Proteome Profiler Human Angiogenesis Array Kit
Proteome Profiler Human Angiogenesis Array Kit Summary
A membrane-based antibody array for the parallel determination of the relative levels of selected angiogenesis-related proteins. Validated for analyte detection in cell culture supernates, cell lysates, tissue lysates, serum, plasma and saliva.
Key Benefits
- Detects 55 human angiogenesis-related proteins simultaneously
- Requires no specialized equipment
- Compatible with LI-COR and chemiluminescence detection
Principle of the Assay
The Proteome Profiler Human Angiogenesis Array Kit is a membrane-based sandwich immunoassay. Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2). Captured proteins are visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of bound analyte. Analytes include soluble growth and differentiation factors, extracellular matrix components, proteases, membrane-bound receptors, and intracellular signaling molecules.
Why Use an Antibody Array to Detect Angiogenesis-Related Proteins?
Determining the expression of multiple proteins in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple proteins in a single sample can be cost-effective and also save time and sample.
- 4 Array Membranes
- 4-Well Multi-dish
- Array Buffers
- Wash Buffer
- Antibody Detection Cocktail
- Streptavidin-HRP
- Chemiluminescent Detection Reagents
- Transparency Overlay Template
- Detailed Protocol
For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.
Stability and Storage
Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.
Simultaneously detect the relative levels of these angiogenesis-related proteins in a single sample. | ||
Activin A | FGF-7/KGF | PD-ECGF |
ADAMTS-1 | GDNF | PDGF-AA |
Angiogenin | GM-CSF | PDGF-AB/PDGF-BB |
Angiopoietin-1 | HB-EGF | Persephin |
Angiopoietin-2 | HGF | CXCL4/PF4 |
Angiostatin/Plasminogen | IGFBP-1 | PlGF |
Amphiregulin | IGFBP-2 | Prolactin |
Artemin | IGFBP-3 | Serpin B5/Maspin |
Tissue Factor/Factor III | IL-1 beta | Serpin E1/PAI-1 |
CXCL16 | CXCL8/IL-8 | Serpin F1/PEDF |
DPPIV/CD26 | LAP (TGF-beta 1) | TIMP-1 |
EGF | Leptin | TIMP-4 |
EG-VEGF | CCL2/MCP-1 | Thrombospondin-1 |
Endoglin/CD105 | CCL3/MIP-1 alpha | Thrombospondin-2 |
Endostatin/Collagen XVIII | MMP-8 | uPA |
Endothelin-1 | MMP-9 | Vasohibin |
FGF acidic | NRG1-beta 1 | VEGF |
FGF basic | Pentraxin 3 | VEGF-C |
FGF-4 |
Assays for analytes represented in the Human Angiogenesis Antibody Array Kit
Quantikine® ELISA Kits | DuoSet® ELISA Development Systems | Quantikine® HS (High Sensitivity) ELISA Kits | QuantiGlo® Chemiluminescent ELISA Kits | |
Activin A | DAC00B | DY338 | ||
ADAMTS-1 | DY2197 | |||
Angiogenin | DAN00 | DY265 | ||
Angiopoietin-1 | DANG10 | DY923 | ||
Angiopoietin-2 | DANG20 | DY623 | ||
Angiostatin/Plasminogen | ||||
Amphiregulin | DY262 | |||
Artemin | DY2589 | |||
Tissue Factor/Factor III | DCF300 | DY2339 | ||
CXCL16 | DCX160 | DY1164 | ||
DPPIV/CD26 | DY1180 | |||
EGF | DEG00 | DY236 | ||
EG-VEGF | DY1209 | |||
Endoglin | DNDG00 | DY1097 | ||
Endostatin/Collagen XVII | DNST0 | DY1098 | ||
Endothelin-1 | DET100 | QET00B | ||
FGF acidic | DFA00B | DY232 | ||
FGF basic | DFB50 | DY233 | HSFB00D | |
FGF-4 | DY235 | |||
