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Proteome Profiler Human Angiogenesis Array Kit

ARY007 110 Citations 8 Reviews Datasheet / COA / SDS
Contains 4 membranes - each spotted in duplicate with 55 different angiogenesis antibodies
Catalog # Availability Size / Price Qty
ARY007
Profiling Angiogenesis-Related Proteins in Human Cancer Tissues.
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Proteome Profiler Human Angiogenesis Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of selected angiogenesis-related proteins. Validated for analyte detection in cell culture supernates, cell lysates, tissue lysates, serum, plasma and saliva.

Troubleshooting Guide

Key Benefits

  • Detects 55 human angiogenesis-related proteins simultaneously
  • Requires no specialized equipment
  • Compatible with LI-COR and chemiluminescence detection

Principle of the Assay

The Proteome Profiler Human Angiogenesis Array Kit is a membrane-based sandwich immunoassay. Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2). Captured proteins are visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of bound analyte. Analytes include soluble growth and differentiation factors, extracellular matrix components, proteases, membrane-bound receptors, and intracellular signaling molecules.

Why Use an Antibody Array to Detect Angiogenesis-Related Proteins?

Determining the expression of multiple proteins in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple proteins in a single sample can be cost-effective and also save time and sample.

 

 

Kit Contents
  • 4 Array Membranes
  • 4-Well Multi-dish
  • Array Buffers
  • Wash Buffer
  • Antibody Detection Cocktail
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed Protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.

 
Simultaneously detect the relative levels of these angiogenesis-related proteins in a single sample.
Activin A FGF-7/KGF PD-ECGF
ADAMTS-1 GDNF PDGF-AA
Angiogenin GM-CSF PDGF-AB/PDGF-BB
Angiopoietin-1 HB-EGF Persephin
Angiopoietin-2 HGF CXCL4/PF4
Angiostatin/Plasminogen IGFBP-1 PlGF
Amphiregulin IGFBP-2 Prolactin
Artemin IGFBP-3 Serpin B5/Maspin
Tissue Factor/Factor III IL-1 beta Serpin E1/PAI-1
CXCL16 CXCL8/IL-8 Serpin F1/PEDF
DPPIV/CD26 LAP (TGF-beta 1) TIMP-1
EGF Leptin TIMP-4
EG-VEGF CCL2/MCP-1 Thrombospondin-1
Endoglin/CD105 CCL3/MIP-1 alpha Thrombospondin-2
Endostatin/Collagen XVIII MMP-8 uPA
Endothelin-1 MMP-9 Vasohibin
FGF acidic NRG1-beta 1 VEGF
FGF basic Pentraxin 3 VEGF-C
FGF-4    

 

Assays for analytes represented in the Human Angiogenesis Antibody Array Kit

  Quantikine® ELISA Kits DuoSet® ELISA Development Systems Quantikine® HS (High Sensitivity) ELISA Kits QuantiGlo® Chemiluminescent ELISA Kits
Activin A DAC00B DY338    
ADAMTS-1   DY2197    
Angiogenin DAN00 DY265    
Angiopoietin-1 DANG10 DY923    
Angiopoietin-2 DANG20 DY623    
Angiostatin/Plasminogen        
Amphiregulin   DY262    
Artemin   DY2589    
Tissue Factor/Factor III DCF300 DY2339    
CXCL16 DCX160 DY1164    
DPPIV/CD26   DY1180    
EGF DEG00 DY236    
EG-VEGF   DY1209    
Endoglin DNDG00 DY1097    
Endostatin/Collagen XVII DNST0 DY1098    
Endothelin-1 DET100     QET00B
FGF acidic DFA00B DY232    
FGF basic DFB50 DY233 HSFB00D  
FGF-4   DY235    
FGF-7/KGF DKG00 DY251    
GDNF   DY212    
GM-CSF DGM00 DY215 HSGM0  
HB-EGF   DY259    
HGF DHG00 DY294    
IGFBP-1   DY871    
IGFBP-2 DGB200 DY674    
IGFBP-3 DGB300 DY675    
IL-1 beta DLB50 DY201 HSLB00D QLB00B
CXCL8/IL-8 D8000C DY208 HS800 Q8000B
TGF-beta1 (LAP) DB100B DY240    
Leptin DLP00 DY398    
CCL2/MCP-1 DCP00 DY279    
CCL3/MIP-1 alpha DMA00 DY270    
MMP-8 DMP800 DY908    
MMP-9 DMP900 DY911    
NRG1-beta1   DY377    
Pentraxin 3 DPTX30 DY1826    
PD-ECGF        
PDGF-AA DAA00B DY221    
PDGF-AB/PDGF-BB DHD00C, DBB00 DY222, DY220    
Persephin        
CXCL4/PF4   DY795    
PlGF DPG00 DY264    
Prolactin DPRL00 DY682    
Serpin B5/Maspin        
Serpin E1/PAI-1 DSE100 DY1786    
Serpin F1/PEDF        
TIMP-1 DTM100 DY970    
TIMP-4 DTM400 DY974    
Thrombospondin-1 DTSP10 DY3074    
Thrombospondin-2 DTSP20 DY1635    
uPA DUPA00 DY1310    
Vasohibin        
VEGF DVE00 DY293B   QVE00B
VEGF-C DVEC00 DY752B    

