors: Ostler, Joseph E, Maurya, Santosh, Dials, Justin, Roof, Steve R, Devor, Steven T, Ziolo, Mark T, Periasamy, Muthu
    Am J Physiol Endocrinol Metab, 2014;306(6):E592-605. 2014
  56. Human herpesvirus 6A infection in CD46 transgenic mice: viral persistence in the brain and increased production of proinflammatory chemokines via Toll-like receptor 9.
    Authors: Reynaud J, Jegou J, Welsch J, Horvat B
    J Virol, 2014;88(10):5421-36. 2014
  57. Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis.
    Authors: Zhang, Hanwei, Chin, Arnold I
    PLoS ONE, 2014;9(4):e94793. 2014
  58. Sc65 is a novel endoplasmic reticulum protein that regulates bone mass homeostasis.
    Authors: Gruenwald K, Castagnola P, Besio R, Dimori M, Chen Y, Akel N, Swain F, Skinner R, Eyre D, Gaddy D, Suva L, Morello R
    J Bone Miner Res, 2014;29(3):666-75. 2014
  59. IL-15 deficient tax mice reveal a role for IL-1alpha in tumor immunity.
    Authors: Rauch D, Harding J, Ratner L
    PLoS ONE, 2014;9(1):e85028. 2014
  60. Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample.
    Authors: Altara, Raffaele, Manca, Marco, Hessel, Marleen, Janssen, Ben J, Struijker-Boudier, Harry H, Hermans, Rob J J, Blankesteijn, W Matthi
    BMC Biotechnol, 2014;14(0):63. 2014
  61. Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1alpha/IL-6 loop.
    Authors: Taniguchi K, Arima K, Masuoka M, Ohta S, Shiraishi H, Ontsuka K, Suzuki S, Inamitsu M, Yamamoto K, Simmons O, Toda S, Conway S, Hamasaki Y, Izuhara K
    J Invest Dermatol, 2014;134(5):1295-304. 2014
  62. A paracrine network regulates the cross-talk between human lung stem cells and the stroma.
    Authors: Ruiz E, Oeztuerk-Winder F, Ventura J
    Nat Commun, 2014;5(0):3175. 2014
  63. BMP pathway regulation of and by macrophages.
    Authors: Talati M, West J, Zaynagetdinov R, Hong C, Han W, Blackwell T, Robinson L, Blackwell T, Lane K
    PLoS ONE, 2014;9(4):e94119. 2014
  64. HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells.
    Authors: Stone S, Rossetti R, Bolpetti A, Boccardo E, Souza P, Lepique A
    J Leukoc Biol, 2014;96(4):619-31. 2014
  65. Macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration.
    Authors: Fujihara Y, Takato T, Hoshi K
    Stem Cells, 2014;32(5):1208-19. 2014
  66. Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10).
    Authors: Weber S, Wetzel S, Prox J, Lehmann T, Schneppenheim J, Donners M, Saftig P
    Biochem Biophys Res Commun, 2013;442(3):234-41. 2013
  67. Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation.
    Authors: Nie Y, DU L, Mou Y, Xu Z, Weng L, Du Y, Zhu Y, Hou Y, Wang T
    BMC Cancer, 2013;13(0):582. 2013
  68. Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.
    Authors: Gandhirajan, Rajesh K, Meng, Shu, Chandramoorthy, Harish C, Mallilankaraman, Karthik, Mancarella, Salvator, Gao, Hui, Razmpour, Roshanak, Yang, Xiao-Fen, Houser, Steven R, Chen, Ju, Koch, Walter J, Wang, Hong, Soboloff, Jonathan, Gill, Donald L, Madesh, Muniswam
    J Clin Invest, 2013;123(2):887-902. 2013
  69. Concomitant interferon alpha stimulation and TLR3 activation induces neuronal expression of depression-related genes that are elevated in the brain of suicidal persons.