FGF-7/KGF | DKG00 | DY251 | ||
GDNF | DY212 | |||
GM-CSF | DGM00 | DY215 | HSGM0 | |
HB-EGF | DY259 | |||
HGF | DHG00 | DY294 | ||
IGFBP-1 | DY871 | |||
IGFBP-2 | DGB200 | DY674 | ||
IGFBP-3 | DGB300 | DY675 | ||
IL-1 beta | DLB50 | DY201 | HSLB00D | QLB00B |
CXCL8/IL-8 | D8000C | DY208 | HS800 | Q8000B |
TGF-beta1 (LAP) | DB100B | DY240 | ||
Leptin | DLP00 | DY398 | ||
CCL2/MCP-1 | DCP00 | DY279 | ||
CCL3/MIP-1 alpha | DMA00 | DY270 | ||
MMP-8 | DMP800 | DY908 | ||
MMP-9 | DMP900 | DY911 | ||
NRG1-beta1 | DY377 | |||
Pentraxin 3 | DPTX30 | DY1826 | ||
PD-ECGF | ||||
PDGF-AA | DAA00B | DY221 | ||
PDGF-AB/PDGF-BB | DHD00C, DBB00 | DY222, DY220 | ||
Persephin | ||||
CXCL4/PF4 | DY795 | |||
PlGF | DPG00 | DY264 | ||
Prolactin | DPRL00 | DY682 | ||
Serpin B5/Maspin | ||||
Serpin E1/PAI-1 | DSE100 | DY1786 | ||
Serpin F1/PEDF | ||||
TIMP-1 | DTM100 | DY970 | ||
TIMP-4 | DTM400 | DY974 | ||
Thrombospondin-1 | DTSP10 | DY3074 | ||
Thrombospondin-2 | DTSP20 | DY1635 | ||
uPA | DUPA00 | DY1310 | ||
Vasohibin | ||||
VEGF | DVE00 | DY293B | QVE00B | |
VEGF-C | DVEC00 | DY752B |
Angiogenesis is the tightly regulated process by which new blood vessels are formed from the existing vasculature. This process is physiologically important for development and wound healing, and is also a common driver in multiple diseases including rheumatoid arthritis, atherosclerosis, macular degeneration, and cancer. Angiogenesis occurs in response to a variety of molecular cues. Generally, the angiogenic process includes endothelial cell proliferation, chemotactic endothelial cell migration through the extracellular matrix barrier, and the formation of capillary tubes. Physiological and pathological angiogenesis utilize many of the same cellular processes and molecular signaling networks, however the structures that form during pathological angiogenesis are often functionally abnormal.
Specifications
Product Datasheets
Data Example
Profiling Angiogenesis-Related Proteins in Human Cancer Tissues. A) The Proteome Profiler Human Angiogenesis Antibody Array (Catalog # ARY007) was used to profile angiogenesis-related proteins in tissues from human prostate, ovarian, and breast cancers. B) Histogram profiles for select analytes were generated by quantifying the mean spot pixel densities from the array membrane using image software.
The Human Angiogenesis Array detects multiple analytes in cell culture supernates. A. THP-1 human acute monocytic leukemia cell line treated with 1 µg/mL Recombinant Human IFN-gamma (Catalog # 285-IF) for 8 hours and 1 µg/mL lipopolysaccharide (LPS) for 16 hours. B. HUVEC human umbilical vein endothelial cells treated with 10 mg/ml of LPS for 24 hours. 500 µL of supernate was used for each array shown. Array images were collected and analyzed using the LI-COR Odyssey Infrared Imaging System.
The Human Angiogenesis Array detects multiple analytes in tissue lysate, serum, and plasma. Representative membranes and selective quantification are shown for human ovarian cancer tissue lysate (A., 200 µg), serum (B., 100 µL), and EDTA plasma (C., 100 µL). Array images were collected and analyzed using the LI-COR Odyssey Infrared Imaging System.