Angiogenesis is the tightly regulated process by which new blood vessels are formed from the existing vasculature. This process is physiologically important for development and wound healing, and is also a common driver in multiple diseases including rheumatoid arthritis, atherosclerosis, macular degeneration, and cancer. Angiogenesis occurs in response to a variety of molecular cues. Generally, the angiogenic process includes endothelial cell proliferation, chemotactic endothelial cell migration through the extracellular matrix barrier, and the formation of capillary tubes. Physiological and pathological angiogenesis utilize many of the same cellular processes and molecular signaling networks, however the structures that form during pathological angiogenesis are often functionally abnormal.

Specifications

Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

Product Datasheets

Product Datasheet
COA
SDS

Data Example

Profiling Angiogenesis-Related Proteins in Human Cancer Tissues. View Larger

Profiling Angiogenesis-Related Proteins in Human Cancer Tissues. A) The Proteome Profiler Human Angiogenesis Antibody Array (Catalog # ARY007) was used to profile angiogenesis-related proteins in tissues from human prostate, ovarian, and breast cancers. B) Histogram profiles for select analytes were generated by quantifying the mean spot pixel densities from the array membrane using image software.

The Human Angiogenesis Array detects multiple analytes in cell culture supernates. View Larger

The Human Angiogenesis Array detects multiple analytes in cell culture supernates. A. THP-1 human acute monocytic leukemia cell line treated with 1 µg/mL Recombinant Human IFN-gamma (Catalog # 285-IF) for 8 hours and 1 µg/mL lipopolysaccharide (LPS) for 16 hours. B. HUVEC human umbilical vein endothelial cells treated with 10 mg/ml of LPS for 24 hours. 500 µL of supernate was used for each array shown. Array images were collected and analyzed using the LI-COR Odyssey Infrared Imaging System.

The Human Angiogenesis Array detects multiple analytes in tissue lysate, serum, and plasma. View Larger

The Human Angiogenesis Array detects multiple analytes in tissue lysate, serum, and plasma. Representative membranes and selective quantification are shown for human ovarian cancer tissue lysate (A., 200 µg), serum (B., 100 µL), and EDTA plasma (C., 100 µL). Array images were collected and analyzed using the LI-COR Odyssey Infrared Imaging System.

Reagents Provided

Citations for Proteome Profiler Human Angiogenesis Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