    Authors: Hoyo-Becerra, Carolina, Huebener, Anastasi, Trippler, Martin, Lutterbeck, Melanie, Liu, Zijian J, Truebner, Kurt, Bajanowski, Thomas, Gerken, Guido, Hermann, Dirk M, Schlaak, Joerg F
    PLoS ONE, 2013;8(12):e83149. 2013
  70. Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice.
    Authors: Kakkola L, Denisova O, Tynell J, Viiliainen J, Ysenbaert T, Matos R, Nagaraj A, Ohman T, Kuivanen S, Paavilainen H, Feng L, Yadav B, Julkunen I, Vapalahti O, Hukkanen V, Stenman J, Aittokallio T, Verschuren E, Ojala P, Nyman T, Saelens X, Dzeyk K, Kainov D
    Cell Death Dis, 2013;4(0):e742. 2013
  71. The bradykinin B1 receptor regulates Abeta deposition and neuroinflammation in Tg-SwDI mice.
    Authors: Passos G, Medeiros R, Cheng D, Vasilevko V, Laferla F, Cribbs D
    Am J Pathol, 2013;182(5):1740-9. 2013
  72. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.
    Authors: Chen B, Coon T, Glasser J, McVerry B, Zhao J, Zhao Y, Zou C, Ellis B, Sciurba F, Zhang Y, Mallampalli R
    Nat Immunol, 2013;14(5):470-9. 2013
  73. Interleukin-33 primes mast cells for activation by IgG immune complexes.
    Authors: Kaieda S, Wang J, Shnayder R, Fishgal N, Hei H, Lee R, Stevens R, Nigrovic P
    PLoS ONE, 2012;7(10):e47252. 2012
  74. Dietary blue pigments derived from genipin, attenuate inflammation by inhibiting LPS-induced iNOS and COX-2 expression via the NF-kappaB inactivation.
    Authors: Wang QS, Xiang Y, Cui YL, Lin KM, Zhang XF
    PLoS ONE, 2012;7(3):e34122. 2012
  75. Macrophage Dectin-1 Expression Is Controlled by Leukotriene B4 via a GM-CSF/PU.1 Axis.
    Authors: Serezani CH, Kane S, Collins L
    J. Immunol., 2012;189(2):906-15. 2012
  76. Histone Deacetylase 3 Mediates Allergic Skin Inflammation by Regulating Expression of MCP1 Protein.
    Authors: Kim Y, Kim K, Park D, Lee E, Lee H, Lee YS, Choe J, Jeoung D
    J. Biol. Chem., 2012;287(31):25844-59. 2012
  77. The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice.
    Authors: Tran K, Risingsong R, Royce D
    Cancer Prev Res (Phila), 2012;5(5):726-34. 2012
  78. Clusterin induces the secretion of TNF-α and the chemotactic migration of macrophages.
    Authors: Shim YJ, Kang BH, Choi BK, Park IS, Min BH
    Biochem. Biophys. Res. Commun., 2012;422(1):200-5. 2012
  79. The effect of oxidized low density lipoprotein (oxLDL)-induced heme oxygenase-1 on LPS-induced inflammation in RAW 264.7 macrophage cells.
    Authors: Min KJ, Cho KH, Kwon TK
    Cell. Signal., 2012;24(6):1215-21. 2012
  80. Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity.
    Authors: Kotzka J, Knebel B, Haas J, Kremer L, Jacob S, Hartwig S, Nitzgen U, Muller-Wieland D
    PLoS ONE, 2012;7(2):e32609. 2012
  81. Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.
    Authors: Soond DR, Garcon F, Patton DT, Rolf J, Turner M, Scudamore C, Garden OA, Okkenhaug K
    J. Immunol., 2012;188(12):5935-43. 2012
  82. The MSHA Strain of Pseudomonas Aeruginosa Activated TLR Pathway and Enhanced HIV-1 DNA Vaccine Immunoreactivity.
    Authors: Hou J, Liu Y, Liu Y, Shao Y
    PLoS ONE, 2012;7(10):e47724. 2012
  83. Exosomes isolated from mycobacteria-infected mice or cultured macrophages can recruit and activate immune cells in vitro and in vivo.