Citations for Proteome Profiler Human Angiogenesis Array Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Human Peripheral Blood-Derived Endothelial Colony-Forming Cells Are Highly Similar to Mature Vascular Endothelial Cells yet Demonstrate a Transitional Transcriptomic Signature
Authors: AG Kutikhin, AE Tupikin, VG Matveeva, DK Shishkova, LV Antonova, MR Kabilov, EA Velikanova
Cells, 2020;9(4):. 2020
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Resveratrol Promotes Tumor Microvessel Growth via Endoglin and Extracellular Signal-Regulated Kinase Signaling Pathway and Enhances the Anticancer Efficacy of Gemcitabine against Lung Cancer
Authors: SH Qin, ATY Lau, ZL Liang, HW Tan, YC Ji, QH Zhong, XY Zhao, YM Xu
Cancers (Basel), 2020;12(4):. 2020
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Natural Histogel-Based Bio-Scaffolds for Sustaining Angiogenesis in Beige Adipose Tissue
Authors: M Di Somma, W Schaafsma, E Grillo, M Vliora, E Dakou, M Corsini, C Ravelli, R Ronca, P Sakellario, J Vanparijs, B Castro, S Mitola
Cells, 2019;8(11):. 2019
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Thrombin Preconditioning of Extracellular Vesicles Derived from Mesenchymal Stem Cells Accelerates Cutaneous Wound Healing by Boosting Their Biogenesis and Enriching Cargo Content
Authors: DK Sung, YS Chang, SI Sung, SY Ahn, WS Park
J Clin Med, 2019;8(4):. 2019
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Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts
Authors: EE Hedlund, PC McDonald, O Nemirovsky, S Awrey, LDE Jensen, S Dedhar
Cancers (Basel), 2019;11(7):. 2019
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Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
Authors: T Matsui, T Chiyo, H Kobara, S Fujihara, K Fujita, D Namima, M Nakahara, N Kobayashi, N Nishiyama, T Yachida, A Morishita, H Iwama, T Masaki
Int J Mol Sci, 2019;20(13):. 2019
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TGFBI Protein Is Increased in the Urine of Patients with High-Grade Urothelial Carcinomas, and Promotes Cell Proliferation and Migration
Authors: K Lang, S Kahveci, N Bonberg, K Wichert, T Behrens, J Hovanec, F Roghmann, J Noldus, YC Tam, A Tannapfel, HU Käfferlein, T Brüning
Int J Mol Sci, 2019;20(18):. 2019
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Homotypic and Heterotypic Activation of the Notch Pathway in Multiple Myeloma-Enhanced Angiogenesis: A Novel Therapeutic Target?
Authors: I Saltarella, MA Frassanito, A Lamanuzzi, A Brevi, P Leone, V Desantis, L Di Marzo, M Bellone, D Derudas, D Ribatti, R Chiaramont, MT Palano, A Neri, MA Mariggiò, R Fumarulo, F Dammacco, V Racanelli, A Vacca, R Ria
Neoplasia, 2019;21(1):93-105. 2019
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The Composition of Hyperacute Serum and Platelet-Rich Plasma Is Markedly Different despite the Similar Production Method
Authors: D Kardos, M Simon, G Vácz, A Hinsenkamp, T Holczer, D Cseh, A Sárközi, K Szenthe, F Bánáti, S Szathmary, S Nehrer, O Kuten, M Masteling, Z Lacza, I Hornyák
Int J Mol Sci, 2019;20(3):. 2019
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Characterization of the Angiogenic Potential of Human Regulatory Macrophages (Mreg) after Ischemia/Reperfusion Injury In Vitro
Authors: L Hummitzsch, K Zitta, R Rusch, J Cremer, M Steinfath, J Gross, F Fandrich, R Berndt, M Albrecht
Stem Cells Int, 2019;2019(0):3725863. 2019
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Impaired Regeneration Potential in Urinary Stem Cells Diagnosed from the Patients with Diabetic Nephropathy
Authors: G Xiong, W Tang, D Zhang, D He, G Wei, A Atala, XJ Liang, AJ Bleyer, ME Bleyer, J Yu, JA Aloi, JX Ma, CM Furdui, Y Zhang
Theranostics, 2019;9(14):4221-4232. 2019
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The efficacy of conditioned medium released by tonsil-derived mesenchymal stem cells in a chronic murine colitis model
Authors: KE Lee, SA Jung, YH Joo, EM Song, CM Moon, SE Kim, I Jo
PLoS ONE, 2019;14(12):e0225739. 2019
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Hematoma-derived exosomes of chronic subdural hematoma promote abnormal angiogenesis and inhibit hematoma absorption through miR-144-5p
Authors: C Gao, Z Gong, D Wang, J Huang, Y Qian, M Nie, W Jiang, X Liu, H Luo, J Yuan, T Xiang, S An, W Quan, H Wei, J Zhang, R Jiang
Aging (Albany NY), 2019;11(24):12147-12164. 2019
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B-Cell Activating Factor Enhances Hepatocyte-Driven Angiogenesis via B-Cell CLL/Lymphoma 10/Nuclear Factor-KappaB Signaling during Liver Regeneration
Authors: CH Chou, CM Ho, SL Lai, CN Chen, YM Wu, CT Shun, WF Wen, HS Lai
Int J Mol Sci, 2019;20(20):. 2019
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Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures