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  1. Human Peripheral Blood-Derived Endothelial Colony-Forming Cells Are Highly Similar to Mature Vascular Endothelial Cells yet Demonstrate a Transitional Transcriptomic Signature
    Authors: AG Kutikhin, AE Tupikin, VG Matveeva, DK Shishkova, LV Antonova, MR Kabilov, EA Velikanova
    Cells, 2020;9(4):.  2020
  2. Resveratrol Promotes Tumor Microvessel Growth via Endoglin and Extracellular Signal-Regulated Kinase Signaling Pathway and Enhances the Anticancer Efficacy of Gemcitabine against Lung Cancer
    Authors: SH Qin, ATY Lau, ZL Liang, HW Tan, YC Ji, QH Zhong, XY Zhao, YM Xu
    Cancers (Basel), 2020;12(4):.  2020
  3. Natural Histogel-Based Bio-Scaffolds for Sustaining Angiogenesis in Beige Adipose Tissue
    Authors: M Di Somma, W Schaafsma, E Grillo, M Vliora, E Dakou, M Corsini, C Ravelli, R Ronca, P Sakellario, J Vanparijs, B Castro, S Mitola
    Cells, 2019;8(11):.  2019
  4. Thrombin Preconditioning of Extracellular Vesicles Derived from Mesenchymal Stem Cells Accelerates Cutaneous Wound Healing by Boosting Their Biogenesis and Enriching Cargo Content
    Authors: DK Sung, YS Chang, SI Sung, SY Ahn, WS Park
    J Clin Med, 2019;8(4):.  2019
  5. Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts
    Authors: EE Hedlund, PC McDonald, O Nemirovsky, S Awrey, LDE Jensen, S Dedhar
    Cancers (Basel), 2019;11(7):.  2019
  6. Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
    Authors: T Matsui, T Chiyo, H Kobara, S Fujihara, K Fujita, D Namima, M Nakahara, N Kobayashi, N Nishiyama, T Yachida, A Morishita, H Iwama, T Masaki
    Int J Mol Sci, 2019;20(13):.  2019
  7. TGFBI Protein Is Increased in the Urine of Patients with High-Grade Urothelial Carcinomas, and Promotes Cell Proliferation and Migration
    Authors: K Lang, S Kahveci, N Bonberg, K Wichert, T Behrens, J Hovanec, F Roghmann, J Noldus, YC Tam, A Tannapfel, HU Käfferlein, T Brüning
    Int J Mol Sci, 2019;20(18):.  2019
  8. Homotypic and Heterotypic Activation of the Notch Pathway in Multiple Myeloma-Enhanced Angiogenesis: A Novel Therapeutic Target?
    Authors: I Saltarella, MA Frassanito, A Lamanuzzi, A Brevi, P Leone, V Desantis, L Di Marzo, M Bellone, D Derudas, D Ribatti, R Chiaramont, MT Palano, A Neri, MA Mariggiò, R Fumarulo, F Dammacco, V Racanelli, A Vacca, R Ria
    Neoplasia, 2019;21(1):93-105.  2019
  9. The Composition of Hyperacute Serum and Platelet-Rich Plasma Is Markedly Different despite the Similar Production Method
    Authors: D Kardos, M Simon, G Vácz, A Hinsenkamp, T Holczer, D Cseh, A Sárközi, K Szenthe, F Bánáti, S Szathmary, S Nehrer, O Kuten, M Masteling, Z Lacza, I Hornyák
    Int J Mol Sci, 2019;20(3):.  2019
  10. Characterization of the Angiogenic Potential of Human Regulatory Macrophages (Mreg) after Ischemia/Reperfusion Injury In Vitro
    Authors: L Hummitzsch, K Zitta, R Rusch, J Cremer, M Steinfath, J Gross, F Fandrich, R Berndt, M Albrecht
    Stem Cells Int, 2019;2019(0):3725863.  2019
  11. Impaired Regeneration Potential in Urinary Stem Cells Diagnosed from the Patients with Diabetic Nephropathy
    Authors: G Xiong, W Tang, D Zhang, D He, G Wei, A Atala, XJ Liang, AJ Bleyer, ME Bleyer, J Yu, JA Aloi, JX Ma, CM Furdui, Y Zhang
    Theranostics, 2019;9(14):4221-4232.  2019
  12. The efficacy of conditioned medium released by tonsil-derived mesenchymal stem cells in a chronic murine colitis model
    Authors: KE Lee, SA Jung, YH Joo, EM Song, CM Moon, SE Kim, I Jo
    PLoS ONE, 2019;14(12):e0225739.  2019
  13. Hematoma-derived exosomes of chronic subdural hematoma promote abnormal angiogenesis and inhibit hematoma absorption through miR-144-5p
    Authors: C Gao, Z Gong, D Wang, J Huang, Y Qian, M Nie, W Jiang, X Liu, H Luo, J Yuan, T Xiang, S An, W Quan, H Wei, J Zhang, R Jiang
    Aging (Albany NY), 2019;11(24):12147-12164.  2019
  14. B-Cell Activating Factor Enhances Hepatocyte-Driven Angiogenesis via B-Cell CLL/Lymphoma 10/Nuclear Factor-KappaB Signaling during Liver Regeneration
    Authors: CH Chou, CM Ho, SL Lai, CN Chen, YM Wu, CT Shun, WF Wen, HS Lai
    Int J Mol Sci, 2019;20(20):.  2019
  15. Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures
    Authors: J Kelleher, A Dickinson, S Cain, Y Hu, N Bates, A Harvey, J Ren, W Zhang, FC Moreton, KW Muir, C Ward, RM Touyz, P Sharma, Q Xu, SJ Kimber, T Wang
    Stem Cell Reports, 2019;13(5):817-831.  2019
