Proteome Profiler Mouse Cytokine Array Kit, Panel A
Proteome Profiler Mouse Cytokine Array Kit, Panel A Summary
A membrane-based antibody array for the parallel determination of the relative levels of selected mouse cytokines and chemokines. Validated for analyte detection in cell culture supernates, cell lysates, tissue lysates, serum, and plasma.
Key Benefits
- Detects 40 mouse cytokines, chemokines, and acute phase proteins simultaneously
- Requires no specialized equipment
- Compatible with LI-COR and chemiluminescence detection
Principle of the Assay
The Proteome Profiler Mouse Cytokine Array Kit, Panel A is a membrane-based sandwich immunoassay. Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2). Captured proteins are visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of analyte bound.
Why Use an Antibody Array to Detect Multiple Cytokines?
Determining the expression of multiple cytokines in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple cytokines in a single sample can be cost-effective and also save time and sample.
- Rectangular 4-Well Multi-dish
- 4 Mouse Cytokine Array, Panel A nitrocellulose membranes spotted with 40 different antibodies to mouse cytokines, chemokines, and acute phase proteins
- Array Buffer 4
- Array Buffer 6
- Chemi Reagent 1
- Chemi Reagent 2
- Detection Antibody Cocktail, Mouse Cytokine Array, Panel A
- Streptavidin-HRP
- Transparency Overlay Template
- Wash Buffer Concentrate (25X)
For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.
Stability and Storage
Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.
Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample. | ||
CXCL13/BLC/BCA-1 | IL-5 | M-CSF |
C5a | IL-6 | CCL2/JE/MCP-1 |
G-CSF | IL-7 | CCL12/MCP-5 |
GM-CSF | IL-10 | CXCL9/MIG |
CCL1/I-309 | IL-12 p70 | CCL3/MIP-1 alpha |
CCL11/Eotaxin | IL-13 | CCL4/MIP-1 beta |
ICAM-1 | IL-16 | CXCL2/MIP-2 |
IFN-gamma | IL-17 | CCL5/RANTES |
IL-1 alpha/IL-1F1 | IL-23 | CXCL12/SDF-1 |
IL-1 beta/IL-1F2 | IL-27 | CCL17/TARC |
IL-1ra/IL-1F3 | CXCL10/IP-10 | TIMP-1 |
IL-2 | CXCL11/I-TAC | TNF-alpha |
IL-3 | CXCL1/KC | TREM-1 |
IL-4 |
Assays for Analytes represented in the Mouse Cytokine Array Kit, Panel A
Analyte | Quantikine® ELISA Kits | DuoSet® ELISA Development Systems |
CXCL13/BLC/BCA-1 | MCX130 | DY470 |
C5a | DY2150 | |
G-CSF | MCS00 | DY414 |
GM-CSF | MGM00 | DY415 |
CCL1/I-309/TCA-3 | DY845 | |
CCL11/Eotaxin | MME00 | DY420 |
ICAM-1 | MIC100 | DY796 |
IFN-gamma | MIF00 | DY485 |
IL-1 alpha | MLA00 | DY400 |
IL-1 beta | MLB00B | DY401 |
IL-1ra | MRA00 | DY480 |
IL-2 | M2000 | DY402 |
IL-3 | M3000 | DY403 |
IL-4 | M4000B | DY404 |
IL-5 | M5000 | DY405 |
IL-6 | M6000B | DY406 |
IL-7 | M7000 | DY407 |
IL-10 | M1000b | DY417 |
IL-12 p70 | M1270 | DY419 |
IL-13 | M1300CB | DY413 |
IL-16 | ||
IL-17 | M1700 | DY421 |
IL-23 | M2300 | DY1887 |
IL-27 | M2728 | |
CXCL10/IP-10/CRG-2 | MCX100 | DY466 |
CXCL11/I-TAC | DY572 | |
CXCL1/KC | MKC00B | DY453 |
M-CSF | MMC00 | DY416 |
CCL2/MCP-1/JE | MJE00 | DY479 |
CCL12/MCP-5 | MCC120 | DY428 |
CXCL9/MIG | MCX900 | DY492 |
CCL3/MIP-1 alpha | MMA00 | DY450 |
CCL4/MIP-1 beta | MMB00 | DY451 |
CXCL2/MIP-2 | MM200 | DY452 |
CCL5/RANTES | MMR00 | DY478 |
CXCL12/SDF-1 | MCX120 | DY460 |
CCL17/TARC | DY529 | |
TIMP-1 | MTM100 | DY980 |
TNF-alpha | MTA00 | DY410 |
TREM-1 | MTRM10 | DY1187 |
Specifications
Product Datasheets
Data Example
The Mouse Cytokine Array, Panel A utilizes capture antibodies spotted onto a nitrocellulose membrane to allow high-throughput multi-analyte profiling of 40 cytokines, chemokines, and more in a single sample. Mouse splenocytes treated with 100 ng/mL LPS for 20 hours were mixed with a cocktail of biotinylated detection antibodies, and then incubated with the Mouse Cytokine Array. The array was then incubated with streptavidin-horseradish peroxidase followed by chemiluminescent detection. After detection, the array data were quantitated to generate a protein profile (histogram). The table shows the analytes detected and their location on the membrane.