Authors: J Kelleher, A Dickinson, S Cain, Y Hu, N Bates, A Harvey, J Ren, W Zhang, FC Moreton, KW Muir, C Ward, RM Touyz, P Sharma, Q Xu, SJ Kimber, T Wang
Stem Cell Reports, 2019;13(5):817-831. 2019
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Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin� protein MP0250: a preclinical study
Authors: L Rao, K De Veirman, D Giannico, I Saltarella, V Desantis, MA Frassanito, AG Solimando, D Ribatti, M Prete, A Harstrick, U Fiedler, H De Raeve, V Racanelli, K Vanderkerk, A Vacca
Oncotarget, 2018;9(17):13366-13381. 2018
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Mitochondrial dysfunction is a key determinant of the rare disease lymphangioleiomyomatosis and provides a novel therapeutic target
Authors: EMM Abdelwahab, S Pal, K Kvell, V Sarosi, P Bai, R Rue, V Krymskaya, D McPhail, A Porter, JE Pongracz
Oncogene, 2018;0(0):. 2018
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Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells
Authors: A Kim, JY Ma
Front Pharmacol, 2018;9(0):1455. 2018
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Protein array profiling of circulating angiogenesis-related factors during bevacizumab containing treatment in metastatic colorectal cancer
Authors: H Hagman, PO Bendahl, J Lidfeldt, M Belting, A Johnsson
PLoS ONE, 2018;13(12):e0209838. 2018
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Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells
Authors: CM Galmarini, M Martin, BP Bouchet, MJ Guillen-Na, M Martínez-D, JF Martinez-L, A Akhmanova, P Aviles
BMC Cancer, 2018;18(1):164. 2018
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A Subset of Paracrine Factors as Efficient Biomarkers for Predicting Vascular Regenerative Efficacy of Mesenchymal Stromal/Stem Cells
Authors: HK Kim, SG Lee, SW Lee, BJ Oh, JH Kim, JA Kim, G Lee, JD Jang, YA Joe
Stem Cells, 2018;0(0):. 2018
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Multipotent Adult Progenitor Cells Support Lymphatic Regeneration at Multiple Anatomical Levels during Wound Healing and Lymphedema
Authors: M Beerens, XL Aranguren, B Hendrickx, W Dheedene, T Dresselaer, U Himmelreic, C Verfaillie, A Luttun
Sci Rep, 2018;8(1):3852. 2018
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Increased platelet factor 4 and aberrant permeability of follicular fluid in PCOS
Authors: CC Huang, CH Chou, SU Chen, HN Ho, YS Yang, MJ Chen
J. Formos. Med. Assoc., 2018;0(0):. 2018
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Nintedanib inhibits growth of human prostate carcinoma cells by modulating both cell cycle and angiogenesis regulators
Authors: RF da Silva, D Dhar, K Raina, D Kumar, R Kant, VHA Cagnon, C Agarwal, R Agarwal
Sci Rep, 2018;8(1):9540. 2018
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hiPSC-derived neural stem cells from patients with schizophrenia induce an impaired angiogenesis
Authors: BS Casas, G Vitória, MN do Costa, R Madeiro da, P Trindade, R Maciel, N Navarrete, SK Rehen, V Palma
Transl Psychiatry, 2018;8(1):48. 2018
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Human dental pulp stromal cell conditioned medium alters endothelial cell behavior
Authors: MA Gharaei, Y Xue, K Mustafa, SA Lie, I Fristad
Stem Cell Res Ther, 2018;9(1):69. 2018
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Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer
Authors: SL Lin, SM Wu, IH Chung, YH Lin, CY Chen, HC Chi, TK Lin, CT Yeh, KH Lin
Neoplasia, 2018;20(1):57-68. 2018
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Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions
Authors: JUG Wagner, E Chavakis, EM Rogg, M Muhly-Rein, SF Glaser, S Günther, D John, F Bonini, AM Zeiher, L Schaefer, MJ Hannocks, RA Boon, S Dimmeler
Arterioscler. Thromb. Vasc. Biol., 2018;0(0):. 2018
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Extracellular Matrix composition modulates PDAC parenchymal and stem cell plasticity and behavior through the secretome
Authors: G Biondani, K Zeeberg, MR Greco, S Cannone, I Dando, ED Pozza, M Mastrodona, S Forciniti, V Casavola, M Palmieri, SJ Reshkin, RA Cardone
FEBS J., 2018;0(0):. 2018
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Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379
Authors: KP O'Brien, S Khan, KE Gilligan, H Zafar, P Lalor, C Glynn, C O'Flathart, H Ingoldsby, P Dockery, A De Bhulbh, JR Schweber, K St John, M Leahy, JM Murphy, WM Gallagher, T O'Brien, MJ Kerin, RM Dwyer
Oncogene, 2018;0(0):. 2018
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Intranasal delivery of VEGF enhances compensatory lung growth in mice
Authors: DT Dao, JT Vuong, L Anez-Busti, A Pan, PD Mitchell, GL Fell, MA Baker, DR Bielenberg, M Puder