  16. Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin� protein MP0250: a preclinical study
    Authors: L Rao, K De Veirman, D Giannico, I Saltarella, V Desantis, MA Frassanito, AG Solimando, D Ribatti, M Prete, A Harstrick, U Fiedler, H De Raeve, V Racanelli, K Vanderkerk, A Vacca
    Oncotarget, 2018;9(17):13366-13381.  2018
  17. Mitochondrial dysfunction is a key determinant of the rare disease lymphangioleiomyomatosis and provides a novel therapeutic target
    Authors: EMM Abdelwahab, S Pal, K Kvell, V Sarosi, P Bai, R Rue, V Krymskaya, D McPhail, A Porter, JE Pongracz
    Oncogene, 2018;0(0):.  2018
  18. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells
    Authors: A Kim, JY Ma
    Front Pharmacol, 2018;9(0):1455.  2018
  19. Protein array profiling of circulating angiogenesis-related factors during bevacizumab containing treatment in metastatic colorectal cancer
    Authors: H Hagman, PO Bendahl, J Lidfeldt, M Belting, A Johnsson
    PLoS ONE, 2018;13(12):e0209838.  2018
  20. Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells
    Authors: CM Galmarini, M Martin, BP Bouchet, MJ Guillen-Na, M Martínez-D, JF Martinez-L, A Akhmanova, P Aviles
    BMC Cancer, 2018;18(1):164.  2018
  21. A Subset of Paracrine Factors as Efficient Biomarkers for Predicting Vascular Regenerative Efficacy of Mesenchymal Stromal/Stem Cells
    Authors: HK Kim, SG Lee, SW Lee, BJ Oh, JH Kim, JA Kim, G Lee, JD Jang, YA Joe
    Stem Cells, 2018;0(0):.  2018
  22. Multipotent Adult Progenitor Cells Support Lymphatic Regeneration at Multiple Anatomical Levels during Wound Healing and Lymphedema
    Authors: M Beerens, XL Aranguren, B Hendrickx, W Dheedene, T Dresselaer, U Himmelreic, C Verfaillie, A Luttun
    Sci Rep, 2018;8(1):3852.  2018
  23. Increased platelet factor 4 and aberrant permeability of follicular fluid in PCOS
    Authors: CC Huang, CH Chou, SU Chen, HN Ho, YS Yang, MJ Chen
    J. Formos. Med. Assoc., 2018;0(0):.  2018
  24. Nintedanib inhibits growth of human prostate carcinoma cells by modulating both cell cycle and angiogenesis regulators
    Authors: RF da Silva, D Dhar, K Raina, D Kumar, R Kant, VHA Cagnon, C Agarwal, R Agarwal
    Sci Rep, 2018;8(1):9540.  2018
  25. hiPSC-derived neural stem cells from patients with schizophrenia induce an impaired angiogenesis
    Authors: BS Casas, G Vitória, MN do Costa, R Madeiro da, P Trindade, R Maciel, N Navarrete, SK Rehen, V Palma
    Transl Psychiatry, 2018;8(1):48.  2018
  26. Human dental pulp stromal cell conditioned medium alters endothelial cell behavior
    Authors: MA Gharaei, Y Xue, K Mustafa, SA Lie, I Fristad
    Stem Cell Res Ther, 2018;9(1):69.  2018
  27. Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer
    Authors: SL Lin, SM Wu, IH Chung, YH Lin, CY Chen, HC Chi, TK Lin, CT Yeh, KH Lin
    Neoplasia, 2018;20(1):57-68.  2018
  28. Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions
    Authors: JUG Wagner, E Chavakis, EM Rogg, M Muhly-Rein, SF Glaser, S Günther, D John, F Bonini, AM Zeiher, L Schaefer, MJ Hannocks, RA Boon, S Dimmeler
    Arterioscler. Thromb. Vasc. Biol., 2018;0(0):.  2018
  29. Extracellular Matrix composition modulates PDAC parenchymal and stem cell plasticity and behavior through the secretome
    Authors: G Biondani, K Zeeberg, MR Greco, S Cannone, I Dando, ED Pozza, M Mastrodona, S Forciniti, V Casavola, M Palmieri, SJ Reshkin, RA Cardone
    FEBS J., 2018;0(0):.  2018
  30. Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379
    Authors: KP O'Brien, S Khan, KE Gilligan, H Zafar, P Lalor, C Glynn, C O'Flathart, H Ingoldsby, P Dockery, A De Bhulbh, JR Schweber, K St John, M Leahy, JM Murphy, WM Gallagher, T O'Brien, MJ Kerin, RM Dwyer
    Oncogene, 2018;0(0):.  2018
  31. Intranasal delivery of VEGF enhances compensatory lung growth in mice
    Authors: DT Dao, JT Vuong, L Anez-Busti, A Pan, PD Mitchell, GL Fell, MA Baker, DR Bielenberg, M Puder
    PLoS ONE, 2018;13(6):e0198700.  2018
  32. SCO-spondin oligopeptide inhibits angiogenesis in glioblastoma
    Authors: R Bibes, S Gobron, F Vincent, C Mélin, N Vedrenne, A Perraud, F Labrousse, MO Jauberteau, F Lalloué
    Oncotarget, 2017;8(49):85969-85983.  2017
  33. Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism
    Authors: R El Bezawy, M De Cesare, M Pennati, M Deraco, P Gandellini, V Zuco, N Zaffaroni
    J Hematol Oncol, 2017;10(1):19.  2017