The Mouse Cytokine Array detects multiple analytes in cell culture lysates and supernates. (A. and B.) Lysates of RAW264.7 mouse monocyte/macrophage cell line untreated or treated with 100 ng/mL LPS for 24 hours. 100 µg of lysate was used for each array shown. (C. and D.) Supernates of RAW264.7 mouse monocyte/macrophage cell line untreated or treated with 100 ng/mL LPS for 24 hours. 100 µL of supernate was used for each array shown. Array images were collected and analyzed using the LI-COR Odyssey Infrared Imaging System.
The Mouse Cytokine Array detects multiple analytes in mouse serum and tissue lysates. (A and B.) Samples of mouse serum from two different vendors. 200 µL of serum was used for each array shown. (C. and D.) Lysates of mouse lung tissue and mouse stomach tissue. 200 µg of lysate was used for each array shown. Array images were collected and analyzed using the LI-COR Odyssey Infrared Imaging System.
Citations for Proteome Profiler Mouse Cytokine Array Kit, Panel A
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Cellular Virotherapy Increases Tumor-Infiltrating Lymphocytes (TIL) and Decreases their PD-1+ Subsets in Mouse Immunocompetent Models
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HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution
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The role of HFE genotype in macrophage phenotype
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Impaired immune surveillance accelerates accumulation of senescent cells and aging
Authors: Y Ovadya, T Landsberge, H Leins, E Vadai, H Gal, A Biran, R Yosef, A Sagiv, A Agrawal, A Shapira, J Windheim, M Tsoory, R Schirmbeck, I Amit, H Geiger, V Krizhanovs
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Myeloid p38? signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis
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A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
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Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration
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Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance
Authors: J Gilleron, G Bouget, S Ivanov, C Meziat, F Ceppo, B Vergoni, M Djedaini, A Soprani, K Dumas, A Jacquel, L Yvan-Charv, N Venteclef, JF Tanti, M Cormont
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Unique pattern of neutrophil migration and function during tumor progression
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LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent
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Sci Rep, 2018;8(1):14969. 2018
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Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis
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A severe atherosclerosis mouse model on the resistant NOD background
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Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer
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Cancer Res., 2018;0(0):. 2018
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Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice
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Stem Cell Res Ther, 2018;9(1):183. 2018
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Inflammaging impairs peripheral nerve maintenance and regeneration
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Caveolin-1-Knockout Mouse as a Model of Inflammatory Diseases
Authors: E Codrici, L Albulescu, ID Popescu, S Mihai, AM Enciu, R Albulescu, C Tanase, ME Hinescu
J Immunol Res, 2018;2018(0):2498576. 2018
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Bone marrow mesenchymal stem cells tune the differentiation of myeloid-derived suppressor cells in bleomycin-induced lung injury
Authors: X Su, L Yang, Y Yin, J Huang, F Qiao, Y Fang, L Yu, Y Wang, K Zhou, J Wang
Stem Cell Res Ther, 2018;9(1):253. 2018
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CLEC16A regulates splenocyte and NK cell function in part through MEK signaling
Authors: R Pandey, M Bakay, HS Hain, B Strenkowsk, BZB Elsaqa, JD Roizen, JA Kushner, JS Orange, H Hakonarson
PLoS ONE, 2018;13(9):e0203952. 2018
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Akt1-Mediated Muscle Growth Promotes Blood Flow Recovery After Hindlimb Ischemia by Enhancing Heme Oxygenase-1 in Neighboring Cells
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Circ. J., 2018;0(0):. 2018
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Molecular and cellular identification of the immune response in peripheral ganglia following nerve injury