PLoS ONE, 2018;13(6):e0198700. 2018
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SCO-spondin oligopeptide inhibits angiogenesis in glioblastoma
Authors: R Bibes, S Gobron, F Vincent, C Mélin, N Vedrenne, A Perraud, F Labrousse, MO Jauberteau, F Lalloué
Oncotarget, 2017;8(49):85969-85983. 2017
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Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism
Authors: R El Bezawy, M De Cesare, M Pennati, M Deraco, P Gandellini, V Zuco, N Zaffaroni
J Hematol Oncol, 2017;10(1):19. 2017
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Human adipose-derived mesenchymal stem cell-secreted CXCL1 and CXCL8 facilitate breast tumor growth by promoting angiogenesis
Authors: Y Wang, J Liu, Q Jiang, J Deng, F Xu, X Chen, F Cheng, Y Zhang, Y Yao, Z Xia, X Xu, X Su, M Huang, L Dai, Y Yang, S Zhang, D Yu, RC Zhao, Y Wei, H Deng
Stem Cells, 2017;0(0):. 2017
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Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway
Authors: G Jin, Y Yang, K Liu, J Zhao, X Chen, H Liu, R Bai, X Li, Y Jiang, X Zhang, J Lu, Z Dong
Oncogenesis, 2017;6(10):e384. 2017
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Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival
Authors: RJ Chen, CT Shun, ML Yen, CH Chou, MC Lin
Oncotarget, 2017;8(37):62081-62098. 2017
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Adipose progenitor cell secretion of GM-CSF and MMP9 promotes a stromal and immunological microenvironment that supports breast cancer progression
Authors: F Reggiani, V Labanca, P Mancuso, C Rabascio, G Talarico, S Orecchioni, A Manconi, F Bertolini
Cancer Res., 2017;0(0):. 2017
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Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet-Derived Growth Factor on Human Retinal Ganglion Cells
Authors: A Osborne, J Sanderson, KR Martin
Stem Cells, 2017;0(0):. 2017
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Sonic hedgehog (SHH) signaling improves the angiogenic potential of Wharton's jelly-derived mesenchymal stem cells�(WJ-MSC)
Authors: G Zavala, CP Prieto, AA Villanueva, V Palma
Stem Cell Res Ther, 2017;8(1):203. 2017
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NF-?B Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance
Authors: S Yang, L Qiang, A Sample, P Shah, YY He
J. Biol. Chem., 2017;292(8):3379-3388. 2017
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Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells
Authors: A Gabrielyan, E Neumann, M Gelinsky, A Rösen-Wolf
Stem Cell Res Ther, 2017;8(1):212. 2017
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CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect
Authors: S Sakimoto, V Marchetti, E Aguilar, K Lee, Y Usui, S Murinello, F Bucher, JK Trombley, R Fallon, R Wagey, C Peters, EL Scheppke, PD Westenskow, M Friedlande
JCI Insight, 2017;2(2):e89906. 2017
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Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo
Authors: HR Jung, HM Kang, JW Ryu, DS Kim, KH Noh, ES Kim, HJ Lee, KS Chung, HS Cho, NS Kim, DS Im, JH Lim, CR Jung
Sci Rep, 2017;7(1):10499. 2017
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15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1
Authors: S Tunçer, AG Ke?kü?, M Çolako?lu, I Çimen, C Yener, Ö Konu, S Banerjee
Cell. Signal., 2017;39(0):44-54. 2017
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Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide
Authors: SS Kim, JB Harford, M Moghe, A Rait, KF Pirollo, EH Chang
Nucleic Acids Res., 2017;0(0):. 2017
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Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
Authors: L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He
Autophagy, 2017;0(0):0. 2017
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VLDL and LDL, but not HDL, promote breast cancer cell proliferation, metastasis and angiogenesis
Authors: Chun-Wun Lu
Cancer Lett, 2016;388(0):130-138. 2016
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Identification of neuronal and angiogenic growth factors in an in vitroblood-brain barrier model system: Relevance in barrier integrity and tight junction formation and complexity
Authors: Christian Freese
Microvasc. Res, 2016;0(0):. 2016
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Synergic effects of VEGF-A and SDF-1 on the angiogenic properties of endothelial progenitor cells
Authors: Gabriela Odent Grig
J Tissue Eng Regen Med, 2016;0(0):. 2016
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Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment
PLoS ONE, 2016;11(7):e0159013. 2016