    Authors: Singh PP, Smith VL, Karakousis PC, Schorey JS
    J. Immunol., 2012;189(2):777-85. 2012
  84. Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes.
    Diabetes, 2012;61(8):2114-25. 2012
  85. NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases.
    Authors: Chow M, Sceneay J, Paget C, Wong C, Duret H, Tschopp J, Moller A, Smyth M
    Cancer Res, 2012;72(22):5721-32. 2012
  86. A new human DSG2-transgenic mouse model for studying the tropism and pathology of human adenoviruses.
    Authors: Wang H, Beyer I, Persson J, Song H, Li Z, Richter M, Cao H, van Rensburg R, Yao X, Hudkins K, Yumul R, Zhang XB, Yu M, Fender P, Hemminki A, Lieber A
    J. Virol., 2012;86(11):6286-302. 2012
  87. Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung.
    J. Immunol., 2012;189(5):2545-52. 2012
  88. Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass.
    Authors: Knebel B, Haas J, Hartwig S, Jacob S, Kollmer C, Nitzgen U, Muller-Wieland D, Kotzka J
    PLoS ONE, 2012;7(2):e31812. 2012
  89. CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation.
    Authors: Denoyer A, Godefroy D, Celerier I, Frugier J, Riancho L, Baudouin F, Rostene W, Baudouin C
    Mucosal Immunol, 2012;5(0):702. 2012
  90. A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-kappaB signaling and improves survival in mouse models of sepsis.
    Acta Pharmacol. Sin., 2012;33(9):1204-16. 2012
  91. Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice.
    J. Neurochem., 2012;233(0):456-469. 2012
  92. Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kgamma-dependent fluid-phase pinocytosis of native LDL.
    Authors: Anzinger JJ, Chang J, Xu Q, Barthwal MK, Bohnacker T, Wymann MP, Kruth HS
    J. Lipid Res., 2012;53(1):34-42. 2012
  93. The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems.
    Authors: Chuquimia OD, Petursdottir DH, Rahman MJ, Hartl K, Singh M, Fernandez C
    PLoS ONE, 2012;7(2):e32125. 2012
  94. TGFbeta signalling plays an important role in IL4-induced alternative activation of microglia.
    J Neuroinflammation, 2012;9(0):210. 2012
  95. Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.
    Authors: Wolf A, Beuerlein K, Eckart C, Weiser H, Dickkopf B, Muller H, Sakurai H, Kracht M
    PLoS ONE, 2011;6(12):e29256. 2011
  96. HEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation.
    Authors: Braunstein M, Anderson MK,
    Mol. Cell. Biol., 2011;31(5):971-82. 2011
  97. SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis.
    Authors: McLarren KW, Cole AE, Weisser SB, Voglmaier NS, Conlin VS, Jacobson K, Popescu O, Boucher JL, Sly LM
    Am. J. Pathol., 2011;179(1):180-8. 2011
  98. TGF-beta limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.
    Authors: Rani R, Smulian AG, Greaves DR, Hogan SP, Herbert DR
    Eur. J. Immunol., 2011;41(7):2000-9. 2011
  99. Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-beta signalling.
    Authors: Weidenaar AC, Ter Elst A, Kampen KR, Meeuwsen-de Boer TG, de Jonge HJ, Scherpen FJ, den Dunnen WF, Kamps WA, de Bont ES
    Br. J. Cancer, 2011;105(12):1856-63. 2011
  100. Inhibition of IL-32 activation by alpha-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.
    Authors: Marcondes AM, Li X, Tabellini L, Bartenstein M, Kabacka J, Sale GE, Hansen JA, Dinarello CA, Deeg HJ
    Blood, 2011;118(18):5031-9. 2011
  101. TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines.
    Authors: Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ, Bourgoin SG
    J. Lipid Res., 2011;52(7):1307-18. 2011
  102. Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors.