Authors: JA Lindborg, JP Niemi, MA Howarth, KW Liu, CZ Moore, D Mahajan, RE Zigmond
J Neuroinflammation, 2018;15(1):192. 2018
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Choline transport links macrophage phospholipid metabolism and inflammation
Authors: SA Snider, KD Margison, P Ghorbani, ND LeBlond, C O'Dwyer, JR Nunes, T Nguyen, H Xu, SA Bennett, MD Fullerton
J. Biol. Chem., 2018;0(0):. 2018
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Impact of eosinophil-peroxidase (EPX) deficiency on eosinophil structure and function in mouse airways
Authors: CM Percopo, JO Krumholz, ER Fischer, LS Kraemer, M Ma, K Laky, HF Rosenberg
J. Leukoc. Biol., 2018;0(0):. 2018
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Human Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Atopic Dermatitis by Regulating the Expression of MIP-2, miR-122a-SOCS1 Axis, and Th1/Th2 Responses
Authors: M Kim, SH Lee, Y Kim, Y Kwon, Y Park, HK Lee, HS Jung, D Jeoung
Front Pharmacol, 2018;9(0):1175. 2018
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Gene and Protein Expression Profiles in a Mouse Model of Collagen-Induced Arthritis
Authors: SY Gwon, KJ Rhee, HJ Sung
Int J Med Sci, 2018;15(1):77-85. 2018
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Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema
Authors: K Rashid, IK Sundar, J Gerloff, D Li, I Rahman
Sci Rep, 2018;8(1):9023. 2018
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EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes
Authors: A Rutkowska, DR Shimshek, AW Sailer, KK Dev
Neuropharmacology, 2018;133(0):121-128. 2018
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Effects of Graphene Oxide Nanoparticles on the Immune System Biomarkers Produced by RAW 264.7 and Human Whole Blood Cell Cultures
Authors: K Lategan, H Alghadi, M Bayati, MF de Cortale, E Pool
Nanomaterials (Basel), 2018;8(2):. 2018
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Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease by exerting anti-inflammatory and neuroprotective effects
Authors: C Scuderi, MR Bronzuoli, R Facchinett, L Pace, L Ferraro, KD Broad, G Serviddio, F Bellanti, G Palombelli, G Carpinelli, R Canese, S Gaetani, L Steardo, L Steardo, T Cassano
Transl Psychiatry, 2018;8(1):32. 2018
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Carbon Monoxide Impairs CD11bLy-6CMonocyte Migration from the Blood to Inflamed Pancreas via Inhibition of the CCL2/CCR2 Axis
Authors: J Wu, R Zhang, G Hu, HH Zhu, WQ Gao, J Xue
J. Immunol., 2018;0(0):. 2018
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Alternaria alternata challenge at the nasal mucosa results in eosinophilic inflammation and increased susceptibility to influenza virus infection
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Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis.
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PLoS ONE, 2014;9(4):e94793. 2014
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IL-1alpha and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells.
Authors: Di Paolo N, Baldwin L, Irons E, Papayannopoulou T, Tomlinson S, Shayakhmetov D
PLoS Pathog, 2014;10(3):e1004035. 2014
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The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
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J Exp Med, 2014;211(10):1993-2011. 2014
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Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation.
Authors: Nie Y, DU L, Mou Y, Xu Z, Weng L, Du Y, Zhu Y, Hou Y, Wang T
BMC Cancer, 2013;13(0):582. 2013
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Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.
Authors: Gandhirajan, Rajesh K, Meng, Shu, Chandramoorthy, Harish C, Mallilankaraman, Karthik, Mancarella, Salvator, Gao, Hui, Razmpour, Roshanak, Yang, Xiao-Fen, Houser, Steven R, Chen, Ju, Koch, Walter J, Wang, Hong, Soboloff, Jonathan, Gill, Donald L, Madesh, Muniswam
J Clin Invest, 2013;123(2):887-902. 2013
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Concomitant interferon alpha stimulation and TLR3 activation induces neuronal expression of depression-related genes that are elevated in the brain of suicidal persons.
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PLoS ONE, 2013;8(12):e83149. 2013
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Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10).
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Biochem Biophys Res Commun, 2013;442(3):234-41. 2013
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The bradykinin B1 receptor regulates Abeta deposition and neuroinflammation in Tg-SwDI mice.