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The Development of an Angiogenic Protein Signature in Ovarian Cancer Ascites as a Tool for Biologic and Prognostic Profiling
Authors: Sofia-Paraskevi Trachana
PLoS ONE, 2016;11(6):e0156403. 2016
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IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma
Authors: Matthew N Svalina
Sci Rep, 2016;6(0):27012. 2016
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The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts
Sci Rep, 2016;6(0):39460. 2016
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Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor
Stem Cell Res Ther, 2016;7(1):173. 2016
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A Long-Gap Peripheral Nerve Injury Therapy Using Human Skeletal Muscle-Derived Stem Cells (Sk-SCs): An Achievement of Significant Morphological, Numerical and Functional Recovery
PLoS ONE, 2016;11(11):e0166639. 2016
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Ethanol extract of Lophatheri Herba exhibits anti-cancer activity in human cancer cells by suppression of metastatic and angiogenic potential
Sci Rep, 2016;6(0):36277. 2016
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Lysyl Oxidase (LOX) transcriptionally regulates SNAI2 expression and TIMP4 secretion in human cancers
Authors: M Boufraqech, L Zhang, N Nilubol, SM Sadowski, S Kotian, MM Quezado, E Kebebew
Clin Cancer Res, 2016;0(0):. 2016
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Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia
Authors: Y Deng, Z Yang, T Terry, S Pan, DG Woodside, J Wang, K Ruan, JT Willerson, RA Dixon, Q Liu
Nat Commun, 2016;7(0):11276. 2016
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RECK controls breast cancer metastasis by modulating a convergent, STAT3-dependent neoangiogenic switch.
Authors: Walsh, L A, Roy, D M, Reyngold, M, Giri, D, Snyder, A, Turcan, S, Badwe, C R, Lyman, J, Bromberg, J, King, T A, Chan, T A
Oncogene, 2015;34(17):2189-203. 2015
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Inhibition of IGF-1-Mediated Cellular Migration and Invasion by Migracin A in Ovarian Clear Cell Carcinoma Cells.
Authors: Ukaji T, Lin Y, Banno K, Okada S, Umezawa K
PLoS ONE, 2015;10(9):e0137663. 2015
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Deficiency of endothelium-specific transcription factor Sox17 induces intracranial aneurysm.
Authors: Lee S, Kim I, Ahn J, Woo D, Kim S, Song S, Koh G, Kim H, Jeon B, Kim I
, 2015;0(0):. 2015
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Signaling via PI3K/FOXO1A pathway modulates formation and survival of human embryonic stem cell-derived endothelial cells.
Authors: Merkely B, Gara E, Lendvai Z, Skopal J, Leja T, Zhou W, Kosztin A, Varady G, Mioulane M, Bagyura Z, Nemeth T, Harding S, Foldes G
Stem Cells Dev, 2015;24(7):869-78. 2015
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Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.
Authors: Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, Kim Y, Adam J, Lichter P, Solary E, Berchem G, Moussay E
Blood, 2015;126(9):1106-17. 2015
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Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.
Authors: Chung S, Dwabe S, Elshimali Y, Sukhija H, Aroh C, Vadgama J
PLoS ONE, 2015;10(8):e0134948. 2015
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Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?
Authors: Spampinato S, Obermeier B, Cotleur A, Love A, Takeshita Y, Sano Y, Kanda T, Ransohoff R
PLoS ONE, 2015;10(7):e0133392. 2015
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Intratumoral CD14+ Cells and Circulating CD14+HLA-DRlo/neg Monocytes Correlate with Decreased Survival in Patients with Clear Cell Renal Cell Carcinoma.
Authors: Gustafson M, Lin Y, Bleeker J, Warad D, Tollefson M, Crispen P, Bulur P, Harrington S, Laborde R, Gastineau D, Leibovich B, Cheville J, Kwon E, Dietz A
Clin Cancer Res, 2015;21(18):4224-33. 2015
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CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.
Authors: Mazumdar, Sohini, Arendt, Lisa M, Phillips, Sarah, Sedic, Maja, Kuperwasser, Charlott, Gill, Grace
PLoS ONE, 2015;10(3):e0121281. 2015
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Sourcing of an alternative pericyte-like cell type from peripheral blood in clinically relevant numbers for therapeutic angiogenic applications.
Authors: Blocki A, Wang Y, Koch M, Goralczyk A, Beyer S, Agarwal N, Lee M, Moonshi S, Dewavrin J, Peh P, Schwarz H, Bhakoo K, Raghunath M
Mol Ther, 2015;23(3):510-22. 2015
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PTEN expression is involved in the invasive properties of HNSCC: a key protein to consider in locoregional recurrence.