    Authors: Falcon BL, Barr S, Gokhale PC, Chou J, Fogarty J, Depeille P, Miglarese M, Epstein DM, McDonald DM
    Cancer Res., 2011;71(5):1573-83. 2011
  103. Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6.
    Authors: Diao J, Zhao J, Winter E
    J. Immunol., 2011;186(9):5058-67. 2011
  104. Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation.
    Authors: Koroskenyi K, Duro E, Pallai A, Sarang Z, Kloor D, Ucker DS, Beceiro S, Castrillo A, Chawla A, Ledent CA, Fésüs L, Szondy Z
    J. Immunol., 2011;186(12):7144-55. 2011
  105. Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice.
    Authors: Kim ES, Chang YS, Choi SJ, Kim JK, Yoo HS, Ahn SY, Sung DK, Kim SY, Park YR, Park WS
    Respir. Res., 2011;12(0):108. 2011
  106. Immuno-therapy with anti-CTLA4 antibodies in tolerized and non-tolerized mouse tumor models.
    Authors: Persson J, Beyer I, Yumul R, Li Z, Kiem HP, Roffler S, Lieber A
    PLoS ONE, 2011;6(7):e22303. 2011
  107. Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II.
    Authors: Burton VJ, Holmes AM, Ciuclan LI
    Blood, 2011;118(17):4750-8. 2011
  108. Fine-tuning nucleophosmin in macrophage differentiation and activation.
    Authors: Guery L, Benikhlef N, Gautier T, Paul C, Jego G, Dufour E, Jacquel A, Cally R, Manoury B, Vanden Berghe T, Vandenabeele P, Droin N, Solary E
    Blood, 2011;118(17):4694-704. 2011
  109. Comparative kinetic analyses of gene profiles of naive CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations.
    Authors: Mirza N, Pollock K, Hoelzinger DB, Dominguez AL, Lustgarten J
    Aging Cell, 2011;10(5):853-67. 2011
  110. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
    Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES
    Eur. J. Cancer, 2010;46(5):974-82. 2010
  111. Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice.
    Authors: Marttila-Ichihara F, Castermans K, Auvinen K, oude Egbrink MG, Jalkanen S, Griffioen AW, Salmi M
    J. Immunol., 2010;184(6):3164-73. 2010
  112. Salmonella enterica serovar Typhimurium-induced placental inflammation and not bacterial burden correlates with pathology and fatal maternal disease.
    Authors: Chattopadhyay A, Robinson N, Sandhu JK, Finlay BB, Sad S, Krishnan L
    Infect. Immun., 2010;78(5):2292-301. 2010
  113. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis.
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    Vaccine, 2010;28(10):2249-58. 2010
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    J. Immunol., 2010;184(3):1261-7. 2010
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    Authors: Cedeno-Laurent F, Barthel SR, Opperman MJ, Lee DM, Clark RA, Dimitroff CJ
    J. Immunol., 2010;185(8):4659-72. 2010
  120. Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy.
    Authors: Yang SJ, IglayReger HB, Kadouh HC, Bodary PF
    Diabetologia, 2009;52(0):972-81. 2009
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    Authors: Hood JL, Pan H, Lanza GM, Wickline SA,
    Lab. Invest., 2009;89(11):1317-28. 2009
  122. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.
    Authors: McKee AS, Munks MW, MacLeod MK, Fleenor CJ, Van Rooijen N, Kappler JW, Marrack P
    J. Immunol., 2009;183(7):4403-14. 2009
  123. Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.
    Authors: Di Paolo NC, Miao EA, Iwakura Y, Murali-Krishna K, Aderem A, Flavell RA, Papayannopoulou T, Shayakhmetov DM
    Immunity, 2009;31(1):110-21. 2009
  124. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain.
    Authors: Gao YJ, Zhang L, Samad OA, Suter MR, Yasuhiko K, Xu ZZ, Park JY, Lind AL, Ma Q, Ji RR
    J. Neurosci., 2009;29(13):4096-108. 2009
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