  34. Human adipose-derived mesenchymal stem cell-secreted CXCL1 and CXCL8 facilitate breast tumor growth by promoting angiogenesis
    Authors: Y Wang, J Liu, Q Jiang, J Deng, F Xu, X Chen, F Cheng, Y Zhang, Y Yao, Z Xia, X Xu, X Su, M Huang, L Dai, Y Yang, S Zhang, D Yu, RC Zhao, Y Wei, H Deng
    Stem Cells, 2017;0(0):.  2017
  35. Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway
    Authors: G Jin, Y Yang, K Liu, J Zhao, X Chen, H Liu, R Bai, X Li, Y Jiang, X Zhang, J Lu, Z Dong
    Oncogenesis, 2017;6(10):e384.  2017
  36. Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival
    Authors: RJ Chen, CT Shun, ML Yen, CH Chou, MC Lin
    Oncotarget, 2017;8(37):62081-62098.  2017
  37. Adipose progenitor cell secretion of GM-CSF and MMP9 promotes a stromal and immunological microenvironment that supports breast cancer progression
    Authors: F Reggiani, V Labanca, P Mancuso, C Rabascio, G Talarico, S Orecchioni, A Manconi, F Bertolini
    Cancer Res., 2017;0(0):.  2017
  38. Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet-Derived Growth Factor on Human Retinal Ganglion Cells
    Authors: A Osborne, J Sanderson, KR Martin
    Stem Cells, 2017;0(0):.  2017
  39. Sonic hedgehog (SHH) signaling improves the angiogenic potential of Wharton's jelly-derived mesenchymal stem cells�(WJ-MSC)
    Authors: G Zavala, CP Prieto, AA Villanueva, V Palma
    Stem Cell Res Ther, 2017;8(1):203.  2017
  40. NF-?B Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance
    Authors: S Yang, L Qiang, A Sample, P Shah, YY He
    J. Biol. Chem., 2017;292(8):3379-3388.  2017
  41. Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells
    Authors: A Gabrielyan, E Neumann, M Gelinsky, A Rösen-Wolf
    Stem Cell Res Ther, 2017;8(1):212.  2017
  42. CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect
    Authors: S Sakimoto, V Marchetti, E Aguilar, K Lee, Y Usui, S Murinello, F Bucher, JK Trombley, R Fallon, R Wagey, C Peters, EL Scheppke, PD Westenskow, M Friedlande
    JCI Insight, 2017;2(2):e89906.  2017
  43. Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo
    Authors: HR Jung, HM Kang, JW Ryu, DS Kim, KH Noh, ES Kim, HJ Lee, KS Chung, HS Cho, NS Kim, DS Im, JH Lim, CR Jung
    Sci Rep, 2017;7(1):10499.  2017
  44. 15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1
    Authors: S Tunçer, AG Ke?kü?, M Çolako?lu, I Çimen, C Yener, Ö Konu, S Banerjee
    Cell. Signal., 2017;39(0):44-54.  2017
  45. Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide
    Authors: SS Kim, JB Harford, M Moghe, A Rait, KF Pirollo, EH Chang
    Nucleic Acids Res., 2017;0(0):.  2017
  46. Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
    Authors: L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He
    Autophagy, 2017;0(0):0.  2017
  47. VLDL and LDL, but not HDL, promote breast cancer cell proliferation, metastasis and angiogenesis
    Authors: Chun-Wun Lu
    Cancer Lett, 2016;388(0):130-138.  2016
  48. Identification of neuronal and angiogenic growth factors in an in vitroblood-brain barrier model system: Relevance in barrier integrity and tight junction formation and complexity
    Authors: Christian Freese
    Microvasc. Res, 2016;0(0):.  2016
  49. Synergic effects of VEGF-A and SDF-1 on the angiogenic properties of endothelial progenitor cells
    Authors: Gabriela Odent Grig
    J Tissue Eng Regen Med, 2016;0(0):.  2016
  50. Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment
    PLoS ONE, 2016;11(7):e0159013.  2016
  51. The Development of an Angiogenic Protein Signature in Ovarian Cancer Ascites as a Tool for Biologic and Prognostic Profiling
    Authors: Sofia-Paraskevi Trachana
    PLoS ONE, 2016;11(6):e0156403.  2016
  52. IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma
    Authors: Matthew N Svalina
    Sci Rep, 2016;6(0):27012.  2016
  53. The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts
    Sci Rep, 2016;6(0):39460.  2016
  54. Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor
    Stem Cell Res Ther, 2016;7(1):173.  2016
  55. A Long-Gap Peripheral Nerve Injury Therapy Using Human Skeletal Muscle-Derived Stem Cells (Sk-SCs): An Achievement of Significant Morphological, Numerical and Functional Recovery
    PLoS ONE, 2016;11(11):e0166639.  2016
  56. Ethanol extract of Lophatheri Herba exhibits anti-cancer activity in human cancer cells by suppression of metastatic and angiogenic potential
    Sci Rep, 2016;6(0):36277.  2016