Authors: Mriouah J, Boura C, Gargouri M, Plenat F, Faivre B
Int J Oncol, 2014;44(3):709-16. 2014
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Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent paracrine pathway.
Authors: Kryza T, Achard C, Parent C, Marchand-Adam S, Guillon-Munos A, Iochmann S, Korkmaz B, Respaud R, Courty Y, Heuze-Vourc'h N
FASEB J, 2014;28(2):740-51. 2014
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Lysophosphatidic acid enhanced the angiogenic capability of human chondrocytes by regulating Gi/NF-kB-dependent angiogenic factor expression.
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PLoS ONE, 2014;9(5):e95180. 2014
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Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
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Circulation, 2014;129(17):1770-80. 2014
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Lymphatic endothelial cells support tumor growth in breast cancer.
Authors: Lee, Esak, Pandey, Niranjan, Popel, Aleksand
Sci Rep, 2014;4(0):5853. 2014
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Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion in the Equine Model.
Authors: Bussche L, Van de Walle G
Stem Cells Transl Med, 2014;3(12):1514-25. 2014
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Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
Authors: Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A
Nat Commun, 2014;5(0):4715. 2014
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Ionizing radiation induces tumor cell lysyl oxidase secretion.
Authors: Shen C, Sharma A, Vuong D, Erler J, Pruschy M, Broggini-Tenzer A
BMC Cancer, 2014;14(0):532. 2014
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Mesenchymal stromal cells: inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potential.
Authors: Ball S, Worthington J, Canfield A, Merry C, Kielty C
Stem Cells, 2014;32(3):694-705. 2014
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Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors.
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J Cell Sci, 2014;127(0):3983-97. 2014
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Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin.
Authors: Hutzen, Brian, Bid, Hemant K, Houghton, Peter J, Pierson, Christop, Powell, Kimerly, Bratasz, Anna, Raffel, Corey, Studebaker, Adam W
BMC Cancer, 2014;14(0):206. 2014
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Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis.
Authors: Eom S, Kim Y, Park D, Lee H, Lee Y, Choe J, Kim Y, Jeoung D
J Biol Chem, 2014;289(17):12126-44. 2014
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Surgical sutures filled with adipose-derived stem cells promote wound healing.
Authors: Reckhenrich A, Kirsch B, Wahl E, Schenck T, Rezaeian F, Harder Y, Foehr P, Machens H, Egana J
PLoS ONE, 2014;9(3):e91169. 2014
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Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFbeta signaling.
Authors: Santhekadur P, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson C, Mukhopadhyay N, Fisher P, Sarkar D
FEBS Open Bio, 2014;4(0):353-61. 2014
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Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells.
Authors: Ruma I, Putranto E, Kondo E, Watanabe R, Saito K, Inoue Y, Yamamoto K, Nakata S, Kaihata M, Murata H, Sakaguchi M
Int J Oncol, 2014;45(1):209-18. 2014
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Ultraviolet B preconditioning enhances the hair growth-promoting effects of adipose-derived stem cells via generation of reactive oxygen species.
Stem Cells Dev, 2013;22(1):158-68. 2013
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Fibroblasts derived from human pluripotent stem cells activate angiogenic responses in vitro and in vivo.
Authors: Shamis Y, Silva E, Hewitt K, Brudno Y, Levenberg S, Mooney D, Garlick J
PLoS ONE, 2013;8(12):e83755. 2013
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A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
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J Biol Chem, 2013;288(52):37355-64. 2013
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A novel serum protein signature associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in head and neck squamous cell carcinoma.
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Eur J Cancer, 2013;49(0):2512-21. 2013
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Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone.
Cytokine, 2013;61(1):285-96. 2013
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Functional and molecular characterization of ex vivo cultured epiretinal membrane cells from human proliferative diabetic retinopathy.
Authors: Vereb Z, Lumi X, Andjelic S, Globocnik-Petrovic M, Urbancic M, Hawlina M, Facsko A, Petrovski G
Biomed Res Int, 2013;2013(0):492376. 2013
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Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.
Authors: Porter, Donald C, Farmaki, Elena, Altilia, Serena, Schools, Gary P, West, Deborah, Chen, Mengqian, Chang, Bey-Dih, Puzyrev, Anatoliy, Lim, Chang-uk, Rokow-Kittell, Rebecca, Friedhoff, Lawrence, Papavassiliou, Athanasi, Kalurupalle, Swathi, Hurteau, Gregory, Shi, Jun, Baran, Phil S, Gyorffy, Balazs, Wentland, Mark P, Broude, Eugenia, Kiaris, Hippokra, Roninson, Igor B
Proc Natl Acad Sci U S A, 2012;109(34):13799-804. 2012
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Tumor-initiating cells of various tumor types exhibit differential angiogenic properties and react differently to antiangiogenic drugs.