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Am J Pathol, 2013;182(5):1740-9. 2013
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A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.
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Nat Immunol, 2013;14(5):470-9. 2013
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Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice.
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Cell Death Dis, 2013;4(0):e742. 2013
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Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity.
Authors: Kotzka J, Knebel B, Haas J, Kremer L, Jacob S, Hartwig S, Nitzgen U, Muller-Wieland D
PLoS ONE, 2012;7(2):e32609. 2012
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CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation.
Authors: Denoyer A, Godefroy D, Celerier I, Frugier J, Riancho L, Baudouin F, Rostene W, Baudouin C
Mucosal Immunol, 2012;5(0):702. 2012
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Dietary blue pigments derived from genipin, attenuate inflammation by inhibiting LPS-induced iNOS and COX-2 expression via the NF-kappaB inactivation.
Authors: Wang QS, Xiang Y, Cui YL, Lin KM, Zhang XF
PLoS ONE, 2012;7(3):e34122. 2012
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Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes.
Diabetes, 2012;61(8):2114-25. 2012
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Histone Deacetylase 3 Mediates Allergic Skin Inflammation by Regulating Expression of MCP1 Protein.
Authors: Kim Y, Kim K, Park D, Lee E, Lee H, Lee YS, Choe J, Jeoung D
J. Biol. Chem., 2012;287(31):25844-59. 2012
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The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice.
Authors: Tran K, Risingsong R, Royce D
Cancer Prev Res (Phila), 2012;5(5):726-34. 2012
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Exosomes isolated from mycobacteria-infected mice or cultured macrophages can recruit and activate immune cells in vitro and in vivo.
Authors: Singh PP, Smith VL, Karakousis PC, Schorey JS
J. Immunol., 2012;189(2):777-85. 2012
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A new human DSG2-transgenic mouse model for studying the tropism and pathology of human adenoviruses.
Authors: Wang H, Beyer I, Persson J, Song H, Li Z, Richter M, Cao H, van Rensburg R, Yao X, Hudkins K, Yumul R, Zhang XB, Yu M, Fender P, Hemminki A, Lieber A
J. Virol., 2012;86(11):6286-302. 2012
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The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems.
Authors: Chuquimia OD, Petursdottir DH, Rahman MJ, Hartl K, Singh M, Fernandez C
PLoS ONE, 2012;7(2):e32125. 2012
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Clusterin induces the secretion of TNF-α and the chemotactic migration of macrophages.
Authors: Shim YJ, Kang BH, Choi BK, Park IS, Min BH
Biochem. Biophys. Res. Commun., 2012;422(1):200-5. 2012
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The MSHA Strain of Pseudomonas Aeruginosa Activated TLR Pathway and Enhanced HIV-1 DNA Vaccine Immunoreactivity.
Authors: Hou J, Liu Y, Liu Y, Shao Y
PLoS ONE, 2012;7(10):e47724. 2012
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Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass.
Authors: Knebel B, Haas J, Hartwig S, Jacob S, Kollmer C, Nitzgen U, Muller-Wieland D, Kotzka J
PLoS ONE, 2012;7(2):e31812. 2012
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Macrophage Dectin-1 Expression Is Controlled by Leukotriene B4 via a GM-CSF/PU.1 Axis.
Authors: Serezani CH, Kane S, Collins L
J. Immunol., 2012;189(2):906-15. 2012
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A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-kappaB signaling and improves survival in mouse models of sepsis.
Acta Pharmacol. Sin., 2012;33(9):1204-16. 2012
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Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung.
J. Immunol., 2012;189(5):2545-52. 2012
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NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases.
Authors: Chow M, Sceneay J, Paget C, Wong C, Duret H, Tschopp J, Moller A, Smyth M
Cancer Res, 2012;72(22):5721-32. 2012
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TGFbeta signalling plays an important role in IL4-induced alternative activation of microglia.
J Neuroinflammation, 2012;9(0):210. 2012
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Interleukin-33 primes mast cells for activation by IgG immune complexes.
Authors: Kaieda S, Wang J, Shnayder R, Fishgal N, Hei H, Lee R, Stevens R, Nigrovic P
PLoS ONE, 2012;7(10):e47252. 2012
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Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.