  57. Lysyl Oxidase (LOX) transcriptionally regulates SNAI2 expression and TIMP4 secretion in human cancers
    Authors: M Boufraqech, L Zhang, N Nilubol, SM Sadowski, S Kotian, MM Quezado, E Kebebew
    Clin Cancer Res, 2016;0(0):.  2016
  58. Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia
    Authors: Y Deng, Z Yang, T Terry, S Pan, DG Woodside, J Wang, K Ruan, JT Willerson, RA Dixon, Q Liu
    Nat Commun, 2016;7(0):11276.  2016
  59. RECK controls breast cancer metastasis by modulating a convergent, STAT3-dependent neoangiogenic switch.
    Authors: Walsh, L A, Roy, D M, Reyngold, M, Giri, D, Snyder, A, Turcan, S, Badwe, C R, Lyman, J, Bromberg, J, King, T A, Chan, T A
    Oncogene, 2015;34(17):2189-203.  2015
  60. Inhibition of IGF-1-Mediated Cellular Migration and Invasion by Migracin A in Ovarian Clear Cell Carcinoma Cells.
    Authors: Ukaji T, Lin Y, Banno K, Okada S, Umezawa K
    PLoS ONE, 2015;10(9):e0137663.  2015
  61. Deficiency of endothelium-specific transcription factor Sox17 induces intracranial aneurysm.
    Authors: Lee S, Kim I, Ahn J, Woo D, Kim S, Song S, Koh G, Kim H, Jeon B, Kim I
    , 2015;0(0):.  2015
  62. Signaling via PI3K/FOXO1A pathway modulates formation and survival of human embryonic stem cell-derived endothelial cells.
    Authors: Merkely B, Gara E, Lendvai Z, Skopal J, Leja T, Zhou W, Kosztin A, Varady G, Mioulane M, Bagyura Z, Nemeth T, Harding S, Foldes G
    Stem Cells Dev, 2015;24(7):869-78.  2015
  63. Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.
    Authors: Paggetti J, Haderk F, Seiffert M, Janji B, Distler U, Ammerlaan W, Kim Y, Adam J, Lichter P, Solary E, Berchem G, Moussay E
    Blood, 2015;126(9):1106-17.  2015
  64. Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.
    Authors: Chung S, Dwabe S, Elshimali Y, Sukhija H, Aroh C, Vadgama J
    PLoS ONE, 2015;10(8):e0134948.  2015
  65. Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?
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  66. Intratumoral CD14+ Cells and Circulating CD14+HLA-DRlo/neg Monocytes Correlate with Decreased Survival in Patients with Clear Cell Renal Cell Carcinoma.
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  68. Sourcing of an alternative pericyte-like cell type from peripheral blood in clinically relevant numbers for therapeutic angiogenic applications.
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  69. PTEN expression is involved in the invasive properties of HNSCC: a key protein to consider in locoregional recurrence.
    Authors: Mriouah J, Boura C, Gargouri M, Plenat F, Faivre B
    Int J Oncol, 2014;44(3):709-16.  2014
  70. Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent paracrine pathway.
    Authors: Kryza T, Achard C, Parent C, Marchand-Adam S, Guillon-Munos A, Iochmann S, Korkmaz B, Respaud R, Courty Y, Heuze-Vourc'h N
    FASEB J, 2014;28(2):740-51.  2014
  71. Lysophosphatidic acid enhanced the angiogenic capability of human chondrocytes by regulating Gi/NF-kB-dependent angiogenic factor expression.
    Authors: Chuang, Yi-Wen, Chang, Wen-Ming, Chen, Kai-Hua, Hong, Chang-Ze, Chang, Pey-Jium, Hsu, Hung-Chi
    PLoS ONE, 2014;9(5):e95180.  2014
  72. Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
    Authors: Wojciak-Stothard B, Abdul-Salam V, Lao K, Tsang H, Irwin D, Lisk C, Loomis Z, Stenmark K, Edwards J, Yuspa S, Howard L, Edwards R, Rhodes C, Gibbs J, Wharton J, Zhao L, Wilkins M
    Circulation, 2014;129(17):1770-80.  2014
  73. Lymphatic endothelial cells support tumor growth in breast cancer.
    Authors: Lee, Esak, Pandey, Niranjan, Popel, Aleksand
    Sci Rep, 2014;4(0):5853.  2014
  74. Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion in the Equine Model.
    Authors: Bussche L, Van de Walle G
    Stem Cells Transl Med, 2014;3(12):1514-25.  2014
  75. Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
    Authors: Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A
    Nat Commun, 2014;5(0):4715.  2014
  76. Ionizing radiation induces tumor cell lysyl oxidase secretion.
    Authors: Shen C, Sharma A, Vuong D, Erler J, Pruschy M, Broggini-Tenzer A
    BMC Cancer, 2014;14(0):532.  2014
  77. Mesenchymal stromal cells: inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potential.
    Authors: Ball S, Worthington J, Canfield A, Merry C, Kielty C
    Stem Cells, 2014;32(3):694-705.  2014
  78. Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors.