Authors: Benayoun L, Gingis-Velitski S, Voloshin T, Segal E, Segev R, Munster M, Bril R, Satchi-Fainaro R, Scherer S, Shaked Y
Stem Cells, 2012;30(9):1831-41. 2012
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Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.
Authors: Sceneay J, Chow M, Chen A, Halse H, Wong C, Andrews D, Sloan E, Parker B, Bowtell D, Smyth M, Moller A
Cancer Res, 2012;72(16):3906-11. 2012
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Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin alphavbeta5-induced secretion of VEGF-A.
Am. J. Pathol., 2012;181(2):693-705. 2012
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Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221.
Authors: Santhekadur PK, Das SK, Gredler R, Chen D, Srivastava J, Robertson C, Baldwin AS, Fisher PB, Sarkar D
J. Biol. Chem., 2012;287(17):13952-8. 2012
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Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
EMBO J., 2012;31(17):3513-23. 2012
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Differentiation state determines neural effects on microvascular endothelial cells.
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Exp Cell Res, 2012;318(16):2085-93. 2012
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Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behavior.
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Oncogene, 2012;31(24):2919-30. 2012
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Met Receptor Tyrosine Kinase Signaling Induces Secretion of the Angiogenic Chemokine Interleukin-8/CXCL8 in Pancreatic Cancer.
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PLoS ONE, 2012;7(7):e40420. 2012
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The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells.
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Diabetologia, 2012;55(5):1514-25. 2012
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Age-related changes in expression and function of Toll-like receptors in human skin.
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Development, 2012;139(22):4210-9. 2012
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Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9).
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J. Biol. Chem., 2012;287(5):3425-32. 2012
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Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis.
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Oncogene, 2011;30(5):548-60. 2011
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Human amniotic fluid-derived mesenchymal stem cells as therapeutic vehicles: a novel approach for the treatment of bladder cancer.
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Stem Cells Dev., 2011;21(7):1097-111. 2011
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Protein profiling of angiogenesis-related growth factors in laryngeal carcinoma: Pattern of protein expression in relation to tumour progression.
Authors: Korampalli TS, Green VL, Greenman J
Int. J. Oncol., 2011;39(4):1033-9. 2011
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LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma.
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Oncogene, 2011;30(15):1753-63. 2011
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Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms.
Authors: Kachgal S, Putnam AJ
Angiogenesis, 2011;14(1):47-59. 2011
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Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion.
Authors: Miyanishi N, Suzuki Y, Simizu S, Kuwabara Y, Banno K, Umezawa K
Biochem. Biophys. Res. Commun., 2010;403(1):154-9. 2010
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Syndecan-1 knock-down in decidualized human endometrial stromal cells leads to significant changes in cytokine and angiogenic factor expression patterns.
Authors: Baston-Bust DM, Gotte M, Janni W, Krussel JS, Hess AP
Reprod. Biol. Endocrinol., 2010;8(0):133. 2010
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p53-mediated inhibition of angiogenesis in diffuse low-grade astrocytomas.
Authors: Gaiser T, Becker MR, Meyer J
Neurochem. Int., 2009;54(7):458-63. 2009
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MBP-1 inhibits breast cancer growth and metastasis in immunocompetent mice.
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Cancer Res., 2009;69(0):9354-9. 2009
FAQs
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Will the Array identification number stamped on the Array membrane interfere with detection if it is not cut-off before the membrane is blocked?
The dye used for printing the Array identification number on the membranes will fluoresce and interfere with the LI-COR detection. It is critical that the number is cut off before beginning the experiment.
Reviews for Proteome Profiler Human Angiogenesis Array Kit
Average Rating: 4.9 (Based on 8 Reviews)
Have you used Proteome Profiler Human Angiogenesis Array Kit?
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Worked well to look at THP-1 angiogenesis factors.
It worked well in cell culture supernatants using 125 ug of total protein per membrane.
Used it on Conditioned medium collected from Breast Cancer Cells treated with Angiotensin II to look into its effect on Angiogenesis. Angiogenesis array worked really well and very easy to use. It provided some new promising gene targets which we did not know before.
Human Angiogenesis Antibody Array was used to evaluate mesenchymal stem cells secretion profiles when seeded in various extracellular matrices. Great tool that ganarates lots of data!