Authors: Soond DR, Garcon F, Patton DT, Rolf J, Turner M, Scudamore C, Garden OA, Okkenhaug K
J. Immunol., 2012;188(12):5935-43. 2012
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The effect of oxidized low density lipoprotein (oxLDL)-induced heme oxygenase-1 on LPS-induced inflammation in RAW 264.7 macrophage cells.
Authors: Min KJ, Cho KH, Kwon TK
Cell. Signal., 2012;24(6):1215-21. 2012
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Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice.
J. Neurochem., 2012;233(0):456-469. 2012
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Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kgamma-dependent fluid-phase pinocytosis of native LDL.
Authors: Anzinger JJ, Chang J, Xu Q, Barthwal MK, Bohnacker T, Wymann MP, Kruth HS
J. Lipid Res., 2012;53(1):34-42. 2012
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Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors.
Authors: Falcon BL, Barr S, Gokhale PC, Chou J, Fogarty J, Depeille P, Miglarese M, Epstein DM, McDonald DM
Cancer Res., 2011;71(5):1573-83. 2011
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TGF-beta limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.
Authors: Rani R, Smulian AG, Greaves DR, Hogan SP, Herbert DR
Eur. J. Immunol., 2011;41(7):2000-9. 2011
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SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis.
Authors: McLarren KW, Cole AE, Weisser SB, Voglmaier NS, Conlin VS, Jacobson K, Popescu O, Boucher JL, Sly LM
Am. J. Pathol., 2011;179(1):180-8. 2011
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Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice.
Authors: Kim ES, Chang YS, Choi SJ, Kim JK, Yoo HS, Ahn SY, Sung DK, Kim SY, Park YR, Park WS
Respir. Res., 2011;12(0):108. 2011
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Comparative kinetic analyses of gene profiles of naive CD4+ and CD8+ T cells from young and old animals reveal novel age-related alterations.
Authors: Mirza N, Pollock K, Hoelzinger DB, Dominguez AL, Lustgarten J
Aging Cell, 2011;10(5):853-67. 2011
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TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines.
Authors: Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ, Bourgoin SG
J. Lipid Res., 2011;52(7):1307-18. 2011
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Immuno-therapy with anti-CTLA4 antibodies in tolerized and non-tolerized mouse tumor models.
Authors: Persson J, Beyer I, Yumul R, Li Z, Kiem HP, Roffler S, Lieber A
PLoS ONE, 2011;6(7):e22303. 2011
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Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6.
Authors: Diao J, Zhao J, Winter E
J. Immunol., 2011;186(9):5058-67. 2011
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Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation.
Authors: Koroskenyi K, Duro E, Pallai A, Sarang Z, Kloor D, Ucker DS, Beceiro S, Castrillo A, Chawla A, Ledent CA, Fésüs L, Szondy Z
J. Immunol., 2011;186(12):7144-55. 2011
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Fine-tuning nucleophosmin in macrophage differentiation and activation.
Authors: Guery L, Benikhlef N, Gautier T, Paul C, Jego G, Dufour E, Jacquel A, Cally R, Manoury B, Vanden Berghe T, Vandenabeele P, Droin N, Solary E
Blood, 2011;118(17):4694-704. 2011
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Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.
Authors: Wolf A, Beuerlein K, Eckart C, Weiser H, Dickkopf B, Muller H, Sakurai H, Kracht M
PLoS ONE, 2011;6(12):e29256. 2011
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Inhibition of IL-32 activation by alpha-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.
Authors: Marcondes AM, Li X, Tabellini L, Bartenstein M, Kabacka J, Sale GE, Hansen JA, Dinarello CA, Deeg HJ
Blood, 2011;118(18):5031-9. 2011
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HEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation.
Authors: Braunstein M, Anderson MK,
Mol. Cell. Biol., 2011;31(5):971-82. 2011
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Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II.
Authors: Burton VJ, Holmes AM, Ciuclan LI
Blood, 2011;118(17):4750-8. 2011
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Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-beta signalling.
Authors: Weidenaar AC, Ter Elst A, Kampen KR, Meeuwsen-de Boer TG, de Jonge HJ, Scherpen FJ, den Dunnen WF, Kamps WA, de Bont ES
Br. J. Cancer, 2011;105(12):1856-63. 2011
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Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice.
Authors: Marttila-Ichihara F, Castermans K, Auvinen K, oude Egbrink MG, Jalkanen S, Griffioen AW, Salmi M
J. Immunol., 2010;184(6):3164-73. 2010
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Salmonella enterica serovar Typhimurium-induced placental inflammation and not bacterial burden correlates with pathology and fatal maternal disease.