    Authors: Wilson C, Naves T, Vincent F, Melloni B, Bonnaud F, Lalloue F, Jauberteau M
    J Cell Sci, 2014;127(0):3983-97.  2014
  79. Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin.
    Authors: Hutzen, Brian, Bid, Hemant K, Houghton, Peter J, Pierson, Christop, Powell, Kimerly, Bratasz, Anna, Raffel, Corey, Studebaker, Adam W
    BMC Cancer, 2014;14(0):206.  2014
  80. Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis.
    Authors: Eom S, Kim Y, Park D, Lee H, Lee Y, Choe J, Kim Y, Jeoung D
    J Biol Chem, 2014;289(17):12126-44.  2014
  81. Surgical sutures filled with adipose-derived stem cells promote wound healing.
    Authors: Reckhenrich A, Kirsch B, Wahl E, Schenck T, Rezaeian F, Harder Y, Foehr P, Machens H, Egana J
    PLoS ONE, 2014;9(3):e91169.  2014
  82. Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFbeta signaling.
    Authors: Santhekadur P, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson C, Mukhopadhyay N, Fisher P, Sarkar D
    FEBS Open Bio, 2014;4(0):353-61.  2014
  83. Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells.
    Authors: Ruma I, Putranto E, Kondo E, Watanabe R, Saito K, Inoue Y, Yamamoto K, Nakata S, Kaihata M, Murata H, Sakaguchi M
    Int J Oncol, 2014;45(1):209-18.  2014
  84. Ultraviolet B preconditioning enhances the hair growth-promoting effects of adipose-derived stem cells via generation of reactive oxygen species.
    Stem Cells Dev, 2013;22(1):158-68.  2013
  85. Fibroblasts derived from human pluripotent stem cells activate angiogenic responses in vitro and in vivo.
    Authors: Shamis Y, Silva E, Hewitt K, Brudno Y, Levenberg S, Mooney D, Garlick J
    PLoS ONE, 2013;8(12):e83755.  2013
  86. A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
    Authors: Abuhusain, Hazem J, Matin, Azadeh, Qiao, Qiao, Shen, Han, Kain, Nupur, Day, Bryan W, Stringer, Brett W, Daniels, Benjamin, Laaksonen, Maarit A, Teo, Charlie, McDonald, Kerrie L, Don, Anthony
    J Biol Chem, 2013;288(52):37355-64.  2013
  87. A novel serum protein signature associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in head and neck squamous cell carcinoma.
    Authors: Box C, Mendiola M, Gowan S, Box G, Valenti M, Brandon A, Al-Lazikani B, Rogers S, Wilkins A, Harrington K, Eccles S
    Eur J Cancer, 2013;49(0):2512-21.  2013
  88. Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone.
    Cytokine, 2013;61(1):285-96.  2013
  89. Functional and molecular characterization of ex vivo cultured epiretinal membrane cells from human proliferative diabetic retinopathy.
    Authors: Vereb Z, Lumi X, Andjelic S, Globocnik-Petrovic M, Urbancic M, Hawlina M, Facsko A, Petrovski G
    Biomed Res Int, 2013;2013(0):492376.  2013
  90. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.
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    Proc Natl Acad Sci U S A, 2012;109(34):13799-804.  2012
  91. Tumor-initiating cells of various tumor types exhibit differential angiogenic properties and react differently to antiangiogenic drugs.
    Authors: Benayoun L, Gingis-Velitski S, Voloshin T, Segal E, Segev R, Munster M, Bril R, Satchi-Fainaro R, Scherer S, Shaked Y
    Stem Cells, 2012;30(9):1831-41.  2012
  92. Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.
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    Cancer Res, 2012;72(16):3906-11.  2012
  93. Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin alphavbeta5-induced secretion of VEGF-A.
    Am. J. Pathol., 2012;181(2):693-705.  2012
  94. Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221.
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    J. Biol. Chem., 2012;287(17):13952-8.  2012
  95. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
    EMBO J., 2012;31(17):3513-23.  2012
  96. Differentiation state determines neural effects on microvascular endothelial cells.
    Authors: Muffley L, Pan S, Smith A, Ga M, Hocking A, Gibran N
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  97. Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behavior.
    Authors: Heinke J, Kerber M, Rahner S
    Oncogene, 2012;31(24):2919-30.  2012
  98. Met Receptor Tyrosine Kinase Signaling Induces Secretion of the Angiogenic Chemokine Interleukin-8/CXCL8 in Pancreatic Cancer.
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    Angiogenesis, 2011;14(1):47-59.  2011
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FAQs