Authors: Chattopadhyay A, Robinson N, Sandhu JK, Finlay BB, Sad S, Krishnan L
Infect. Immun., 2010;78(5):2292-301. 2010
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VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES
Eur. J. Cancer, 2010;46(5):974-82. 2010
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Recruitment and differentiation of conventional dendritic cell precursors in tumors.
Authors: Diao J, Zhao J, Winter E, Cattral MS
J. Immunol., 2010;184(3):1261-7. 2010
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Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin-1 ligands and immune disease modulation.
Authors: Cedeno-Laurent F, Barthel SR, Opperman MJ, Lee DM, Clark RA, Dimitroff CJ
J. Immunol., 2010;185(8):4659-72. 2010
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A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling.
Authors: Kennedy DJ, Kuchibhotla S
Cardiovasc. Res., 2010;0(0):. 2010
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The member of the cyclic di-nucleotide family bis-(3', 5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant.
Authors: Libanova R, Ebensen T, Schulze K, Bruhn D, Norder M, Yevsa T, Morr M, Guzman CA
Vaccine, 2010;28(10):2249-58. 2010
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Tim3 binding to galectin-9 stimulates antimicrobial immunity.
Authors: Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM
J. Exp. Med., 2010;207(11):2343-54. 2010
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Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis.
Authors: Perin L, Sedrakyan S, Giuliani S, Da Sacco S, Carraro G, Shiri L, Lemley KV, Rosol M, Wu S, Atala A, Warburton D, De Filippo RE
PLoS ONE, 2010;5(2):e9357. 2010
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Caspase-3 is transiently activated without cell death during early antigen driven expansion of CD8(+) T cells in vivo.
Authors: McComb S, Mulligan R, Sad S
PLoS ONE, 2010;5(12):e15328. 2010
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JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain.
Authors: Gao YJ, Zhang L, Samad OA, Suter MR, Yasuhiko K, Xu ZZ, Park JY, Lind AL, Ma Q, Ji RR
J. Neurosci., 2009;29(13):4096-108. 2009
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Paracrine induction of endothelium by tumor exosomes.
Authors: Hood JL, Pan H, Lanza GM, Wickline SA,
Lab. Invest., 2009;89(11):1317-28. 2009
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Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.
Authors: Di Paolo NC, Miao EA, Iwakura Y, Murali-Krishna K, Aderem A, Flavell RA, Papayannopoulou T, Shayakhmetov DM
Immunity, 2009;31(1):110-21. 2009
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Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy.
Authors: Yang SJ, IglayReger HB, Kadouh HC, Bodary PF
Diabetologia, 2009;52(0):972-81. 2009
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Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.
Authors: McKee AS, Munks MW, MacLeod MK, Fleenor CJ, Van Rooijen N, Kappler JW, Marrack P
J. Immunol., 2009;183(7):4403-14. 2009
FAQs
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Will the Array identification number stamped on the Array membrane interfere with detection if it is not cut-off before the membrane is blocked?
The dye used for printing the Array identification number on the membranes will fluoresce and interfere with the LI-COR detection. It is critical that the number is cut off before beginning the experiment.
Reviews for Proteome Profiler Mouse Cytokine Array Kit, Panel A
Average Rating: 4.7 (Based on 23 Reviews)
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150UL SERUM WAS USED
mouse tissues
serum from knock-out mice
Followed protocol exactly, 10 min exposure on film wasn't great, boosted to 20 min exposure, still not good. 5 min on digital imager and positive control spots were saturated! Much more sensitive!
T cells isolated and stimulated with various agonists.
This array was used to measure the modulation of inflammation-associated cytokines in LPS-stimulated RAW264.7 macrophages treated with several doses of the non-digestible fraction from a corn/bean snack.
High quality results with simple and straightforward protocol. No optimization needed.
instructions easy to follow. I needed a little longer than the 10 minute exposure due to low protein concentrations from my very small tissues.
Very sensitive cytokine assay!
performed on cell conditoned media from mouse fibroblasts
Assay tested in 200 ug of protein from pool of intestines of 10 dpf zebrafish larvae.
Mouse BALF samples from pooled control and treatment groups in 2 separate arrays to determine the altered cytokine response.
Bronchoalveolar lavage fluid from C57BL/6J mouse