  1. Will the Array identification number stamped on the Array membrane interfere with detection if it is not cut-off before the membrane is blocked?

    • The dye used for printing the Array identification number on the membranes will fluoresce and interfere with the LI-COR detection. It is critical that the number is cut off before beginning the experiment. 

View all Proteome Profiler Antibody Array FAQs

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Reviews for Proteome Profiler Human Angiogenesis Array Kit

Average Rating: 4.9 (Based on 8 Reviews)

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Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 02/07/2019
Application:
Serum Proteome Profiler Human Angiogenesis Array Kit ARY007
Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 02/06/2019
Application:

Worked well to look at THP-1 angiogenesis factors.

Serum Proteome Profiler Human Angiogenesis Array Kit ARY007
Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 10/22/2018
Application:

It worked well in cell culture supernatants using 125 ug of total protein per membrane.

Serum Proteome Profiler Human Angiogenesis Array Kit ARY007
Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 08/08/2018
Application:
Serum Proteome Profiler Human Angiogenesis Array Kit ARY007
Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 05/17/2018
Application:

Used it on Conditioned medium collected from Breast Cancer Cells treated with Angiotensin II to look into its effect on Angiogenesis. Angiogenesis array worked really well and very easy to use. It provided some new promising gene targets which we did not know before.

Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 04/01/2018
Application:
Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 10/30/2017
Application:
Serum Proteome Profiler Human Angiogenesis Array Kit ARY007
Proteome Profiler Human Angiogenesis Array Kit
By Anonymous on 12/06/2016
Application:

Human Angiogenesis Antibody Array was used to evaluate mesenchymal stem cells secretion profiles when seeded in various extracellular matrices. Great tool that ganarates lots of data!